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Protein

Multiple epidermal growth factor-like domains protein 6

Gene

Megf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 6
Short name:
Multiple EGF-like domains protein 6
Alternative name(s):
Epidermal growth factor-like protein 3
Short name:
EGF-like protein 3
Gene namesi
Name:Megf6
Synonyms:Egfl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919351. Megf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000005562827 – 1572Multiple epidermal growth factor-like domains protein 6Add BLAST1546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 107Sequence analysis
Disulfide bondi73 ↔ 79Sequence analysis
Disulfide bondi106 ↔ 119Sequence analysis
Disulfide bondi126 ↔ 137By similarity
Disulfide bondi133 ↔ 146By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi167 ↔ 178By similarity
Disulfide bondi174 ↔ 187By similarity
Disulfide bondi189 ↔ 202By similarity
Disulfide bondi291 ↔ 302By similarity
Disulfide bondi298 ↔ 311By similarity
Disulfide bondi313 ↔ 326By similarity
Disulfide bondi418 ↔ 429By similarity
Disulfide bondi425 ↔ 438By similarity
Disulfide bondi440 ↔ 453By similarity
Disulfide bondi522 ↔ 535By similarity
Disulfide bondi529 ↔ 542By similarity
Disulfide bondi544 ↔ 553By similarity
Disulfide bondi566 ↔ 578By similarity
Disulfide bondi572 ↔ 585By similarity
Disulfide bondi587 ↔ 596By similarity
Disulfide bondi609 ↔ 621By similarity
Disulfide bondi615 ↔ 628By similarity
Disulfide bondi630 ↔ 639By similarity
Disulfide bondi788 ↔ 797By similarity
Disulfide bondi791 ↔ 804By similarity
Disulfide bondi806 ↔ 815By similarity
Disulfide bondi832 ↔ 840By similarity
Disulfide bondi834 ↔ 847By similarity
Disulfide bondi849 ↔ 858By similarity
Disulfide bondi871 ↔ 884By similarity
Disulfide bondi875 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Disulfide bondi915 ↔ 927By similarity
Disulfide bondi921 ↔ 934By similarity
Disulfide bondi936 ↔ 945By similarity
Glycosylationi1000N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1001 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1020By similarity
Disulfide bondi1022 ↔ 1031By similarity
Disulfide bondi1044 ↔ 1056By similarity
Disulfide bondi1050 ↔ 1063By similarity
Disulfide bondi1065 ↔ 1074By similarity
Disulfide bondi1087 ↔ 1099By similarity
Disulfide bondi1093 ↔ 1106By similarity
Disulfide bondi1108 ↔ 1117By similarity
Disulfide bondi1134 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1149By similarity
Disulfide bondi1151 ↔ 1160By similarity
Disulfide bondi1173 ↔ 1185By similarity
Disulfide bondi1177 ↔ 1192By similarity
Disulfide bondi1194 ↔ 1203By similarity
Disulfide bondi1260 ↔ 1272By similarity
Disulfide bondi1266 ↔ 1279By similarity
Disulfide bondi1281 ↔ 1290By similarity
Disulfide bondi1303 ↔ 1315By similarity
Disulfide bondi1309 ↔ 1322By similarity
Disulfide bondi1324 ↔ 1333By similarity
Disulfide bondi1346 ↔ 1358By similarity
Disulfide bondi1352 ↔ 1365By similarity
Disulfide bondi1367 ↔ 1376By similarity
Disulfide bondi1393 ↔ 1401By similarity
Disulfide bondi1395 ↔ 1408By similarity
Disulfide bondi1410 ↔ 1419By similarity
Disulfide bondi1432 ↔ 1444By similarity
Disulfide bondi1438 ↔ 1451By similarity
Disulfide bondi1453 ↔ 1462By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80V70.
PaxDbiQ80V70.
PRIDEiQ80V70.

PTM databases

iPTMnetiQ80V70.
PhosphoSitePlusiQ80V70.

Expressioni

Gene expression databases

CleanExiMM_MEGF6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030897.

Structurei

3D structure databases

ProteinModelPortaliQ80V70.
SMRiQ80V70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 121EMIPROSITE-ProRule annotationAdd BLAST82
Domaini122 – 162EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini163 – 203EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini287 – 327EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini414 – 454EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini518 – 554EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini562 – 597EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini605 – 640EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini785 – 816EGF-like 8PROSITE-ProRule annotationAdd BLAST32
Domaini829 – 859EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini867 – 903EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini911 – 946EGF-like 11PROSITE-ProRule annotationAdd BLAST36
Domaini997 – 1032EGF-like 12PROSITE-ProRule annotationAdd BLAST36
Domaini1040 – 1075EGF-like 13PROSITE-ProRule annotationAdd BLAST36
Domaini1083 – 1118EGF-like 14PROSITE-ProRule annotationAdd BLAST36
Domaini1131 – 1161EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini1169 – 1204EGF-like 16PROSITE-ProRule annotationAdd BLAST36
Domaini1256 – 1291EGF-like 17PROSITE-ProRule annotationAdd BLAST36
Domaini1299 – 1334EGF-like 18PROSITE-ProRule annotationAdd BLAST36
Domaini1342 – 1377EGF-like 19PROSITE-ProRule annotationAdd BLAST36
Domaini1390 – 1420EGF-like 20PROSITE-ProRule annotationAdd BLAST31
Domaini1428 – 1463EGF-like 21PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 21 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
HOGENOMiHOG000097840.
HOVERGENiHBG079790.
InParanoidiQ80V70.
PhylomeDBiQ80V70.
TreeFamiTF332598.

Family and domain databases

InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 2 hits.
PF12661. hEGF. 4 hits.
PF00053. Laminin_EGF. 7 hits.
[Graphical view]
SMARTiSM00181. EGF. 32 hits.
SM00179. EGF_CA. 8 hits.
SM00180. EGF_Lam. 23 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 22 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80V70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVGVEARAS WRVVALTLLL LPAVPAASQP LPPRPLQPSM PHVCAEQKLT
60 70 80 90 100
LVGHRQPCVQ AFSRVVPVWR SGCGQQAWCV GQERRTVYYM SYRQVYATEA
110 120 130 140 150
RTVFRCCPGW SQKPGQEGCL SDVDECANAN GGCEGPCCNT VGGFYCRCPP
160 170 180 190 200
GYQLQGDGKT CQDVDECRSH NGGCQHRCVN TPGSYLCECK PGFRLHTDGR
210 220 230 240 250
TCLAISSCTL GNGGCQHQCV QLTVTQHRCQ CRPQYQLQED GRRCVRRSPC
260 270 280 290 300
ADGNGGCMHT CQELRGLAHC GCHPGYQLAA DRKACEDVDE CALGLAQCAH
310 320 330 340 350
GCLNTQGSFK CVCHAGYELG ADGRQCYRIE MEIVNSCEAG NGGCSHGCSH
360 370 380 390 400
TSTGPLCTCP RGYELDEDQK TCIDIDDCAN SPCCQQVCAN TPGGYECSCF
410 420 430 440 450
AGYRLNTDGC GCEDVDECAS GHSGCEHHCS NLAGSFQCFC EAGYRLDEDR
460 470 480 490 500
RGCTPLEESV VDLDGQLPFV RPLPHIAVLG DELPQLFQDD YGAEEEAVAE
510 520 530 540 550
LRGEHTLTEK FVCLDHSFGH DCSLTCDDCR NGGTCFPGLD GCDCPEGWTG
560 570 580 590 600
IICNETCPPD TFGKNCSSPC ICQNGGTCDP VSGACRCPPG VSGAHCEDGC
610 620 630 640 650
PKGFYGKHCR KKCHCANRGR CHRLYGACLC DPGLYGRFCH LACPPWAFGP
660 670 680 690 700
GCSEDCLCEQ SHTRSCNSKD GSCSCKAGFQ GERCEAECEP GSFGPGCRNR
710 720 730 740 750
CTCRPGVACD PVSGECRTQC PPGYQGEDCG QECPVGTFGV NCSGSCSCVG
760 770 780 790 800
APCHRVTGEC LCPPGKTGED CGADCPEGRW GLGCQEICPA CEHGASCDPE
810 820 830 840 850
TGTCLCLPGF VGSRCQDACP AGWFGTGCQM RCACANDGHC HPATGRCSCA
860 870 880 890 900
PGWTGLSCQR ACDSGHWGPD CIHPCNCSAG HGNCDAVSGL CLCEAGYEGP
910 920 930 940 950
QCEQWCRQGY FGPGCEQKCR CEHGATCDHV SGACTCPAGW RGSFCEHACP
960 970 980 990 1000
AGFFGLDCGS ACNCSAGAPC DAVTGSCICP AGRWGPHCAQ TCPPLTFGLN
1010 1020 1030 1040 1050
CSQICTCFNG ASCDPVLGQC HCAPGWMGPT CLQACPAGLY GKNCQHSCLC
1060 1070 1080 1090 1100
RNGGSCDPIL GQCTCPEGWT GLACENECLP GHHGAGCRLN CSCLNGGTCD
1110 1120 1130 1140 1150
RLTGHCRCPA GWTGDKCQSP CVSGMFGVHC EEHCACRKGA TCHHVTGACL
1160 1170 1180 1190 1200
CPPGWRGSHC EQACPRGWFG EACAQRCHCP PGASCHHVSG ECHCPPGFTG
1210 1220 1230 1240 1250
PGCEQACQPG TFGKDCEHPC QCPGETWACH PASGACVCAA GYHGTDCQQR
1260 1270 1280 1290 1300
CPSGRYGPGC EQICKCLNGG TCDPATGACY CPAGFLGADC SLACPQGRFG
1310 1320 1330 1340 1350
PSCAHVCTCG QGAACDPVSG TCICPPGKTG GHCERGCPQD RFGKGCEHKC
1360 1370 1380 1390 1400
ACRNGGLCHA TNGSCSCPLG WMGPHCEHAC PAGRYGAACL LECSCQNNGS
1410 1420 1430 1440 1450
CEPTSGACLC GPGFYGQACE DTCPAGFHGS GCQRVCECQQ GAPCDPVSGR
1460 1470 1480 1490 1500
CLCPAGFRGQ FCERGCKPGF FGDGCLQQCN SPTGVPCDPI SGLCLCPPGR
1510 1520 1530 1540 1550
AGTTCDLDCR RGRFGPGCAL RCDCGGGADC DPISGQCHCV DSYTGPTCRE
1560 1570
VPTQLSSIRP APQHSSSKAM KH
Length:1,572
Mass (Da):164,723
Last modified:January 9, 2007 - v3
Checksum:i210DD9589B0FD85A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1055S → N in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1110A → T in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1458R → H in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1481S → C in AAH58571 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627123 Genomic DNA. Translation: CAM21839.1.
BC031402 mRNA. Translation: AAH31402.1.
BC039980 mRNA. Translation: AAH39980.1.
BC058571 mRNA. Translation: AAH58571.1.
CCDSiCCDS51398.1.
UniGeneiMm.275216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627123 Genomic DNA. Translation: CAM21839.1.
BC031402 mRNA. Translation: AAH31402.1.
BC039980 mRNA. Translation: AAH39980.1.
BC058571 mRNA. Translation: AAH58571.1.
CCDSiCCDS51398.1.
UniGeneiMm.275216.

3D structure databases

ProteinModelPortaliQ80V70.
SMRiQ80V70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030897.

PTM databases

iPTMnetiQ80V70.
PhosphoSitePlusiQ80V70.

Proteomic databases

MaxQBiQ80V70.
PaxDbiQ80V70.
PRIDEiQ80V70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1919351. Megf6.

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
HOGENOMiHOG000097840.
HOVERGENiHBG079790.
InParanoidiQ80V70.
PhylomeDBiQ80V70.
TreeFamiTF332598.

Miscellaneous databases

ChiTaRSiMegf6. mouse.
PROiQ80V70.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MEGF6.

Family and domain databases

InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 2 hits.
PF12661. hEGF. 4 hits.
PF00053. Laminin_EGF. 7 hits.
[Graphical view]
SMARTiSM00181. EGF. 32 hits.
SM00179. EGF_CA. 8 hits.
SM00180. EGF_Lam. 23 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 22 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEGF6_MOUSE
AccessioniPrimary (citable) accession number: Q80V70
Secondary accession number(s): A2A913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.