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Protein

Interactor protein for cytohesin exchange factors 1

Gene

Ipcef1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.

GO - Molecular functioni

  • protein domain specific binding Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Gene namesi
Name:Ipcef1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi735159. Ipcef1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication

  • Note: Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.

GO - Cellular componenti

  • cytosol Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Interactor protein for cytohesin exchange factors 1PRO_0000326632Add
BLAST

Proteomic databases

PaxDbiQ80VL0.
PRIDEiQ80VL0.

Expressioni

Tissue specificityi

Expressed in brain, spleen, lung, testis and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000018163.

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.2 Publications

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024461.

Structurei

3D structure databases

ProteinModelPortaliQ80VL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 112100PHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni285 – 406122Necessary for interaction with PSCD2 and to translocate to the plasma membraneAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi143 – 257115Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ80VL0.
OMAiPSEANSC.
OrthoDBiEOG091G037J.
PhylomeDBiQ80VL0.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRISCKD LGHADCQGWL YKKKEKGTFL SNKWKKFWVV LKGSSLYWYG
60 70 80 90 100
NQLAEKADGF VNLPDFTVER ASECKKKNAF KINHPQIKTF YFAAENLQEM
110 120 130 140 150
NMWLNKLGFA VTHKESTTKD EECYSESEQE DPETAVEAPP PPSASATSSP
160 170 180 190 200
VAARRASSSS PKRRETSCSF SSLENTVKAP SRFSSSGSKE RQSWLDIVNS
210 220 230 240 250
SPATEDVGHP LSFAVQVHTL ASSEASSCRV SENSSTTPES GCLNSLSSDD
260 270 280 290 300
TSSLNNSQDH LTVPDRASGS RMTDRDEIKS SEDDEMEKLY KSLEQASLSP
310 320 330 340 350
LGDRRPSTKK ELRKSFVKRC KNPSINEKLH KIRTLNSTLK CKEHDLAMIN
360 370 380 390 400
QLLDDPKLTA RKYREWKVMN TLLIQDIYQQ QVPQDPEVTP QEIMNPTSSD

CVENSL
Length:406
Mass (Da):45,686
Last modified:June 1, 2003 - v1
Checksum:i78F84BEC1A36BDB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536192 mRNA. Translation: CAD60208.1.
RefSeqiNP_001164270.1. NM_001170799.1.
UniGeneiRn.230668.

Genome annotation databases

EnsembliENSRNOT00000024460; ENSRNOP00000024461; ENSRNOG00000018163.
GeneIDi361474.
KEGGirno:361474.
UCSCiRGD:735159. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536192 mRNA. Translation: CAD60208.1.
RefSeqiNP_001164270.1. NM_001170799.1.
UniGeneiRn.230668.

3D structure databases

ProteinModelPortaliQ80VL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024461.

Proteomic databases

PaxDbiQ80VL0.
PRIDEiQ80VL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024460; ENSRNOP00000024461; ENSRNOG00000018163.
GeneIDi361474.
KEGGirno:361474.
UCSCiRGD:735159. rat.

Organism-specific databases

CTDi26034.
RGDi735159. Ipcef1.

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ80VL0.
OMAiPSEANSC.
OrthoDBiEOG091G037J.
PhylomeDBiQ80VL0.

Miscellaneous databases

PROiQ80VL0.

Gene expression databases

BgeeiENSRNOG00000018163.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICEF1_RAT
AccessioniPrimary (citable) accession number: Q80VL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.