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Protein

Ubinuclein-2

Gene

Ubn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubinuclein-2
Gene namesi
Name:Ubn2
Synonyms:Kiaa2030
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444236. Ubn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13141314Ubinuclein-2PRO_0000295726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei236 – 2361PhosphoserineBy similarity
Modified residuei238 – 2381PhosphothreonineBy similarity
Modified residuei402 – 4021PhosphoserineCombined sources
Modified residuei405 – 4051PhosphoserineCombined sources
Modified residuei408 – 4081PhosphoserineCombined sources
Modified residuei570 – 5701PhosphoserineBy similarity
Modified residuei1036 – 10361N6-acetyllysineCombined sources
Modified residuei1116 – 11161N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80WC1.
MaxQBiQ80WC1.
PaxDbiQ80WC1.
PRIDEiQ80WC1.

PTM databases

iPTMnetiQ80WC1.
PhosphoSiteiQ80WC1.

Expressioni

Gene expression databases

BgeeiQ80WC1.
CleanExiMM_D130059P03RIK.
ExpressionAtlasiQ80WC1. baseline and differential.
GenevisibleiQ80WC1. MM.

Interactioni

Protein-protein interaction databases

BioGridi236097. 1 interaction.
IntActiQ80WC1. 2 interactions.
MINTiMINT-4111901.
STRINGi10090.ENSMUSP00000124043.

Structurei

3D structure databases

ProteinModelPortaliQ80WC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 10981Pro-richAdd
BLAST
Compositional biasi248 – 33184Lys-richAdd
BLAST
Compositional biasi853 – 1192340Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the ubinuclein family.Curated

Phylogenomic databases

eggNOGiKOG4786. Eukaryota.
ENOG4110DA0. LUCA.
GeneTreeiENSGT00530000063595.
HOGENOMiHOG000154754.
InParanoidiQ80WC1.
KOiK17492.
OMAiGNKGPPV.
OrthoDBiEOG75B866.
PhylomeDBiQ80WC1.
TreeFamiTF326088.

Family and domain databases

InterProiIPR014840. HRD.
IPR026943. Ubinuclein-2.
IPR026947. UBN_middle_dom.
[Graphical view]
PANTHERiPTHR21669:SF10. PTHR21669:SF10. 2 hits.
PfamiPF08729. HUN. 1 hit.
PF14075. UBN_AB. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80WC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPRRVAFI SLSPVRRREA DFAGAEREPP RLEPQPYREP ARAEPAPRAD
60 70 80 90 100
AQPPARDKPL PQREVSRAEP PMALQREPPR PEPPPPPLPL QTPPPRESAS
110 120 130 140 150
RAEPPPRPPK ETVRLELVLK DPTDESCVEF SYPELLLCGE QRKKLVHTED
160 170 180 190 200
PFTDEHKERQ EVEMLAKKFE MKYGGKARKH RKDRLQDLID IGFGYDETDP
210 220 230 240 250
FIDNSEAYDE LVPASLTTKY GGFYINTGTL QFRQASDTEE DDFTDNQKHK
260 270 280 290 300
PPKVPKIKED DIEVKKRKRK EEGEKEKKPR KKVPKQLGVV ALNSHKSEKK
310 320 330 340 350
KKRYKDSLSL AAMIRKFQKE KDALKKESTP KVPVTPSSSS LPKPPCVTTA
360 370 380 390 400
LGDDIPDLGL NSADPDLPIF VSTNEHELFQ EAENALEMLD DFDFDRLLDA
410 420 430 440 450
TSDGSPLSES GGENGNTTHP TFPSQVVPKV VPTLPEGLPV LLEKRIEDLR
460 470 480 490 500
VAAKLFDEEG RKKFFTQDMN NILLDIELQL QELGPVIRSG VYSHLEAFVP
510 520 530 540 550
CNKETLVKRL KKLHLNVQDD RLREPLQKLK LAVSNVMPEQ LFKYQEDCQA
560 570 580 590 600
RSQAKCAKLQ ADEEREKNGS DDDDDEKPGK RVIGPRKKFH WDDTIRTLLC
610 620 630 640 650
NLVEIKLGCY ELEPNKSQSA EDYLKSFMET EVKPLWPKGW MQARMLFKES
660 670 680 690 700
RSVHNHLTSA PAKKKVIPAS KPKVKECSPK KDPKAPASVV ASGGGPSTSS
710 720 730 740 750
STSIVASASS SSAPAQETIC LDDSLDEDLS FPSASLDLVS EALAVINNGN
760 770 780 790 800
KGPSVGSRLN VPTTKPRPGL REEKLASIMS KLPLATPKKL DSTQTAHSSS
810 820 830 840 850
LIAGHTGPVP KKPQDLAHTG ISSGLIAGSS IQNPKVSLEP LPARLLQQGL
860 870 880 890 900
QRSSQIHASS SSQTHVSSSQ AQAAASSHAL GTSEAQDASS LTQVTKVHQH
910 920 930 940 950
SAVQQNYVSP LQATISKSQT NPVVKLSNNP QLSCSSQLLK TSDKPLMYRL
960 970 980 990 1000
PLSTPSPGNG SQGPHPLVSR TAPSTTTSSN YLAKAMVSQI STQGFKSPFS
1010 1020 1030 1040 1050
MAASPKLAAS PKPATSPKPL PSPKPSVSPK PSLSAKPSIS TKQISKSNPA
1060 1070 1080 1090 1100
PKPAVCPSSS SPNTLVAQSS HSTSNNPVHK QPSGMNISRQ SPTLNLLPSN
1110 1120 1130 1140 1150
RTSGLPTTKT LQAPSKLTNS SSTGTAGKNS LSGIPMNVPA SRGSNLNSSG
1160 1170 1180 1190 1200
ANRTSLSGGT GSGTQGATKP LSTPHRPTSA SGSSVVTASV QSTAGASLLA
1210 1220 1230 1240 1250
NASPLTLMTS PLSVTNQTVT PFGMLGGLVP VTMPFQFPLE LLGFGTDTAG
1260 1270 1280 1290 1300
VTATSGSTSA ALHHSLTQNL LKSLQPGAQH AAALPHSPLP AHLQQAFNDG
1310
GQSKGDTKLP RKPQ
Length:1,314
Mass (Da):141,740
Last modified:July 24, 2007 - v2
Checksum:i59CE63A74EE149E5
GO
Isoform 2 (identifier: Q80WC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1192-1203: STAGASLLANAS → FYQKPQRLRTKQ
     1204-1314: Missing.

Note: No experimental confirmation available.
Show »
Length:1,203
Mass (Da):130,796
Checksum:iCFB74113CDAFB9F0
GO
Isoform 3 (identifier: Q80WC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-298: SE → K
     674-674: V → VKAVLVKTLPVRSFPTML
     1192-1194: STA → PSS
     1195-1314: Missing.

Note: No experimental confirmation available.
Show »
Length:1,210
Mass (Da):131,287
Checksum:iC3EF90CB9929AEF4
GO
Isoform 4 (identifier: Q80WC1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-451: V → VVS

Note: No experimental confirmation available.
Show »
Length:1,316
Mass (Da):141,927
Checksum:i61AFABE29E833FFA
GO

Sequence cautioni

The sequence BAC31801.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841P → S in BAC34690 (PubMed:16141072).Curated
Sequence conflicti867 – 8671Missing in AAH51458 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei297 – 2982SE → K in isoform 3. 1 PublicationVSP_027023
Alternative sequencei451 – 4511V → VVS in isoform 4. 1 PublicationVSP_027024
Alternative sequencei674 – 6741V → VKAVLVKTLPVRSFPTML in isoform 3. 1 PublicationVSP_027025
Alternative sequencei1192 – 120312STAGA…LANAS → FYQKPQRLRTKQ in isoform 2. 1 PublicationVSP_027026Add
BLAST
Alternative sequencei1192 – 11943STA → PSS in isoform 3. 1 PublicationVSP_027027
Alternative sequencei1195 – 1314120Missing in isoform 3. 1 PublicationVSP_027028Add
BLAST
Alternative sequencei1204 – 1314111Missing in isoform 2. 1 PublicationVSP_027029Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043095 mRNA. Translation: AAH43095.1.
BC051458 mRNA. Translation: AAH51458.1.
AK044162 mRNA. Translation: BAC31801.1. Different initiation.
AK051609 mRNA. Translation: BAC34690.1.
AK173339 mRNA. Translation: BAD32617.1.
CCDSiCCDS39461.1. [Q80WC1-1]
RefSeqiNP_796159.3. NM_177185.4. [Q80WC1-1]
UniGeneiMm.302831.

Genome annotation databases

EnsembliENSMUST00000039127; ENSMUSP00000036188; ENSMUSG00000038538. [Q80WC1-4]
ENSMUST00000160583; ENSMUSP00000124043; ENSMUSG00000038538. [Q80WC1-1]
GeneIDi320538.
KEGGimmu:320538.
UCSCiuc009bke.2. mouse. [Q80WC1-1]
uc009bkh.2. mouse. [Q80WC1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043095 mRNA. Translation: AAH43095.1.
BC051458 mRNA. Translation: AAH51458.1.
AK044162 mRNA. Translation: BAC31801.1. Different initiation.
AK051609 mRNA. Translation: BAC34690.1.
AK173339 mRNA. Translation: BAD32617.1.
CCDSiCCDS39461.1. [Q80WC1-1]
RefSeqiNP_796159.3. NM_177185.4. [Q80WC1-1]
UniGeneiMm.302831.

3D structure databases

ProteinModelPortaliQ80WC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236097. 1 interaction.
IntActiQ80WC1. 2 interactions.
MINTiMINT-4111901.
STRINGi10090.ENSMUSP00000124043.

PTM databases

iPTMnetiQ80WC1.
PhosphoSiteiQ80WC1.

Proteomic databases

EPDiQ80WC1.
MaxQBiQ80WC1.
PaxDbiQ80WC1.
PRIDEiQ80WC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039127; ENSMUSP00000036188; ENSMUSG00000038538. [Q80WC1-4]
ENSMUST00000160583; ENSMUSP00000124043; ENSMUSG00000038538. [Q80WC1-1]
GeneIDi320538.
KEGGimmu:320538.
UCSCiuc009bke.2. mouse. [Q80WC1-1]
uc009bkh.2. mouse. [Q80WC1-4]

Organism-specific databases

CTDi254048.
MGIiMGI:2444236. Ubn2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4786. Eukaryota.
ENOG4110DA0. LUCA.
GeneTreeiENSGT00530000063595.
HOGENOMiHOG000154754.
InParanoidiQ80WC1.
KOiK17492.
OMAiGNKGPPV.
OrthoDBiEOG75B866.
PhylomeDBiQ80WC1.
TreeFamiTF326088.

Miscellaneous databases

ChiTaRSiUbn2. mouse.
NextBioi396921.
PROiQ80WC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80WC1.
CleanExiMM_D130059P03RIK.
ExpressionAtlasiQ80WC1. baseline and differential.
GenevisibleiQ80WC1. MM.

Family and domain databases

InterProiIPR014840. HRD.
IPR026943. Ubinuclein-2.
IPR026947. UBN_middle_dom.
[Graphical view]
PANTHERiPTHR21669:SF10. PTHR21669:SF10. 2 hits.
PfamiPF08729. HUN. 1 hit.
PF14075. UBN_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-1313 (ISOFORM 3).
    Tissue: Eye.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-1313 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 883-1313 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain, Brain cortex and Spinal ganglion.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 676-1314 (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-402; SER-405 AND SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Pancreas and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1036, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiUBN2_MOUSE
AccessioniPrimary (citable) accession number: Q80WC1
Secondary accession number(s): Q69Z27
, Q80ZZ9, Q8BQ40, Q8BRI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.