Reviewed, UniProtKB/Swiss-Prot Q80V26 (IMPA3_MOUSE)

Names and origin

Protein names

Recommended name:
    Inositol monophosphatase 3
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 3
      Short name=IMPase 3
      Short name=IMP 3
    Myo-inositol monophosphatase A3
    Inositol monophosphatase domain-containing protein 1

Gene names

Name:	Impad1
Synonyms:	Impa3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Inositol monophosphatase 3		PRO_0000289042
Regions
	Transmembrane	13 – 33	21	Potential
	Region	174 – 177	4	Substrate binding By similarity
Sites
	Metal binding	131	1	Magnesium 1 By similarity
	Metal binding	172	1	Magnesium 1 By similarity
	Metal binding	172	1	Magnesium 2 By similarity
	Metal binding	174	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	175	1	Magnesium 2 By similarity
	Metal binding	298	1	Magnesium 2 By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	298	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q80V26-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F01BF0082F5C7C82	FASTA	356	38,616
	10 20 30 40 50 60 MAPMGIRLSP LGVAVFFLLG LGVLYHLYSG FLAGRFSLFG LGSEPAAGEA EVASDGGTVD 70 80 90 100 110 120 LREMLAVAVL AAERGGDEVR RVRESNVLHE KSKGKTREGA DDKMTSGDVL SNRKMFYLLK 130 140 150 160 170 180 TAFPNVQINT EEHVDASDKE VIVWNRKIPE DILKEIAAPK EVPAESVTVW IDPLDATQEY 190 200 210 220 230 240 TEDLRKYVTT MVCVAVNGKP VLGVIHKPFS EYTAWAMVDG GSNVKARSSY NEKTPKIIVS 250 260 270 280 290 300 RSHAGMVKQV ALQTFGNQTS IIPAGGAGYK VLALLDVPDM TQEKADLYIH VTYIKKWDIC 310 320 330 340 350 AGNAILKALG GHMTTLNGEE ISYTGSDGIE GGLLASIRMN HQALVRKLPD LEKSGH

References

[1]

"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC048776 mRNA. Translation: AAH48776.1. AL772346 Genomic DNA. Translation: CAM23643.1.
IPI	IPI00228719.
RefSeq	NP_808398.1.
UniGene	Mm.218889 Mm.369779
3D structure databases
HSSP	HSSP built from PDB template 1INP based on UniProtKB P21327.
ModBase	Search...
Proteomic databases
PRIDE	Q80V26.
Genome annotation databases
Ensembl	ENSMUST00000084949; ENSMUSP00000082013; ENSMUSG00000066324; Mus musculus. [Genome view]
GeneID	242291.
KEGG	mmu:242291.
UCSC	uc008rxc.1. mouse.
Organism-specific databases
CTD	242291.
MGI	MGI:1915720. Impad1.
Phylogenomic databases
HOGENOM	Q80V26.
HOVERGEN	Q80V26.
OMA	TQEYTEN.
Enzyme and pathway databases
BRENDA	3.1.3.25. 244.
Gene expression databases
ArrayExpress	Q80V26.
Bgee	Q80V26.
CleanEx	MM_IMPAD1.
Genevestigator	Q80V26.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PROSITE	PS00629. IMP_1. False negative. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	385292.
SOURCE	Search...

Entry information

Entry name

IMPA3_MOUSE

Accession

Primary (citable) accession number: Q80V26

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)