Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

B-cell scaffold protein with ankyrin repeats

Gene

Bank1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in B-cell receptor (BCR)-induced Ca2+ mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 (By similarity).By similarity

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • negative regulation of B cell activation Source: MGI
  • negative regulation of interleukin-6 secretion Source: MGI
  • negative regulation of protein kinase B signaling Source: MGI
  • negative regulation of translational initiation Source: MGI
  • positive regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell scaffold protein with ankyrin repeats
Alternative name(s):
Protein AVIEF
Gene namesi
Name:Bank1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442120. Bank1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 783783B-cell scaffold protein with ankyrin repeatsPRO_0000251928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei649 – 6491PhosphotyrosineCombined sources

Post-translational modificationi

Phosphorylated on tyrosines upon BCR activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80VH0.
PaxDbiQ80VH0.
PRIDEiQ80VH0.

PTM databases

iPTMnetiQ80VH0.
PhosphoSiteiQ80VH0.

Expressioni

Tissue specificityi

Specifically expressed in spleen. Highly expressed in immature B-cells and recirculating B-cells, and at low levels in pro-B and pre-B cells.1 Publication

Gene expression databases

BgeeiQ80VH0.
CleanExiMM_BANK1.
ExpressionAtlasiQ80VH0. baseline and differential.
GenevisibleiQ80VH0. MM.

Interactioni

Subunit structurei

Interacts with LYN, ITPR1 and ITPR2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat3P422274EBI-646949,EBI-602878

Protein-protein interaction databases

IntActiQ80VH0. 2 interactions.
STRINGi10090.ENSMUSP00000035484.

Structurei

3D structure databases

ProteinModelPortaliQ80VH0.
SMRiQ80VH0. Positions 340-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 326128DBBPROSITE-ProRule annotationAdd
BLAST
Repeati341 – 37030ANK 1Add
BLAST
Repeati377 – 40731ANK 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 154154Interaction with ITPR2By similarityAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.Curated
Contains 1 DBB domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHAS. Eukaryota.
ENOG410ZTCN. LUCA.
GeneTreeiENSGT00390000008787.
HOGENOMiHOG000169281.
HOVERGENiHBG080888.
InParanoidiQ80VH0.
OMAiLERPHFT.
OrthoDBiEOG77DJ53.
TreeFamiTF328570.

Family and domain databases

InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR017893. DBB_domain.
[Graphical view]
PfamiPF14545. DBB. 1 hit.
[Graphical view]
SMARTiSM01282. DBB. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51376. DBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVASGTRG STQDLFQVGL APPGNAKDIL LLYEEDAEEW ALYLREIFMR
60 70 80 90 100
VVEREAILLY PLHSFSSSHL EMLNFYAYKC KLLIISNSLL KDLTPKKCQF
110 120 130 140 150
LEKILHSTGN VVTLLCGMES SDPFYQLLSI PRKRWEISTE QDPDGYISVI
160 170 180 190 200
RQILDQGPED YLEVSIPTDS RAKYPEDTSG QKGTDVLASL RPSVPRVLVL
210 220 230 240 250
PGEIPCEKPG EIFILLKDEL IGEILEVEFI STNKRLRARP ARWNKSVWHM
260 270 280 290 300
KAADFPAGSV TVNIHCDGII KATTEIKYCS AAKATESPFR VSDPGKSLCQ
310 320 330 340 350
KSIEELDNVL ASIFKREIPY YEFKHLQAET YPQKERTHTT ELPTLLHCAA
360 370 380 390 400
KFGLKNLALH LLQCSGATRA ARMKATDGSD LLHIAERHGH EELKEVFEDF
410 420 430 440 450
LSQNTGRNSK QENDYEEDVI SFSTYSPSMP SPASLHELRK THRRNTDRSE
460 470 480 490 500
EPERSVEMKE EEAGAEARRS LSEGERESSE NQYDDLYVFI PGFDTEGNSE
510 520 530 540 550
EPLPHCRPPL LPPRPGTAAS QLERPHFTSQ GKVLEDQMER SQNWNDLNAR
560 570 580 590 600
PETREESSRE EKKEEAQEEE EEEENPYAFA ETEDNEYDLI LASKSVKKRT
610 620 630 640 650
GNRSFIINRP PAPTPRPTHI PPKEETTPYI AQVFQQKAAR RQSDGDKFYS
660 670 680 690 700
LPKKPDKTRM EGPTFPSTRD YLTTGQEELI LLQERVKNGK MSVDEALEKF
710 720 730 740 750
KHWQMGKSGL EMIQQEKLRQ LRDNIIGKRP EDENAYDKLT IVHHPSGNTA
760 770 780
HNENMLYNSP FNSKFPARIQ VEKEFGFCCK KDH
Length:783
Mass (Da):89,406
Last modified:July 27, 2011 - v3
Checksum:i05597B51DE45C65C
GO

Sequence cautioni

The sequence AAO13613.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE33622.1 differs from that shown. Reason: Frameshift at position 768. Curated
The sequence BAE33622.1 differs from that shown. Reason: Erroneous termination at position 480. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631H → R in BAC30875 (PubMed:16141072).Curated
Sequence conflicti75 – 751F → L in AAO13613 (Ref. 1) Curated
Sequence conflicti75 – 751F → L in BAE33622 (PubMed:16141072).Curated
Sequence conflicti375 – 3751A → M in AAO13613 (Ref. 1) Curated
Sequence conflicti375 – 3751A → M in BAE33622 (PubMed:16141072).Curated
Sequence conflicti386 – 3861E → V in BAC30875 (PubMed:16141072).Curated
Sequence conflicti431 – 4311S → P in AAO13613 (Ref. 1) Curated
Sequence conflicti522 – 5221L → V in BAC30875 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY178734 mRNA. Translation: AAO13613.1. Different initiation.
AK041039 mRNA. Translation: BAC30794.1.
AK041242 mRNA. Translation: BAC30875.1.
AK156201 mRNA. Translation: BAE33622.1. Sequence problems.
AC101978 Genomic DNA. No translation available.
AC161171 Genomic DNA. No translation available.
AC166331 Genomic DNA. No translation available.
CCDSiCCDS38645.1.
RefSeqiNP_001028522.2. NM_001033350.3.
UniGeneiMm.30832.

Genome annotation databases

EnsembliENSMUST00000041577; ENSMUSP00000035484; ENSMUSG00000037922.
GeneIDi242248.
KEGGimmu:242248.
UCSCiuc008rmd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY178734 mRNA. Translation: AAO13613.1. Different initiation.
AK041039 mRNA. Translation: BAC30794.1.
AK041242 mRNA. Translation: BAC30875.1.
AK156201 mRNA. Translation: BAE33622.1. Sequence problems.
AC101978 Genomic DNA. No translation available.
AC161171 Genomic DNA. No translation available.
AC166331 Genomic DNA. No translation available.
CCDSiCCDS38645.1.
RefSeqiNP_001028522.2. NM_001033350.3.
UniGeneiMm.30832.

3D structure databases

ProteinModelPortaliQ80VH0.
SMRiQ80VH0. Positions 340-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80VH0. 2 interactions.
STRINGi10090.ENSMUSP00000035484.

PTM databases

iPTMnetiQ80VH0.
PhosphoSiteiQ80VH0.

Proteomic databases

MaxQBiQ80VH0.
PaxDbiQ80VH0.
PRIDEiQ80VH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041577; ENSMUSP00000035484; ENSMUSG00000037922.
GeneIDi242248.
KEGGimmu:242248.
UCSCiuc008rmd.1. mouse.

Organism-specific databases

CTDi55024.
MGIiMGI:2442120. Bank1.

Phylogenomic databases

eggNOGiENOG410IHAS. Eukaryota.
ENOG410ZTCN. LUCA.
GeneTreeiENSGT00390000008787.
HOGENOMiHOG000169281.
HOVERGENiHBG080888.
InParanoidiQ80VH0.
OMAiLERPHFT.
OrthoDBiEOG77DJ53.
TreeFamiTF328570.

Miscellaneous databases

PROiQ80VH0.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VH0.
CleanExiMM_BANK1.
ExpressionAtlasiQ80VH0. baseline and differential.
GenevisibleiQ80VH0. MM.

Family and domain databases

InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR017893. DBB_domain.
[Graphical view]
PfamiPF14545. DBB. 1 hit.
[Graphical view]
SMARTiSM01282. DBB. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51376. DBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "AVIEF sequence."
    Vu H.L., Nguyen H.H., Mestecky J.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Lymph node.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Aorta, Spleen and Vein.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor."
    Yokoyama K., Su I., Tezuka T., Yasuda T., Mikoshiba K., Tarakhovsky A., Yamamoto T.
    EMBO J. 21:83-92(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiBANK1_MOUSE
AccessioniPrimary (citable) accession number: Q80VH0
Secondary accession number(s): E9QMV3
, Q3U178, Q8BRV6, Q8BRY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.