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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Gene

Sgtb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.1 Publication

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • protein folding Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Alternative name(s):
Beta-SGT
Small glutamine-rich protein with tetratricopeptide repeats 2
Gene namesi
Name:Sgtb
Synonyms:Sgt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727976. Sgtb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Small glutamine-rich tetratricopeptide repeat-containing protein betaPRO_0000333275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311N6-acetyllysineBy similarity
Modified residuei293 – 2931PhosphoserineBy similarity
Modified residuei295 – 2951PhosphoserineBy similarity
Modified residuei297 – 2971PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80W98.
PRIDEiQ80W98.

Expressioni

Tissue specificityi

Expressed specifically in brain.1 Publication

Gene expression databases

GenevisibleiQ80W98. RN.

Interactioni

Subunit structurei

Homooligomerize.1 Publication

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi254771. 1 interaction.
STRINGi10116.ENSRNOP00000016129.

Structurei

3D structure databases

ProteinModelPortaliQ80W98.
SMRiQ80W98. Positions 80-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 4935TPR 1Add
BLAST
Repeati85 – 11834TPR 2Add
BLAST
Repeati120 – 15233TPR 3Add
BLAST
Repeati153 – 18634TPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi267 – 27913Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ80W98.
OMAiGMMSNAI.
OrthoDBiEOG78SQJJ.
PhylomeDBiQ80W98.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
PF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80W98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVKPLVYA VIRFLREQSQ MDAYTSDEQE SLEVAIQCLE TVFKISPEDT
60 70 80 90 100
HLAVSQPLTE MFTNSVCKND IRPLSNSVPE DVGKADQLKD EGNNHMKEEN
110 120 130 140 150
YAAAVDCYTQ AIELDPNNAV YYCNRAAAQS KLSHYTDAIK DCEKAIAIDS
160 170 180 190 200
KYSKAYGRMG LALTAMNKFE EAVTSYQKAL DLDPENDSYK SNLKIAEQKL
210 220 230 240 250
REVSSPTGTG LTFDMASLIN NPAFITMAAS LMQNPQVQQL MSGMMTNAIG
260 270 280 290 300
GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSST

EEHS
Length:304
Mass (Da):33,488
Last modified:June 1, 2003 - v1
Checksum:i3D523C528E5DDCEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368280 mRNA. Translation: AAP29458.1.
RefSeqiNP_853660.1. NM_181629.3.
XP_006231944.1. XM_006231882.2.
UniGeneiRn.23400.

Genome annotation databases

EnsembliENSRNOT00000016129; ENSRNOP00000016129; ENSRNOG00000011937.
GeneIDi294708.
KEGGirno:294708.
UCSCiRGD:727976. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368280 mRNA. Translation: AAP29458.1.
RefSeqiNP_853660.1. NM_181629.3.
XP_006231944.1. XM_006231882.2.
UniGeneiRn.23400.

3D structure databases

ProteinModelPortaliQ80W98.
SMRiQ80W98. Positions 80-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254771. 1 interaction.
STRINGi10116.ENSRNOP00000016129.

Proteomic databases

PaxDbiQ80W98.
PRIDEiQ80W98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016129; ENSRNOP00000016129; ENSRNOG00000011937.
GeneIDi294708.
KEGGirno:294708.
UCSCiRGD:727976. rat.

Organism-specific databases

CTDi54557.
RGDi727976. Sgtb.

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ80W98.
OMAiGMMSNAI.
OrthoDBiEOG78SQJJ.
PhylomeDBiQ80W98.
TreeFamiTF313092.

Miscellaneous databases

PROiQ80W98.

Gene expression databases

GenevisibleiQ80W98. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
PF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein."
    Tobaben S., Varoqueaux F., Brose N., Stahl B., Meyer G.
    J. Biol. Chem. 278:38376-38383(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSGTB_RAT
AccessioniPrimary (citable) accession number: Q80W98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.