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Protein

SH3 domain and tetratricopeptide repeat-containing protein 2

Gene

Sh3tc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • myelination in peripheral nervous system Source: MGI
  • peripheral nervous system myelin maintenance Source: MGI
  • regulation of ERBB signaling pathway Source: MGI
  • regulation of intracellular protein transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain and tetratricopeptide repeat-containing protein 2
Gene namesi
Name:Sh3tc2
Synonyms:Kiaa1985
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444417. Sh3tc2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12891289SH3 domain and tetratricopeptide repeat-containing protein 2PRO_0000106357Add
BLAST

Proteomic databases

MaxQBiQ80VA5.
PaxDbiQ80VA5.
PRIDEiQ80VA5.

PTM databases

iPTMnetiQ80VA5.
PhosphoSiteiQ80VA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045629.
CleanExiMM_SH3TC2.
GenevisibleiQ80VA5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055094.

Structurei

3D structure databases

ProteinModelPortaliQ80VA5.
SMRiQ80VA5. Positions 268-327, 923-950, 1006-1031, 1130-1198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 33064SH3PROSITE-ProRule annotationAdd
BLAST
Repeati529 – 56234TPR 1Add
BLAST
Repeati758 – 79134TPR 2Add
BLAST
Repeati837 – 87034TPR 3Add
BLAST
Repeati1002 – 103837TPR 4Add
BLAST
Repeati1085 – 111935TPR 5Add
BLAST
Repeati1120 – 115334TPR 6Add
BLAST
Repeati1167 – 120034TPR 7Add
BLAST
Repeati1211 – 124535TPR 8Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 8 TPR repeats.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFSQ. Eukaryota.
ENOG410Y8HX. LUCA.
GeneTreeiENSGT00530000063812.
HOGENOMiHOG000121783.
HOVERGENiHBG054553.
InParanoidiQ80VA5.
OMAiWFLKNYP.
OrthoDBiEOG091G00MK.
PhylomeDBiQ80VA5.
TreeFamiTF333167.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 2 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
SSF50044. SSF50044. 2 hits.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGCFCIPGE RSLPWGPGKE GSSKDPPGLA EDTSSLENKR KCFLPQNMTQ
60 70 80 90 100
DLVLSFCVKS RSRRCVNAAL QEAARRRLWA LENEAQEVHA LFKDLSARLV
110 120 130 140 150
SVQSQKDQFL ITFKTLEEIW KFSTYLNLGY VSICLEHLFF DHTYWLNSRL
160 170 180 190 200
VDDTEIQVSV DDNHLENIYL GLLLQEGHFF CRAVCSVAQP ADKEGEYLTL
210 220 230 240 250
CKNELISVLS GGESECEAMS LVTGQRGLVP MSALEPLPVP FHQWFLKNHP
260 270 280 290 300
GICGLPRKRD WTGSGQIGRG RCKALMDYEQ EERDELCFLQ GESIDVIGFV
310 320 330 340 350
IPGLQWFIGK SVSSGEVGFV PTRSIDLDSC SPMSKNSAFF SDEERSSLWS
360 370 380 390 400
PGSERKAECS GFLCSLAHTD ITSIYRLSEF EAIQNLQNDL SASQPEGFRE
410 420 430 440 450
ARSGGTWMER QTIGSRRSSG SGDSSPEEDE LISASSDSYH LPEPEDLDDP
460 470 480 490 500
ELFMDLSTSL EEDDVEHFAP ILAFLDHEGY TDHFKSLYDF SFSFLTSSFY
510 520 530 540 550
SFSEEDELVA YLETSRKWAK MSHMTWAHAR LCFLLGRLSI RKTKLSQARV
560 570 580 590 600
YFEEAIRVLD GAFEDLSLVA ALYINLAAIY LRQRLRHKGP TLLEKAGALL
610 620 630 640 650
ACLPDHEFST KNELDVVTYV LRQGIVVGSG LLEARSCFLA IRLLLSLGRH
660 670 680 690 700
EEVVPFAERL QLLSGHPPAS EATATMLSSL YDKKYLPHLA VASVQKRGPQ
710 720 730 740 750
SARGMSLSIW QAYLVLQNAT KILGVPSSNW CEVSALACPT LRQALAACEE
760 770 780 790 800
LSDQDIQRTL CLILSKMYLQ HQSPDGSVHY LSQAHVLGKL LGEEEAFESS
810 820 830 840 850
LCLAWAYLLG RQTEKALEIL EPLLCSLRET ECVTQRGVVH NLLGLAFEDE
860 870 880 890 900
GRTSRAAKSY LRALIRAREM GNIRNQAVSM ANLGHLTLKS CMQQSARGYL
910 920 930 940 950
LQAVRLYSEL QASKETDMEL VQVLLWLGQA SVSGHQLVHS RLCYEMALLF
960 970 980 990 1000
GLRHQHLSSQ LQVTKSLCHF YSSVSPNPDA CITYHEHWLA LAQQLRDREM
1010 1020 1030 1040 1050
EGQLLESLGQ LYRNLNTSRS LRRSLACIKE SLRIFVDLGE RDKAAEAWLG
1060 1070 1080 1090 1100
AGRLHYLMQE DELVELYLQE AIQTALRSEE PSLALKLYEE AGDVFFNGTR
1110 1120 1130 1140 1150
HRHRAVEYYR AGAVPLARRM KALRTELRIF NKLTELQISL EGYEKALEFA
1160 1170 1180 1190 1200
TLAARLSVLT GDQKQELVAF HRLATVYFSL NMYEMAEDCY LKTLSLCPPW
1210 1220 1230 1240 1250
LQSPKEALYY AKVYCRLGRL TFYQLKDAHD ATEYFLLALA AAVLMGDEEL
1260 1270 1280
QNTIKNRLDS ICQSPLWHSN PFGCSSERAR WLSGGSLAL
Length:1,289
Mass (Da):145,144
Last modified:April 13, 2004 - v2
Checksum:iE96C52181ADD9936
GO
Isoform 2 (identifier: Q80VA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-407: Missing.
     1020-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):68,751
Checksum:iAE7EC8945EDAA20E
GO
Isoform 3 (identifier: Q80VA5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-156: YVSICLEHLFFDHTYWLNSRLVDDTEI → MPWVGGGEHLSPSSRLVEPDTGELVCL
     157-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,401
Checksum:i08A9BA72A7A8B9BE
GO
Isoform 4 (identifier: Q80VA5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     959-1001: SQLQVTKSLC...AQQLRDREME → TRCPRTPMRA...WSPLGSFIGT
     1002-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:1,001
Mass (Da):112,135
Checksum:i0A35D21557144991
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 407407Missing in isoform 2. 1 PublicationVSP_009887Add
BLAST
Alternative sequencei130 – 15627YVSIC…DDTEI → MPWVGGGEHLSPSSRLVEPD TGELVCL in isoform 3. 1 PublicationVSP_009888Add
BLAST
Alternative sequencei157 – 12891133Missing in isoform 3. 1 PublicationVSP_009889Add
BLAST
Alternative sequencei959 – 100143SQLQV…DREME → TRCPRTPMRALPIMNTGWPW LSNSGIGRWRDSYWSPLGSF IGT in isoform 4. 1 PublicationVSP_009890Add
BLAST
Alternative sequencei1002 – 1289288Missing in isoform 4. 1 PublicationVSP_009891Add
BLAST
Alternative sequencei1020 – 1289270Missing in isoform 2. 1 PublicationVSP_009892Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031388 mRNA. Translation: BAC27379.1.
AK048066 mRNA. Translation: BAC33233.1.
AK052534 mRNA. Translation: BAC35030.1.
BC037000 mRNA. No translation available.
BC049856 mRNA. Translation: AAH49856.1.
CCDSiCCDS37840.1. [Q80VA5-1]
RefSeqiNP_766216.2. NM_172628.2. [Q80VA5-1]
UniGeneiMm.262320.

Genome annotation databases

EnsembliENSMUST00000051720; ENSMUSP00000055094; ENSMUSG00000045629. [Q80VA5-1]
GeneIDi225608.
KEGGimmu:225608.
UCSCiuc008fcu.1. mouse. [Q80VA5-3]
uc008fcv.1. mouse. [Q80VA5-1]
uc008fcw.1. mouse. [Q80VA5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031388 mRNA. Translation: BAC27379.1.
AK048066 mRNA. Translation: BAC33233.1.
AK052534 mRNA. Translation: BAC35030.1.
BC037000 mRNA. No translation available.
BC049856 mRNA. Translation: AAH49856.1.
CCDSiCCDS37840.1. [Q80VA5-1]
RefSeqiNP_766216.2. NM_172628.2. [Q80VA5-1]
UniGeneiMm.262320.

3D structure databases

ProteinModelPortaliQ80VA5.
SMRiQ80VA5. Positions 268-327, 923-950, 1006-1031, 1130-1198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055094.

PTM databases

iPTMnetiQ80VA5.
PhosphoSiteiQ80VA5.

Proteomic databases

MaxQBiQ80VA5.
PaxDbiQ80VA5.
PRIDEiQ80VA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051720; ENSMUSP00000055094; ENSMUSG00000045629. [Q80VA5-1]
GeneIDi225608.
KEGGimmu:225608.
UCSCiuc008fcu.1. mouse. [Q80VA5-3]
uc008fcv.1. mouse. [Q80VA5-1]
uc008fcw.1. mouse. [Q80VA5-2]

Organism-specific databases

CTDi79628.
MGIiMGI:2444417. Sh3tc2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IFSQ. Eukaryota.
ENOG410Y8HX. LUCA.
GeneTreeiENSGT00530000063812.
HOGENOMiHOG000121783.
HOVERGENiHBG054553.
InParanoidiQ80VA5.
OMAiWFLKNYP.
OrthoDBiEOG091G00MK.
PhylomeDBiQ80VA5.
TreeFamiTF333167.

Miscellaneous databases

ChiTaRSiSh3tc2. mouse.
PROiQ80VA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045629.
CleanExiMM_SH3TC2.
GenevisibleiQ80VA5. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 2 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
SSF50044. SSF50044. 2 hits.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS3TC2_MOUSE
AccessioniPrimary (citable) accession number: Q80VA5
Secondary accession number(s): Q8BWH2, Q8BXB8, Q8C0G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.