Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurotrophin-4

Gene

Ntf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.By similarity

GO - Molecular functioni

  1. growth factor activity Source: GO_Central
  2. neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. cell-cell signaling Source: GO_Central
  3. epidermis development Source: MGI
  4. ganglion mother cell fate determination Source: MGI
  5. innervation Source: MGI
  6. long-term memory Source: MGI
  7. mechanoreceptor differentiation Source: MGI
  8. negative regulation of cell death Source: MGI
  9. negative regulation of neuron apoptotic process Source: GO_Central
  10. neuron projection morphogenesis Source: GO_Central
  11. regulation of neuron differentiation Source: GO_Central
  12. sensory organ boundary specification Source: MGI
  13. taste bud development Source: MGI
  14. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Ntf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:97381. Ntf5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: GO_Central
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 7958PRO_0000019671Add
BLAST
Chaini80 – 209130Neurotrophin-4PRO_0000019672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 169By similarity
Disulfide bondi140 ↔ 198By similarity
Disulfide bondi157 ↔ 200By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80VU4.

Expressioni

Gene expression databases

BgeeiQ80VU4.
CleanExiMM_NTF5.
ExpressionAtlasiQ80VU4. baseline and differential.
GenevestigatoriQ80VU4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057916.

Structurei

3D structure databases

ProteinModelPortaliQ80VU4.
SMRiQ80VU4. Positions 84-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42623.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ80VU4.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiQ80VU4.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80VU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC

TLLSRTGRA
Length:209
Mass (Da):22,346
Last modified:June 1, 2003 - v1
Checksum:i797AE81A2A33EAB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052191 mRNA. Translation: AAH52191.1.
CCDSiCCDS21241.1.
RefSeqiNP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGeneiMm.20344.

Genome annotation databases

EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
GeneIDi78405.
KEGGimmu:78405.
UCSCiuc009gva.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052191 mRNA. Translation: AAH52191.1.
CCDSiCCDS21241.1.
RefSeqiNP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGeneiMm.20344.

3D structure databases

ProteinModelPortaliQ80VU4.
SMRiQ80VU4. Positions 84-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057916.

Proteomic databases

PRIDEiQ80VU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
GeneIDi78405.
KEGGimmu:78405.
UCSCiuc009gva.1. mouse.

Organism-specific databases

CTDi78405.
MGIiMGI:97381. Ntf5.

Phylogenomic databases

eggNOGiNOG42623.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ80VU4.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiQ80VU4.
TreeFamiTF106463.

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

NextBioi348810.
PROiQ80VU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VU4.
CleanExiMM_NTF5.
ExpressionAtlasiQ80VU4. baseline and differential.
GenevestigatoriQ80VU4.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiNTF4_MOUSE
AccessioniPrimary (citable) accession number: Q80VU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.