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Protein

Glutathione S-transferase Mu 7

Gene

Gstm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 7 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 7
Short name:
GSTM-7
Gene namesi
Name:Gstm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915562 Gstm7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332281 – 218Glutathione S-transferase Mu 7Add BLAST218

Proteomic databases

MaxQBiQ80W21
PaxDbiQ80W21
PeptideAtlasiQ80W21
PRIDEiQ80W21

PTM databases

iPTMnetiQ80W21
PhosphoSitePlusiQ80W21
SwissPalmiQ80W21

Expressioni

Gene expression databases

BgeeiENSMUSG00000004035
ExpressionAtlasiQ80W21 baseline and differential
GenevisibleiQ80W21 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212800, 1 interactor
IntActiQ80W21, 1 interactor
STRINGi10090.ENSMUSP00000004137

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Helixi12 – 14Combined sources3
Helixi15 – 23Combined sources9
Beta strandi28 – 33Combined sources6
Helixi44 – 47Combined sources4
Turni48 – 51Combined sources4
Beta strandi60 – 65Combined sources6
Beta strandi68 – 72Combined sources5
Helixi73 – 83Combined sources11
Helixi91 – 115Combined sources25
Helixi120 – 142Combined sources23
Beta strandi150 – 152Combined sources3
Helixi155 – 170Combined sources16
Turni172 – 177Combined sources6
Helixi179 – 190Combined sources12
Helixi192 – 198Combined sources7
Beta strandi214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DC5X-ray1.60A/B1-218[»]
ProteinModelPortaliQ80W21
SMRiQ80W21
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80W21

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GST N-terminalAdd BLAST88
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiQ80W21
KOiK00799
OMAiEFHARIG
OrthoDBiEOG091G0K2E
PhylomeDBiQ80W21
TreeFamiTF353040

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLF LEYTDSSYEE KRYTMGDAPD YDQSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
ENQLMDNRMV LARLCYNADF EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFIA YDVLERNQVF EAKCLDAFPN LKDFIARFEG LKKISDYMKT
210
SRFLPRPMFT KMATWGSN
Length:218
Mass (Da):25,710
Last modified:June 1, 2003 - v1
Checksum:i0A971C2E117BCBC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → V in BAE43145 (PubMed:16141072).Curated1
Sequence conflicti124K → R in BAE36919 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK162441 mRNA Translation: BAE36919.1
AK002213 mRNA Translation: BAE43145.1
BC051924 mRNA Translation: AAH51924.1
CCDSiCCDS38595.1
RefSeqiNP_080948.2, NM_026672.2
UniGeneiMm.458189

Genome annotation databases

EnsembliENSMUST00000004137; ENSMUSP00000004137; ENSMUSG00000004035
GeneIDi68312
KEGGimmu:68312
UCSCiuc008qxt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTM7_MOUSE
AccessioniPrimary (citable) accession number: Q80W21
Secondary accession number(s): Q3TRV7, Q3V4E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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