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Q80VQ0 (AL3B1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 3 member B1
EC=1.2.1.5
Alternative name(s):
Aldehyde dehydrogenase 7
Gene names
Name:Aldh3b1
Synonyms:Aldh7
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes By similarity. Metabolizes also benzaldehyde By similarity. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde By similarity. May not metabolize short chain aldehydes By similarity. May use both NADP+ and NAD+ as cofactors By similarity. May have a protective role against the cytotoxicity induced by lipid peroxidation By similarity.

Catalytic activity

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Tissue specificity

Highly expressed in kidney and liver. In brain is expressed at moderate levels in cortex, striatum and hippocampus, and at lower levels in brainstem and cerebellum. Ref.4

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular aldehyde metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionaldehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Aldehyde dehydrogenase family 3 member B1
PRO_0000056482

Regions

Nucleotide binding188 – 1936NAD By similarity

Sites

Active site2101 By similarity
Active site2441 By similarity

Amino acid modifications

Modified residue3681Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80VQ0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 715B01070A3F7E23

FASTA46852,292
        10         20         30         40         50         60 
MDSFEDKLQQ LREAFKEGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ DLHKSAFEAE 

        70         80         90        100        110        120 
VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI RKEPFGLVLI IVPWNYPINL 

       130        140        150        160        170        180 
TLVPLVGAIA AGNCVVLKPS EISKATEKIL AEVLPRYLDQ SCFTVVLGGR QETGQLLEHK 

       190        200        210        220        230        240 
FDYIFFTGNA YVGKIVMAAA AKHLTPITLE LGGKNPCYVD DNCDPQIVAN RVAWFRYFNA 

       250        260        270        280        290        300 
GQTCVAPDYI LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FKRLQGLLGC 

       310        320        330        340        350        360 
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVRSLDE AIEFMNRREK 

       370        380        390        400        410        420 
PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL PFGGVGTSGM GRYHGKFSFD 

       430        440        450        460 
TFSNQRACLL RSPGMEKIND LRYPPYSSRN LRVLLVAMEE RCCSCTLL

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]Vasiliou V., Pappa A., Manzer R.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-468.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-468.
Strain: C57BL/6J.
Tissue: Testis.
[4]"Expression and initial characterization of human ALDH3B1."
Marchitti S.A., Orlicky D.J., Vasiliou V.
Biochem. Biophys. Res. Commun. 356:792-798(2007) [PubMed: 17382292] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC046597 mRNA. Translation: AAH46597.1.
BC082792 mRNA. Translation: AAH82792.1.
AF362571 mRNA. Translation: AAL56246.1.
AK005615 mRNA. Translation: BAB24152.2.
IPIIPI00330482.
RefSeqNP_080592.2. NM_026316.2.
UniGeneMm.109341.

3D structure databases

ProteinModelPortalQ80VQ0.
SMRQ80VQ0. Positions 3-447.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ80VQ0.

PTM databases

PhosphoSiteQ80VQ0.

Proteomic databases

PRIDEQ80VQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051803; ENSMUSP00000056276; ENSMUSG00000024885.
GeneID67689.
KEGGmmu:67689.
NMPDRfig|10090.3.peg.4373.

Organism-specific databases

CTD221.
MGIMGI:1914939. Aldh3b1.

Phylogenomic databases

GeneTreeENSGT00390000002825.
HOGENOMHBG752218.
HOVERGENHBG050483.
InParanoidQ80VQ0.
OMADKDCFAV.
OrthoDBEOG4PNXGT.
PhylomeDBQ80VQ0.

Gene expression databases

ArrayExpressQ80VQ0.
BgeeQ80VQ0.
CleanExMM_ALDH3B1.
GenevestigatorQ80VQ0.
GermOnlineENSMUSG00000024885. Mus musculus.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00129.
PANTHERPTHR11699:SF15. ALDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325269.
SOURCESearch...

Entry information

Entry nameAL3B1_MOUSE
AccessionPrimary (citable) accession number: Q80VQ0
Secondary accession number(s): Q63ZW3, Q8VHW0, Q9CW05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents