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Protein

Prickle planar cell polarity protein 3

Gene

Prickle3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCilium biogenesis/degradation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Prickle planar cell polarity protein 3By similarity
Alternative name(s):
LIM domain only protein 6
Short name:
LMO-6
Prickle-like protein 3
Short name:
Pk3Curated
Triple LIM domain protein 6
Gene namesi
Name:Prickle3Imported
Synonyms:Lmo6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859635 Prickle3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758231 – 624Prickle planar cell polarity protein 3Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei475PhosphoserineCombined sources1
Modified residuei491PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80VL3
PRIDEiQ80VL3

PTM databases

iPTMnetiQ80VL3
PhosphoSitePlusiQ80VL3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031145
CleanExiMM_PRICKLE3
ExpressionAtlasiQ80VL3 baseline and differential

Interactioni

Subunit structurei

Interacts with VANGL2 via its C-terminus (By similarity). The VANGL2-dependent membrane recruitment of PRICKLE3 is a prerequisite for its polarization (By similarity). Interacts with WTIP. WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127892

Structurei

3D structure databases

ProteinModelPortaliQ80VL3
SMRiQ80VL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 182PETPROSITE-ProRule annotationAdd BLAST109
Domaini184 – 249LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST66
Domaini250 – 309LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini310 – 373LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 153Poly-Glu4
Compositional biasi553 – 566Poly-SerAdd BLAST14

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00550000074438
HOVERGENiHBG106338
InParanoidiQ80VL3
KOiK04511
OMAiDKNCIVA
OrthoDBiEOG091G07C5
PhylomeDBiQ80VL3

Family and domain databases

CDDicd09415 LIM1_Prickle, 1 hit
cd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit
InterProiView protein in InterPro
IPR033725 LIM1_prickle
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

Sequencei

Sequence statusi: Complete.

Q80VL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGSRRRR SGRAPPEAED PARGQPCNSC REQCPGFLLH GWRKICQHCK
60 70 80 90 100
CPREEHAVRT VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL
110 120 130 140 150
KPEQVYQFFS CLPEDKVPYV NSPGEKYRIK QLLHQLPPHD SEAQYCTALE
160 170 180 190 200
EEEKKELRAF SQQRKRENLG RATVRIFPVT ITGAICEECG KQIGGGDIAV
210 220 230 240 250
FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHAGKVYCG RHHAECLRPR
260 270 280 290 300
CQACDEIIFS PECTEAEGRH WHMGHFCCFE CEASLGGQRY VMRQSRPHCC
310 320 330 340 350
ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCSRPLLG
360 370 380 390 400
RPFLPRRGLI FCSRACSLGS ETTAPGPGRR SWSAGTVTTP LTTSTASFSA
410 420 430 440 450
TEGTSETASK GTCTKAEPAA GPEEPSHFLR GAPHRHSMPE LGLRSAPEPP
460 470 480 490 500
TESPGHPAPH PDDNAFGRQS TPRVSFRDPL VSEGGPRRTL SAPPAQRRRP
510 520 530 540 550
RSPPPRTPSC HHHHHHRRRR QRHRRRGSHH HHHHPGRHGH HRCDLGSGSD
560 570 580 590 600
SGSCSSSPSS PSSESSEDDG FFLGERIPLP PHLCRPRTTQ DTSTETFNSP
610 620
AQPLVQESHP VMPRQTRDKN CIVA
Length:624
Mass (Da):69,727
Last modified:June 1, 2003 - v1
Checksum:i2B4DCE249778B640
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318I → V in BAC29758 (PubMed:16141072).Curated1
Sequence conflicti521Q → R in BAC29758 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037217 mRNA Translation: BAC29758.1
AL672231 Genomic DNA No translation available.
BC049258 mRNA Translation: AAH49258.1
CCDSiCCDS72329.1
RefSeqiNP_001277553.1, NM_001290624.1
UniGeneiMm.232232

Genome annotation databases

EnsembliENSMUST00000033485; ENSMUSP00000033485; ENSMUSG00000031145
GeneIDi54630
KEGGimmu:54630
UCSCiuc009slu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPRIC3_MOUSE
AccessioniPrimary (citable) accession number: Q80VL3
Secondary accession number(s): B1AVA9, Q8CAY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome