Q80V72 (IP6K2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol hexakisphosphate kinase 2
Short name=InsP6 kinase 2
EC=2.7.4.21

Alternative name(s):
P(i)-uptake stimulator
Short name=PiUS

Gene names

Name:	Ip6k2
Synonyms:	Ihpk2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport By similarity.
Catalytic activity	ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown).
Subcellular location	Nucleus By similarity.
Tissue specificity	Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. Ref.3
Sequence similarities	Belongs to the inositol phosphokinase (IPK) family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from electronic annotation. Source: Compara phosphate ion transport Inferred from electronic annotation. Source: Compara phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara
Cellular_component	intermediate filament cytoskeleton Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 11502751. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW inositol hexakisphosphate 1-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 5-kinase activity Inferred from electronic annotation. Source: EC inositol-1,4,5-trisphosphate 3-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Inositol hexakisphosphate kinase 2		PRO_0000066878
Regions
	Region	238 – 246	9	Substrate binding By similarity
Experimental info
	Sequence conflict	292	1	M → I in AAH39922. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q80V72 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: A1B483785C5DAE25	FASTA	448	51,644
	10 20 30 40 50 60 MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 70 80 90 100 110 120 RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED EDRNLCLIAY PLKGDHGTVD 130 140 150 160 170 180 IVDNSDCEPK SKLLRWTNKK HHALETEKNP KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV 190 200 210 220 230 240 LYYSVEKKGN VSSQLKHYNP WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV 250 260 270 280 290 300 LDLKMGTRQH GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR 310 320 330 340 350 360 KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS SSLLVIYDGK 370 380 390 400 410 420 EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD VRMIDFAHTT CRLYGEDSVV 430 440 HEGQDAGYIF GLQSLIDIVT EISEESGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases." Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H. Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC168054 Genomic DNA. No translation available. AC173341 Genomic DNA. No translation available. BC039922 mRNA. Translation: AAH39922.1.
IPI	IPI00330397.
RefSeq	NP_083910.2. NM_029634.2.
UniGene	Mm.276336. Mm.490338.
3D structure databases
ProteinModelPortal	Q80V72.
SMR	Q80V72. Positions 226-442.
ModBase	Search...
PTM databases
PhosphoSite	Q80V72.
Proteomic databases
PaxDb	Q80V72.
PRIDE	Q80V72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
GeneID	76500.
KEGG	mmu:76500.
UCSC	uc009rqw.1. mouse.
Organism-specific databases
CTD	51447.
MGI	MGI:1923750. Ip6k2.
Phylogenomic databases
eggNOG	NOG274869.
GeneTree	ENSGT00390000014381.
HOGENOM	HOG000007418.
HOVERGEN	HBG052140.
InParanoid	Q80V72.
KO	K07756.
OMA	KEWVRQH.
OrthoDB	EOG4DR9C8.
Gene expression databases
Bgee	Q80V72.
CleanEx	MM_IHPK2.
Genevestigator	Q80V72.
GermOnline	ENSMUSG00000032599. Mus musculus.
Family and domain databases
InterPro	IPR005522. IPK. [Graphical view]
PANTHER	PTHR12400. PTHR12400. 1 hit.
Pfam	PF03770. IPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IP6K2. mouse.
NextBio	345268.
SOURCE	Search...

Entry information

Entry name

IP6K2_MOUSE

Accession

Primary (citable) accession number: Q80V72
Secondary accession number(s): E9QMT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program