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Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport (By similarity).By similarity

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855191 Synthesis of IPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923750 Ip6k2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668781 – 448Inositol hexakisphosphate kinase 2Add BLAST448

Proteomic databases

PaxDbiQ80V72
PeptideAtlasiQ80V72
PRIDEiQ80V72

PTM databases

iPTMnetiQ80V72
PhosphoSitePlusiQ80V72

Expressioni

Tissue specificityi

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000032599
CleanExiMM_IHPK2
ExpressionAtlasiQ80V72 baseline and differential
GenevisibleiQ80V72 MM

Interactioni

Protein-protein interaction databases

BioGridi218156, 2 interactors
STRINGi10090.ENSMUSP00000082091

Structurei

3D structure databases

ProteinModelPortaliQ80V72
SMRiQ80V72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 246Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YB60 LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000007418
HOVERGENiHBG052140
InParanoidiQ80V72
KOiK07756
OMAiLRWTNKK
OrthoDBiEOG091G0JK2
TreeFamiTF314066

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q80V72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ
60 70 80 90 100
FYETLPAEMR RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED
110 120 130 140 150
EDRNLCLIAY PLKGDHGTVD IVDNSDCEPK SKLLRWTNKK HHALETEKNP
160 170 180 190 200
KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV LYYSVEKKGN VSSQLKHYNP
210 220 230 240 250
WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV LDLKMGTRQH
260 270 280 290 300
GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR
310 320 330 340 350
KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS
360 370 380 390 400
SSLLVIYDGK EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD
410 420 430 440
VRMIDFAHTT CRLYGEDSVV HEGQDAGYIF GLQSLIDIVT EISEESGE
Length:448
Mass (Da):51,644
Last modified:July 27, 2011 - v2
Checksum:iA1B483785C5DAE25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292M → I in AAH39922 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC168054 Genomic DNA No translation available.
AC173341 Genomic DNA No translation available.
BC039922 mRNA Translation: AAH39922.1
CCDSiCCDS23537.1
RefSeqiNP_083910.2, NM_029634.2
XP_006511913.1, XM_006511850.2
XP_006511914.1, XM_006511851.3
UniGeneiMm.276336
Mm.490338

Genome annotation databases

EnsembliENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599
ENSMUST00000201336; ENSMUSP00000144020; ENSMUSG00000106672
GeneIDi76500
KEGGimmu:76500
UCSCiuc009rqw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIP6K2_MOUSE
AccessioniPrimary (citable) accession number: Q80V72
Secondary accession number(s): E9QMT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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