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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

Aldh3b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:25286108). Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity).By similarity1 Publication

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.1 Publication

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase family 3 member B2 (Aldh3b2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.5. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.
R-MMU-6798695. Neutrophil degranulation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.51 Publication)
Alternative name(s):
Aldehyde dehydrogenase 7
Gene namesi
Name:Aldh3b1
Synonyms:Aldh7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914939. Aldh3b1.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchor 1 Publication

  • Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • plasma membrane Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi462 – 463CC → SS: Abolishes palmitoylation. 1 Publication2
Mutagenesisi462C → S: Reduces palmitoylation. 1 Publication1
Mutagenesisi463C → S: Reduces palmitoylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564821 – 465Aldehyde dehydrogenase family 3 member B1Add BLAST465
PropeptideiPRO_0000424194466 – 468Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Lipidationi462S-palmitoyl cysteine1 Publication1
Lipidationi463S-palmitoyl cysteine1 Publication1
Modified residuei465Cysteine methyl esterCurated1
Lipidationi465S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiQ80VQ0.
PaxDbiQ80VQ0.
PRIDEiQ80VQ0.

PTM databases

iPTMnetiQ80VQ0.
PhosphoSitePlusiQ80VQ0.
SwissPalmiQ80VQ0.

Expressioni

Tissue specificityi

Highly expressed in kidney and liver. In brain is expressed at moderate levels in cortex, striatum and hippocampus, and at lower levels in brainstem and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000024885.
CleanExiMM_ALDH3B1.
ExpressionAtlasiQ80VQ0. baseline and differential.
GenevisibleiQ80VQ0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ80VQ0. 1 interactor.
MINTiMINT-4120234.
STRINGi10090.ENSMUSP00000056276.

Structurei

3D structure databases

ProteinModelPortaliQ80VQ0.
SMRiQ80VQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ80VQ0.
KOiK00129.
OMAiRYPPQSP.
OrthoDBiEOG091G05HC.
PhylomeDBiQ80VQ0.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80VQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFEDKLQQ LREAFKEGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ
60 70 80 90 100
DLHKSAFEAE VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IVPWNYPINL TLVPLVGAIA AGNCVVLKPS EISKATEKIL
160 170 180 190 200
AEVLPRYLDQ SCFTVVLGGR QETGQLLEHK FDYIFFTGNA YVGKIVMAAA
210 220 230 240 250
AKHLTPITLE LGGKNPCYVD DNCDPQIVAN RVAWFRYFNA GQTCVAPDYI
260 270 280 290 300
LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FKRLQGLLGC
310 320 330 340 350
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVRSLDE
360 370 380 390 400
AIEFMNRREK PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL
410 420 430 440 450
PFGGVGTSGM GRYHGKFSFD TFSNQRACLL RSPGMEKIND LRYPPYSSRN
460
LRVLLVAMEE RCCSCTLL
Length:468
Mass (Da):52,292
Last modified:June 1, 2003 - v1
Checksum:i715B01070A3F7E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046597 mRNA. Translation: AAH46597.1.
BC082792 mRNA. Translation: AAH82792.1.
AF362571 mRNA. Translation: AAL56246.1.
AK005615 mRNA. Translation: BAB24152.2.
CCDSiCCDS29403.1.
RefSeqiNP_080592.2. NM_026316.2.
XP_006531893.1. XM_006531830.3.
UniGeneiMm.109341.

Genome annotation databases

EnsembliENSMUST00000051803; ENSMUSP00000056276; ENSMUSG00000024885.
GeneIDi67689.
KEGGimmu:67689.
UCSCiuc008fxq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046597 mRNA. Translation: AAH46597.1.
BC082792 mRNA. Translation: AAH82792.1.
AF362571 mRNA. Translation: AAL56246.1.
AK005615 mRNA. Translation: BAB24152.2.
CCDSiCCDS29403.1.
RefSeqiNP_080592.2. NM_026316.2.
XP_006531893.1. XM_006531830.3.
UniGeneiMm.109341.

3D structure databases

ProteinModelPortaliQ80VQ0.
SMRiQ80VQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80VQ0. 1 interactor.
MINTiMINT-4120234.
STRINGi10090.ENSMUSP00000056276.

PTM databases

iPTMnetiQ80VQ0.
PhosphoSitePlusiQ80VQ0.
SwissPalmiQ80VQ0.

Proteomic databases

MaxQBiQ80VQ0.
PaxDbiQ80VQ0.
PRIDEiQ80VQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051803; ENSMUSP00000056276; ENSMUSG00000024885.
GeneIDi67689.
KEGGimmu:67689.
UCSCiuc008fxq.1. mouse.

Organism-specific databases

CTDi221.
MGIiMGI:1914939. Aldh3b1.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ80VQ0.
KOiK00129.
OMAiRYPPQSP.
OrthoDBiEOG091G05HC.
PhylomeDBiQ80VQ0.
TreeFamiTF314264.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BRENDAi1.2.1.5. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ80VQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024885.
CleanExiMM_ALDH3B1.
ExpressionAtlasiQ80VQ0. baseline and differential.
GenevisibleiQ80VQ0. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B1_MOUSE
AccessioniPrimary (citable) accession number: Q80VQ0
Secondary accession number(s): Q63ZW3, Q8VHW0, Q9CW05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.