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Q80VU4

- NTF4_MOUSE

UniProt

Q80VU4 - NTF4_MOUSE

Protein

Neurotrophin-4

Gene

Ntf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Could serve as a target-derived trophic factor for sensory and sympathetic neurons.By similarity

    GO - Molecular functioni

    1. neurotrophin p75 receptor binding Source: MGI

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. epidermis development Source: MGI
    3. ganglion mother cell fate determination Source: MGI
    4. innervation Source: MGI
    5. long-term memory Source: MGI
    6. mechanoreceptor differentiation Source: MGI
    7. negative regulation of cell death Source: MGI
    8. sensory organ boundary specification Source: MGI
    9. taste bud development Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-4
    Short name:
    NT-4
    Alternative name(s):
    Neurotrophin-5
    Short name:
    NT-5
    Neutrophic factor 4
    Gene namesi
    Name:Ntf4
    Synonyms:Ntf5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:97381. Ntf5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 7958PRO_0000019671Add
    BLAST
    Chaini80 – 209130Neurotrophin-4PRO_0000019672Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 169By similarity
    Disulfide bondi140 ↔ 198By similarity
    Disulfide bondi157 ↔ 200By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ80VU4.

    Expressioni

    Gene expression databases

    BgeeiQ80VU4.
    CleanExiMM_NTF5.
    GenevestigatoriQ80VU4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057916.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80VU4.
    SMRiQ80VU4. Positions 84-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42623.
    GeneTreeiENSGT00390000007725.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiQ80VU4.
    KOiK12457.
    OMAiSVPMEPH.
    OrthoDBiEOG7RBZ8Z.
    PhylomeDBiQ80VU4.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR020432. Neurotrophin-4.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01915. NEUROTROPHN4.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80VU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG    50
    APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS 100
    GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP 150
    GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC 200
    TLLSRTGRA 209
    Length:209
    Mass (Da):22,346
    Last modified:June 1, 2003 - v1
    Checksum:i797AE81A2A33EAB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC052191 mRNA. Translation: AAH52191.1.
    CCDSiCCDS21241.1.
    RefSeqiNP_937833.1. NM_198190.1.
    XP_006541375.1. XM_006541312.1.
    XP_006541376.1. XM_006541313.1.
    UniGeneiMm.20344.

    Genome annotation databases

    EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
    GeneIDi78405.
    KEGGimmu:78405.
    UCSCiuc009gva.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC052191 mRNA. Translation: AAH52191.1 .
    CCDSi CCDS21241.1.
    RefSeqi NP_937833.1. NM_198190.1.
    XP_006541375.1. XM_006541312.1.
    XP_006541376.1. XM_006541313.1.
    UniGenei Mm.20344.

    3D structure databases

    ProteinModelPortali Q80VU4.
    SMRi Q80VU4. Positions 84-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057916.

    Proteomic databases

    PRIDEi Q80VU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058879 ; ENSMUSP00000057916 ; ENSMUSG00000074121 .
    GeneIDi 78405.
    KEGGi mmu:78405.
    UCSCi uc009gva.1. mouse.

    Organism-specific databases

    CTDi 78405.
    MGIi MGI:97381. Ntf5.

    Phylogenomic databases

    eggNOGi NOG42623.
    GeneTreei ENSGT00390000007725.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi Q80VU4.
    KOi K12457.
    OMAi SVPMEPH.
    OrthoDBi EOG7RBZ8Z.
    PhylomeDBi Q80VU4.
    TreeFami TF106463.

    Enzyme and pathway databases

    Reactomei REACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Miscellaneous databases

    NextBioi 348810.
    PROi Q80VU4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80VU4.
    CleanExi MM_NTF5.
    Genevestigatori Q80VU4.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR020432. Neurotrophin-4.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01915. NEUROTROPHN4.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.

    Entry informationi

    Entry nameiNTF4_MOUSE
    AccessioniPrimary (citable) accession number: Q80VU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3