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Protein

CAAX prenyl protease 1 homolog

Gene

Zmpste24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.1 Publication

Catalytic activityi

The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351Zinc; catalyticBy similarity
Active sitei336 – 3361By similarity
Metal bindingi339 – 3391Zinc; catalyticBy similarity
Metal bindingi415 – 4151Zinc; catalyticBy similarity
Active sitei419 – 4191Proton donorBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: MGI

GO - Biological processi

  • CAAX-box protein processing Source: InterPro
  • nuclear envelope organization Source: MGI
  • prenylated protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.84. 3474.

Protein family/group databases

MEROPSiM48.003.

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX prenyl protease 1 homolog (EC:3.4.24.84)
Alternative name(s):
Farnesylated proteins-converting enzyme 1
Short name:
FACE-1
Prenyl protein-specific endoprotease 1
Zinc metalloproteinase Ste24 homolog
Gene namesi
Name:Zmpste24
Synonyms:Face1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1890508. Zmpste24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818LumenalSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 8142NuclearSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 12321LumenalSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 17026NuclearSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 1954LumenalSequence analysis
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 347131NuclearSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38214LumenalSequence analysisAdd
BLAST
Transmembranei383 – 40523HelicalSequence analysisAdd
BLAST
Topological domaini406 – 47570NuclearSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475CAAX prenyl protease 1 homologPRO_0000138845Add
BLAST

Proteomic databases

EPDiQ80W54.
MaxQBiQ80W54.
PaxDbiQ80W54.
PRIDEiQ80W54.

PTM databases

iPTMnetiQ80W54.
PhosphoSiteiQ80W54.
SwissPalmiQ80W54.

Expressioni

Gene expression databases

BgeeiQ80W54.
ExpressionAtlasiQ80W54. baseline and differential.
GenevisibleiQ80W54. MM.

Interactioni

Protein-protein interaction databases

IntActiQ80W54. 2 interactions.
MINTiMINT-4117976.
STRINGi10090.ENSMUSP00000053900.

Chemistry

BindingDBiQ80W54.

Structurei

3D structure databases

ProteinModelPortaliQ80W54.
SMRiQ80W54. Positions 2-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The metalloprotease domain is constituted by the two C-terminal nuclear regions.By similarity

Sequence similaritiesi

Belongs to the peptidase M48A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2719. Eukaryota.
COG0501. LUCA.
GeneTreeiENSGT00390000002053.
HOGENOMiHOG000257874.
HOVERGENiHBG051541.
InParanoidiQ80W54.
KOiK06013.
OMAiKKQGCNN.
OrthoDBiEOG7RRF70.
PhylomeDBiQ80W54.
TreeFamiTF105972.

Family and domain databases

InterProiIPR027057. CAXX_Prtase_1.
IPR001915. Peptidase_M48.
IPR032456. Peptidase_M48_N.
[Graphical view]
PANTHERiPTHR10120:SF24. PTHR10120:SF24. 2 hits.
PfamiPF01435. Peptidase_M48. 1 hit.
PF16491. Peptidase_M48_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80W54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMWASVDAM WDFPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTR
60 70 80 90 100
VPAELEQIMD SDTFEKSRLY QLDKSTFSFW SGLYSEVEGT FILLFGGIPY
110 120 130 140 150
LWRLSGQFCS SAGFGPEYEI IQSLVFLLLA TLFSALTGLP WSLYNTFVIE
160 170 180 190 200
EKHGFNHQTL EFFMKDAIKK FIVTQCILLP VSALLLYIIK IGGDYFFIYA
210 220 230 240 250
WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKQEIEV MAKSIDFPLT
260 270 280 290 300
KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVP NKDNQEESGM
310 320 330 340 350
EARNEGEGDS EEVKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII
360 370 380 390 400
ISQMNSFLCF FLFAVLIGRR ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN
410 420 430 440 450
EVLSFCLTVL SRRFEFQADA FAKKLGKAKD LYSALIKLNK DNLGFPVSDW
460 470
LFSTWHYSHP PLLERLQALK NAKQD
Length:475
Mass (Da):54,735
Last modified:September 13, 2005 - v2
Checksum:i509B82D757FC7A4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531A → S in CAD31792 (PubMed:11923874).Curated
Sequence conflicti153 – 1531H → Q in AAK38172 (PubMed:11399759).Curated
Sequence conflicti157 – 1571H → Q in AAK38172 (PubMed:11399759).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029194 mRNA. Translation: AAK38172.1.
AJ487544 mRNA. Translation: CAD31792.1.
AK083566 mRNA. Translation: BAC38953.1.
CCDSiCCDS18600.1.
RefSeqiNP_766288.1. NM_172700.2.
UniGeneiMm.34399.

Genome annotation databases

EnsembliENSMUST00000058754; ENSMUSP00000053900; ENSMUSG00000043207.
GeneIDi230709.
KEGGimmu:230709.
UCSCiuc008uny.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029194 mRNA. Translation: AAK38172.1.
AJ487544 mRNA. Translation: CAD31792.1.
AK083566 mRNA. Translation: BAC38953.1.
CCDSiCCDS18600.1.
RefSeqiNP_766288.1. NM_172700.2.
UniGeneiMm.34399.

3D structure databases

ProteinModelPortaliQ80W54.
SMRiQ80W54. Positions 2-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80W54. 2 interactions.
MINTiMINT-4117976.
STRINGi10090.ENSMUSP00000053900.

Chemistry

BindingDBiQ80W54.
ChEMBLiCHEMBL1075286.

Protein family/group databases

MEROPSiM48.003.

PTM databases

iPTMnetiQ80W54.
PhosphoSiteiQ80W54.
SwissPalmiQ80W54.

Proteomic databases

EPDiQ80W54.
MaxQBiQ80W54.
PaxDbiQ80W54.
PRIDEiQ80W54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058754; ENSMUSP00000053900; ENSMUSG00000043207.
GeneIDi230709.
KEGGimmu:230709.
UCSCiuc008uny.1. mouse.

Organism-specific databases

CTDi10269.
MGIiMGI:1890508. Zmpste24.

Phylogenomic databases

eggNOGiKOG2719. Eukaryota.
COG0501. LUCA.
GeneTreeiENSGT00390000002053.
HOGENOMiHOG000257874.
HOVERGENiHBG051541.
InParanoidiQ80W54.
KOiK06013.
OMAiKKQGCNN.
OrthoDBiEOG7RRF70.
PhylomeDBiQ80W54.
TreeFamiTF105972.

Enzyme and pathway databases

BRENDAi3.4.24.84. 3474.

Miscellaneous databases

PROiQ80W54.
SOURCEiSearch...

Gene expression databases

BgeeiQ80W54.
ExpressionAtlasiQ80W54. baseline and differential.
GenevisibleiQ80W54. MM.

Family and domain databases

InterProiIPR027057. CAXX_Prtase_1.
IPR001915. Peptidase_M48.
IPR032456. Peptidase_M48_N.
[Graphical view]
PANTHERiPTHR10120:SF24. PTHR10120:SF24. 2 hits.
PfamiPF01435. Peptidase_M48. 1 hit.
PF16491. Peptidase_M48_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase deficient mice."
    Pendas A.M., Zhou Z., Cadinanos J., Freije J.M.P., Wang J., Hultenby K., Astudillo A., Wernerson A., Rodriguez F., Triggvason K., Lopez-Otin C.
    Nat. Genet. 31:94-99(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN LAMIN A/C PROCESSING.
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiFACE1_MOUSE
AccessioniPrimary (citable) accession number: Q80W54
Secondary accession number(s): Q8BJK4, Q8K569
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.