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Protein

Eukaryotic translation initiation factor 4E-binding protein 3

Gene

Eif4ebp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 3
Short name:
4E-BP3
Short name:
eIF4E-binding protein 3
Gene namesi
Name:Eif4ebp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1270847. Eif4ebp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Eukaryotic translation initiation factor 4E-binding protein 3PRO_0000190519Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80VV3.
PRIDEiQ80VV3.

PTM databases

iPTMnetiQ80VV3.
PhosphoSiteiQ80VV3.

Expressioni

Gene expression databases

BgeeiQ80VV3.
GenevisibleiQ80VV3. MM.

Interactioni

Subunit structurei

EIF4EBP3 interacts with EIF4E.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039298.

Structurei

3D structure databases

ProteinModelPortaliQ80VV3.
SMRiQ80VV3. Positions 15-47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 467YXXXXLphi motifBy similarity
Motifi97 – 1015TOS motifBy similarity

Sequence similaritiesi

Belongs to the eIF4E-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J2Z0. Eukaryota.
ENOG4112779. LUCA.
GeneTreeiENSGT00390000013843.
HOGENOMiHOG000231190.
HOVERGENiHBG050425.
InParanoidiQ80VV3.
KOiK18645.
OMAiNQFEMDI.
OrthoDBiEOG7B31Q1.
PhylomeDBiQ80VV3.
TreeFamiTF101530.

Family and domain databases

InterProiIPR008606. EIF4EBP.
[Graphical view]
PfamiPF05456. eIF_4EBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSTSCPIP GCRDQLPDGY STTPGGTLYA TTPGGTRIIY DRKFLLECKN
60 70 80 90 100
SPIARTPPCC LPQIPGVTTL PAVPPSKLEL LKEQKQTEVE ITDDEQFEMD

M
Length:101
Mass (Da):11,019
Last modified:June 1, 2003 - v1
Checksum:i78F82052696A9BD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226182 mRNA. Translation: AAO73448.1.
BC061242 mRNA. Translation: AAH61242.1.
BC111107 mRNA. Translation: AAI11108.1.
CCDSiCCDS29155.1.
RefSeqiNP_957708.1. NM_201256.4.
UniGeneiMm.24790.

Genome annotation databases

EnsembliENSMUST00000036765; ENSMUSP00000039298; ENSMUSG00000090264.
GeneIDi108112.
KEGGimmu:108112.
UCSCiuc008enx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226182 mRNA. Translation: AAO73448.1.
BC061242 mRNA. Translation: AAH61242.1.
BC111107 mRNA. Translation: AAI11108.1.
CCDSiCCDS29155.1.
RefSeqiNP_957708.1. NM_201256.4.
UniGeneiMm.24790.

3D structure databases

ProteinModelPortaliQ80VV3.
SMRiQ80VV3. Positions 15-47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039298.

PTM databases

iPTMnetiQ80VV3.
PhosphoSiteiQ80VV3.

Proteomic databases

PaxDbiQ80VV3.
PRIDEiQ80VV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036765; ENSMUSP00000039298; ENSMUSG00000090264.
GeneIDi108112.
KEGGimmu:108112.
UCSCiuc008enx.2. mouse.

Organism-specific databases

CTDi8637.
MGIiMGI:1270847. Eif4ebp3.

Phylogenomic databases

eggNOGiENOG410J2Z0. Eukaryota.
ENOG4112779. LUCA.
GeneTreeiENSGT00390000013843.
HOGENOMiHOG000231190.
HOVERGENiHBG050425.
InParanoidiQ80VV3.
KOiK18645.
OMAiNQFEMDI.
OrthoDBiEOG7B31Q1.
PhylomeDBiQ80VV3.
TreeFamiTF101530.

Miscellaneous databases

PROiQ80VV3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VV3.
GenevisibleiQ80VV3. MM.

Family and domain databases

InterProiIPR008606. EIF4EBP.
[Graphical view]
PfamiPF05456. eIF_4EBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two overlapping reading frames in the second exon of the translational inhibitor 4E-BP3."
    Poulin F., Sonenberg N.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry namei4EBP3_MOUSE
AccessioniPrimary (citable) accession number: Q80VV3
Secondary accession number(s): Q2TA53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.