Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Gene

Sgtb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.1 Publication

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • protein folding Source: RGD

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Alternative name(s):
Beta-SGT
Small glutamine-rich protein with tetratricopeptide repeats 2
Gene namesi
Name:Sgtb
Synonyms:Sgt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727976 Sgtb

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332751 – 304Small glutamine-rich tetratricopeptide repeat-containing protein betaAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei297PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80W98
PRIDEiQ80W98

Expressioni

Tissue specificityi

Expressed specifically in brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000011937
GenevisibleiQ80W98 RN

Interactioni

Subunit structurei

Homooligomerize.1 Publication

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi254771, 1 interactor
STRINGi10116.ENSRNOP00000016129

Structurei

3D structure databases

ProteinModelPortaliQ80W98
SMRiQ80W98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 49TPR 1Add BLAST35
Repeati85 – 118TPR 2Add BLAST34
Repeati120 – 152TPR 3Add BLAST33
Repeati153 – 186TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 279Gln-richAdd BLAST13

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiQ80W98
OMAiPAMMNMA
OrthoDBiEOG091G0C0Q
PhylomeDBiQ80W98
TreeFamiTF313092

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVKPLVYA VIRFLREQSQ MDAYTSDEQE SLEVAIQCLE TVFKISPEDT
60 70 80 90 100
HLAVSQPLTE MFTNSVCKND IRPLSNSVPE DVGKADQLKD EGNNHMKEEN
110 120 130 140 150
YAAAVDCYTQ AIELDPNNAV YYCNRAAAQS KLSHYTDAIK DCEKAIAIDS
160 170 180 190 200
KYSKAYGRMG LALTAMNKFE EAVTSYQKAL DLDPENDSYK SNLKIAEQKL
210 220 230 240 250
REVSSPTGTG LTFDMASLIN NPAFITMAAS LMQNPQVQQL MSGMMTNAIG
260 270 280 290 300
GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSST

EEHS
Length:304
Mass (Da):33,488
Last modified:June 1, 2003 - v1
Checksum:i3D523C528E5DDCEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368280 mRNA Translation: AAP29458.1
RefSeqiNP_853660.1, NM_181629.3
XP_006231944.1, XM_006231882.3
UniGeneiRn.23400

Genome annotation databases

EnsembliENSRNOT00000016129; ENSRNOP00000016129; ENSRNOG00000011937
GeneIDi294708
KEGGirno:294708
UCSCiRGD:727976 rat

Similar proteinsi

Entry informationi

Entry nameiSGTB_RAT
AccessioniPrimary (citable) accession number: Q80W98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health