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Protein

Nucleoplasmin-2

Gene

Npm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

GO - Molecular functioni

  • chromatin binding Source: MGI
  • enzyme binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionChaperone, Chromatin regulator, Developmental protein
Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-2
Gene namesi
Name:Npm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1890811 Npm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194881 – 207Nucleoplasmin-2Add BLAST207

Proteomic databases

PaxDbiQ80W85
PRIDEiQ80W85

2D gel databases

REPRODUCTION-2DPAGEiQ80W85

PTM databases

iPTMnetiQ80W85
PhosphoSitePlusiQ80W85

Expressioni

Tissue specificityi

Ovary specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000047911
CleanExiMM_NPM2

Interactioni

Subunit structurei

Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction between pentamersBy similarity1
Sitei84Interaction between pentamersBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi236605, 1 interactor
STRINGi10090.ENSMUSP00000057365

Structurei

3D structure databases

ProteinModelPortaliQ80W85
SMRiQ80W85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 152Acidic tract A2By similarityAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 180Bipartite nuclear localization signalBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 141Poly-GluAdd BLAST14
Compositional biasi168 – 171Poly-Lys4

Domaini

The acidic tract A2 mediates histone binding.By similarity

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiENOG410IYZ7 Eukaryota
ENOG410XY21 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000056457
HOVERGENiHBG045601
InParanoidiQ80W85
KOiK11277
OMAiQEKRTWT
OrthoDBiEOG091G0XZ8
PhylomeDBiQ80W85
TreeFamiTF327704

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHSTSSVT ETTAKNMLWG SELNQEKQTC TFRGQGEKKD SCKLLLSTIC
60 70 80 90 100
LGEKAKEEVN RVEVLSQEGR KPPITIATLK ASVLPMVTVS GIELSPPVTF
110 120 130 140 150
RLRTGSGPVF LSGLECYETS DLTWEDDEEE EEEEEEEDED EDADISLEEI
160 170 180 190 200
PVKQVKRVAP QKQMSIAKKK KVEKEEDETV VRPSPQDKSP WKKEKSTPRA

KKPVTKK
Length:207
Mass (Da):23,309
Last modified:June 1, 2003 - v1
Checksum:i8B8A8931F85032EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196S → F in BAC35815 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262112 mRNA Translation: AAP33133.1
AK054533 mRNA Translation: BAC35815.1
CCDSiCCDS27261.1
RefSeqiNP_851990.2, NM_181345.3
XP_006519206.1, XM_006519143.2
XP_006519208.1, XM_006519145.3
XP_006519209.1, XM_006519146.3
XP_006519210.1, XM_006519147.2
XP_011243393.1, XM_011245091.2
XP_017171550.1, XM_017316061.1
UniGeneiMm.347749

Genome annotation databases

EnsembliENSMUST00000062629; ENSMUSP00000057365; ENSMUSG00000047911
GeneIDi328440
KEGGimmu:328440
UCSCiuc007uot.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNPM2_MOUSE
AccessioniPrimary (citable) accession number: Q80W85
Secondary accession number(s): Q8BW23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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