Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II elongation factor ELL3

Gene

Ell3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT).2 Publications

GO - Molecular functioni

  • enhancer binding Source: UniProtKB

GO - Biological processi

  • DNA-templated transcription, elongation Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • negative regulation of signal transduction by p53 class mediator Source: MGI
  • positive regulation of DNA-templated transcription, elongation Source: MGI
  • positive regulation of neural precursor cell proliferation Source: MGI
  • positive regulation of neurogenesis Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of epithelial to mesenchymal transition Source: UniProtKB
  • snRNA transcription by RNA polymerase II Source: UniProtKB
  • stem cell differentiation Source: UniProtKB
  • transcription by RNA polymerase II Source: UniProtKB
  • transcription elongation from RNA polymerase II promoter Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL3
Gene namesi
Name:Ell3
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2673679 Ell3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467371 – 395RNA polymerase II elongation factor ELL3Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80VR2
PaxDbiQ80VR2
PeptideAtlasiQ80VR2
PRIDEiQ80VR2

PTM databases

PhosphoSitePlusiQ80VR2

Expressioni

Tissue specificityi

Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000027246
CleanExiMM_ELL3
GenevisibleiQ80VR2 MM

Interactioni

Subunit structurei

Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2 (By similarity). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with AFF4.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028679

Structurei

3D structure databases

ProteinModelPortaliQ80VR2
SMRiQ80VR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796 Eukaryota
ENOG410ZNGU LUCA
GeneTreeiENSGT00550000074378
HOGENOMiHOG000231840
HOVERGENiHBG051462
InParanoidiQ80VR2
KOiK15183
OMAiHAYEQDF
OrthoDBiEOG091G043D
PhylomeDBiQ80VR2
TreeFamiTF337345

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR031175 ELL3
IPR019464 ELL_N
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF18 PTHR23288:SF18, 1 hit
PfamiView protein in Pfam
PF10390 ELL, 1 hit
PF07303 Occludin_ELL, 1 hit

Sequencei

Sequence statusi: Complete.

Q80VR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTQEALSG KMRLLFTPAA RTSLLMLRLN EAALRALQEC QQQQVRPVIA
60 70 80 90 100
FQGHRGYLRF PGPGWSCLFS FIVSQCGQEG TNGGLDLVYQ RLGRSGPNCL
110 120 130 140 150
HCLGSLRERL TIWAAMDTIP APLLAQEHLT EGTRESESWQ DTGDEPEGHP
160 170 180 190 200
QLAPDEVSDP LASHHEQSLP GSSSEPMAQW EMRNHTYLPS REPDQSLLSP
210 220 230 240 250
ASQKRLDKKR SAPITTEEPE EKRLRALPLA SSPLQGLANQ DSQEGEDWGQ
260 270 280 290 300
DEDEEGDEDG DSRLEQSLSA PSASESPSPE EVPDYLLQYR AIHSTEQQQA
310 320 330 340 350
YEQDFETDYA EYRILHARVG AASQRFTELG AEIKRLQRGT PEHKVLEDKI
360 370 380 390
VQEYKKFRKR YPSYREEKHR CEYLHQKLSH IKGLILEFEE KNRGS
Length:395
Mass (Da):44,762
Last modified:June 1, 2003 - v1
Checksum:i9297E95C5AD222EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845466 Genomic DNA No translation available.
BC045151 mRNA Translation: AAH45151.1
CCDSiCCDS16644.1
RefSeqiNP_666085.2, NM_145973.2
UniGeneiMm.330522

Genome annotation databases

EnsembliENSMUST00000028679; ENSMUSP00000028679; ENSMUSG00000027246
ENSMUST00000116432; ENSMUSP00000112133; ENSMUSG00000027246
GeneIDi269344
KEGGimmu:269344
UCSCiuc008lzc.1 mouse

Entry informationi

Entry nameiELL3_MOUSE
AccessioniPrimary (citable) accession number: Q80VR2
Secondary accession number(s): A2ARQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health