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Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport (By similarity).By similarity

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_333840. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923750. Ip6k2.

Subcellular locationi

GO - Cellular componenti

  • intermediate filament cytoskeleton Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Inositol hexakisphosphate kinase 2PRO_0000066878Add
BLAST

Proteomic databases

PaxDbiQ80V72.
PRIDEiQ80V72.

PTM databases

PhosphoSiteiQ80V72.

Expressioni

Tissue specificityi

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.1 Publication

Gene expression databases

BgeeiQ80V72.
CleanExiMM_IHPK2.
ExpressionAtlasiQ80V72. baseline and differential.
GenevisibleiQ80V72. MM.

Interactioni

Protein-protein interaction databases

BioGridi218156. 1 interaction.
STRINGi10090.ENSMUSP00000082091.

Structurei

3D structure databases

ProteinModelPortaliQ80V72.
SMRiQ80V72. Positions 226-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 2469Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ80V72.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80V72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ
60 70 80 90 100
FYETLPAEMR RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED
110 120 130 140 150
EDRNLCLIAY PLKGDHGTVD IVDNSDCEPK SKLLRWTNKK HHALETEKNP
160 170 180 190 200
KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV LYYSVEKKGN VSSQLKHYNP
210 220 230 240 250
WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV LDLKMGTRQH
260 270 280 290 300
GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR
310 320 330 340 350
KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS
360 370 380 390 400
SSLLVIYDGK EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD
410 420 430 440
VRMIDFAHTT CRLYGEDSVV HEGQDAGYIF GLQSLIDIVT EISEESGE
Length:448
Mass (Da):51,644
Last modified:July 27, 2011 - v2
Checksum:iA1B483785C5DAE25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921M → I in AAH39922 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC168054 Genomic DNA. No translation available.
AC173341 Genomic DNA. No translation available.
BC039922 mRNA. Translation: AAH39922.1.
CCDSiCCDS23537.1.
RefSeqiNP_083910.2. NM_029634.2.
XP_006511913.1. XM_006511850.2.
XP_006511914.1. XM_006511851.2.
UniGeneiMm.276336.
Mm.490338.

Genome annotation databases

EnsembliENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
GeneIDi76500.
KEGGimmu:76500.
UCSCiuc009rqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC168054 Genomic DNA. No translation available.
AC173341 Genomic DNA. No translation available.
BC039922 mRNA. Translation: AAH39922.1.
CCDSiCCDS23537.1.
RefSeqiNP_083910.2. NM_029634.2.
XP_006511913.1. XM_006511850.2.
XP_006511914.1. XM_006511851.2.
UniGeneiMm.276336.
Mm.490338.

3D structure databases

ProteinModelPortaliQ80V72.
SMRiQ80V72. Positions 226-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218156. 1 interaction.
STRINGi10090.ENSMUSP00000082091.

PTM databases

PhosphoSiteiQ80V72.

Proteomic databases

PaxDbiQ80V72.
PRIDEiQ80V72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
GeneIDi76500.
KEGGimmu:76500.
UCSCiuc009rqw.1. mouse.

Organism-specific databases

CTDi51447.
MGIiMGI:1923750. Ip6k2.

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ80V72.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
TreeFamiTF314066.

Enzyme and pathway databases

ReactomeiREACT_333840. Synthesis of IPs in the nucleus.

Miscellaneous databases

ChiTaRSiIp6k2. mouse.
NextBioi345268.
PROiQ80V72.
SOURCEiSearch...

Gene expression databases

BgeeiQ80V72.
CleanExiMM_IHPK2.
ExpressionAtlasiQ80V72. baseline and differential.
GenevisibleiQ80V72. MM.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
    Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
    Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIP6K2_MOUSE
AccessioniPrimary (citable) accession number: Q80V72
Secondary accession number(s): E9QMT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.