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Protein

Carboxypeptidase M

Gene

Cpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity).By similarity

Catalytic activityi

Cleavage of C-terminal arginine or lysine residues from polypeptides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Zinc; catalyticBy similarity
Metal bindingi86 – 861Zinc; catalyticBy similarity
Metal bindingi190 – 1901Zinc; catalyticBy similarity
Active sitei281 – 2811Proton donor/acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.12. 3474.

Protein family/group databases

MEROPSiM14.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase M (EC:3.4.17.12)
Short name:
CPM
Gene namesi
Name:Cpm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917824. Cpm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 423406Carboxypeptidase MPRO_0000004392Add
BLAST
Propeptidei424 – 44320Removed in mature formBy similarityPRO_0000251911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi138 ↔ 285By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi341 ↔ 410By similarity
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence analysis
Lipidationi423 – 4231GPI-anchor amidated serineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ80V42.
MaxQBiQ80V42.
PaxDbiQ80V42.
PRIDEiQ80V42.

PTM databases

PhosphoSiteiQ80V42.

Expressioni

Gene expression databases

BgeeiQ80V42.
CleanExiMM_CPM.
GenevisibleiQ80V42. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020399.

Structurei

3D structure databases

ProteinModelPortaliQ80V42.
SMRiQ80V42. Positions 18-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ80V42.
KOiK01296.
OMAiFYSNGRE.
OrthoDBiEOG7B8S32.
PhylomeDBiQ80V42.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR027062. CPM.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF40. PTHR11532:SF40. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80V42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRARLWLGL LLPVVAALDF RYHHQEGMEA FLKSVAQNYS SITHLHSIGK
60 70 80 90 100
SVRGRNLWVL VVGQTPKEHR VGIPEFKYVA NMHGDETVGR ELLLHLIDYL
110 120 130 140 150
VSSYRKDPEI THLIDSTRIH IMPSMNPDGF EAVQKPDCYY SNGRENYNNY
160 170 180 190 200
DLNRNFPDAF ENNNVTKQPE TLAIMEWLKT ETFVLSANLH GGALVASYPF
210 220 230 240 250
DNGVQATGTL LSRSLTPDDD VFQHLAYTYA SRNPNMTKGD QCKNKRNFPN
260 270 280 290 300
GIINGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPLFWNDN
310 320 330 340 350
KASLIEYIKQ VHLGVKGQVF DQSGAPLPNV IVEVQDRKHI CPFRTNKLGE
360 370 380 390 400
YYLLLLPGSY VINVTVPGHD SYLTKLTIPG KSQPFSALKK DFHLPLRWQP
410 420 430 440
DSISVSNPSC PMIPLYKFMP SHSAATKPSL GVFFMTLLYV FFK
Length:443
Mass (Da):50,556
Last modified:July 19, 2005 - v2
Checksum:iAC7F6F9E35FA3271
GO
Isoform 2 (identifier: Q80V42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-262: YSWYPLQ → MRCACFA

Show »
Length:188
Mass (Da):21,464
Checksum:i629A37EF06CDC17F
GO

Sequence cautioni

The sequence AAH47389.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 255255Missing in isoform 2. 1 PublicationVSP_014606Add
BLAST
Alternative sequencei256 – 2627YSWYPLQ → MRCACFA in isoform 2. 1 PublicationVSP_014607

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017670 mRNA. Translation: BAB30865.1.
BC047389 mRNA. Translation: AAH47389.1. Different initiation.
BC100404 mRNA. Translation: AAI00405.1.
CCDSiCCDS48696.1. [Q80V42-1]
RefSeqiNP_081744.1. NM_027468.1. [Q80V42-1]
UniGeneiMm.339332.

Genome annotation databases

EnsembliENSMUST00000020399; ENSMUSP00000020399; ENSMUSG00000020183. [Q80V42-1]
GeneIDi70574.
KEGGimmu:70574.
UCSCiuc007hdi.2. mouse. [Q80V42-1]
uc007hdk.2. mouse. [Q80V42-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017670 mRNA. Translation: BAB30865.1.
BC047389 mRNA. Translation: AAH47389.1. Different initiation.
BC100404 mRNA. Translation: AAI00405.1.
CCDSiCCDS48696.1. [Q80V42-1]
RefSeqiNP_081744.1. NM_027468.1. [Q80V42-1]
UniGeneiMm.339332.

3D structure databases

ProteinModelPortaliQ80V42.
SMRiQ80V42. Positions 18-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020399.

Protein family/group databases

MEROPSiM14.006.

PTM databases

PhosphoSiteiQ80V42.

Proteomic databases

EPDiQ80V42.
MaxQBiQ80V42.
PaxDbiQ80V42.
PRIDEiQ80V42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020399; ENSMUSP00000020399; ENSMUSG00000020183. [Q80V42-1]
GeneIDi70574.
KEGGimmu:70574.
UCSCiuc007hdi.2. mouse. [Q80V42-1]
uc007hdk.2. mouse. [Q80V42-2]

Organism-specific databases

CTDi1368.
MGIiMGI:1917824. Cpm.

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ80V42.
KOiK01296.
OMAiFYSNGRE.
OrthoDBiEOG7B8S32.
PhylomeDBiQ80V42.
TreeFamiTF315592.

Enzyme and pathway databases

BRENDAi3.4.17.12. 3474.

Miscellaneous databases

PROiQ80V42.
SOURCEiSearch...

Gene expression databases

BgeeiQ80V42.
CleanExiMM_CPM.
GenevisibleiQ80V42. MM.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR027062. CPM.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF40. PTHR11532:SF40. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: 129 and C57BL/6J.
    Tissue: Kidney and Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Lung.

Entry informationi

Entry nameiCBPM_MOUSE
AccessioniPrimary (citable) accession number: Q80V42
Secondary accession number(s): Q497S5, Q9CYH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.