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Protein

Spermatogenesis-associated protein 7 homolog

Gene

Spata7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in photoreceptor cells maintenance (PubMed:25398945). It is required for recruitement and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (PubMed:25398945).1 Publication

GO - Biological processi

  • photoreceptor cell maintenance Source: UniProtKB
  • protein localization to photoreceptor connecting cilium Source: UniProtKB
  • protein localization to photoreceptor outer segment Source: UniProtKB
  • response to stimulus Source: UniProtKB-KW
  • spermatogenesis Source: Ensembl
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 7 homolog
Gene namesi
Name:Spata7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144877. Spata7.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • microtubule cytoskeleton Source: UniProtKB
  • photoreceptor connecting cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

STATA7 knockdown results in photoreceptor cells degeneration and severe early-onset retinal defects. At molecular level, a substantial reduction of RPGRIP1 levels at the CC and its mislocalization to the inner segment are observed in mutant mice, as well as impaired RHO trafficking from the inner to the outer segment of photoreceptors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Spermatogenesis-associated protein 7 homologPRO_0000072105Add
BLAST

Proteomic databases

PRIDEiQ80VP2.

PTM databases

PhosphoSiteiQ80VP2.

Expressioni

Tissue specificityi

Expressed in the retina (PubMed:19268277). Found in the photoreceptor cell layer, where localizes at the region between the inner segment and outer segment (PubMed:25398945).2 Publications

Gene expression databases

BgeeiQ80VP2.
CleanExiMM_SPATA7.
ExpressionAtlasiQ80VP2. baseline and differential.
GenevisibleiQ80VP2. MM.

Interactioni

Subunit structurei

Interacts with RPGRIP1 (PubMed:25398945).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045827.

Structurei

3D structure databases

ProteinModelPortaliQ80VP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG78294.
GeneTreeiENSGT00390000014113.
HOGENOMiHOG000132972.
HOVERGENiHBG055067.
InParanoidiQ80VP2.
OMAiETSVNVI.
OrthoDBiEOG7NKKP7.
PhylomeDBiQ80VP2.
TreeFamiTF330591.

Family and domain databases

InterProiIPR029357. SPATA7.
[Graphical view]
PfamiPF15244. HSD3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSRRVRAT SVLPRYSPPC LFTGHLSTKS NAFCTDSSSL RLSTLQLVKN
60 70 80 90 100
HMAIHYNKIL SAKAAVDCSI PVSVNTSIKY ADQQRREKLR KELARCEKEF
110 120 130 140 150
KLSKSAMQTN SKMNSKFFVN SLQKPSGEPQ DQDVFIEEMT RYPSFSKSLI
160 170 180 190 200
PSSEGLHLSL PESSKMLMSG TQKHASTSPS RHSGCGHGCD RRPRSAHQFQ
210 220 230 240 250
VALAKTPSGD LLEKHSDLFS NKQSPFTPRT LKTEAKSFLS QYRYYTPAKR
260 270 280 290 300
RKDFSDQRME AETQTELSSF NSELGTAEKT SSKDSEVNIN QVPNYTRNGA
310 320 330 340 350
EDKIAPLPSQ GQNLAWDSIQ DGILQQSSER ASCKLSTEFS PDSKIYSDEE
360 370 380 390 400
ELLYLSFMEN VTDEILKLGL FSNRFLERLF ERHIKKNKHH LEEGKMRYLL
410 420 430 440 450
HGLKVDLGCI SEEDPAKQKH FRMLNQLHFQ KALISRENEF VSDEETVSHH
460 470 480 490 500
ERQQYQEALD MLSAVPKDEN KMFSLPGEFL IPAHKVKHSE GVIIQQVNDE
510 520 530 540 550
TDNEASPWNE NNPSVSDSVI DQETSVDVIE GDSDFERAET SRELCCLSTS
560 570 580
LSPSGPFPSI NGGSNHGKEL STLRIMGMSI ED
Length:582
Mass (Da):65,655
Last modified:June 1, 2003 - v1
Checksum:i414A6A684A421DF5
GO

Sequence cautioni

The sequence BAC36832.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077500 mRNA. Translation: BAC36832.1. Different initiation.
BC046960 mRNA. Translation: AAH46960.1.
CCDSiCCDS26097.1.
RefSeqiNP_849245.2. NM_178914.4.
XP_011242281.1. XM_011243979.1.
UniGeneiMm.210053.

Genome annotation databases

EnsembliENSMUST00000048402; ENSMUSP00000045827; ENSMUSG00000021007.
GeneIDi104871.
UCSCiuc007ora.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077500 mRNA. Translation: BAC36832.1. Different initiation.
BC046960 mRNA. Translation: AAH46960.1.
CCDSiCCDS26097.1.
RefSeqiNP_849245.2. NM_178914.4.
XP_011242281.1. XM_011243979.1.
UniGeneiMm.210053.

3D structure databases

ProteinModelPortaliQ80VP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045827.

PTM databases

PhosphoSiteiQ80VP2.

Proteomic databases

PRIDEiQ80VP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048402; ENSMUSP00000045827; ENSMUSG00000021007.
GeneIDi104871.
UCSCiuc007ora.2. mouse.

Organism-specific databases

CTDi55812.
MGIiMGI:2144877. Spata7.

Phylogenomic databases

eggNOGiNOG78294.
GeneTreeiENSGT00390000014113.
HOGENOMiHOG000132972.
HOVERGENiHBG055067.
InParanoidiQ80VP2.
OMAiETSVNVI.
OrthoDBiEOG7NKKP7.
PhylomeDBiQ80VP2.
TreeFamiTF330591.

Miscellaneous databases

NextBioi357336.
PROiQ80VP2.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VP2.
CleanExiMM_SPATA7.
ExpressionAtlasiQ80VP2. baseline and differential.
GenevisibleiQ80VP2. MM.

Family and domain databases

InterProiIPR029357. SPATA7.
[Graphical view]
PfamiPF15244. HSD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epithelium.
  3. Cited for: TISSUE SPECIFICITY.
  4. Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RPGRIP1.

Entry informationi

Entry nameiSPAT7_MOUSE
AccessioniPrimary (citable) accession number: Q80VP2
Secondary accession number(s): Q8BK23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.