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Q80V72 (IP6K2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 2

Short name=InsP6 kinase 2
EC=2.7.4.21
Alternative name(s):
P(i)-uptake stimulator
Short name=PiUS
Gene names
Name:Ip6k2
Synonyms:Ihpk2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport By similarity.

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. Ref.3

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Inositol hexakisphosphate kinase 2
PRO_0000066878

Regions

Region238 – 2469Substrate binding By similarity

Experimental info

Sequence conflict2921M → I in AAH39922. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q80V72 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: A1B483785C5DAE25

FASTA44851,644
        10         20         30         40         50         60 
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 

        70         80         90        100        110        120 
RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED EDRNLCLIAY PLKGDHGTVD 

       130        140        150        160        170        180 
IVDNSDCEPK SKLLRWTNKK HHALETEKNP KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV 

       190        200        210        220        230        240 
LYYSVEKKGN VSSQLKHYNP WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV 

       250        260        270        280        290        300 
LDLKMGTRQH GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR 

       310        320        330        340        350        360 
KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS SSLLVIYDGK 

       370        380        390        400        410        420 
EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD VRMIDFAHTT CRLYGEDSVV 

       430        440 
HEGQDAGYIF GLQSLIDIVT EISEESGE 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC168054 Genomic DNA. No translation available.
AC173341 Genomic DNA. No translation available.
BC039922 mRNA. Translation: AAH39922.1.
RefSeqNP_083910.2. NM_029634.2.
XP_006511913.1. XM_006511850.1.
XP_006511914.1. XM_006511851.1.
UniGeneMm.276336.
Mm.490338.

3D structure databases

ProteinModelPortalQ80V72.
SMRQ80V72. Positions 226-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid218156. 1 interaction.

PTM databases

PhosphoSiteQ80V72.

Proteomic databases

PaxDbQ80V72.
PRIDEQ80V72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
GeneID76500.
KEGGmmu:76500.
UCSCuc009rqw.1. mouse.

Organism-specific databases

CTD51447.
MGIMGI:1923750. Ip6k2.

Phylogenomic databases

eggNOGNOG274869.
GeneTreeENSGT00390000014381.
HOGENOMHOG000007418.
HOVERGENHBG052140.
InParanoidQ80V72.
KOK07756.
OMAKEWVRQH.
OrthoDBEOG747PHX.
TreeFamTF314066.

Gene expression databases

BgeeQ80V72.
CleanExMM_IHPK2.
GenevestigatorQ80V72.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIP6K2. mouse.
NextBio345268.
PROQ80V72.
SOURCESearch...

Entry information

Entry nameIP6K2_MOUSE
AccessionPrimary (citable) accession number: Q80V72
Secondary accession number(s): E9QMT6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot