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Protein

Carboxypeptidase M

Gene

Cpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity).By similarity

Catalytic activityi

Cleavage of C-terminal arginine or lysine residues from polypeptides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc; catalyticBy similarity1
Metal bindingi86Zinc; catalyticBy similarity1
Metal bindingi190Zinc; catalyticBy similarity1
Active sitei281Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.12. 3474.

Protein family/group databases

MEROPSiM14.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase M (EC:3.4.17.12)
Short name:
CPM
Gene namesi
Name:Cpm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917824. Cpm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000439218 – 423Carboxypeptidase MAdd BLAST406
PropeptideiPRO_0000251911424 – 443Removed in mature formBy similarityAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi138 ↔ 285By similarity
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi341 ↔ 410By similarity
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Lipidationi423GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ80V42.
PaxDbiQ80V42.
PeptideAtlasiQ80V42.
PRIDEiQ80V42.

PTM databases

PhosphoSitePlusiQ80V42.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020183.
CleanExiMM_CPM.
GenevisibleiQ80V42. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020399.

Structurei

3D structure databases

ProteinModelPortaliQ80V42.
SMRiQ80V42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ80V42.
KOiK01296.
OMAiFYSNGRE.
OrthoDBiEOG091G06A9.
PhylomeDBiQ80V42.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR027062. CPM.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF40. PTHR11532:SF40. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80V42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRARLWLGL LLPVVAALDF RYHHQEGMEA FLKSVAQNYS SITHLHSIGK
60 70 80 90 100
SVRGRNLWVL VVGQTPKEHR VGIPEFKYVA NMHGDETVGR ELLLHLIDYL
110 120 130 140 150
VSSYRKDPEI THLIDSTRIH IMPSMNPDGF EAVQKPDCYY SNGRENYNNY
160 170 180 190 200
DLNRNFPDAF ENNNVTKQPE TLAIMEWLKT ETFVLSANLH GGALVASYPF
210 220 230 240 250
DNGVQATGTL LSRSLTPDDD VFQHLAYTYA SRNPNMTKGD QCKNKRNFPN
260 270 280 290 300
GIINGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPLFWNDN
310 320 330 340 350
KASLIEYIKQ VHLGVKGQVF DQSGAPLPNV IVEVQDRKHI CPFRTNKLGE
360 370 380 390 400
YYLLLLPGSY VINVTVPGHD SYLTKLTIPG KSQPFSALKK DFHLPLRWQP
410 420 430 440
DSISVSNPSC PMIPLYKFMP SHSAATKPSL GVFFMTLLYV FFK
Length:443
Mass (Da):50,556
Last modified:July 19, 2005 - v2
Checksum:iAC7F6F9E35FA3271
GO
Isoform 2 (identifier: Q80V42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-262: YSWYPLQ → MRCACFA

Show »
Length:188
Mass (Da):21,464
Checksum:i629A37EF06CDC17F
GO

Sequence cautioni

The sequence AAH47389 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146061 – 255Missing in isoform 2. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_014607256 – 262YSWYPLQ → MRCACFA in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017670 mRNA. Translation: BAB30865.1.
BC047389 mRNA. Translation: AAH47389.1. Different initiation.
BC100404 mRNA. Translation: AAI00405.1.
CCDSiCCDS48696.1. [Q80V42-1]
RefSeqiNP_081744.1. NM_027468.1. [Q80V42-1]
UniGeneiMm.339332.

Genome annotation databases

EnsembliENSMUST00000020399; ENSMUSP00000020399; ENSMUSG00000020183. [Q80V42-1]
GeneIDi70574.
KEGGimmu:70574.
UCSCiuc007hdi.2. mouse. [Q80V42-1]
uc007hdk.2. mouse. [Q80V42-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017670 mRNA. Translation: BAB30865.1.
BC047389 mRNA. Translation: AAH47389.1. Different initiation.
BC100404 mRNA. Translation: AAI00405.1.
CCDSiCCDS48696.1. [Q80V42-1]
RefSeqiNP_081744.1. NM_027468.1. [Q80V42-1]
UniGeneiMm.339332.

3D structure databases

ProteinModelPortaliQ80V42.
SMRiQ80V42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020399.

Protein family/group databases

MEROPSiM14.006.

PTM databases

PhosphoSitePlusiQ80V42.

Proteomic databases

EPDiQ80V42.
PaxDbiQ80V42.
PeptideAtlasiQ80V42.
PRIDEiQ80V42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020399; ENSMUSP00000020399; ENSMUSG00000020183. [Q80V42-1]
GeneIDi70574.
KEGGimmu:70574.
UCSCiuc007hdi.2. mouse. [Q80V42-1]
uc007hdk.2. mouse. [Q80V42-2]

Organism-specific databases

CTDi1368.
MGIiMGI:1917824. Cpm.

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ80V42.
KOiK01296.
OMAiFYSNGRE.
OrthoDBiEOG091G06A9.
PhylomeDBiQ80V42.
TreeFamiTF315592.

Enzyme and pathway databases

BRENDAi3.4.17.12. 3474.

Miscellaneous databases

PROiQ80V42.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020183.
CleanExiMM_CPM.
GenevisibleiQ80V42. MM.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR027062. CPM.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF40. PTHR11532:SF40. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPM_MOUSE
AccessioniPrimary (citable) accession number: Q80V42
Secondary accession number(s): Q497S5, Q9CYH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.