Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80W14

- PR40B_MOUSE

UniProt

Q80W14 - PR40B_MOUSE

Protein

Pre-mRNA-processing factor 40 homolog B

Gene

Prpf40b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in pre-mRNA splicing.By similarity

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-processing factor 40 homolog B
    Alternative name(s):
    Huntingtin yeast partner C
    Huntingtin-interacting protein C
    Gene namesi
    Name:Prpf40b
    Synonyms:Hypc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1925583. Prpf40b.

    Subcellular locationi

    Nucleus speckle By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Pre-mRNA-processing factor 40 homolog BPRO_0000309283Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481N6-acetyllysineBy similarity
    Modified residuei764 – 7641PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ80W14.
    PaxDbiQ80W14.
    PRIDEiQ80W14.

    PTM databases

    PhosphoSiteiQ80W14.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80W14.
    BgeeiQ80W14.
    GenevestigatoriQ80W14.

    Interactioni

    Subunit structurei

    Interacts with the N-terminus of HD.By similarity

    Protein-protein interaction databases

    IntActiQ80W14. 1 interaction.
    MINTiMINT-4601260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80W14.
    SMRiQ80W14. Positions 80-173, 273-328, 626-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 12534WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 16634WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini276 – 33055FF 1Add
    BLAST
    Domaini340 – 39758FF 2Add
    BLAST
    Domaini410 – 47061FF 3Add
    BLAST
    Domaini490 – 55061FF 4Add
    BLAST
    Domaini554 – 61057FF 5Add
    BLAST
    Domaini625 – 68258FF 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili604 – 64037Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 7270Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PRPF40 family.Curated
    Contains 6 FF domains.Curated
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5104.
    GeneTreeiENSGT00740000115182.
    HOGENOMiHOG000231802.
    HOVERGENiHBG059634.
    KOiK12821.
    OrthoDBiEOG77Q4X2.
    TreeFamiTF318732.

    Family and domain databases

    Gene3Di1.10.10.440. 4 hits.
    InterProiIPR002713. FF_domain.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF01846. FF. 2 hits.
    PF00397. WW. 2 hits.
    [Graphical view]
    SMARTiSM00441. FF. 4 hits.
    SM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 2 hits.
    SSF81698. SSF81698. 5 hits.
    PROSITEiPS51676. FF. 6 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80W14-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMPPPFMPPP GLPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP    50
    PLTQIPGMVP PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE 100
    HVAPDGRIYY YNADDKQSVW EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY 150
    YYNNQSQESR WTRPKDLDDL EALVKQESAG KQQTQQLQTL QPQPPQPQPD 200
    PPPIPPGPIP VPMALLEPEP GRSEDCDVLE AAQPLEQGFL QREEGPSSST 250
    GQHRQPQEEE EAKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ 300
    AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL 350
    QHFLEQHERM TSTTRYRRAE QTFGDLEVWA VVPERERKEV YDDVLFFLAK 400
    KEKEQAKQLR RRNIQALKSI LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDQ 450
    QLQNMDKEDA LICFEEHIRA LEREEEEERE RARLRERRQQ RKNREAFQSF 500
    LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP LDLFKFYVEE 550
    LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI 600
    KLTFNSLLEK AEARETEREK EEARRMRRRE AAFRSMLRQA VPALELGTAW 650
    EEVRERFVCD SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR 700
    KGKKHHRKRS HSPSGSESDE EELPPPSLRP PKRRRRNPSE SGSEPSSSLD 750
    SVESGGAALG GPGSPSSHLL LGSDHGLRKT KKPKKKTKKR RHKSTSPDSE 800
    TDPEDKAGKE SEDREQEQDR EPRQAELPNR SPGFGIKKEK TGWDTSESEL 850
    SEGELERRRR TLLQQLDDHQ 870
    Length:870
    Mass (Da):99,300
    Last modified:November 13, 2007 - v2
    Checksum:i4D0C2429AF35EAD7
    GO
    Isoform 2 (identifier: Q80W14-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         538-557: STPLDLFKFYVEELKARFHD → KAARLPLVCSAFLPCQPLWT
         558-870: Missing.

    Show »
    Length:557
    Mass (Da):63,277
    Checksum:i74DB650883C35523
    GO
    Isoform 3 (identifier: Q80W14-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         685-685: Missing.
         714-714: S → SVSRQ

    Show »
    Length:873
    Mass (Da):99,642
    Checksum:iE3FD869C37279BFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti616 – 6161T → R in AAD39464. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei538 – 55720STPLD…ARFHD → KAARLPLVCSAFLPCQPLWT in isoform 2. 2 PublicationsVSP_029122Add
    BLAST
    Alternative sequencei558 – 870313Missing in isoform 2. 2 PublicationsVSP_029123Add
    BLAST
    Alternative sequencei685 – 6851Missing in isoform 3. 1 PublicationVSP_029124
    Alternative sequencei714 – 7141S → SVSRQ in isoform 3. 1 PublicationVSP_029125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135440 mRNA. Translation: AAD39464.1.
    AK019183 mRNA. Translation: BAB31591.1.
    AK140075 mRNA. Translation: BAE24230.1.
    BC051961 mRNA. Translation: AAH51961.1.
    BC082994 mRNA. Translation: AAH82994.1.
    CCDSiCCDS27818.1. [Q80W14-3]
    RefSeqiNP_061256.1. NM_018786.2.
    UniGeneiMm.358668.

    Genome annotation databases

    EnsembliENSMUST00000145482; ENSMUSP00000115869; ENSMUSG00000023007.
    GeneIDi54614.
    KEGGimmu:54614.
    UCSCiuc007xph.1. mouse. [Q80W14-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135440 mRNA. Translation: AAD39464.1 .
    AK019183 mRNA. Translation: BAB31591.1 .
    AK140075 mRNA. Translation: BAE24230.1 .
    BC051961 mRNA. Translation: AAH51961.1 .
    BC082994 mRNA. Translation: AAH82994.1 .
    CCDSi CCDS27818.1. [Q80W14-3 ]
    RefSeqi NP_061256.1. NM_018786.2.
    UniGenei Mm.358668.

    3D structure databases

    ProteinModelPortali Q80W14.
    SMRi Q80W14. Positions 80-173, 273-328, 626-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80W14. 1 interaction.
    MINTi MINT-4601260.

    PTM databases

    PhosphoSitei Q80W14.

    Proteomic databases

    MaxQBi Q80W14.
    PaxDbi Q80W14.
    PRIDEi Q80W14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000145482 ; ENSMUSP00000115869 ; ENSMUSG00000023007 .
    GeneIDi 54614.
    KEGGi mmu:54614.
    UCSCi uc007xph.1. mouse. [Q80W14-3 ]

    Organism-specific databases

    CTDi 25766.
    MGIi MGI:1925583. Prpf40b.

    Phylogenomic databases

    eggNOGi COG5104.
    GeneTreei ENSGT00740000115182.
    HOGENOMi HOG000231802.
    HOVERGENi HBG059634.
    KOi K12821.
    OrthoDBi EOG77Q4X2.
    TreeFami TF318732.

    Miscellaneous databases

    ChiTaRSi PRPF40B. mouse.
    NextBioi 311428.
    PROi Q80W14.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80W14.
    Bgeei Q80W14.
    Genevestigatori Q80W14.

    Family and domain databases

    Gene3Di 1.10.10.440. 4 hits.
    InterProi IPR002713. FF_domain.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF01846. FF. 2 hits.
    PF00397. WW. 2 hits.
    [Graphical view ]
    SMARTi SM00441. FF. 4 hits.
    SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 2 hits.
    SSF81698. SSF81698. 5 hits.
    PROSITEi PS51676. FF. 6 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FBP11, a mammalian ortholog of the essential yeast splicing factor PRP40."
      Bedford M.T., Das R., Reed R., Leder P.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-870 (ISOFORM 1/3).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain and Embryo.

    Entry informationi

    Entry nameiPR40B_MOUSE
    AccessioniPrimary (citable) accession number: Q80W14
    Secondary accession number(s): Q5XKB4, Q9CS39, Q9WVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3