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Protein

Iron-sulfur cluster assembly 1 homolog, mitochondrial

Gene

Isca1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571IronBy similarity
Metal bindingi121 – 1211IronBy similarity
Metal bindingi123 – 1231IronBy similarity

GO - Molecular functioni

GO - Biological processi

  • endocrine process Source: RGD
  • iron-sulfur cluster assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Alternative name(s):
HESB-like domain-containing protein 2
Iron-sulfur assembly protein IscA
Gene namesi
Name:Isca1
Synonyms:Hbld2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727792. Isca1.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionSequence analysisAdd
BLAST
Chaini13 – 129117Iron-sulfur cluster assembly 1 homolog, mitochondrialPRO_0000042737Add
BLAST

Proteomic databases

PaxDbiQ80W96.
PRIDEiQ80W96.

Interactioni

Subunit structurei

Interacts with CRY2, but not with CRY1 (in vitro).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024781.

Structurei

3D structure databases

ProteinModelPortaliQ80W96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ80W96.
KOiK13628.
OrthoDBiEOG780RPV.
PhylomeDBiQ80W96.
TreeFamiTF314956.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80W96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASLVRATV RAVSKRKLQP TRAALTLTPS AVNKIKQLLK DKPEHVGLKV
60 70 80 90 100
GVRTRGCNGL SYSLEYTKTK GDADEEVIQD GVRVFIEKKA QLTLLGTEMD
110 120
YVEDKLSSEF VFNNPNIKGT CGCGESFNV
Length:129
Mass (Da):14,149
Last modified:June 1, 2003 - v1
Checksum:i2C3693C453688233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508158 mRNA. Translation: AAP29778.1.
BC070929 mRNA. Translation: AAH70929.1.
BC078677 mRNA. Translation: AAH78677.1.
RefSeqiNP_853657.1. NM_181626.3.
UniGeneiRn.1180.

Genome annotation databases

GeneIDi290985.
KEGGirno:290985.
UCSCiRGD:727792. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508158 mRNA. Translation: AAP29778.1.
BC070929 mRNA. Translation: AAH70929.1.
BC078677 mRNA. Translation: AAH78677.1.
RefSeqiNP_853657.1. NM_181626.3.
UniGeneiRn.1180.

3D structure databases

ProteinModelPortaliQ80W96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024781.

Proteomic databases

PaxDbiQ80W96.
PRIDEiQ80W96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi290985.
KEGGirno:290985.
UCSCiRGD:727792. rat.

Organism-specific databases

CTDi81689.
RGDi727792. Isca1.

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ80W96.
KOiK13628.
OrthoDBiEOG780RPV.
PhylomeDBiQ80W96.
TreeFamiTF314956.

Miscellaneous databases

PROiQ80W96.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiISCA1_RAT
AccessioniPrimary (citable) accession number: Q80W96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.