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Q80W85

- NPM2_MOUSE

UniProt

Q80W85 - NPM2_MOUSE

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Protein

Nucleoplasmin-2

Gene

Npm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 571Interaction between pentamersBy similarity
Sitei84 – 841Interaction between pentamersBy similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. chromatin remodeling Source: UniProtKB
  2. embryo development Source: UniProtKB
  3. oocyte differentiation Source: UniProtKB
  4. positive regulation of catalytic activity Source: Ensembl
  5. positive regulation of DNA replication Source: Ensembl
  6. positive regulation of meiosis Source: UniProtKB
  7. protein homooligomerization Source: Ensembl
  8. regulation of exit from mitosis Source: UniProtKB
  9. single fertilization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Chromatin regulator, Developmental protein

Keywords - Biological processi

Fertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-2
Gene namesi
Name:Npm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1890811. Npm2.

Subcellular locationi

Nucleus 1 Publication
Note: Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.

GO - Cellular componenti

  1. cytoplasmic chromatin Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Nucleoplasmin-2PRO_0000219488Add
BLAST

Proteomic databases

PRIDEiQ80W85.

2D gel databases

REPRODUCTION-2DPAGEQ80W85.

PTM databases

PhosphoSiteiQ80W85.

Expressioni

Tissue specificityi

Ovary specific.1 Publication

Gene expression databases

BgeeiQ80W85.
CleanExiMM_NPM2.
ExpressionAtlasiQ80W85. baseline.
GenevestigatoriQ80W85.

Interactioni

Subunit structurei

Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously By similarity.By similarity

Protein-protein interaction databases

BioGridi236605. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80W85.
SMRiQ80W85. Positions 17-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 15224Acidic tract A2By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi165 – 18016Bipartite nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi128 – 14114Poly-GluAdd
BLAST
Compositional biasi168 – 1714Poly-Lys

Domaini

The acidic tract A2 mediates histone binding.By similarity

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiNOG78586.
GeneTreeiENSGT00440000034554.
HOGENOMiHOG000056457.
HOVERGENiHBG045601.
InParanoidiQ80W85.
KOiK11277.
OMAiSTICLGE.
OrthoDBiEOG7ZWD4F.
PhylomeDBiQ80W85.
TreeFamiTF327704.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80W85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRHSTSSVT ETTAKNMLWG SELNQEKQTC TFRGQGEKKD SCKLLLSTIC
60 70 80 90 100
LGEKAKEEVN RVEVLSQEGR KPPITIATLK ASVLPMVTVS GIELSPPVTF
110 120 130 140 150
RLRTGSGPVF LSGLECYETS DLTWEDDEEE EEEEEEEDED EDADISLEEI
160 170 180 190 200
PVKQVKRVAP QKQMSIAKKK KVEKEEDETV VRPSPQDKSP WKKEKSTPRA

KKPVTKK
Length:207
Mass (Da):23,309
Last modified:June 1, 2003 - v1
Checksum:i8B8A8931F85032EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961S → F in BAC35815. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262112 mRNA. Translation: AAP33133.1.
AK054533 mRNA. Translation: BAC35815.1.
CCDSiCCDS27261.1.
RefSeqiNP_851990.2. NM_181345.3.
XP_006519206.1. XM_006519143.1.
XP_006519207.1. XM_006519144.1.
XP_006519208.1. XM_006519145.1.
XP_006519209.1. XM_006519146.1.
XP_006519210.1. XM_006519147.1.
UniGeneiMm.347749.

Genome annotation databases

EnsembliENSMUST00000062629; ENSMUSP00000057365; ENSMUSG00000047911.
GeneIDi328440.
KEGGimmu:328440.
UCSCiuc007uot.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262112 mRNA. Translation: AAP33133.1 .
AK054533 mRNA. Translation: BAC35815.1 .
CCDSi CCDS27261.1.
RefSeqi NP_851990.2. NM_181345.3.
XP_006519206.1. XM_006519143.1.
XP_006519207.1. XM_006519144.1.
XP_006519208.1. XM_006519145.1.
XP_006519209.1. XM_006519146.1.
XP_006519210.1. XM_006519147.1.
UniGenei Mm.347749.

3D structure databases

ProteinModelPortali Q80W85.
SMRi Q80W85. Positions 17-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 236605. 1 interaction.

PTM databases

PhosphoSitei Q80W85.

2D gel databases

REPRODUCTION-2DPAGE Q80W85.

Proteomic databases

PRIDEi Q80W85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062629 ; ENSMUSP00000057365 ; ENSMUSG00000047911 .
GeneIDi 328440.
KEGGi mmu:328440.
UCSCi uc007uot.2. mouse.

Organism-specific databases

CTDi 10361.
MGIi MGI:1890811. Npm2.

Phylogenomic databases

eggNOGi NOG78586.
GeneTreei ENSGT00440000034554.
HOGENOMi HOG000056457.
HOVERGENi HBG045601.
InParanoidi Q80W85.
KOi K11277.
OMAi STICLGE.
OrthoDBi EOG7ZWD4F.
PhylomeDBi Q80W85.
TreeFami TF327704.

Miscellaneous databases

NextBioi 398309.
PROi Q80W85.
SOURCEi Search...

Gene expression databases

Bgeei Q80W85.
CleanExi MM_NPM2.
ExpressionAtlasi Q80W85. baseline.
Genevestigatori Q80W85.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos."
    Burns K.H., Viveiros M.M., Ren Y., Wang P., DeMayo F.J., Frail D.E., Eppig J.J., Matzuk M.M.
    Science 300:633-636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: 129S6/SvEv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Ovary.

Entry informationi

Entry nameiNPM2_MOUSE
AccessioniPrimary (citable) accession number: Q80W85
Secondary accession number(s): Q8BW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3