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Protein

CAAX prenyl protease 1 homolog

Gene

Zmpste24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.1 Publication

Catalytic activityi

The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi335Zinc; catalyticBy similarity1
Active sitei336By similarity1
Metal bindingi339Zinc; catalyticBy similarity1
Metal bindingi415Zinc; catalyticBy similarity1
Active sitei419Proton donorBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: MGI

GO - Biological processi

  • CAAX-box protein processing Source: GO_Central
  • nuclear envelope organization Source: MGI
  • prenylated protein catabolic process Source: MGI

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.84 3474

Protein family/group databases

MEROPSiM48.003

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX prenyl protease 1 homolog (EC:3.4.24.84)
Alternative name(s):
Farnesylated proteins-converting enzyme 1
Short name:
FACE-1
Prenyl protein-specific endoprotease 1
Zinc metalloproteinase Ste24 homolog
Gene namesi
Name:Zmpste24
Synonyms:Face1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1890508 Zmpste24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18LumenalSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 81NuclearSequence analysisAdd BLAST42
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 123LumenalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 170NuclearSequence analysisAdd BLAST26
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 195LumenalSequence analysis4
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 347NuclearSequence analysisAdd BLAST131
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 382LumenalSequence analysisAdd BLAST14
Transmembranei383 – 405HelicalSequence analysisAdd BLAST23
Topological domaini406 – 475NuclearSequence analysisAdd BLAST70

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001388451 – 475CAAX prenyl protease 1 homologAdd BLAST475

Proteomic databases

EPDiQ80W54
MaxQBiQ80W54
PaxDbiQ80W54
PRIDEiQ80W54

PTM databases

iPTMnetiQ80W54
PhosphoSitePlusiQ80W54
SwissPalmiQ80W54

Expressioni

Gene expression databases

BgeeiENSMUSG00000043207
ExpressionAtlasiQ80W54 baseline and differential
GenevisibleiQ80W54 MM

Interactioni

Protein-protein interaction databases

IntActiQ80W54, 2 interactors
MINTiQ80W54
STRINGi10090.ENSMUSP00000053900

Chemistry databases

BindingDBiQ80W54

Structurei

3D structure databases

ProteinModelPortaliQ80W54
SMRiQ80W54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The metalloprotease domain is constituted by the two C-terminal nuclear regions.By similarity

Sequence similaritiesi

Belongs to the peptidase M48A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2719 Eukaryota
COG0501 LUCA
GeneTreeiENSGT00390000002053
HOGENOMiHOG000257874
HOVERGENiHBG051541
InParanoidiQ80W54
KOiK06013
OMAiRFEYQAD
OrthoDBiEOG091G074G
PhylomeDBiQ80W54
TreeFamiTF105972

Family and domain databases

CDDicd07343 M48A_Zmpste24p_like, 1 hit
InterProiView protein in InterPro
IPR027057 CAXX_Prtase_1
IPR001915 Peptidase_M48
IPR032456 Peptidase_M48_N
PANTHERiPTHR10120 PTHR10120, 1 hit
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit
PF16491 Peptidase_M48_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMWASVDAM WDFPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTR
60 70 80 90 100
VPAELEQIMD SDTFEKSRLY QLDKSTFSFW SGLYSEVEGT FILLFGGIPY
110 120 130 140 150
LWRLSGQFCS SAGFGPEYEI IQSLVFLLLA TLFSALTGLP WSLYNTFVIE
160 170 180 190 200
EKHGFNHQTL EFFMKDAIKK FIVTQCILLP VSALLLYIIK IGGDYFFIYA
210 220 230 240 250
WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKQEIEV MAKSIDFPLT
260 270 280 290 300
KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVP NKDNQEESGM
310 320 330 340 350
EARNEGEGDS EEVKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII
360 370 380 390 400
ISQMNSFLCF FLFAVLIGRR ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN
410 420 430 440 450
EVLSFCLTVL SRRFEFQADA FAKKLGKAKD LYSALIKLNK DNLGFPVSDW
460 470
LFSTWHYSHP PLLERLQALK NAKQD
Length:475
Mass (Da):54,735
Last modified:September 13, 2005 - v2
Checksum:i509B82D757FC7A4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53A → S in CAD31792 (PubMed:11923874).Curated1
Sequence conflicti153H → Q in AAK38172 (PubMed:11399759).Curated1
Sequence conflicti157H → Q in AAK38172 (PubMed:11399759).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029194 mRNA Translation: AAK38172.1
AJ487544 mRNA Translation: CAD31792.1
AK083566 mRNA Translation: BAC38953.1
CCDSiCCDS18600.1
RefSeqiNP_766288.1, NM_172700.2
UniGeneiMm.34399

Genome annotation databases

EnsembliENSMUST00000058754; ENSMUSP00000053900; ENSMUSG00000043207
GeneIDi230709
KEGGimmu:230709
UCSCiuc008uny.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFACE1_MOUSE
AccessioniPrimary (citable) accession number: Q80W54
Secondary accession number(s): Q8BJK4, Q8K569
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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