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Protein

PR domain zinc finger protein 4

Gene

Prdm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a transcription factor involved in cell differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri593 – 615C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • histone methyltransferase binding Source: ParkinsonsUK-UCL
  • metal ion binding Source: UniProtKB-KW
  • methyltransferase activity Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 4 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 4
Gene namesi
Name:Prdm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920093 Prdm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307921 – 803PR domain zinc finger protein 4Add BLAST803

Proteomic databases

PaxDbiQ80V63
PRIDEiQ80V63

PTM databases

PhosphoSitePlusiQ80V63

Expressioni

Gene expression databases

BgeeiENSMUSG00000035529
CleanExiMM_PRDM4
ExpressionAtlasiQ80V63 baseline and differential
GenevisibleiQ80V63 MM

Interactioni

GO - Molecular functioni

  • histone methyltransferase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi215601, 1 interactor
STRINGi10090.ENSMUSP00000041942

Structurei

3D structure databases

ProteinModelPortaliQ80V63
SMRiQ80V63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 532SETPROSITE-ProRule annotationAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Ser6
Compositional biasi89 – 94Poly-Pro6
Compositional biasi759 – 763Poly-Ser5

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri593 – 615C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG2461 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00830000128284
HOGENOMiHOG000060213
HOVERGENiHBG053672
InParanoidiQ80V63
KOiK12463
OMAiELLFYYS
OrthoDBiEOG091G01VM
PhylomeDBiQ80V63
TreeFamiTF332513

Family and domain databases

InterProiView protein in InterPro
IPR017124 PRDM4
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PIRSFiPIRSF037161 PRDM4, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q80V63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDMNLSPVG MEQLSSSSVS NALPVSGSHL GLAASPSHSA IPAPGLPVAI
60 70 80 90 100
PNLGPSLSSL PSALSLMLPV GIGDRGVMCG LPERNYTLPP PPYPHLESSY
110 120 130 140 150
FRTILPGILS YLADRPPPQY IHPNSINVDG NTALSITNNP SALDPYQANG
160 170 180 190 200
NVGLELGIVS IDSRSVNTHG AQSLHPNDGH EVALDTTITM ENVSRVTSPI
210 220 230 240 250
STDGMAEELT MDGVTGEHPQ IPNGSRSHEP LSVDSVSNSL TAEAVGHGGV
260 270 280 290 300
IPIHGNGLEL PVVMETDHIA NRVNGMSDST LSDSIHTVAM STNSVSVALS
310 320 330 340 350
TSHNLASLES VSLHEVGLSL EPVAVSSITQ EVAMGTGHVD VSSDSLSFVP
360 370 380 390 400
SSLQMEDSNS NKENMATLFT IWCTLCDRAY PSDCPDHGPV TFVPDTPIES
410 420 430 440 450
RARLSLPKQL VLRQSIVGTD VVGVLPLIGV WTAETIPVRT CFGPLIGQQS
460 470 480 490 500
HSLEVAEWTD KAVNHVWKIY HTGVLEFCII TTDENECNWM MFVRKARNRE
510 520 530 540 550
EQNLVAYPHD GKIYFCTSQD IPPESELLFY YSRNYAQQIG VPEHPDVHLC
560 570 580 590 600
NCGKECSSYS EFKAHLTSHI HNHLPSQGHS SSHGPSHSKE RKWKCSMCPQ
610 620 630 640 650
AFISPSKLHV HFMGHMGMKP HKCDFCSKAF SDPSNLRTHL KIHTGQKNYR
660 670 680 690 700
CTLCDKSFTQ KAHLESHMVI HTGEKNLKCD YCDKLFMRRQ DLKQHVLIHT
710 720 730 740 750
QERQIKCPKC DKLFLRTNHL KKHLNSHEGK RDYVCEKCTK AYLTKYHLTR
760 770 780 790 800
HLKTCKEPSS SSSAQEEEDD ESEEEDLADS MRTEDCRMGS AVYSTDESLS

AHK
Length:803
Mass (Da):88,145
Last modified:April 4, 2006 - v2
Checksum:i99A0DDBEDC54561E
GO

Sequence cautioni

The sequence AAH42516 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042516 mRNA Translation: AAH42516.1 Different initiation.
BC139409 mRNA Translation: AAI39410.1
CCDSiCCDS24093.1
RefSeqiNP_857633.2, NM_181650.3
XP_006514256.1, XM_006514193.3
XP_006514257.1, XM_006514194.3
XP_011241884.1, XM_011243582.1
UniGeneiMm.25307

Genome annotation databases

EnsembliENSMUST00000220032; ENSMUSP00000151931; ENSMUSG00000035529
GeneIDi72843
KEGGimmu:72843
UCSCiuc011xkq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPRDM4_MOUSE
AccessioniPrimary (citable) accession number: Q80V63
Secondary accession number(s): B2RTL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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