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Protein

tRNA selenocysteine 1-associated protein 1

Gene

Trnau1ap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • selenocysteine incorporation Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA selenocysteine 1-associated protein 1
Alternative name(s):
SECp43
tRNA selenocysteine-associated protein 1
Gene namesi
Name:Trnau1ap
Synonyms:Secp43, Trspap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919037. Trnau1ap.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049181 – 287tRNA selenocysteine 1-associated protein 1Add BLAST287

Proteomic databases

EPDiQ80VC6.
MaxQBiQ80VC6.
PaxDbiQ80VC6.
PeptideAtlasiQ80VC6.
PRIDEiQ80VC6.

PTM databases

iPTMnetiQ80VC6.
PhosphoSitePlusiQ80VC6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028898.
CleanExiMM_TRSPAP1.
ExpressionAtlasiQ80VC6. baseline and differential.
GenevisibleiQ80VC6. MM.

Interactioni

Subunit structurei

Found in a complex with tRNA(Sec) (By similarity). Interacts with SEPSECS (By similarity). Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Associates with mRNP and/or polysomes.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030730.

Structurei

3D structure databases

ProteinModelPortaliQ80VC6.
SMRiQ80VC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 86RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini96 – 175RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 225Tyr-richAdd BLAST41

Sequence similaritiesi

Belongs to the RRM TRSPAP family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00510000047100.
HOGENOMiHOG000234338.
HOVERGENiHBG056959.
InParanoidiQ80VC6.
OMAiEDPTPQL.
OrthoDBiEOG091G0CAW.
PhylomeDBiQ80VC6.
TreeFamiTF313275.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80VC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV
60 70 80 90 100
EFADLATAEK CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV
110 120 130 140 150
GDLTPDVDDG MLYEFFVKVY PSCRGGKVVL DPTGVSKGYG FVKFTDELEQ
160 170 180 190 200
KRALTECQGA VGLGCKPVRL SVAIPKASRV KPVEYSQMYS YSYNQYYQQY
210 220 230 240 250
QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA LEDPAPQLDV
260 270 280
TEANKEFMEQ SEELYDALMD CHWQPLDTVS SEIPAMM
Length:287
Mass (Da):32,423
Last modified:July 5, 2005 - v2
Checksum:i54840556B804F6E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31M → L in AAH05795 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK152986 mRNA. Translation: BAE31634.1.
CR752656 Genomic DNA. Translation: CAM28198.1.
BC005795 mRNA. Translation: AAH05795.1.
BC048840 mRNA. Translation: AAH48840.2.
BC055454 mRNA. Translation: AAH55454.1.
BC099594 mRNA. Translation: AAH99594.1.
CCDSiCCDS18722.1.
RefSeqiNP_082201.2. NM_027925.3.
UniGeneiMm.239183.

Genome annotation databases

EnsembliENSMUST00000030730; ENSMUSP00000030730; ENSMUSG00000028898.
GeneIDi71787.
KEGGimmu:71787.
UCSCiuc008vbb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK152986 mRNA. Translation: BAE31634.1.
CR752656 Genomic DNA. Translation: CAM28198.1.
BC005795 mRNA. Translation: AAH05795.1.
BC048840 mRNA. Translation: AAH48840.2.
BC055454 mRNA. Translation: AAH55454.1.
BC099594 mRNA. Translation: AAH99594.1.
CCDSiCCDS18722.1.
RefSeqiNP_082201.2. NM_027925.3.
UniGeneiMm.239183.

3D structure databases

ProteinModelPortaliQ80VC6.
SMRiQ80VC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030730.

PTM databases

iPTMnetiQ80VC6.
PhosphoSitePlusiQ80VC6.

Proteomic databases

EPDiQ80VC6.
MaxQBiQ80VC6.
PaxDbiQ80VC6.
PeptideAtlasiQ80VC6.
PRIDEiQ80VC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030730; ENSMUSP00000030730; ENSMUSG00000028898.
GeneIDi71787.
KEGGimmu:71787.
UCSCiuc008vbb.1. mouse.

Organism-specific databases

CTDi54952.
MGIiMGI:1919037. Trnau1ap.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00510000047100.
HOGENOMiHOG000234338.
HOVERGENiHBG056959.
InParanoidiQ80VC6.
OMAiEDPTPQL.
OrthoDBiEOG091G0CAW.
PhylomeDBiQ80VC6.
TreeFamiTF313275.

Miscellaneous databases

ChiTaRSiTrnau1ap. mouse.
PROiQ80VC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028898.
CleanExiMM_TRSPAP1.
ExpressionAtlasiQ80VC6. baseline and differential.
GenevisibleiQ80VC6. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSAP1_MOUSE
AccessioniPrimary (citable) accession number: Q80VC6
Secondary accession number(s): Q05DN9, Q4FZE9, Q7TMM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.