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Protein

Calmodulin-regulated spectrin-associated protein 3

Gene

Camsap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity).By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 3Curated
Alternative name(s):
Marshalin1 Publication
Protein Nezha1 Publication
Gene namesi
Name:Camsap3Imported
Synonyms:Kiaa15431 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916947. Camsap3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice are viable but show growth defects (PubMed:26715742). Disorganization of epithelial architecture, characterized by impaired apical-to-basal polarity of microtubules in epithelial cells (PubMed:26715742). Defects in the stereotypic positioning of the nucleus and Golgi apparatus (PubMed:26715742).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi608 – 612LEEKR → AAAAA: Retains the ability to interact with microtubules but abolishes the apical localization in epithelial cells. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508001 – 1252Calmodulin-regulated spectrin-associated protein 3Add BLAST1252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphothreonineBy similarity1
Modified residuei193PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1
Modified residuei561PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1
Modified residuei797PhosphothreonineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80VC9.
PaxDbiQ80VC9.
PeptideAtlasiQ80VC9.
PRIDEiQ80VC9.

PTM databases

iPTMnetiQ80VC9.
PhosphoSitePlusiQ80VC9.

Expressioni

Tissue specificityi

In cochlea, restricted to the organ of Corti and increases during development (at protein level) (PubMed:24244856). Highly expressed in both sensory hair cells and supporting cells (PubMed:24244856).1 Publication

Gene expression databases

BgeeiENSMUSG00000044433.
CleanExiMM_2310057J16RIK.
ExpressionAtlasiQ80VC9. baseline and differential.
GenevisibleiQ80VC9. MM.

Interactioni

Subunit structurei

Interacts with PLEKHA7 (By similarity). Interacts with CAMSAP2 (PubMed:23169647). Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP3-decorated microtubule stretches (By similarity). Interacts with AKAP9; regulating Golgi assembly in epithelial cells (By similarity). Interacts with MACF1 (By similarity). Interacts with isoform C of CDH23; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Camsap2Q8C1B12EBI-2125556,EBI-8839434

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213622. 2 interactors.
DIPiDIP-52404N.
IntActiQ80VC9. 3 interactors.
MINTiMINT-4112709.
STRINGi10090.ENSMUSP00000125993.

Structurei

Secondary structure

11252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1125 – 1134Combined sources10
Turni1135 – 1137Combined sources3
Helixi1143 – 1155Combined sources13
Beta strandi1161 – 1169Combined sources9
Beta strandi1171 – 1178Combined sources8
Beta strandi1185 – 1192Combined sources8
Beta strandi1194 – 1196Combined sources3
Turni1198 – 1200Combined sources3
Beta strandi1201 – 1208Combined sources8
Turni1209 – 1212Combined sources4
Beta strandi1213 – 1216Combined sources4
Beta strandi1218 – 1221Combined sources4
Beta strandi1227 – 1231Combined sources5
Turni1234 – 1236Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UGJNMR-A1113-1240[»]
5LZNX-ray1.40A1121-1239[»]
5M50electron microscopy5.30C1121-1238[»]
ProteinModelPortaliQ80VC9.
SMRiQ80VC9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80VC9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 312Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST110
Domaini1112 – 1246CKKPROSITE-ProRule annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili595 – 629Sequence analysisAdd BLAST35
Coiled coili696 – 727Sequence analysisAdd BLAST32
Coiled coili896 – 943Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi496 – 549Pro-richAdd BLAST54
Compositional biasi728 – 839Pro-richAdd BLAST112

Domaini

The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules.PROSITE-ProRule annotationBy similarity

Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3654. Eukaryota.
ENOG4111D0B. LUCA.
GeneTreeiENSGT00390000010026.
HOGENOMiHOG000059671.
InParanoidiQ80VC9.
KOiK17493.
PhylomeDBiQ80VC9.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR036872. Calponin-like_dom_sf.
IPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like_sf.
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiView protein in Pfam
PF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
SMARTiView protein in SMART
SM01051. CAMSAP_CKK. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiView protein in PROSITE
PS50021. CH. 1 hit.
PS51508. CKK. 1 hit.

Sequences (17)i

Sequence statusi: Complete.

This entry describes 17 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VC9-1) [UniParc]FASTAAdd to basket
Also known as: Ld1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEAAPAGSG PLRRTFLVPE IKSLDQYDFS RAKAAASLAW VLRAAFGGAE
60 70 80 90 100
HVPPELWEPF YTDQYAQEHV KPPVTRLLLS AELYCRAWRQ ALPQLEPSPS
110 120 130 140 150
PSALLALLAR RGTVPSLPEH PVREADLKHQ PILMGAHLAV IDALMVAFSF
160 170 180 190 200
EWTKTLPGPL ALSSLEHKLL FWVDTTVRRL QEKTEQEAAQ RASPAAPLDG
210 220 230 240 250
ASPAQPSIRY RKDRAIARRA PCFPNVTTLQ DLASGAALAA TIHCYCPQLL
260 270 280 290 300
RLEEVCLKDP MSVADSLYNL QLVQDFCASH LPRGCPLSLE DLLYVPPPLK
310 320 330 340 350
VNLVVLLAEM YMCFEVLKPD FVQAKDLPDG HAVSPRNTET VPSQNNSGSS
360 370 380 390 400
SPVFNFRHPL LSPGGPQSPL RGSTGSLKSS PSMSHMEALG KAWNRQLSRP
410 420 430 440 450
LSQAVSFSTP FGLDSDVDVV MGDPVLLRSV SSDSLGPPRP VSTSSRNSAQ
460 470 480 490 500
PAPESGDLPT IEEALQIIHS AEPRLLPDGA ADGSFYLHSP EGLSKPPLSP
510 520 530 540 550
YPPEGASKPL SDRLNKAPIY ISHPENPSKS SPCSTGEILK PPPPSEGSPK
560 570 580 590 600
AVASSPAANN SEVKMTSFAE RKKQLVKAEA ESGLGSPTST PVAPEALSSE
610 620 630 640 650
MSELGARLEE KRRAIEAQKR RIEAIFAKHR QRLGKSAFLQ VQPREAAGEA
660 670 680 690 700
EEEAELGSVP GGERPAGEGQ GEPSLRHKSV TFSPDLGPVP PEGLGDYNRA
710 720 730 740 750
VSKLSAALSS LQRDMQRLTD QQQRLLAPPE APGPAPPPAA WVIPGPATGP
760 770 780 790 800
KAASPSPARR APAARRSPGP GPSPTPRSPK HARPAELKLA PLTRVLTPPH
810 820 830 840 850
DVDSLPHLRK FSPSQVPVQT RSSILLSEGT PPEEPTTKPA LIEIPLASLG
860 870 880 890 900
EPAADEEGDG SPPGAEDSLE EEASSEGEPR SGLGFFYKDE DKPEDEMAQK
910 920 930 940 950
RASLLERQQR RVEEARRRKQ WQEAEKEQKR EEAARLAQEA PGLAFTTPVV
960 970 980 990 1000
ASAAPVATLA PTTRAMAPAE EEVGPRRGDF TRLEYERRAQ LKLMDDLDKV
1010 1020 1030 1040 1050
LRPRASGTGG PGRGGRRATR PRSGCCDDSA LARSPARGLL GSRLSKVYSQ
1060 1070 1080 1090 1100
STLSLSTVAN EAPNNLGVKR PTSRAPSPSG LMSPSRLPGS RERDWENGSN
1110 1120 1130 1140 1150
ASSPASVPEY TGPRLYKEPS AKSNKFIIHN ALSHCCLAGK VNEPQKNRIL
1160 1170 1180 1190 1200
EEIEKSKANH FLILFRDSSC QFRALYTLSG ETEELSRLAG YGPRTVTPAM
1210 1220 1230 1240 1250
VEGIYKYNSD RKRFTQIPAK TMSMSVDAFT IQGHLWQSKK PTTPKKGGGT

PK
Length:1,252
Mass (Da):135,175
Last modified:June 1, 2003 - v1
Checksum:i1E14AA8640108CF4
GO
Isoform 2 (identifier: Q80VC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1111: Missing.

Note: No experimental confirmation available.
Show »
Length:1,182
Mass (Da):127,774
Checksum:i0B344DA6F21D8D2F
GO
Isoform 3 (identifier: Q80VC9-3) [UniParc]FASTAAdd to basket
Also known as: Lc variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP

Show »
Length:1,263
Mass (Da):136,606
Checksum:i79077CD26F4C298F
GO
Isoform 4 (identifier: Q80VC9-4) [UniParc]FASTAAdd to basket
Also known as: Lb variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM

Show »
Length:1,268
Mass (Da):136,900
Checksum:i26BA3AAEEA18C6F6
GO
Isoform 5 (identifier: Q80VC9-5) [UniParc]FASTAAdd to basket
Also known as: La variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM

Show »
Length:1,279
Mass (Da):138,331
Checksum:i2A8645E0CA0164E3
GO
Isoform 6 (identifier: Q80VC9-6) [UniParc]FASTAAdd to basket
Also known as: Sc variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     398-813: Missing.

Show »
Length:847
Mass (Da):92,893
Checksum:i13BEF58139993A3E
GO
Isoform 7 (identifier: Q80VC9-7) [UniParc]FASTAAdd to basket
Also known as: Sb variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     398-813: Missing.

Show »
Length:852
Mass (Da):93,187
Checksum:iD381D5023C40C828
GO
Isoform 8 (identifier: Q80VC9-8) [UniParc]FASTAAdd to basket
Also known as: Sa variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     398-813: Missing.

Show »
Length:863
Mass (Da):94,618
Checksum:i95C49E4A44A97518
GO
Isoform 9 (identifier: Q80VC9-9) [UniParc]FASTAAdd to basket
Also known as: Sd variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     398-813: Missing.

Show »
Length:836
Mass (Da):91,462
Checksum:iBE33607687BF91FB
GO
Isoform 10 (identifier: Q80VC9-10) [UniParc]FASTAAdd to basket
Also known as: Ld variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: H → HV

Show »
Length:1,253
Mass (Da):135,274
Checksum:i4B51EB0D2090CB95
GO
Isoform 11 (identifier: Q80VC9-11) [UniParc]FASTAAdd to basket
Also known as: Lb variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     331-331: H → HV

Show »
Length:1,269
Mass (Da):136,999
Checksum:i4809459D083AC3DF
GO
Isoform 12 (identifier: Q80VC9-12) [UniParc]FASTAAdd to basket
Also known as: Lc variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     331-331: H → HV

Show »
Length:1,264
Mass (Da):136,705
Checksum:i0566F8DB74BF9730
GO
Isoform 13 (identifier: Q80VC9-13) [UniParc]FASTAAdd to basket
Also known as: Sd variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: H → HV
     398-813: Missing.

Show »
Length:837
Mass (Da):91,561
Checksum:i32C2E0B9A927A919
GO
Isoform 14 (identifier: Q80VC9-14) [UniParc]FASTAAdd to basket
Also known as: La variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     331-331: H → HV

Show »
Length:1,280
Mass (Da):138,430
Checksum:i547579E2461ADA7D
GO
Isoform 15 (identifier: Q80VC9-15) [UniParc]FASTAAdd to basket
Also known as: Sc variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     331-331: H → HV
     398-813: Missing.

Show »
Length:848
Mass (Da):92,992
Checksum:i811F6D2C5E998FB2
GO
Isoform 16 (identifier: Q80VC9-16) [UniParc]FASTAAdd to basket
Also known as: Sb variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     331-331: H → HV
     398-813: Missing.

Show »
Length:853
Mass (Da):93,286
Checksum:i9F7F520CDD9C5640
GO
Isoform 17 (identifier: Q80VC9-17) [UniParc]FASTAAdd to basket
Also known as: Sa variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     331-331: H → HV
     398-813: Missing.

Show »
Length:864
Mass (Da):94,717
Checksum:iB239174795E4BFFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199 – 207DGASPAQPS → LTSLSSCPQ in BAD90256 (Ref. 6) Curated9
Sequence conflicti892K → E in BAC38313 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059237207S → SCPTRWYWKLVP in isoform 3, isoform 6, isoform 12 and isoform 15. 1
Alternative sequenceiVSP_059238207S → SHAIAFCLKESGNKPPM in isoform 4, isoform 7, isoform 11 and isoform 16. 1
Alternative sequenceiVSP_059239207S → SCPTRWYWKLVPHAIAFCLK ESGNKPPM in isoform 5, isoform 8, isoform 14 and isoform 17. 1
Alternative sequenceiVSP_059240331H → HV in isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16 and isoform 17. 1
Alternative sequenceiVSP_059241398 – 813Missing in isoform 6, isoform 7, isoform 8, isoform 9, isoform 13, isoform 15, isoform 16 and isoform 17. Add BLAST416
Alternative sequenceiVSP_0137051042 – 1111Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC426930 mRNA. Translation: AGX24909.1.
KC426931 mRNA. Translation: AGX24910.1.
KC426932 mRNA. Translation: AGX24911.1.
KC426933 mRNA. Translation: AGX24912.1.
KC426934 mRNA. Translation: AGX24913.1.
KC426935 mRNA. Translation: AGX24914.1.
KC426936 mRNA. Translation: AGX24915.1.
KC426937 mRNA. Translation: AGX24916.1.
KC426938 mRNA. Translation: AGX24917.1.
KC426939 mRNA. Translation: AGX24918.1.
KC426940 mRNA. Translation: AGX24919.1.
KC426941 mRNA. Translation: AGX24920.1.
KC426942 mRNA. Translation: AGX24921.1.
KC426943 mRNA. Translation: AGX24922.1.
KC426944 mRNA. Translation: AGX24923.1.
KC426945 mRNA. Translation: AGX24924.1.
AK081728 mRNA. Translation: BAC38313.1.
AC170806 Genomic DNA. No translation available.
CH466566 Genomic DNA. Translation: EDL21921.1.
BC048787 mRNA. Translation: AAH48787.1.
AK220401 Transcribed RNA. Translation: BAD90256.1.
CCDSiCCDS22064.1. [Q80VC9-1]
RefSeqiNP_001157221.1. NM_001163749.1.
NP_081447.2. NM_027171.3. [Q80VC9-1]
UniGeneiMm.390010.

Genome annotation databases

EnsembliENSMUST00000057028; ENSMUSP00000058958; ENSMUSG00000044433. [Q80VC9-1]
GeneIDi69697.
KEGGimmu:69697.
UCSCiuc009krw.2. mouse. [Q80VC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCAMP3_MOUSE
AccessioniPrimary (citable) accession number: Q80VC9
Secondary accession number(s): E9Q5B0
, Q5DTW9, Q8BUZ0, U5LGR7, U5LGS1, U5LGS5, U5LGT0, U5LHT8, U5LHU4, U5LHW1, U5LHW4, U5LHW9, U5LK15, U5LK19, U5LK24, U5LK70, U5LK74, U5LK79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families