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Protein

Trinucleotide repeat-containing gene 18 protein

Gene

Tnrc18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 18 protein
Alternative name(s):
Zinc finger protein 469
Gene namesi
Name:Tnrc18
Synonyms:Kiaa1856, Zfp469
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3648294. Tnrc18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28782878Trinucleotide repeat-containing gene 18 proteinPRO_0000330826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991PhosphoserineCombined sources
Modified residuei540 – 5401PhosphoserineCombined sources
Modified residuei1053 – 10531PhosphoserineBy similarity
Modified residuei1062 – 10621PhosphoserineBy similarity
Modified residuei1469 – 14691PhosphoserineBy similarity
Modified residuei1789 – 17891PhosphoserineBy similarity
Modified residuei1795 – 17951PhosphoserineBy similarity
Modified residuei2077 – 20771PhosphothreonineBy similarity
Cross-linki2260 – 2260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei2681 – 26811PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ80WC3.
PaxDbiQ80WC3.
PeptideAtlasiQ80WC3.
PRIDEiQ80WC3.

PTM databases

iPTMnetiQ80WC3.
PhosphoSiteiQ80WC3.

Expressioni

Gene expression databases

BgeeiQ80WC3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040287.

Structurei

3D structure databases

ProteinModelPortaliQ80WC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2727 – 2872146BAHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1410 – 144233Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi257 – 436180Pro-richAdd
BLAST
Compositional biasi824 – 85835Gln-richAdd
BLAST
Compositional biasi918 – 1074157Pro-richAdd
BLAST
Compositional biasi1747 – 177428Glu-richAdd
BLAST
Compositional biasi2290 – 236980Pro-richAdd
BLAST
Compositional biasi2489 – 258799Ser-richAdd
BLAST
Compositional biasi2593 – 264149Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1886. Eukaryota.
ENOG410XQP1. LUCA.
HOGENOMiHOG000168449.
HOVERGENiHBG108592.
InParanoidiQ80WC3.
PhylomeDBiQ80WC3.

Family and domain databases

InterProiIPR001025. BAH_dom.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
[Graphical view]
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80WC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPS SGLPGPPPPG
60 70 80 90 100
KYMAGLNLHP HPGFSHLPSG LYPSYLHLNH LDPPSSGSPL LSQLGQPSIF
110 120 130 140 150
DTQKDGFYLP APGTLHAHTP SSRTPSGHSS GGPAKGSSRE GTGKDRAGRG
160 170 180 190 200
GDPPPLFGKK DPRAREEVSG PRGVVDLTQE ARAEGRQDRG SSRLAERLSP
210 220 230 240 250
FLAEVKAKGA LQPSALSLCN GVVDAGLVAE LGRGGAKEVA RQEENARLLR
260 270 280 290 300
RAEALLPAAR PCGSPLPPPP PLPPKGPPAP PSSTPAGVYT VFREPGREHR
310 320 330 340 350
VVAPTFVPSV EAFDERVGPI QIASQARDVR AREREPGRPG VLQGPPGSPR
360 370 380 390 400
LERPEVLREK SSVIRSLKRP PPSDGPPAAR SSRSSPDARA YLPPKELLKP
410 420 430 440 450
EADPRPCERA PRGPSASAAQ QAAKLFGLEP SRPPGPEHKW KPFELGNFAT
460 470 480 490 500
TQMAVLAAQH HHASRAEEEA AVATASKKAY LDPGGAMPRA SATCGRPGAD
510 520 530 540 550
LHSAAHGPGE ASAMQSLIKY SGSFAREAVA VRPGGCGKKS PFGGLGTMKP
560 570 580 590 600
EPTPTSAGPP RAQARLTHPG VPTAGGGRQL KRDPERPESA KAFGREGSGA
610 620 630 640 650
QGEAEVRHPP VGIAVAVARQ KDSGSSSRLG PGLGDQERTL SLNNVKGHGR
660 670 680 690 700
TDDECDRARH REDRLLGTRL DRDQEKLLRE SKELADLARL HPTSCAPNGL
710 720 730 740 750
NPNLMVTGGP TLAGSGRWSA DPAAHLATNP WLPRSGSTSM WLAGHPYGLG
760 770 780 790 800
PPSLHQGMAP AFPPGLGGSL PSAYQFVRDP QSGQLVVIPS DHLPHFAELM
810 820 830 840 850
ERAAVPPLWP ALYPPGRSPL HHAQQLQLFS QQHFLRQQEL LYLQQQAAQA
860 870 880 890 900
LELQRSAQLV ERLKAQEHRT EMEEKISKRS LETTGKAGLS AAGPGLLPRK
910 920 930 940 950
SAGLANGPAG SHGKAVSPPP SPRASPVTSL KAKVIQKVED VSKPPAYTYP
960 970 980 990 1000
ATPSSHPSSP PPASPPPTPG LTRKEEAPEN VVEKKDLELE KETPSPFQAL
1010 1020 1030 1040 1050
FTDIPPRYPF QALPPHYGRP YPFLLQPAAA SDADGLAPDV PLPADGPERL
1060 1070 1080 1090 1100
ALSPEDKPIC LSPSKIPEPP RDSPEEEQLA DREVKAEVED IEEGPTELPP
1110 1120 1130 1140 1150
LESPLALPVP ETMVAVSPAG GCGGSPLEAQ ALSTAGPGCR EPSEVSDFAQ
1160 1170 1180 1190 1200
VAEPQIELPS KTEHRMTALE LGTQLTPEPL VETKEEPVEV PLDVPMEEPT
1210 1220 1230 1240 1250
TEAGPEDSLP QPSLTEPQPS LELSDCDLPV PEGQCLNLEA QEAVPAPAST
1260 1270 1280 1290 1300
CYLEETHSES LLPGLDDPLA GMNALAAAAE LPQARPLPSL GPGVPAGEKL
1310 1320 1330 1340 1350
DTAPSLVLEH SFLQGITLLS EIAELELDRR GQEAADPEPN LVVRPSLESL
1360 1370 1380 1390 1400
LAASSHMLKE VLESPFSDPL KNLRLPRELN SNKKYSWMQK KEERMFAMKS
1410 1420 1430 1440 1450
SLEDMDALEL DFRMRLAEVQ RRYKEKQREL VKLQRRRDSG DRHEDAHRSL
1460 1470 1480 1490 1500
ARRGPGRPRK RTHTLSALSP PCKRKSHSSS GKGLSSKSLL TSDDYDLGAG
1510 1520 1530 1540 1550
IRKRHKGPEE EQEALMGMGK ARSRNQSWDD HDSSSDFMSQ LKIKKKKMAS
1560 1570 1580 1590 1600
DQEQLASKLD RALSLTKQDK LKSPFKFSDG PGGKPKTGGG CGRFLTQYDS
1610 1620 1630 1640 1650
LLGKDRKALA KGLGLSLKPS REGKHKRASK ARKMEGGFQA RGQPKSVHSP
1660 1670 1680 1690 1700
FASEVSSQSY NTDSDEDEDF LKNEWSAQGP SSSKLTSSLL CGMVPKNSKP
1710 1720 1730 1740 1750
ATGPKLTKRG LAGPRTLKPK VVTSRKQSFC LLLREAEARS SFSDSSEEDS
1760 1770 1780 1790 1800
FDQDDSSEEE EEELEEEEED EEEEGIGSYR LGAGEQALSP SLEESGLGLL
1810 1820 1830 1840 1850
ARFAASALPS PVVGPPLSVV QLEAEQKARK KEERQSLLGT EFEYTDSESE
1860 1870 1880 1890 1900
VKVPKQSAAG LLRTKKGVGE PGQSLAAPGP GSRASGPSSP DKAKLVSEKG
1910 1920 1930 1940 1950
RKARKIRGPK EPGFEAGPEA SDDDLWTRRR SERIFLHDAS AAVQATSNTA
1960 1970 1980 1990 2000
PATKPSRCGR GGAPSPRKDT GRAKDRKDPR KKKRGKEAGS AATLPPPRVS
2010 2020 2030 2040 2050
TLPDSRAPHP GALATAKRSK AKARGKEAKK ENRGKGGAVS KLMECMAAEE
2060 2070 2080 2090 2100
DFEANQDSSF SEDEHLPRGG ATERPLTPAP RSCIIDKEEL KDGLRVLIPL
2110 2120 2130 2140 2150
DDKLLYAGHV QTVHSPDIYR VVVEGERGNR PHIYCLEQLL QEAIIDVRPA
2160 2170 2180 2190 2200
STRFLPQGTR IAAYWSQQYR CLYPGTVVRG LLDLEDDGDL ITVEFDDGDT
2210 2220 2230 2240 2250
GRIPLSHIRL LPPDYKIQCA EPSPALLVPS AKRRSRKTSK DTGEVKEGAA
2260 2270 2280 2290 2300
TGPQEATGGK ARGRGRKPST KAKADRAVVL EEGAATNEVP SAPLALEPIS
2310 2320 2330 2340 2350
TPNSKKSTPE PVDKRARAPK ARSISAQPSP VPPTFSSCPA PEPFGELPTP
2360 2370 2380 2390 2400
ATAPLVTMPV TMPATRPKPK KARAAEGSGA KGPRRPGEDD ELLVKLDHEG
2410 2420 2430 2440 2450
VMSPKSKKAK EALLLREDPG PGGWPESTGL LSLGSYSPAV GSSEPKATWP
2460 2470 2480 2490 2500
KGLDGDLTQE PGPGLPLEDP GNSKNPDKAQ AEQDGAEESE TTSSSSSSSS
2510 2520 2530 2540 2550
SSSSSSSSSS SSSSSSSGSE TEGEEDAEKN REDGRGAGGR TCSAASSRAS
2560 2570 2580 2590 2600
SPASSSSSSS SSSSSSSSSS SSSSSSSTTD EDSSCSSDEE AAPAPAAGPS
2610 2620 2630 2640 2650
TQPALPTKVS KPPSKARSSA HSPGKKAPTT TQPPPQPPPQ PQQTLQPKTQ
2660 2670 2680 2690 2700
AGAGAKSRPK KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW
2710 2720 2730 2740 2750
FGKPTQRRGM KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR
2760 2770 2780 2790 2800
IQSMWESWGN NMVVRVKWFY HPEETSPGKQ FHEGQHWDQK SGHSLPAALR
2810 2820 2830 2840 2850
ASSQRKDFME RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD
2860 2870
SEGLYYLAGT YEPTTGMIFS TDGVPVLC
Note: No experimental confirmation available.
Length:2,878
Mass (Da):307,635
Last modified:April 29, 2008 - v2
Checksum:iBE28353487DC666B
GO
Isoform 2 (identifier: Q80WC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1754-1755: DD → GY
     1756-2878: Missing.

Note: No experimental confirmation available.
Show »
Length:1,755
Mass (Da):187,744
Checksum:iA26D7F93B4004B17
GO
Isoform 3 (identifier: Q80WC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-629: Missing.
     1440-1482: Missing.
     1566-2710: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:1,061
Mass (Da):116,245
Checksum:i31A4188FD3093D91
GO

Sequence cautioni

The sequence AAI15864.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti670 – 6701L → Q in AAI15864 (PubMed:15489334).Curated
Sequence conflicti860 – 8601V → VQ in AAI15864 (PubMed:15489334).Curated
Sequence conflicti860 – 8601V → VQ in BAD32558 (PubMed:15368895).Curated
Sequence conflicti965 – 9651P → A in AAI15864 (PubMed:15489334).Curated
Sequence conflicti1564 – 15641S → F in BAD32558 (PubMed:15368895).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 629629Missing in isoform 3. 1 PublicationVSP_033130Add
BLAST
Alternative sequencei1440 – 148243Missing in isoform 3. 1 PublicationVSP_033131Add
BLAST
Alternative sequencei1566 – 27101145Missing in isoform 3. 1 PublicationVSP_033132Add
BLAST
Alternative sequencei1754 – 17552DD → GY in isoform 2. 1 PublicationVSP_033133
Alternative sequencei1756 – 28781123Missing in isoform 2. 1 PublicationVSP_033134Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC175314 Genomic DNA. No translation available.
AC184111 Genomic DNA. No translation available.
AC175490 Genomic DNA. No translation available.
AC182436 Genomic DNA. No translation available.
AC175488 Genomic DNA. No translation available.
AC144818 Genomic DNA. No translation available.
BC049818 mRNA. Translation: AAH49818.1.
BC115863 mRNA. Translation: AAI15864.1. Different initiation.
AK173280 mRNA. Translation: BAD32558.1.
RefSeqiNP_001116202.2. NM_001122730.2.
NP_839973.1. NM_178242.2.
UniGeneiMm.354649.
Mm.480618.

Genome annotation databases

GeneIDi231861.
KEGGimmu:231861.
UCSCiuc033inn.1. mouse. [Q80WC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC175314 Genomic DNA. No translation available.
AC184111 Genomic DNA. No translation available.
AC175490 Genomic DNA. No translation available.
AC182436 Genomic DNA. No translation available.
AC175488 Genomic DNA. No translation available.
AC144818 Genomic DNA. No translation available.
BC049818 mRNA. Translation: AAH49818.1.
BC115863 mRNA. Translation: AAI15864.1. Different initiation.
AK173280 mRNA. Translation: BAD32558.1.
RefSeqiNP_001116202.2. NM_001122730.2.
NP_839973.1. NM_178242.2.
UniGeneiMm.354649.
Mm.480618.

3D structure databases

ProteinModelPortaliQ80WC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040287.

PTM databases

iPTMnetiQ80WC3.
PhosphoSiteiQ80WC3.

Proteomic databases

MaxQBiQ80WC3.
PaxDbiQ80WC3.
PeptideAtlasiQ80WC3.
PRIDEiQ80WC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231861.
KEGGimmu:231861.
UCSCiuc033inn.1. mouse. [Q80WC3-1]

Organism-specific databases

CTDi84629.
MGIiMGI:3648294. Tnrc18.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1886. Eukaryota.
ENOG410XQP1. LUCA.
HOGENOMiHOG000168449.
HOVERGENiHBG108592.
InParanoidiQ80WC3.
PhylomeDBiQ80WC3.

Miscellaneous databases

ChiTaRSiTnrc18. mouse.
PROiQ80WC3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80WC3.

Family and domain databases

InterProiIPR001025. BAH_dom.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
[Graphical view]
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Limb.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-2878 (ISOFORM 3).
    Tissue: Embryonic tail.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199 AND SER-540, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue and Kidney.

Entry informationi

Entry nameiTNC18_MOUSE
AccessioniPrimary (citable) accession number: Q80WC3
Secondary accession number(s): Q1LZJ7, Q69Z86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Gene prediction inferred by homology with the human sequence. First thought to be the product of 2 distinct genes Tnrc18 and Zfp469.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.