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Protein

TOX high mobility group box family member 3

Gene

Tox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi254 – 322HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 3
Alternative name(s):
Trinucleotide repeat-containing gene 9 protein
Gene namesi
Name:Tox3
Synonyms:Tnrc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3039593. Tox3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863541 – 575TOX high mobility group box family member 3Add BLAST575

Proteomic databases

MaxQBiQ80W03.
PaxDbiQ80W03.
PRIDEiQ80W03.

PTM databases

iPTMnetiQ80W03.
PhosphoSitePlusiQ80W03.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043668.
CleanExiMM_TOX3.
ExpressionAtlasiQ80W03. baseline and differential.
GenevisibleiQ80W03. MM.

Interactioni

Subunit structurei

Homodimer. Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form). Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232663. 8 interactors.
STRINGi10090.ENSMUSP00000105250.

Structurei

3D structure databases

ProteinModelPortaliQ80W03.
SMRiQ80W03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 249Poly-Lys6
Compositional biasi430 – 571Gln-richAdd BLAST142

Domaini

the C-terminus is required for calcium responsiveness but not for transactivation activity.By similarity
The N-terminus is absolutely necessary for transactivation activity.By similarity

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051183.
InParanoidiQ80W03.
OMAiQYRQDHS.
OrthoDBiEOG091G12A3.
PhylomeDBiQ80W03.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80W03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRFYPAAA GDPAGLDFAQ CLGYYGYSKL GNNNYMNMAE ANNAFFAASE
60 70 80 90 100
QTFHTPSLGD EEFEIPPITP PPESDPTLGM PDALLPFQTL SDPLPSQGTE
110 120 130 140 150
FTPQFPPQSL DLPSITISRN LVEQDGVLHS NGLHMDQSHT QVSQYRQDPS
160 170 180 190 200
LVMRSIVHMT DGARSGIMPP AQLTTINQSQ LSAQLGLNLG GANVSHTSPS
210 220 230 240 250
PPASKSATPS PSSSINEEDA DDANRAIGEK RTAPDSGKKP KTPKKKKKKD
260 270 280 290 300
PNEPQKPVSA YALFFRDTQA AIKGQNPNAT FGEVSKIVAS MWDSLGEEQK
310 320 330 340 350
QVYKRKTEAA KKEYLKALAA YRASLVSKAA AESAEAQTIR SVQQTLASTN
360 370 380 390 400
LTSSLLLNTS LSQHGTVPAS PQTLPQSLPR SIAPKPLTMR LPMSQIVTSV
410 420 430 440 450
TIAANMPSNI GAPLISSMGT TMVGSATSTQ VSPSVQTQQH QMQLQQQQQQ
460 470 480 490 500
QQQMQQMQQQ QLQQHQMHQQ IQQQMQQQHF QHHMQQHLQQ QQQQHLQQQL
510 520 530 540 550
SQQQLQQQLQ QHLQLQQLQH MQHQSQPSPR QHSPVTSQIT SPIPAIGSPQ
560 570
PASQQHQPQI QSQTQTQVLP QVSIF
Length:575
Mass (Da):63,174
Last modified:June 1, 2003 - v1
Checksum:iE1B95AD9F3BCFC91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → G in BAC38545 (PubMed:16141072).Curated1
Sequence conflicti14A → S in BAC38545 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082602 mRNA. Translation: BAC38545.1.
BC052044 mRNA. Translation: AAH52044.1.
CCDSiCCDS22516.1.
RefSeqiNP_766501.2. NM_172913.3.
UniGeneiMm.302755.

Genome annotation databases

EnsembliENSMUST00000109621; ENSMUSP00000105250; ENSMUSG00000043668.
GeneIDi244579.
KEGGimmu:244579.
UCSCiuc009msb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082602 mRNA. Translation: BAC38545.1.
BC052044 mRNA. Translation: AAH52044.1.
CCDSiCCDS22516.1.
RefSeqiNP_766501.2. NM_172913.3.
UniGeneiMm.302755.

3D structure databases

ProteinModelPortaliQ80W03.
SMRiQ80W03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232663. 8 interactors.
STRINGi10090.ENSMUSP00000105250.

PTM databases

iPTMnetiQ80W03.
PhosphoSitePlusiQ80W03.

Proteomic databases

MaxQBiQ80W03.
PaxDbiQ80W03.
PRIDEiQ80W03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109621; ENSMUSP00000105250; ENSMUSG00000043668.
GeneIDi244579.
KEGGimmu:244579.
UCSCiuc009msb.2. mouse.

Organism-specific databases

CTDi27324.
MGIiMGI:3039593. Tox3.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051183.
InParanoidiQ80W03.
OMAiQYRQDHS.
OrthoDBiEOG091G12A3.
PhylomeDBiQ80W03.
TreeFamiTF106481.

Miscellaneous databases

ChiTaRSiTox3. mouse.
PROiQ80W03.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043668.
CleanExiMM_TOX3.
ExpressionAtlasiQ80W03. baseline and differential.
GenevisibleiQ80W03. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOX3_MOUSE
AccessioniPrimary (citable) accession number: Q80W03
Secondary accession number(s): Q8BIV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.