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Q80VU4

- NTF4_MOUSE

UniProt

Q80VU4 - NTF4_MOUSE

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Protein
Neurotrophin-4
Gene
Ntf4, Ntf5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons By similarity.

GO - Molecular functioni

  1. neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. epidermis development Source: MGI
  3. ganglion mother cell fate determination Source: MGI
  4. innervation Source: MGI
  5. long-term memory Source: MGI
  6. mechanoreceptor differentiation Source: MGI
  7. negative regulation of cell death Source: MGI
  8. sensory organ boundary specification Source: MGI
  9. taste bud development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Ntf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:97381. Ntf5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Propeptidei22 – 7958
PRO_0000019671Add
BLAST
Chaini80 – 209130Neurotrophin-4
PRO_0000019672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 169 By similarity
Disulfide bondi140 ↔ 198 By similarity
Disulfide bondi157 ↔ 200 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80VU4.

Expressioni

Gene expression databases

BgeeiQ80VU4.
CleanExiMM_NTF5.
GenevestigatoriQ80VU4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057916.

Structurei

3D structure databases

ProteinModelPortaliQ80VU4.
SMRiQ80VU4. Positions 84-207.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42623.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ80VU4.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiQ80VU4.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80VU4-1 [UniParc]FASTAAdd to Basket

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MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG    50
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS 100
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP 150
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC 200
TLLSRTGRA 209
Length:209
Mass (Da):22,346
Last modified:June 1, 2003 - v1
Checksum:i797AE81A2A33EAB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052191 mRNA. Translation: AAH52191.1.
CCDSiCCDS21241.1.
RefSeqiNP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGeneiMm.20344.

Genome annotation databases

EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
GeneIDi78405.
KEGGimmu:78405.
UCSCiuc009gva.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052191 mRNA. Translation: AAH52191.1 .
CCDSi CCDS21241.1.
RefSeqi NP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGenei Mm.20344.

3D structure databases

ProteinModelPortali Q80VU4.
SMRi Q80VU4. Positions 84-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057916.

Proteomic databases

PRIDEi Q80VU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058879 ; ENSMUSP00000057916 ; ENSMUSG00000074121 .
GeneIDi 78405.
KEGGi mmu:78405.
UCSCi uc009gva.1. mouse.

Organism-specific databases

CTDi 78405.
MGIi MGI:97381. Ntf5.

Phylogenomic databases

eggNOGi NOG42623.
GeneTreei ENSGT00390000007725.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi Q80VU4.
KOi K12457.
OMAi SVPMEPH.
OrthoDBi EOG7RBZ8Z.
PhylomeDBi Q80VU4.
TreeFami TF106463.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

NextBioi 348810.
PROi Q80VU4.
SOURCEi Search...

Gene expression databases

Bgeei Q80VU4.
CleanExi MM_NTF5.
Genevestigatori Q80VU4.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiNTF4_MOUSE
AccessioniPrimary (citable) accession number: Q80VU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi