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Q80V72

- IP6K2_MOUSE

UniProt

Q80V72 - IP6K2_MOUSE

Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport By similarity.By similarity

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of cell growth Source: Ensembl
    2. phosphate ion transport Source: Ensembl
    3. phosphatidylinositol phosphorylation Source: Ensembl
    4. positive regulation of apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196480. Synthesis of IPs in the nucleus.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 2
    Alternative name(s):
    P(i)-uptake stimulator
    Short name:
    PiUS
    Gene namesi
    Name:Ip6k2
    Synonyms:Ihpk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1923750. Ip6k2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. intermediate filament cytoskeleton Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Inositol hexakisphosphate kinase 2PRO_0000066878Add
    BLAST

    Proteomic databases

    PaxDbiQ80V72.
    PRIDEiQ80V72.

    PTM databases

    PhosphoSiteiQ80V72.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.1 Publication

    Gene expression databases

    BgeeiQ80V72.
    CleanExiMM_IHPK2.
    GenevestigatoriQ80V72.

    Interactioni

    Protein-protein interaction databases

    BioGridi218156. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80V72.
    SMRiQ80V72. Positions 226-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni238 – 2469Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    GeneTreeiENSGT00390000014381.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    InParanoidiQ80V72.
    KOiK07756.
    OMAiKEWVRQH.
    OrthoDBiEOG747PHX.
    TreeFamiTF314066.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80V72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ    50
    FYETLPAEMR RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED 100
    EDRNLCLIAY PLKGDHGTVD IVDNSDCEPK SKLLRWTNKK HHALETEKNP 150
    KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV LYYSVEKKGN VSSQLKHYNP 200
    WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV LDLKMGTRQH 250
    GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR 300
    KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS 350
    SSLLVIYDGK EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD 400
    VRMIDFAHTT CRLYGEDSVV HEGQDAGYIF GLQSLIDIVT EISEESGE 448
    Length:448
    Mass (Da):51,644
    Last modified:July 27, 2011 - v2
    Checksum:iA1B483785C5DAE25
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti292 – 2921M → I in AAH39922. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC168054 Genomic DNA. No translation available.
    AC173341 Genomic DNA. No translation available.
    BC039922 mRNA. Translation: AAH39922.1.
    CCDSiCCDS23537.1.
    RefSeqiNP_083910.2. NM_029634.2.
    XP_006511913.1. XM_006511850.1.
    XP_006511914.1. XM_006511851.1.
    UniGeneiMm.276336.
    Mm.490338.

    Genome annotation databases

    EnsembliENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
    GeneIDi76500.
    KEGGimmu:76500.
    UCSCiuc009rqw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC168054 Genomic DNA. No translation available.
    AC173341 Genomic DNA. No translation available.
    BC039922 mRNA. Translation: AAH39922.1 .
    CCDSi CCDS23537.1.
    RefSeqi NP_083910.2. NM_029634.2.
    XP_006511913.1. XM_006511850.1.
    XP_006511914.1. XM_006511851.1.
    UniGenei Mm.276336.
    Mm.490338.

    3D structure databases

    ProteinModelPortali Q80V72.
    SMRi Q80V72. Positions 226-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218156. 1 interaction.

    PTM databases

    PhosphoSitei Q80V72.

    Proteomic databases

    PaxDbi Q80V72.
    PRIDEi Q80V72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085018 ; ENSMUSP00000082091 ; ENSMUSG00000032599 .
    GeneIDi 76500.
    KEGGi mmu:76500.
    UCSCi uc009rqw.1. mouse.

    Organism-specific databases

    CTDi 51447.
    MGIi MGI:1923750. Ip6k2.

    Phylogenomic databases

    eggNOGi NOG274869.
    GeneTreei ENSGT00390000014381.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    InParanoidi Q80V72.
    KOi K07756.
    OMAi KEWVRQH.
    OrthoDBi EOG747PHX.
    TreeFami TF314066.

    Enzyme and pathway databases

    Reactomei REACT_196480. Synthesis of IPs in the nucleus.

    Miscellaneous databases

    ChiTaRSi IP6K2. mouse.
    NextBioi 345268.
    PROi Q80V72.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80V72.
    CleanExi MM_IHPK2.
    Genevestigatori Q80V72.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
      Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
      Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIP6K2_MOUSE
    AccessioniPrimary (citable) accession number: Q80V72
    Secondary accession number(s): E9QMT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3