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Q80VY9

- DHX33_MOUSE

UniProt

Q80VY9 - DHX33_MOUSE

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Protein
Putative ATP-dependent RNA helicase DHX33
Gene
Dhx33
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization By similarity.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 958ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. activating transcription factor binding Source: UniProtKB
  4. rDNA binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX33 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 33
Gene namesi
Name:Dhx33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2445102. Dhx33.

Subcellular locationi

Nucleusnucleolus
Note: During mitosis, localizes with the nucleolar organizing regions By similarity.1 Publication

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi94 – 941K → N or R: Loss of stimulation of rRNA synthesis. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Putative ATP-dependent RNA helicase DHX33
PRO_0000055165Add
BLAST

Proteomic databases

PRIDEiQ80VY9.

PTM databases

PhosphoSiteiQ80VY9.

Expressioni

Gene expression databases

ArrayExpressiQ80VY9.
BgeeiQ80VY9.
CleanExiMM_DHX33.
GenevestigatoriQ80VY9.

Interactioni

Subunit structurei

Interacts with UBTF.1 Publication

Protein-protein interaction databases

BioGridi229816. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80VY9.
SMRiQ80VY9. Positions 62-689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 243169Helicase ATP-binding
Add
BLAST
Domaini271 – 441171Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi185 – 1884DEAH box
Motifi536 – 55015Critical for rDNA-binding
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00750000117594.
HOGENOMiHOG000175261.
HOVERGENiHBG039428.
InParanoidiQ80VY9.
KOiK17820.
OMAiGDMESVR.
OrthoDBiEOG718KC0.
PhylomeDBiQ80VY9.
TreeFamiTF354245.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VY9-1 [UniParc]FASTAAdd to Basket

« Hide

MPEEASLPPA KRFRPGSCPP GRRVVMLLTA GGGGGAGGGR RQTPPLAQPS    50
ASPYREALEL QRRSLPIFRA RGQLLAQLRN LDNAVLIGET GSGKTTQIPQ 100
YLYEGGISRQ GIIAVTQPRR VAAISLATRV SDEKRTELGK LVGYTVRFED 150
VTSEDTRIKF LTDGMLLREA ISDSLLRKYS CVILDEAHER TIHTDVLFGV 200
VKTAQKRRKE LGKLPLKVIV MSATMDVDLF SQYFNRAPVL YLEGRQHPIQ 250
IFYTKQPQQD YLHAALVSVF QIHQEAPASQ DILVFLTGQE EIEAMSKTCR 300
DIARHLPDGC PSMLVLPLYA SLPYSQQLRV FQGAPKGYRK VIISTNIAET 350
SITITGIKYV VDTGMVKAKK YNPDSGLEVL AVQRVSKTQA WQRTGRAGRE 400
DSGICYRLYT EDEFEKFEKM TVPEIQRCNL ASVILQLLAM KVPNVLTFDF 450
MSKPSPDHIE AAIAQLDLLG ALEHKDDQLT LTPIGRKMAA FPLEPRFAKT 500
ILLSSKFHCT EEILTIVSLL SVDSVLYNPP ARRDEVQSVR KKFISSEGDH 550
ITLLNIYRTF KNIGGNKDWC KENFVNSKNM LLVAEVRAQL REICLKMSMP 600
IMSSRGDMES VRRCMAHSLF MNTAELQTDG TYATTDTHQP VAIHPSSVLF 650
HCKPACVVYT SLLYTNKCYM RDLCVVDAEW LYEAAPDYFR RKLRTARN 698
Length:698
Mass (Da):78,347
Last modified:June 1, 2003 - v1
Checksum:i7DFF1F220C69544E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti470 – 4701G → V in BAC28969. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035177 mRNA. Translation: BAC28969.1.
BC052172 mRNA. Translation: AAH52172.1.
CCDSiCCDS24971.1.
RefSeqiNP_848144.3. NM_178367.4.
UniGeneiMm.35399.

Genome annotation databases

EnsembliENSMUST00000108527; ENSMUSP00000104167; ENSMUSG00000040620.
GeneIDi216877.
KEGGimmu:216877.
UCSCiuc007jxg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035177 mRNA. Translation: BAC28969.1 .
BC052172 mRNA. Translation: AAH52172.1 .
CCDSi CCDS24971.1.
RefSeqi NP_848144.3. NM_178367.4.
UniGenei Mm.35399.

3D structure databases

ProteinModelPortali Q80VY9.
SMRi Q80VY9. Positions 62-689.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229816. 1 interaction.

PTM databases

PhosphoSitei Q80VY9.

Proteomic databases

PRIDEi Q80VY9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108527 ; ENSMUSP00000104167 ; ENSMUSG00000040620 .
GeneIDi 216877.
KEGGi mmu:216877.
UCSCi uc007jxg.1. mouse.

Organism-specific databases

CTDi 56919.
MGIi MGI:2445102. Dhx33.

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00750000117594.
HOGENOMi HOG000175261.
HOVERGENi HBG039428.
InParanoidi Q80VY9.
KOi K17820.
OMAi GDMESVR.
OrthoDBi EOG718KC0.
PhylomeDBi Q80VY9.
TreeFami TF354245.

Miscellaneous databases

ChiTaRSi DHX33. mouse.
NextBioi 375442.
PROi Q80VY9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80VY9.
Bgeei Q80VY9.
CleanExi MM_DHX33.
Genevestigatori Q80VY9.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic limb.
  3. "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."
    Zhang Y., Forys J.T., Miceli A.P., Gwinn A.S., Weber J.D.
    Mol. Cell. Biol. 31:4676-4691(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UBTF, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-94.

Entry informationi

Entry nameiDHX33_MOUSE
AccessioniPrimary (citable) accession number: Q80VY9
Secondary accession number(s): Q8BS50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi