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Protein

Glutathione S-transferase Mu 7

Gene

Gstm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 7 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 7
Short name:
GSTM-7
Gene namesi
Name:Gstm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915562. Gstm7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332281 – 218Glutathione S-transferase Mu 7Add BLAST218

Proteomic databases

MaxQBiQ80W21.
PaxDbiQ80W21.
PeptideAtlasiQ80W21.
PRIDEiQ80W21.

PTM databases

iPTMnetiQ80W21.
PhosphoSitePlusiQ80W21.
SwissPalmiQ80W21.

Expressioni

Gene expression databases

BgeeiENSMUSG00000004035.
ExpressionAtlasiQ80W21. baseline and differential.
GenevisibleiQ80W21. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80W21. 1 interactor.
MINTiMINT-1869154.
STRINGi10090.ENSMUSP00000004137.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Helixi12 – 14Combined sources3
Helixi15 – 23Combined sources9
Beta strandi28 – 33Combined sources6
Helixi44 – 47Combined sources4
Turni48 – 51Combined sources4
Beta strandi60 – 65Combined sources6
Beta strandi68 – 72Combined sources5
Helixi73 – 83Combined sources11
Helixi91 – 115Combined sources25
Helixi120 – 142Combined sources23
Beta strandi150 – 152Combined sources3
Helixi155 – 170Combined sources16
Turni172 – 177Combined sources6
Helixi179 – 190Combined sources12
Helixi192 – 198Combined sources7
Beta strandi214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DC5X-ray1.60A/B1-218[»]
ProteinModelPortaliQ80W21.
SMRiQ80W21.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80W21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GST N-terminalAdd BLAST88
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiQ80W21.
KOiK00799.
OMAiRITESWA.
OrthoDBiEOG091G0K2E.
PhylomeDBiQ80W21.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80W21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLF LEYTDSSYEE KRYTMGDAPD YDQSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
ENQLMDNRMV LARLCYNADF EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFIA YDVLERNQVF EAKCLDAFPN LKDFIARFEG LKKISDYMKT
210
SRFLPRPMFT KMATWGSN
Length:218
Mass (Da):25,710
Last modified:June 1, 2003 - v1
Checksum:i0A971C2E117BCBC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → V in BAE43145 (PubMed:16141072).Curated1
Sequence conflicti124K → R in BAE36919 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK162441 mRNA. Translation: BAE36919.1.
AK002213 mRNA. Translation: BAE43145.1.
BC051924 mRNA. Translation: AAH51924.1.
CCDSiCCDS38595.1.
RefSeqiNP_080948.2. NM_026672.2.
UniGeneiMm.458189.

Genome annotation databases

EnsembliENSMUST00000004137; ENSMUSP00000004137; ENSMUSG00000004035.
GeneIDi68312.
KEGGimmu:68312.
UCSCiuc008qxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK162441 mRNA. Translation: BAE36919.1.
AK002213 mRNA. Translation: BAE43145.1.
BC051924 mRNA. Translation: AAH51924.1.
CCDSiCCDS38595.1.
RefSeqiNP_080948.2. NM_026672.2.
UniGeneiMm.458189.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DC5X-ray1.60A/B1-218[»]
ProteinModelPortaliQ80W21.
SMRiQ80W21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80W21. 1 interactor.
MINTiMINT-1869154.
STRINGi10090.ENSMUSP00000004137.

PTM databases

iPTMnetiQ80W21.
PhosphoSitePlusiQ80W21.
SwissPalmiQ80W21.

Proteomic databases

MaxQBiQ80W21.
PaxDbiQ80W21.
PeptideAtlasiQ80W21.
PRIDEiQ80W21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004137; ENSMUSP00000004137; ENSMUSG00000004035.
GeneIDi68312.
KEGGimmu:68312.
UCSCiuc008qxt.1. mouse.

Organism-specific databases

CTDi68312.
MGIiMGI:1915562. Gstm7.

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiQ80W21.
KOiK00799.
OMAiRITESWA.
OrthoDBiEOG091G0K2E.
PhylomeDBiQ80W21.
TreeFamiTF353040.

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTraceiQ80W21.
PROiQ80W21.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004035.
ExpressionAtlasiQ80W21. baseline and differential.
GenevisibleiQ80W21. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM7_MOUSE
AccessioniPrimary (citable) accession number: Q80W21
Secondary accession number(s): Q3TRV7, Q3V4E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.