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Q80VU4 (NTF4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrophin-4

Short name=NT-4
Alternative name(s):
Neurotrophin-5
Short name=NT-5
Neutrophic factor 4
Gene names
Name:Ntf4
Synonyms:Ntf5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could serve as a target-derived trophic factor for sensory and sympathetic neurons By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the NGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 7958
PRO_0000019671
Chain80 – 209130Neurotrophin-4
PRO_0000019672

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 169 By similarity
Disulfide bond140 ↔ 198 By similarity
Disulfide bond157 ↔ 200 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80VU4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 797AE81A2A33EAB6

FASTA20922,346
        10         20         30         40         50         60 
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG APAGPPLLFL 

        70         80         90        100        110        120 
LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS GWVTDRRTAV DLRGREVEVL 

       130        140        150        160        170        180 
GEVPAAGGSP LRQYFFETRC KAESAGEGGP GVGGGGCRGV DRRHWLSECK AKQSYVRALT 

       190        200 
ADSQGRVGWR WIRIDTACVC TLLSRTGRA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC052191 mRNA. Translation: AAH52191.1.
RefSeqNP_937833.1. NM_198190.1.
XP_006541375.1. XM_006541312.1.
XP_006541376.1. XM_006541313.1.
UniGeneMm.20344.

3D structure databases

ProteinModelPortalQ80VU4.
SMRQ80VU4. Positions 84-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000057916.

Proteomic databases

PRIDEQ80VU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
GeneID78405.
KEGGmmu:78405.
UCSCuc009gva.1. mouse.

Organism-specific databases

CTD78405.
MGIMGI:97381. Ntf5.

Phylogenomic databases

eggNOGNOG42623.
GeneTreeENSGT00390000007725.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidQ80VU4.
KOK12457.
OMASVPMEPH.
OrthoDBEOG7RBZ8Z.
PhylomeDBQ80VU4.
TreeFamTF106463.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeQ80VU4.
CleanExMM_NTF5.
GenevestigatorQ80VU4.

Family and domain databases

InterProIPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio348810.
PROQ80VU4.
SOURCESearch...

Entry information

Entry nameNTF4_MOUSE
AccessionPrimary (citable) accession number: Q80VU4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot