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Protein

Steroid receptor RNA activator 1

Gene

Sra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).By similarity

Miscellaneous

Appears to be the first example of a new class of functional RNAs also able to encode a protein.By similarity

GO - Molecular functioni

  • DNA binding Source: MGI
  • ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  • RNA binding Source: UniProtKB
  • thyroid hormone receptor coactivator activity Source: MGI
  • transcription coactivator activity Source: UniProtKB
  • transcription cofactor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, Receptor, Ribonucleoprotein
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid receptor RNA activator 1
Alternative name(s):
Steroid receptor RNA activator protein
Short name:
SRAP
Gene namesi
Name:Sra1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1344414 Sra1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002341061 – 232Steroid receptor RNA activator 1Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80VJ2
MaxQBiQ80VJ2
PaxDbiQ80VJ2
PeptideAtlasiQ80VJ2
PRIDEiQ80VJ2

2D gel databases

REPRODUCTION-2DPAGEiIPI00317966

PTM databases

iPTMnetiQ80VJ2
PhosphoSitePlusiQ80VJ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000006050
CleanExiMM_SRA1
ExpressionAtlasiQ80VJ2 baseline and differential
GenevisibleiQ80VJ2 MM

Interactioni

Subunit structurei

SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.By similarity1 Publication

Protein-protein interaction databases

BioGridi204880, 2 interactors
IntActiQ80VJ2, 2 interactors
MINTiQ80VJ2
STRINGi10090.ENSMUSP00000133360

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi109 – 124Combined sources16
Helixi129 – 148Combined sources20
Helixi153 – 168Combined sources16
Helixi171 – 183Combined sources13
Helixi186 – 189Combined sources4
Turni190 – 192Combined sources3
Helixi193 – 206Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRUNMR-A102-206[»]
ProteinModelPortaliQ80VJ2
SMRiQ80VJ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80VJ2

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 101Pro-richAdd BLAST46

Sequence similaritiesi

Belongs to the SRA1 family.Curated

Phylogenomic databases

eggNOGiENOG410IK8X Eukaryota
ENOG4112996 LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000127508
HOVERGENiHBG061820
InParanoidiQ80VJ2
TreeFamiTF314789

Family and domain databases

InterProiView protein in InterPro
IPR009917 SRA1-protein/COPII_Sec31
PfamiView protein in Pfam
PF07304 SRA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q80VJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRCPAGGAE VEMAELYVKP GNKERGWNDP PQFSYGLQTQ TGGPKRTPLT
60 70 80 90 100
KRVAAPQDGS PRAPETSGPP PVDHPPPSSK ASRPPPMGSC PATGVEPPSS
110 120 130 140 150
PVIESETLIE DVLRPLEQAL EDCHGHTKKQ VCDDISRRLA LLREQWAGGK
160 170 180 190 200
LSIPVKKRMA LLVQELLHHQ WDAADDIHRS LMVDHVTEVS QWMVGVKRLI
210 220 230
AEKKSLSSEE TKEEKFTVEP ENQTIPGFQQ PS
Length:232
Mass (Da):25,557
Last modified:June 28, 2011 - v3
Checksum:i0838CA544C75A678
GO

Sequence cautioni

The sequence AAH26480 differs from that shown. Contaminating sequence.Curated
The sequence AAH26480 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH48362 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB24943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26893 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE32451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5P → A in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti10E → G in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti27W → G in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti140A → V in AAH48362 (PubMed:15489334).Curated1
Sequence conflicti185H → Y in AAH48362 (PubMed:15489334).Curated1
Sequence conflicti204K → R in AAH48362 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115631 Genomic DNA No translation available.
AK007302 mRNA Translation: BAB24943.1 Different initiation.
AK010375 mRNA Translation: BAB26893.1 Different initiation.
AK154232 mRNA Translation: BAE32451.1 Different initiation.
BC026480 mRNA Translation: AAH26480.1 Sequence problems.
BC048362 mRNA Translation: AAH48362.1 Different initiation.
CN836515 mRNA No translation available.
CCDSiCCDS29156.2
RefSeqiNP_001157878.1, NM_001164406.1
NP_079567.2, NM_025291.3
UniGeneiMm.29058

Genome annotation databases

EnsembliENSMUST00000173875; ENSMUSP00000133360; ENSMUSG00000006050
GeneIDi24068
KEGGimmu:24068
UCSCiuc008eny.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSRA1_MOUSE
AccessioniPrimary (citable) accession number: Q80VJ2
Secondary accession number(s): E9QM44
, Q8R0S3, Q9CWU7, Q9D973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health