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Protein

Prickle-like protein 3

Gene

Prickle3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Prickle-like protein 3
Alternative name(s):
LIM domain only protein 6
Short name:
LMO-6
Triple LIM domain protein 6
Gene namesi
Name:Prickle3
Synonyms:Lmo6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859635. Prickle3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758231 – 624Prickle-like protein 3Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei475PhosphoserineCombined sources1
Modified residuei491PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80VL3.
PRIDEiQ80VL3.

PTM databases

iPTMnetiQ80VL3.
PhosphoSitePlusiQ80VL3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031145.
CleanExiMM_PRICKLE3.
ExpressionAtlasiQ80VL3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127892.

Structurei

3D structure databases

ProteinModelPortaliQ80VL3.
SMRiQ80VL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 182PETPROSITE-ProRule annotationAdd BLAST109
Domaini184 – 249LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST66
Domaini250 – 309LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini310 – 373LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 153Poly-Glu4
Compositional biasi553 – 566Poly-SerAdd BLAST14

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
Contains 1 PET domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
HOVERGENiHBG106338.
InParanoidiQ80VL3.
OMAiDKNCIVA.
OrthoDBiEOG091G07C5.
PhylomeDBiQ80VL3.

Family and domain databases

CDDicd09415. LIM1_Prickle. 1 hit.
cd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033725. LIM1_prickle.
IPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGSRRRR SGRAPPEAED PARGQPCNSC REQCPGFLLH GWRKICQHCK
60 70 80 90 100
CPREEHAVRT VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL
110 120 130 140 150
KPEQVYQFFS CLPEDKVPYV NSPGEKYRIK QLLHQLPPHD SEAQYCTALE
160 170 180 190 200
EEEKKELRAF SQQRKRENLG RATVRIFPVT ITGAICEECG KQIGGGDIAV
210 220 230 240 250
FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHAGKVYCG RHHAECLRPR
260 270 280 290 300
CQACDEIIFS PECTEAEGRH WHMGHFCCFE CEASLGGQRY VMRQSRPHCC
310 320 330 340 350
ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCSRPLLG
360 370 380 390 400
RPFLPRRGLI FCSRACSLGS ETTAPGPGRR SWSAGTVTTP LTTSTASFSA
410 420 430 440 450
TEGTSETASK GTCTKAEPAA GPEEPSHFLR GAPHRHSMPE LGLRSAPEPP
460 470 480 490 500
TESPGHPAPH PDDNAFGRQS TPRVSFRDPL VSEGGPRRTL SAPPAQRRRP
510 520 530 540 550
RSPPPRTPSC HHHHHHRRRR QRHRRRGSHH HHHHPGRHGH HRCDLGSGSD
560 570 580 590 600
SGSCSSSPSS PSSESSEDDG FFLGERIPLP PHLCRPRTTQ DTSTETFNSP
610 620
AQPLVQESHP VMPRQTRDKN CIVA
Length:624
Mass (Da):69,727
Last modified:June 1, 2003 - v1
Checksum:i2B4DCE249778B640
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318I → V in BAC29758 (PubMed:16141072).Curated1
Sequence conflicti521Q → R in BAC29758 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037217 mRNA. Translation: BAC29758.1.
AL672231 Genomic DNA. Translation: CAM25959.1.
BC049258 mRNA. Translation: AAH49258.1.
CCDSiCCDS72329.1.
RefSeqiNP_001277553.1. NM_001290624.1.
UniGeneiMm.232232.

Genome annotation databases

EnsembliENSMUST00000033485; ENSMUSP00000033485; ENSMUSG00000031145.
GeneIDi54630.
KEGGimmu:54630.
UCSCiuc009slu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037217 mRNA. Translation: BAC29758.1.
AL672231 Genomic DNA. Translation: CAM25959.1.
BC049258 mRNA. Translation: AAH49258.1.
CCDSiCCDS72329.1.
RefSeqiNP_001277553.1. NM_001290624.1.
UniGeneiMm.232232.

3D structure databases

ProteinModelPortaliQ80VL3.
SMRiQ80VL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127892.

PTM databases

iPTMnetiQ80VL3.
PhosphoSitePlusiQ80VL3.

Proteomic databases

PaxDbiQ80VL3.
PRIDEiQ80VL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033485; ENSMUSP00000033485; ENSMUSG00000031145.
GeneIDi54630.
KEGGimmu:54630.
UCSCiuc009slu.2. mouse.

Organism-specific databases

CTDi4007.
MGIiMGI:1859635. Prickle3.

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
HOVERGENiHBG106338.
InParanoidiQ80VL3.
OMAiDKNCIVA.
OrthoDBiEOG091G07C5.
PhylomeDBiQ80VL3.

Miscellaneous databases

ChiTaRSiPrickle3. mouse.
PROiQ80VL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031145.
CleanExiMM_PRICKLE3.
ExpressionAtlasiQ80VL3. baseline and differential.

Family and domain databases

CDDicd09415. LIM1_Prickle. 1 hit.
cd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033725. LIM1_prickle.
IPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRIC3_MOUSE
AccessioniPrimary (citable) accession number: Q80VL3
Secondary accession number(s): B1AVA9, Q8CAY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.