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Protein

Acyl-coenzyme A synthetase ACSM4, mitochondrial

Gene

Acsm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).By similarity

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei455 – 4551ATPBy similarity
Binding sitei470 – 4701ATPBy similarity
Binding sitei566 – 5661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATPBy similarity
Nucleotide bindingi368 – 3736ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC:6.2.1.2)
Alternative name(s):
Olfactory specific medium-chain acyl CoA synthetase
Short name:
O-MACS
Gene namesi
Name:Acsm4
Synonyms:Omacs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2681844. Acsm4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence analysisAdd
BLAST
Chaini23 – 580558Acyl-coenzyme A synthetase ACSM4, mitochondrialPRO_0000306104Add
BLAST

Proteomic databases

MaxQBiQ80W40.
PaxDbiQ80W40.
PRIDEiQ80W40.

PTM databases

PhosphoSiteiQ80W40.

Expressioni

Gene expression databases

BgeeiQ80W40.
CleanExiMM_ACSM4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045160.

Structurei

3D structure databases

ProteinModelPortaliQ80W40.
SMRiQ80W40. Positions 46-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ80W40.
KOiK01896.
OMAiIFFRYQT.
OrthoDBiEOG7D85VZ.
PhylomeDBiQ80W40.
TreeFamiTF354287.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80W40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLHCQRL RFIWLAKPAG RHFHRDSQLW APLTLDDFEA INRCEKPLPK
60 70 80 90 100
NFNFAADVLD QWSLKEKSGE RPANPALWWV NGKGDEVKWS FQELGSLSRK
110 120 130 140 150
AANVLTKPCG LQRGDRVAVI LPRIPEWWLI NVACMRTGLV FMPGTIQLTR
160 170 180 190 200
KDILYRLQAS KAKCIVASEE VAPAVDSIVS ECPSLKTKLL VSPHHWDGWL
210 220 230 240 250
NFQELLQSAS EEHNCVETGS QEPMAIYFTS GTTGSPKMAQ HSQGSLGIGY
260 270 280 290 300
TLCGRYWLDL TSSDIMWNMS DTGWIKAAIG SVFSTWLRGA CVFVHRMAQF
310 320 330 340 350
DTDIFLDTLT TYPITTLCSA PTVYRMLVQK DLKRYQFKRL RHCLTGGEPL
360 370 380 390 400
NPEVLEQWKM QTGLELYEGY GQTEVGIICA NRKGEAIKPG SMGKGVVPYD
410 420 430 440 450
VQIIDENGNI LPSGKEGEIA LRLKSDRPFC FFSEYVDNPE KTDATIRRNF
460 470 480 490 500
YVTGDRGVMD DDGYFWFVGR ADDVIISSGY RIGPFEVESA LIEHPAVVES
510 520 530 540 550
AVVSSPDPIR GEVVKAFIVL AAPYKCSNRE KLTAELQDHV KNSTAPYKYP
560 570 580
RKVEFVQELP KTITGKIKRN VLRDQEWGRA
Length:580
Mass (Da):65,427
Last modified:June 1, 2003 - v1
Checksum:i56A74EC03217D1C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132127 mRNA. Translation: BAE20992.1.
BC048390 mRNA. Translation: AAH48390.1.
CCDSiCCDS21784.1.
RefSeqiNP_848501.1. NM_178414.3.
UniGeneiMm.240412.

Genome annotation databases

EnsembliENSMUST00000047045; ENSMUSP00000045160; ENSMUSG00000047026.
GeneIDi233801.
KEGGimmu:233801.
UCSCiuc009jln.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132127 mRNA. Translation: BAE20992.1.
BC048390 mRNA. Translation: AAH48390.1.
CCDSiCCDS21784.1.
RefSeqiNP_848501.1. NM_178414.3.
UniGeneiMm.240412.

3D structure databases

ProteinModelPortaliQ80W40.
SMRiQ80W40. Positions 46-577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045160.

PTM databases

PhosphoSiteiQ80W40.

Proteomic databases

MaxQBiQ80W40.
PaxDbiQ80W40.
PRIDEiQ80W40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047045; ENSMUSP00000045160; ENSMUSG00000047026.
GeneIDi233801.
KEGGimmu:233801.
UCSCiuc009jln.2. mouse.

Organism-specific databases

CTDi341392.
MGIiMGI:2681844. Acsm4.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ80W40.
KOiK01896.
OMAiIFFRYQT.
OrthoDBiEOG7D85VZ.
PhylomeDBiQ80W40.
TreeFamiTF354287.

Miscellaneous databases

PROiQ80W40.
SOURCEiSearch...

Gene expression databases

BgeeiQ80W40.
CleanExiMM_ACSM4.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiACSM4_MOUSE
AccessioniPrimary (citable) accession number: Q80W40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.