Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurotrophin-4

Gene

Ntf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.By similarity

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cell-cell signaling Source: GO_Central
  • epidermis development Source: MGI
  • ganglion mother cell fate determination Source: MGI
  • innervation Source: MGI
  • long-term memory Source: MGI
  • mechanoreceptor differentiation Source: MGI
  • negative regulation of cell death Source: MGI
  • negative regulation of neuron apoptotic process Source: GO_Central
  • neuron projection morphogenesis Source: GO_Central
  • regulation of neuron differentiation Source: GO_Central
  • sensory organ boundary specification Source: MGI
  • taste bud development Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Ntf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97381 Ntf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001967122 – 79Add BLAST58
ChainiPRO_000001967280 – 209Neurotrophin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 169By similarity
Disulfide bondi140 ↔ 198By similarity
Disulfide bondi157 ↔ 200By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80VU4
PRIDEiQ80VU4

PTM databases

PhosphoSitePlusiQ80VU4

Expressioni

Gene expression databases

BgeeiENSMUSG00000074121
CleanExiMM_NTF5
ExpressionAtlasiQ80VU4 baseline and differential
GenevisibleiQ80VU4 MM

Interactioni

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • neurotrophin p75 receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057916

Structurei

3D structure databases

ProteinModelPortaliQ80VU4
SMRiQ80VU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIFY Eukaryota
ENOG4111839 LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiQ80VU4
KOiK12457
OMAiSVPMEPH
OrthoDBiEOG091G0GHL
PhylomeDBiQ80VU4
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01915 NEUROTROPHN4
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80VU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC

TLLSRTGRA
Length:209
Mass (Da):22,346
Last modified:June 1, 2003 - v1
Checksum:i797AE81A2A33EAB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052191 mRNA Translation: AAH52191.1
CCDSiCCDS21241.1
RefSeqiNP_937833.1, NM_198190.1
XP_006541375.1, XM_006541312.3
XP_006541376.1, XM_006541313.2
XP_011249221.1, XM_011250919.2
UniGeneiMm.20344

Genome annotation databases

EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121
GeneIDi78405
KEGGimmu:78405
UCSCiuc009gva.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNTF4_MOUSE
AccessioniPrimary (citable) accession number: Q80VU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health