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Protein

Carboxypeptidase M

Gene

Cpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity).By similarity

Catalytic activityi

Cleavage of C-terminal arginine or lysine residues from polypeptides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc; catalyticBy similarity1
Metal bindingi86Zinc; catalyticBy similarity1
Metal bindingi190Zinc; catalyticBy similarity1
Active sitei281Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.12 3474
ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

MEROPSiM14.006

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase M (EC:3.4.17.12)
Short name:
CPM
Gene namesi
Name:Cpm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1917824 Cpm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000439218 – 423Carboxypeptidase MAdd BLAST406
PropeptideiPRO_0000251911424 – 443Removed in mature formBy similarityAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 285By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi341 ↔ 410By similarity
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi423GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ80V42
PaxDbiQ80V42
PeptideAtlasiQ80V42
PRIDEiQ80V42

PTM databases

PhosphoSitePlusiQ80V42

Expressioni

Gene expression databases

BgeeiENSMUSG00000020183
CleanExiMM_CPM
GenevisibleiQ80V42 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020399

Structurei

3D structure databases

ProteinModelPortaliQ80V42
SMRiQ80V42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649 Eukaryota
ENOG410XX0H LUCA
GeneTreeiENSGT00760000119124
HOGENOMiHOG000232185
HOVERGENiHBG003410
InParanoidiQ80V42
KOiK01296
OMAiAPQHYRP
OrthoDBiEOG091G06A9
PhylomeDBiQ80V42
TreeFamiTF315592

Family and domain databases

InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
SUPFAMiSSF49464 SSF49464, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80V42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRARLWLGL LLPVVAALDF RYHHQEGMEA FLKSVAQNYS SITHLHSIGK
60 70 80 90 100
SVRGRNLWVL VVGQTPKEHR VGIPEFKYVA NMHGDETVGR ELLLHLIDYL
110 120 130 140 150
VSSYRKDPEI THLIDSTRIH IMPSMNPDGF EAVQKPDCYY SNGRENYNNY
160 170 180 190 200
DLNRNFPDAF ENNNVTKQPE TLAIMEWLKT ETFVLSANLH GGALVASYPF
210 220 230 240 250
DNGVQATGTL LSRSLTPDDD VFQHLAYTYA SRNPNMTKGD QCKNKRNFPN
260 270 280 290 300
GIINGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPLFWNDN
310 320 330 340 350
KASLIEYIKQ VHLGVKGQVF DQSGAPLPNV IVEVQDRKHI CPFRTNKLGE
360 370 380 390 400
YYLLLLPGSY VINVTVPGHD SYLTKLTIPG KSQPFSALKK DFHLPLRWQP
410 420 430 440
DSISVSNPSC PMIPLYKFMP SHSAATKPSL GVFFMTLLYV FFK
Length:443
Mass (Da):50,556
Last modified:July 19, 2005 - v2
Checksum:iAC7F6F9E35FA3271
GO
Isoform 2 (identifier: Q80V42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-262: YSWYPLQ → MRCACFA

Show »
Length:188
Mass (Da):21,464
Checksum:i629A37EF06CDC17F
GO

Sequence cautioni

The sequence AAH47389 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146061 – 255Missing in isoform 2. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_014607256 – 262YSWYPLQ → MRCACFA in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017670 mRNA Translation: BAB30865.1
BC047389 mRNA Translation: AAH47389.1 Different initiation.
BC100404 mRNA Translation: AAI00405.1
CCDSiCCDS48696.1 [Q80V42-1]
RefSeqiNP_081744.1, NM_027468.1 [Q80V42-1]
UniGeneiMm.339332

Genome annotation databases

EnsembliENSMUST00000020399; ENSMUSP00000020399; ENSMUSG00000020183 [Q80V42-1]
GeneIDi70574
KEGGimmu:70574
UCSCiuc007hdi.2 mouse [Q80V42-1]
uc007hdk.2 mouse [Q80V42-2]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiCBPM_MOUSE
AccessioniPrimary (citable) accession number: Q80V42
Secondary accession number(s): Q497S5, Q9CYH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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