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Q80W21

- GSTM7_MOUSE

UniProt

Q80W21 - GSTM7_MOUSE

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Protein

Glutathione S-transferase Mu 7

Gene

Gstm7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateBy similarity

GO - Molecular functioni

  1. glutathione binding Source: Ensembl
  2. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular detoxification of nitrogen compound Source: Ensembl
  2. cellular response to caffeine Source: Ensembl
  3. glutathione metabolic process Source: Ensembl
  4. negative regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  5. nitrobenzene metabolic process Source: Ensembl
  6. positive regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  7. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: Ensembl
  8. xenobiotic catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 7 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 7
Short name:
GSTM-7
Gene namesi
Name:Gstm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915562. Gstm7.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase Mu 7PRO_0000333228Add
BLAST

Proteomic databases

MaxQBiQ80W21.
PaxDbiQ80W21.
PRIDEiQ80W21.

PTM databases

PhosphoSiteiQ80W21.

Expressioni

Gene expression databases

BgeeiQ80W21.
ExpressionAtlasiQ80W21. baseline and differential.
GenevestigatoriQ80W21.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1869154.
STRINGi10090.ENSMUSP00000122567.

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 119Combined sources
Helixi12 – 143Combined sources
Helixi15 – 239Combined sources
Beta strandi28 – 336Combined sources
Helixi44 – 474Combined sources
Turni48 – 514Combined sources
Beta strandi60 – 656Combined sources
Beta strandi68 – 725Combined sources
Helixi73 – 8311Combined sources
Helixi91 – 11525Combined sources
Helixi120 – 14223Combined sources
Beta strandi150 – 1523Combined sources
Helixi155 – 17016Combined sources
Turni172 – 1776Combined sources
Helixi179 – 19012Combined sources
Helixi192 – 1987Combined sources
Beta strandi214 – 2163Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DC5X-ray1.60A/B1-218[»]
ProteinModelPortaliQ80W21.
SMRiQ80W21. Positions 1-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80W21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione bindingBy similarity
Regioni46 – 505Glutathione bindingBy similarity
Regioni59 – 602Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiQ80W21.
KOiK00799.
OMAiNSHLEST.
OrthoDBiEOG7KH9M3.
PhylomeDBiQ80W21.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80W21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLF LEYTDSSYEE KRYTMGDAPD YDQSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
ENQLMDNRMV LARLCYNADF EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFIA YDVLERNQVF EAKCLDAFPN LKDFIARFEG LKKISDYMKT
210
SRFLPRPMFT KMATWGSN
Length:218
Mass (Da):25,710
Last modified:June 1, 2003 - v1
Checksum:i0A971C2E117BCBC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → V in BAE43145. (PubMed:16141072)Curated
Sequence conflicti124 – 1241K → R in BAE36919. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK162441 mRNA. Translation: BAE36919.1.
AK002213 mRNA. Translation: BAE43145.1.
BC051924 mRNA. Translation: AAH51924.1.
CCDSiCCDS38595.1.
RefSeqiNP_080948.2. NM_026672.2.
UniGeneiMm.458189.

Genome annotation databases

EnsembliENSMUST00000004137; ENSMUSP00000004137; ENSMUSG00000004035.
GeneIDi68312.
KEGGimmu:68312.
UCSCiuc008qxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK162441 mRNA. Translation: BAE36919.1 .
AK002213 mRNA. Translation: BAE43145.1 .
BC051924 mRNA. Translation: AAH51924.1 .
CCDSi CCDS38595.1.
RefSeqi NP_080948.2. NM_026672.2.
UniGenei Mm.458189.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DC5 X-ray 1.60 A/B 1-218 [» ]
ProteinModelPortali Q80W21.
SMRi Q80W21. Positions 1-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1869154.
STRINGi 10090.ENSMUSP00000122567.

PTM databases

PhosphoSitei Q80W21.

Proteomic databases

MaxQBi Q80W21.
PaxDbi Q80W21.
PRIDEi Q80W21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004137 ; ENSMUSP00000004137 ; ENSMUSG00000004035 .
GeneIDi 68312.
KEGGi mmu:68312.
UCSCi uc008qxt.1. mouse.

Organism-specific databases

CTDi 68312.
MGIi MGI:1915562. Gstm7.

Phylogenomic databases

eggNOGi NOG300089.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi Q80W21.
KOi K00799.
OMAi NSHLEST.
OrthoDBi EOG7KH9M3.
PhylomeDBi Q80W21.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTracei Q80W21.
NextBioi 326981.
PROi Q80W21.
SOURCEi Search...

Gene expression databases

Bgeei Q80W21.
ExpressionAtlasi Q80W21. baseline and differential.
Genevestigatori Q80W21.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Crystal structure of mouse glutathione s-transferase, mu7 (gstm7) at 1.6 A resolution."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiGSTM7_MOUSE
AccessioniPrimary (citable) accession number: Q80W21
Secondary accession number(s): Q3TRV7, Q3V4E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3