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Q80VU4

- NTF4_MOUSE

UniProt

Q80VU4 - NTF4_MOUSE

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Protein

Neurotrophin-4

Gene

Ntf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.By similarity

GO - Molecular functioni

  1. neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. epidermis development Source: MGI
  3. ganglion mother cell fate determination Source: MGI
  4. innervation Source: MGI
  5. long-term memory Source: MGI
  6. mechanoreceptor differentiation Source: MGI
  7. negative regulation of cell death Source: MGI
  8. sensory organ boundary specification Source: MGI
  9. taste bud development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Ntf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:97381. Ntf5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 7958PRO_0000019671Add
BLAST
Chaini80 – 209130Neurotrophin-4PRO_0000019672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 169By similarity
Disulfide bondi140 ↔ 198By similarity
Disulfide bondi157 ↔ 200By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80VU4.

Expressioni

Gene expression databases

BgeeiQ80VU4.
CleanExiMM_NTF5.
ExpressionAtlasiQ80VU4. baseline and differential.
GenevestigatoriQ80VU4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057916.

Structurei

3D structure databases

ProteinModelPortaliQ80VU4.
SMRiQ80VU4. Positions 84-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42623.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ80VU4.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiQ80VU4.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80VU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC

TLLSRTGRA
Length:209
Mass (Da):22,346
Last modified:June 1, 2003 - v1
Checksum:i797AE81A2A33EAB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052191 mRNA. Translation: AAH52191.1.
CCDSiCCDS21241.1.
RefSeqiNP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGeneiMm.20344.

Genome annotation databases

EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
GeneIDi78405.
KEGGimmu:78405.
UCSCiuc009gva.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052191 mRNA. Translation: AAH52191.1 .
CCDSi CCDS21241.1.
RefSeqi NP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGenei Mm.20344.

3D structure databases

ProteinModelPortali Q80VU4.
SMRi Q80VU4. Positions 84-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057916.

Proteomic databases

PRIDEi Q80VU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058879 ; ENSMUSP00000057916 ; ENSMUSG00000074121 .
GeneIDi 78405.
KEGGi mmu:78405.
UCSCi uc009gva.1. mouse.

Organism-specific databases

CTDi 78405.
MGIi MGI:97381. Ntf5.

Phylogenomic databases

eggNOGi NOG42623.
GeneTreei ENSGT00390000007725.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi Q80VU4.
KOi K12457.
OMAi SVPMEPH.
OrthoDBi EOG7RBZ8Z.
PhylomeDBi Q80VU4.
TreeFami TF106463.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

NextBioi 348810.
PROi Q80VU4.
SOURCEi Search...

Gene expression databases

Bgeei Q80VU4.
CleanExi MM_NTF5.
ExpressionAtlasi Q80VU4. baseline and differential.
Genevestigatori Q80VU4.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiNTF4_MOUSE
AccessioniPrimary (citable) accession number: Q80VU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3