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Protein

Sex comb on midleg-like protein 4

Gene

Scml4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex comb on midleg-like protein 4
Gene namesi
Name:Scml4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2446140. Scml4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Sex comb on midleg-like protein 4PRO_0000337172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80VG1.
MaxQBiQ80VG1.
PaxDbiQ80VG1.
PRIDEiQ80VG1.

PTM databases

PhosphoSiteiQ80VG1.

Expressioni

Gene expression databases

BgeeiQ80VG1.
ExpressionAtlasiQ80VG1. baseline and differential.
GenevisibleiQ80VG1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053157.

Structurei

3D structure databases

ProteinModelPortaliQ80VG1.
SMRiQ80VG1. Positions 95-207, 337-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 40667SAMAdd
BLAST

Sequence similaritiesi

Belongs to the SCM family.Curated

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000236280.
HOVERGENiHBG056406.
InParanoidiQ80VG1.
KOiK11466.
OMAiVDDVVWF.
OrthoDBiEOG73BVC2.
PhylomeDBiQ80VG1.
TreeFamiTF106488.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTQRVPGRK RGRPPLHSTR VQMAVHNLYS ASAASVPAVT IPKKRGRKPR
60 70 80 90 100
YKIKSPVLMT PLALSPPRST PEPDLSSIPQ DAATIPSLVV PEALTVCLYI
110 120 130 140 150
NKQADVGPYL ERRKLQQLPE RLGPERPATV LQQAVQACID CAHQPRLVFS
160 170 180 190 200
LVKQGYRGEL VSVSASFDGK QHLRSLPVVN SVGYVLRFLT KLCRSLLCDN
210 220 230 240 250
LFSHLPFPGS IGASDKAQER EDGRTESAKV ATAEECLANA VGMNRYAMDF
260 270 280 290 300
SHRGSVTHSS SLYKRLTCGD SHLAGGPATT TSGSRTNPVP SGGSSSPGLR
310 320 330 340 350
LPASSPKRNG TAIEGNRCAP SPSPEVQDTR RPSSRNPSTW TVEDVVRFVK
360 370 380 390 400
DADPEALGPH VELFRKHEID GNALLLLRSD MIMKYLGLKL GPALKLCYHI

DKLKQAKF
Length:408
Mass (Da):44,445
Last modified:May 20, 2008 - v2
Checksum:i59DDD91591D10D59
GO
Isoform 2 (identifier: Q80VG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:350
Mass (Da):37,959
Checksum:i9D31CA31B3996EC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311A → T in AAH43310 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_033947Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034171 mRNA. Translation: BAC28615.1.
AK047972 mRNA. Translation: BAE20663.1.
AK172160 mRNA. Translation: BAE42854.1.
BC043310 mRNA. Translation: AAH43310.1.
AK220309 mRNA. Translation: BAD90230.1.
CCDSiCCDS23816.1. [Q80VG1-1]
RefSeqiNP_766526.3. NM_172938.3. [Q80VG1-1]
XP_006512816.1. XM_006512753.2. [Q80VG1-2]
UniGeneiMm.98731.

Genome annotation databases

EnsembliENSMUST00000063063; ENSMUSP00000053157; ENSMUSG00000044770. [Q80VG1-1]
ENSMUST00000105494; ENSMUSP00000101133; ENSMUSG00000044770. [Q80VG1-2]
GeneIDi268297.
KEGGimmu:268297.
UCSCiuc007eza.2. mouse. [Q80VG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034171 mRNA. Translation: BAC28615.1.
AK047972 mRNA. Translation: BAE20663.1.
AK172160 mRNA. Translation: BAE42854.1.
BC043310 mRNA. Translation: AAH43310.1.
AK220309 mRNA. Translation: BAD90230.1.
CCDSiCCDS23816.1. [Q80VG1-1]
RefSeqiNP_766526.3. NM_172938.3. [Q80VG1-1]
XP_006512816.1. XM_006512753.2. [Q80VG1-2]
UniGeneiMm.98731.

3D structure databases

ProteinModelPortaliQ80VG1.
SMRiQ80VG1. Positions 95-207, 337-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053157.

PTM databases

PhosphoSiteiQ80VG1.

Proteomic databases

EPDiQ80VG1.
MaxQBiQ80VG1.
PaxDbiQ80VG1.
PRIDEiQ80VG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063063; ENSMUSP00000053157; ENSMUSG00000044770. [Q80VG1-1]
ENSMUST00000105494; ENSMUSP00000101133; ENSMUSG00000044770. [Q80VG1-2]
GeneIDi268297.
KEGGimmu:268297.
UCSCiuc007eza.2. mouse. [Q80VG1-1]

Organism-specific databases

CTDi256380.
MGIiMGI:2446140. Scml4.

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000236280.
HOVERGENiHBG056406.
InParanoidiQ80VG1.
KOiK11466.
OMAiVDDVVWF.
OrthoDBiEOG73BVC2.
PhylomeDBiQ80VG1.
TreeFamiTF106488.

Miscellaneous databases

NextBioi392228.
PROiQ80VG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80VG1.
ExpressionAtlasiQ80VG1. baseline and differential.
GenevisibleiQ80VG1. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Diencephalon, Head and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-408.
    Tissue: Fetal brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiSCML4_MOUSE
AccessioniPrimary (citable) accession number: Q80VG1
Secondary accession number(s): Q3TA16
, Q3V358, Q5DU61, Q8CC08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.