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Q80VW5 (WHRN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Whirlin
Gene names
Name:Dfnb31
Synonyms:Kiaa1526, Whrn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length918 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Ref.8

Subunit structure

Forms homooligomers. Binds CASK, MPP1/p55 and MYO15A via the C-terminal PDZ domain. Binding to MYO15A is necessary for localization of DFNB31/WHRN to stereocilia tips. Interacts with USH2A, GPR98/MASS1 and LRRC4C/NGL1. Interacts with RPGR. Interacts with EPS8. Ref.1 Ref.2 Ref.9 Ref.10 Ref.11 Ref.13 Ref.14

Subcellular location

Cytoplasm. Cell projectionstereocilium. Cell projectiongrowth cone. Note: Detected at the level of stereocilia in inner and outer hair cells of the cochlea and vestibule. Colocalizes with the growing ends of actin filaments. Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Ref.1 Ref.8 Ref.9 Ref.13

Tissue specificity

Expressed in the retina. Colocalizes with RPGR in the photoreceptor connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (at protein level). Detected in the inner ear throughout development from embryonic day 12 to 20 days after birth. Displays a dynamic pattern of expression after birth, demonstrating an ordered appearance and fade-out across stereocilia rows. Ref.2 Ref.7 Ref.8

Developmental stage

Expression decreases by 11 days after birth in inner ear hair cells and by 14 days after birth in outer ear hair cells. Expressed in vestibular hair cells at high levels through to adulthood. Ref.8

Involvement in disease

Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them. Ref.6 Ref.7 Ref.12

Sequence similarities

Contains 3 PDZ (DHR) domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Lrrc4cQ8C0314EBI-7417603,EBI-7417983
Myo15aQ9QZZ45EBI-7417603,EBI-4281382

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80VW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80VW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: G → GSGLR
     544-554: Missing.
Isoform 3 (identifier: Q80VW5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     544-554: Missing.
Note: Major isoform.
Isoform 4 (identifier: Q80VW5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     544-554: Missing.
     758-758: Missing.
Isoform 5 (identifier: Q80VW5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-357: Missing.
     358-402: KDVGRLPHAR...GDHTEEGTSK → MTTWCHRPRV...SSGLCPSVFQ
     544-554: Missing.
Isoform 6 (identifier: Q80VW5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.
Isoform 7 (identifier: Q80VW5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.
     544-554: Missing.
Isoform 8 (identifier: Q80VW5-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-503: Missing.
     544-554: Missing.
Isoform 9 (identifier: Q80VW5-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.
Isoform 10 (identifier: Q80VW5-10)

The sequence of this isoform differs from the canonical sequence as follows:
     544-571: ERLLWLIDLMENTLDLEGTGETTQGSTN → VSHPCPILGEKVRARIRCFPPKPRVPHL
     572-918: Missing.
Note: No experimental confirmation available.
Isoform 11 (identifier: Q80VW5-11)

Also known as: WhirlinNT2;

The sequence of this isoform differs from the canonical sequence as follows:
     555-566: NTLDLEGTGETT → VPSFCRGRLGVP
     567-918: Missing.
Note: May be due to intron retention.
Isoform 12 (identifier: Q80VW5-12)

Also known as: WhirlinNT1;

The sequence of this isoform differs from the canonical sequence as follows:
     323-918: Missing.
Note: May be due to intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 918918Whirlin
PRO_0000065969

Regions

Domain141 – 22484PDZ 1
Domain280 – 36283PDZ 2
Domain827 – 91084PDZ 3
Compositional bias9 – 3224Ala/Gly/Ser-rich
Compositional bias584 – 723140Pro-rich

Natural variations

Alternative sequence1 – 552552Missing in isoform 9.
VSP_029934
Alternative sequence1 – 503503Missing in isoform 8.
VSP_029935
Alternative sequence1 – 442442Missing in isoform 6 and isoform 7.
VSP_029936
Alternative sequence1 – 357357Missing in isoform 5.
VSP_029937
Alternative sequence323 – 918596Missing in isoform 12.
VSP_045293
Alternative sequence358 – 40245KDVGR…EGTSK → MTTWCHRPRVRWSGSCVCGD HQHNARSHSLPRSLDSSGLC PSVFQ in isoform 5.
VSP_029938
Alternative sequence3901G → GSGLR in isoform 2.
VSP_029939
Alternative sequence544 – 57128ERLLW…QGSTN → VSHPCPILGEKVRARIRCFP PKPRVPHL in isoform 10.
VSP_029940
Alternative sequence544 – 55411Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 8.
VSP_029941
Alternative sequence555 – 56612NTLDL…TGETT → VPSFCRGRLGVP in isoform 11.
VSP_045294
Alternative sequence567 – 918352Missing in isoform 11.
VSP_045295
Alternative sequence572 – 918347Missing in isoform 10.
VSP_029942
Alternative sequence7581Missing in isoform 4.
VSP_029943

Experimental info

Sequence conflict5041M → V in BAE34281. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 3.
Checksum: 7D5EA44DE0645AA4

FASTA91898,012
        10         20         30         40         50         60 
MNAQLDGLSV SSSSTGSLGS AAAAAGGGGG AGLRLLSANV RQLHQALTAL LSEPEREQFT 

        70         80         90        100        110        120 
HCLNAYHARR NVFDLVRTLR VLLDSPVKRR LLPMLRLVIP RSDQLLFDQY TAEGLYLPAT 

       130        140        150        160        170        180 
TPYRQPAWAA PDGAGPGEVR LVSLRRAKAH EGLGFSIRGG SEHGVGIYVS LVEPGSLAEK 

       190        200        210        220        230        240 
EGLRVGDQIL RVNDKSLARV THAEAVKALK GSKKLVLSVY SAGRIPGGYV TNHIYTWVDP 

       250        260        270        280        290        300 
QGRSTSPPSS LPQPHGSTLR QREDDRRSTL HLLQSGDEKK VNLVLGDGRS LGLTIRGGAE 

       310        320        330        340        350        360 
YGLGIYITGV DPGSEAESSG LKVGDQILEV NGRSFLNILH DEAVKLLKSS RHLILTVKDV 

       370        380        390        400        410        420 
GRLPHARTTV DQTKWIASSR IGESVANSAG FPGDHTEEGT SKPGFYKGPA GSQVTLSSLG 

       430        440        450        460        470        480 
NQTRALLDDQ ARHLLTEQER ATMMYYLAQY RGGTISVEAM VMALFELLNT HAKFSLLSEV 

       490        500        510        520        530        540 
RSIISPQDLD RFDHLVLRRE IESMKARQPP GPGVGDTYSM VSYSDTGSST GSHGTSTTVS 

       550        560        570        580        590        600 
SARERLLWLI DLMENTLDLE GTGETTQGST NALPDVSVDD VKSPSEDLPG IKPPPPPPPL 

       610        620        630        640        650        660 
AQGHDRLLGQ PRKPGREDPA PLSSAAHSGI VFSAPRNRSP PPGTAPTPGP SSAQDSPSSP 

       670        680        690        700        710        720 
IYASISHANP SSRKPLDTHL ALVNQHPIGP FPRVQSPPHL KSPPAETPGA GACLPPPSPS 

       730        740        750        760        770        780 
EHPDAVGANQ HFVLVEVHRP DSEPDVNEVR ALPQTRTAST LSQLSDSGQT LSEDSGVDAG 

       790        800        810        820        830        840 
ETEASTSGRG RQTASAKNKN GKEQPRTERT AEGANKPPGL LEPTSTLVRV RKSAATLGIA 

       850        860        870        880        890        900 
IEGGANTRQP LPRIVTIQRG GSAHNCGQLK VGHVILEVNG QTLRGKEHKE AARIIAEAFK 

       910 
TKERDYIDFL VTEFNVML 

« Hide

Isoform 2 [UniParc].

Checksum: 3195E2DB7907E92F
Show »

FASTA91197,013
Isoform 3 [UniParc].

Checksum: C23C5823AE9BD457
Show »

FASTA90796,600
Isoform 4 [UniParc].

Checksum: F96EFC6C1DF9D029
Show »

FASTA90696,528
Isoform 5 [UniParc].

Checksum: FB4D9E8BDD6DD09B
Show »

FASTA55058,669
Isoform 6 [UniParc].

Checksum: BDA13DA400C3E0F4
Show »

FASTA47650,709
Isoform 7 [UniParc].

Checksum: 5EE7EB675198EBE2
Show »

FASTA46549,296
Isoform 8 [UniParc].

Checksum: 47E37E2D1D9647EE
Show »

FASTA40442,208
Isoform 9 [UniParc].

Checksum: 4EECE4260B616897
Show »

FASTA36638,480
Isoform 10 [UniParc].

Checksum: B1B7F2811EF53A9D
Show »

FASTA57161,584
Isoform 11 (WhirlinNT2) [UniParc].

Checksum: 4EEDB18EC7979658
Show »

FASTA56661,080
Isoform 12 (WhirlinNT1) [UniParc].

Checksum: 7DC71EAD135F55ED
Show »

FASTA32234,324

References

« Hide 'large scale' references
[1]"Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia."
Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B.
Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9), INTERACTION WITH MYO15A, SUBCELLULAR LOCATION.
Strain: C57BL/6.
Tissue: Inner ear.
[2]"RpgrORF15 connects to the usher protein network through direct interactions with multiple whirlin isoforms."
Wright R.N., Hong D.H., Perkins B.
Invest. Ophthalmol. Vis. Sci. 53:1519-1529(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 11 AND 12), INTERACTION WITH RPGR, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Retina.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
Strain: C57BL/6J.
Tissue: Inner ear.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-918 (ISOFORM 4).
Tissue: Brain.
[6]"Elongation of hair cell stereocilia is defective in the mouse mutant whirler."
Holme R.H., Kiernan B.W., Brown S.D.M., Steel K.P.
J. Comp. Neurol. 450:94-102(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
[7]"Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31."
Mburu P., Mustapha M., Varela A., Weil D., El-Amraoui A., Holme R.H., Rump A., Hardisty R.E., Blanchard S., Coimbra R.S., Perfettini I., Parkinson N., Mallon A.-M., Glenister P., Rogers M.J., Paige A.J., Moir L., Clay J. expand/collapse author list , Rosenthal A., Liu X.Z., Blanco G., Steel K.P., Petit C., Brown S.D.
Nat. Genet. 34:421-428(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[8]"Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium."
Kikkawa Y., Mburu P., Morse S., Kominami R., Townsend S., Brown S.D.M.
Hum. Mol. Genet. 14:391-400(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[9]"Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly."
Delprat B., Michel V., Goodyear R., Yamasaki Y., Michalski N., El-Amraoui A., Perfettini I., Legrain P., Richardson G., Hardelin J.-P., Petit C.
Hum. Mol. Genet. 14:401-410(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, INTERACTION WITH LRRC4C; MYO7A AND MYO15A, SUBCELLULAR LOCATION.
[10]"Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells."
Adato A., Lefevre G., Delprat B., Michel V., Michalski N., Chardenoux S., Weil D., El-Amraoui A., Petit C.
Hum. Mol. Genet. 14:3921-3932(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH USH2A.
[11]"Whirlin complexes with p55 at the stereocilia tip during hair cell development."
Mburu P., Kikkawa Y., Townsend S., Romero R., Yonekawa H., Brown S.D.
Proc. Natl. Acad. Sci. U.S.A. 103:10973-10978(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MPP1.
[12]"The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development."
Mogensen M.M., Rzadzinska A., Steel K.P.
Cell Motil. Cytoskeleton 64:496-508(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
[13]"MPP1 links the Usher protein network and the Crumbs protein complex in the retina."
Gosens I., van Wijk E., Kersten F.F., Krieger E., van der Zwaag B., Maerker T., Letteboer S.J., Dusseljee S., Peters T., Spierenburg H.A., Punte I.M., Wolfrum U., Cremers F.P.M., Kremer H., Roepman R.
Hum. Mol. Genet. 16:1993-2003(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MPP1, SUBCELLULAR LOCATION.
[14]"Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8."
Manor U., Disanza A., Grati M., Andrade L., Lin H., Di Fiore P.P., Scita G., Kachar B.
Curr. Biol. 21:167-172(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EPS8.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY739114 mRNA. Translation: AAV87519.1.
AY739115 mRNA. Translation: AAV87520.1.
AY739116 mRNA. Translation: AAV87521.1.
AY739117 mRNA. Translation: AAV87522.1.
AY739118 mRNA. Translation: AAV87523.1.
AY739119 mRNA. Translation: AAV87524.1.
AY739120 mRNA. Translation: AAV87525.1.
AY739121 mRNA. Translation: AAV87526.1.
AY739122 mRNA. Translation: AAV87527.1.
HQ148552 mRNA. Translation: AEL23234.1.
HQ148553 mRNA. Translation: AEL23235.1.
AK157955 mRNA. Translation: BAE34281.1.
AL683828 Genomic DNA. Translation: CAD62267.1.
AL683828 Genomic DNA. Translation: CAD62268.1.
AL683828 Genomic DNA. Translation: CAM21546.1.
AL683828 Genomic DNA. Translation: CAM21547.1.
AL683828 Genomic DNA. Translation: CAM21548.1.
AK122523 mRNA. Translation: BAC65805.1.
RefSeqNP_001008791.1. NM_001008791.2.
NP_001008792.1. NM_001008792.2.
NP_001008793.1. NM_001008793.2.
NP_001263300.1. NM_001276371.1.
NP_082916.1. NM_028640.2.
UniGeneMm.300397.

3D structure databases

ProteinModelPortalQ80VW5.
SMRQ80VW5. Positions 44-379, 824-915.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80VW5. 3 interactions.
MINTMINT-1895268.

PTM databases

PhosphoSiteQ80VW5.

Proteomic databases

PaxDbQ80VW5.
PRIDEQ80VW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063650; ENSMUSP00000069664; ENSMUSG00000039137. [Q80VW5-3]
ENSMUST00000063672; ENSMUSP00000065838; ENSMUSG00000039137. [Q80VW5-10]
ENSMUST00000084510; ENSMUSP00000081557; ENSMUSG00000039137. [Q80VW5-1]
ENSMUST00000095037; ENSMUSP00000092647; ENSMUSG00000039137. [Q80VW5-8]
ENSMUST00000095038; ENSMUSP00000092648; ENSMUSG00000039137. [Q80VW5-6]
ENSMUST00000102867; ENSMUSP00000099931; ENSMUSG00000039137. [Q80VW5-4]
ENSMUST00000107393; ENSMUSP00000103016; ENSMUSG00000039137. [Q80VW5-2]
ENSMUST00000119294; ENSMUSP00000114030; ENSMUSG00000039137. [Q80VW5-7]
GeneID73750.
KEGGmmu:73750.
UCSCuc008tgf.1. mouse. [Q80VW5-9]
uc008tgg.1. mouse. [Q80VW5-5]
uc008tgh.1. mouse. [Q80VW5-1]
uc008tgi.1. mouse. [Q80VW5-4]
uc008tgj.1. mouse. [Q80VW5-2]
uc008tgk.1. mouse. [Q80VW5-3]
uc008tgm.1. mouse. [Q80VW5-8]
uc008tgn.1. mouse. [Q80VW5-7]
uc008tgp.1. mouse. [Q80VW5-10]

Organism-specific databases

CTD73750.
MGIMGI:2682003. Whrn.
RougeSearch...

Phylogenomic databases

eggNOGNOG291372.
GeneTreeENSGT00530000063178.
HOVERGENHBG056634.
InParanoidQ80VW5.
OMAAPQNRSP.
OrthoDBEOG7J9VQG.
TreeFamTF325033.

Gene expression databases

ArrayExpressQ80VW5.
BgeeQ80VW5.
CleanExMM_WHRN.
GenevestigatorQ80VW5.

Family and domain databases

InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 3 hits.
[Graphical view]
SMARTSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMSSF50156. SSF50156. 3 hits.
PROSITEPS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDFNB31. mouse.
NextBio338987.
PROQ80VW5.
SOURCESearch...

Entry information

Entry nameWHRN_MOUSE
AccessionPrimary (citable) accession number: Q80VW5
Secondary accession number(s): A2AGD2 expand/collapse secondary AC list , I6MML6, I6MML7, Q3TZC8, Q5MLF1, Q5MLF2, Q5MLF3, Q5MLF4, Q5MLF5, Q5MLF6, Q5MLF7, Q5MLF8, Q5MLF9, Q80TC2, Q80VW4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 4, 2007
Last modified: March 19, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot