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Protein

Sex comb on midleg-like protein 4

Gene

Scml4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex comb on midleg-like protein 4
Gene namesi
Name:Scml4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2446140 Scml4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371721 – 408Sex comb on midleg-like protein 4Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80VG1
PRIDEiQ80VG1

PTM databases

iPTMnetiQ80VG1
PhosphoSitePlusiQ80VG1

Expressioni

Gene expression databases

BgeeiENSMUSG00000044770
ExpressionAtlasiQ80VG1 baseline and differential
GenevisibleiQ80VG1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053157

Structurei

3D structure databases

ProteinModelPortaliQ80VG1
SMRiQ80VG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 406SAMAdd BLAST67

Sequence similaritiesi

Belongs to the SCM family.Curated

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000236280
HOVERGENiHBG056406
InParanoidiQ80VG1
KOiK11466
OMAiQALTVCI
OrthoDBiEOG091G05BW
PhylomeDBiQ80VG1
TreeFamiTF106488

Family and domain databases

Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR033763 SCML2_RBR
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF17208 RBR, 1 hit
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTQRVPGRK RGRPPLHSTR VQMAVHNLYS ASAASVPAVT IPKKRGRKPR
60 70 80 90 100
YKIKSPVLMT PLALSPPRST PEPDLSSIPQ DAATIPSLVV PEALTVCLYI
110 120 130 140 150
NKQADVGPYL ERRKLQQLPE RLGPERPATV LQQAVQACID CAHQPRLVFS
160 170 180 190 200
LVKQGYRGEL VSVSASFDGK QHLRSLPVVN SVGYVLRFLT KLCRSLLCDN
210 220 230 240 250
LFSHLPFPGS IGASDKAQER EDGRTESAKV ATAEECLANA VGMNRYAMDF
260 270 280 290 300
SHRGSVTHSS SLYKRLTCGD SHLAGGPATT TSGSRTNPVP SGGSSSPGLR
310 320 330 340 350
LPASSPKRNG TAIEGNRCAP SPSPEVQDTR RPSSRNPSTW TVEDVVRFVK
360 370 380 390 400
DADPEALGPH VELFRKHEID GNALLLLRSD MIMKYLGLKL GPALKLCYHI

DKLKQAKF
Length:408
Mass (Da):44,445
Last modified:May 20, 2008 - v2
Checksum:i59DDD91591D10D59
GO
Isoform 2 (identifier: Q80VG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:350
Mass (Da):37,959
Checksum:i9D31CA31B3996EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31A → T in AAH43310 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339471 – 58Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034171 mRNA Translation: BAC28615.1
AK047972 mRNA Translation: BAE20663.1
AK172160 mRNA Translation: BAE42854.1
BC043310 mRNA Translation: AAH43310.1
AK220309 mRNA Translation: BAD90230.1
CCDSiCCDS23816.1 [Q80VG1-1]
RefSeqiNP_766526.3, NM_172938.3 [Q80VG1-1]
XP_006512816.1, XM_006512753.3
UniGeneiMm.98731

Genome annotation databases

EnsembliENSMUST00000063063; ENSMUSP00000053157; ENSMUSG00000044770 [Q80VG1-1]
ENSMUST00000105494; ENSMUSP00000101133; ENSMUSG00000044770 [Q80VG1-2]
GeneIDi268297
KEGGimmu:268297
UCSCiuc007eza.2 mouse [Q80VG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiSCML4_MOUSE
AccessioniPrimary (citable) accession number: Q80VG1
Secondary accession number(s): Q3TA16
, Q3V358, Q5DU61, Q8CC08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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