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Q80V72

- IP6K2_MOUSE

UniProt

Q80V72 - IP6K2_MOUSE

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Protein
Inositol hexakisphosphate kinase 2
Gene
Ip6k2, Ihpk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport By similarity.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  3. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  5. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro

GO - Biological processi

  1. negative regulation of cell growth Source: Ensembl
  2. phosphate ion transport Source: Ensembl
  3. phosphatidylinositol phosphorylation Source: Ensembl
  4. positive regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196480. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1923750. Ip6k2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Inositol hexakisphosphate kinase 2
PRO_0000066878Add
BLAST

Proteomic databases

PaxDbiQ80V72.
PRIDEiQ80V72.

PTM databases

PhosphoSiteiQ80V72.

Expressioni

Tissue specificityi

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.1 Publication

Gene expression databases

BgeeiQ80V72.
CleanExiMM_IHPK2.
GenevestigatoriQ80V72.

Interactioni

Protein-protein interaction databases

BioGridi218156. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80V72.
SMRiQ80V72. Positions 226-442.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 2469Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ80V72.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80V72-1 [UniParc]FASTAAdd to Basket

« Hide

MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ    50
FYETLPAEMR RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED 100
EDRNLCLIAY PLKGDHGTVD IVDNSDCEPK SKLLRWTNKK HHALETEKNP 150
KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV LYYSVEKKGN VSSQLKHYNP 200
WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV LDLKMGTRQH 250
GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR 300
KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS 350
SSLLVIYDGK EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD 400
VRMIDFAHTT CRLYGEDSVV HEGQDAGYIF GLQSLIDIVT EISEESGE 448
Length:448
Mass (Da):51,644
Last modified:July 27, 2011 - v2
Checksum:iA1B483785C5DAE25
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921M → I in AAH39922. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC168054 Genomic DNA. No translation available.
AC173341 Genomic DNA. No translation available.
BC039922 mRNA. Translation: AAH39922.1.
CCDSiCCDS23537.1.
RefSeqiNP_083910.2. NM_029634.2.
XP_006511913.1. XM_006511850.1.
XP_006511914.1. XM_006511851.1.
UniGeneiMm.276336.
Mm.490338.

Genome annotation databases

EnsembliENSMUST00000085018; ENSMUSP00000082091; ENSMUSG00000032599.
GeneIDi76500.
KEGGimmu:76500.
UCSCiuc009rqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC168054 Genomic DNA. No translation available.
AC173341 Genomic DNA. No translation available.
BC039922 mRNA. Translation: AAH39922.1 .
CCDSi CCDS23537.1.
RefSeqi NP_083910.2. NM_029634.2.
XP_006511913.1. XM_006511850.1.
XP_006511914.1. XM_006511851.1.
UniGenei Mm.276336.
Mm.490338.

3D structure databases

ProteinModelPortali Q80V72.
SMRi Q80V72. Positions 226-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 218156. 1 interaction.

PTM databases

PhosphoSitei Q80V72.

Proteomic databases

PaxDbi Q80V72.
PRIDEi Q80V72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085018 ; ENSMUSP00000082091 ; ENSMUSG00000032599 .
GeneIDi 76500.
KEGGi mmu:76500.
UCSCi uc009rqw.1. mouse.

Organism-specific databases

CTDi 51447.
MGIi MGI:1923750. Ip6k2.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOGENOMi HOG000007418.
HOVERGENi HBG052140.
InParanoidi Q80V72.
KOi K07756.
OMAi KEWVRQH.
OrthoDBi EOG747PHX.
TreeFami TF314066.

Enzyme and pathway databases

Reactomei REACT_196480. Synthesis of IPs in the nucleus.

Miscellaneous databases

ChiTaRSi IP6K2. mouse.
NextBioi 345268.
PROi Q80V72.
SOURCEi Search...

Gene expression databases

Bgeei Q80V72.
CleanExi MM_IHPK2.
Genevestigatori Q80V72.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
    Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
    Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIP6K2_MOUSE
AccessioniPrimary (citable) accession number: Q80V72
Secondary accession number(s): E9QMT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi