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Reviewed, UniProtKB/Swiss-Prot Q80VQ0 (AL3B1_MOUSE)

Last modified November 25, 2008. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase family 3 member B1
    EC=1.2.1.5
Alternative name(s):
    Aldehyde dehydrogenase 7
Gene names
Name: Aldh3b1
Synonyms: Aldh7
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processcellular aldehyde metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionaldehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Aldehyde dehydrogenase family 3 member B1
PRO_0000056482

Regions

Nucleotide binding188 – 1936NAD By similarity

Sites

Active site2101 By similarity
Active site2441 By similarity

Amino acid modifications

Modified residue3681Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q80VQ0-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 715B01070A3F7E23

FASTA46852,292
        10         20         30         40         50         60 
MDSFEDKLQQ LREAFKEGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ DLHKSAFEAE 

        70         80         90        100        110        120 
VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI RKEPFGLVLI IVPWNYPINL 

       130        140        150        160        170        180 
TLVPLVGAIA AGNCVVLKPS EISKATEKIL AEVLPRYLDQ SCFTVVLGGR QETGQLLEHK 

       190        200        210        220        230        240 
FDYIFFTGNA YVGKIVMAAA AKHLTPITLE LGGKNPCYVD DNCDPQIVAN RVAWFRYFNA 

       250        260        270        280        290        300 
GQTCVAPDYI LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FKRLQGLLGC 

       310        320        330        340        350        360 
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVRSLDE AIEFMNRREK 

       370        380        390        400        410        420 
PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL PFGGVGTSGM GRYHGKFSFD 

       430        440        450        460 
TFSNQRACLL RSPGMEKIND LRYPPYSSRN LRVLLVAMEE RCCSCTLL

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References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]Vasiliou V., Pappa A., Manzer R.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-468.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-468.
Strain: C57BL/6J.
Tissue: Testis.

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Cross-references

Sequence databases

BC046597 mRNA. Translation: AAH46597.1.
BC082792 mRNA. Translation: AAH82792.1.
AF362571 mRNA. Translation: AAL56246.1.
AK005615 mRNA. Translation: BAB24152.2.
RefSeqNP_080592.2.
UniGeneMm.109341

3D structure databases

HSSPHSSP built from PDB template 1AD3 based on UniProtKB P11883.
ModBaseSearch...

PTM databases

PhosphoSiteQ80VQ0.

Genome annotation databases

EnsemblENSMUSG00000024885. Mus musculus. [Contig view]
GeneID67689.
KEGGmmu:67689.
NMPDRfig|10090.3.peg.4373.

Organism-specific databases

MGIMGI:1914939. Aldh3b1.

Phylogenomic databases

HOGENOMQ80VQ0.
HOVERGENQ80VQ0.

Gene expression databases

ArrayExpressQ80VQ0.
CleanExMM_ALDH3B1.
GermOnlineENSMUSG00000024885. Mus musculus.

Family and domain databases

InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR012394. Ald_DHase_NAD(P).
IPR015590. Aldehyde_DHase.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF15. ALDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio325269.
SOURCESearch...

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Entry information

Entry nameAL3B1_MOUSE
AccessionPrimary (citable) accession number: Q80VQ0
Secondary accession number(s): Q63ZW3, Q8VHW0, Q9CW05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: November 25, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents