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Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

Tecpr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
Gene namesi
Name:Tecpr1
Synonyms:Kiaa1358
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917631. Tecpr1.

Subcellular locationi

  • Cytoplasmic vesicleautophagosome membrane By similarity
  • Lysosome membrane By similarity

  • Note: Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11661166Tectonin beta-propeller repeat-containing protein 1PRO_0000337061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861PhosphoserineCombined sources
Modified residuei388 – 3881PhosphoserineCombined sources
Modified residuei391 – 3911PhosphoserineCombined sources
Modified residuei413 – 4131PhosphoserineCombined sources
Modified residuei418 – 4181PhosphoserineCombined sources
Modified residuei943 – 9431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80VP0.
MaxQBiQ80VP0.
PaxDbiQ80VP0.
PRIDEiQ80VP0.

PTM databases

iPTMnetiQ80VP0.
PhosphoSiteiQ80VP0.

Expressioni

Gene expression databases

BgeeiQ80VP0.
GenevisibleiQ80VP0. MM.

Interactioni

Subunit structurei

Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082844.

Structurei

3D structure databases

ProteinModelPortaliQ80VP0.
SMRiQ80VP0. Positions 579-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 24032TECPR 1Add
BLAST
Repeati254 – 28532TECPR 2Add
BLAST
Repeati301 – 33232TECPR 3Add
BLAST
Repeati344 – 37633TECPR 4Add
BLAST
Domaini616 – 722107PHAdd
BLAST
Repeati734 – 76128TECPR 5Add
BLAST
Repeati958 – 98932TECPR 6Add
BLAST
Repeati1003 – 103432TECPR 7Add
BLAST
Repeati1049 – 108032TECPR 8Add
BLAST
Repeati1092 – 113241TECPR 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 3918Poly-Ser

Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P).By similarity

Sequence similaritiesi

Belongs to the TECPR1 family.Curated
Contains 1 PH domain.Curated
Contains 9 TECPR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ80VP0.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG7HXCQ5.
TreeFamiTF323648.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTSVLWAVD LFGRVYTLST AGQYWELCKD VQLEFKRVSA ATQCCWGIAG
60 70 80 90 100
DNQVYLYVCS SDVPIRHREE AYENQRWNPM GGFCEKLLPS DRWPWSDVSG
110 120 130 140 150
LQHRPLDGVA LPSPHWEWES DWYVDENFGG EPTEKGGWTY AMDFPATYTR
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDSWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYREDVSHPN PEGSSWSLVE TPGEVVQISC
260 270 280 290 300
GPHDLIWATL WEGQALVREG VCRNNPKGSY WSMVEPPGSE NGIMHVSAGV
310 320 330 340 350
SVVWAITKDR KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GLNDQVWGIS
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIVVGRE SDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
DEVRGSGTES APSDTDASLE VERQGPEQPL PKEALDNSTN LKGSLSKGHE
460 470 480 490 500
TSGNTDHSTE NACLTEGKEK APETSRSDEC RGPASTPAEL PWTNIDLKEP
510 520 530 540 550
KKVSNQPAAG FPETAGLSSL GLFPMGMEEP YGADDHPLWA WVSGGACAVE
560 570 580 590 600
AGSTLKWFTI QSGLSPSVQT LSLSITPAQT AAWRKQIFQQ LTERTKRELE
610 620 630 640 650
SFRHYEQAVE QSVWVKTGAL QWWCDWKPHK WVDVRVALEQ FTGHDGARDS
660 670 680 690 700
ILFIYYVVHE EKKYLHVFLN EVTVLVPVLN EAKHSFALYT PERTRQRWPV
710 720 730 740 750
RLAAATEQDM NDWLALLSLS CCESRKVHGR PSPQAIWSVT CKGDIFVSEP
760 770 780 790 800
SPDLEARERL LPCDQMFWRQ MGGHLRIIEA NSRGVVWGIG YDHTAWVYTG
810 820 830 840 850
GYGGGCFQGL ASSTSNIYTQ SDVKSVYIYE NQRWNPVTGY TSRGLPTDRF
860 870 880 890 900
MWSDVTGLQE CTKAGTKPPS LQWTWVSDWY VDFSVPGGTD QEGWQYASDF
910 920 930 940 950
PASYHGYKTM KDFVRRRCWA RKCKLVTSGP WLEVAPITLS DVSIIPESAH
960 970 980 990 1000
ADGRGHNVAL WAVSDKGDVL CRLGVSELNP AGSSWLHVGT DQPFASVSIG
1010 1020 1030 1040 1050
ACYQVWAVAR DGSAFYRGSV SPSQPAGDCW YHIPSPPKQK LTQVSVGQTS
1060 1070 1080 1090 1100
VYALDENGNL WYRAGITPSY PQGSSWEHVS NNVRKVSVGP LDQVWVIANK
1110 1120 1130 1140 1150
VQGSHGLSRG TVCRRMGVQP REPKGQGWDY GIGGGWDHIS VRANATRVPR
1160
NMSRDREARG PGPVCC
Length:1,166
Mass (Da):130,266
Last modified:June 1, 2003 - v1
Checksum:i5DA166A7ACA30908
GO
Isoform 2 (identifier: Q80VP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:1,025
Mass (Da):114,030
Checksum:iBD3C9D50E903E07C
GO

Sequence cautioni

The sequence AAH25567.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC41478.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti725 – 7251R → W in BAC41478 (PubMed:12465718).Curated
Sequence conflicti1014 – 10141A → T in AAH04058 (PubMed:15489334).Curated
Sequence conflicti1159 – 11591R → C in AAH04058 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_033862Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093295 mRNA. Translation: BAC41478.1. Different initiation.
AK008701 mRNA. Translation: BAB25841.1.
AK169888 mRNA. Translation: BAE41437.1.
AK170108 mRNA. Translation: BAE41568.1.
BC004058 mRNA. Translation: AAH04058.1.
BC025567 mRNA. Translation: AAH25567.1. Different initiation.
BC046968 mRNA. Translation: AAH46968.1.
CCDSiCCDS39377.1. [Q80VP0-1]
RefSeqiNP_081686.1. NM_027410.1. [Q80VP0-1]
UniGeneiMm.239412.
Mm.458463.

Genome annotation databases

EnsembliENSMUST00000085701; ENSMUSP00000082844; ENSMUSG00000066621. [Q80VP0-1]
GeneIDi70381.
KEGGimmu:70381.
UCSCiuc009alj.2. mouse. [Q80VP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093295 mRNA. Translation: BAC41478.1. Different initiation.
AK008701 mRNA. Translation: BAB25841.1.
AK169888 mRNA. Translation: BAE41437.1.
AK170108 mRNA. Translation: BAE41568.1.
BC004058 mRNA. Translation: AAH04058.1.
BC025567 mRNA. Translation: AAH25567.1. Different initiation.
BC046968 mRNA. Translation: AAH46968.1.
CCDSiCCDS39377.1. [Q80VP0-1]
RefSeqiNP_081686.1. NM_027410.1. [Q80VP0-1]
UniGeneiMm.239412.
Mm.458463.

3D structure databases

ProteinModelPortaliQ80VP0.
SMRiQ80VP0. Positions 579-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082844.

PTM databases

iPTMnetiQ80VP0.
PhosphoSiteiQ80VP0.

Proteomic databases

EPDiQ80VP0.
MaxQBiQ80VP0.
PaxDbiQ80VP0.
PRIDEiQ80VP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085701; ENSMUSP00000082844; ENSMUSG00000066621. [Q80VP0-1]
GeneIDi70381.
KEGGimmu:70381.
UCSCiuc009alj.2. mouse. [Q80VP0-1]

Organism-specific databases

CTDi25851.
MGIiMGI:1917631. Tecpr1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ80VP0.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG7HXCQ5.
TreeFamiTF323648.

Miscellaneous databases

ChiTaRSiTecpr1. mouse.
PROiQ80VP0.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VP0.
GenevisibleiQ80VP0. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor and Olfactory epithelium.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-388; SER-391; SER-413 AND SER-418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTCPR1_MOUSE
AccessioniPrimary (citable) accession number: Q80VP0
Secondary accession number(s): Q8CHA3
, Q8R3E0, Q99KQ5, Q9CVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.