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Protein

Transcription cofactor vestigial-like protein 4

Gene

Vgll4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 4
Short name:
Vgl-4
Gene namesi
Name:Vgll4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2652840. Vgll4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Transcription cofactor vestigial-like protein 4PRO_0000191352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei271 – 2711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80V24.
PaxDbiQ80V24.
PeptideAtlasiQ80V24.
PRIDEiQ80V24.

PTM databases

iPTMnetiQ80V24.
PhosphoSiteiQ80V24.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030315.
CleanExiMM_VGLL4.
ExpressionAtlasiQ80V24. baseline and differential.
GenevisibleiQ80V24. MM.

Interactioni

Subunit structurei

Interacts with TEFs. Interacts with IRF2BP2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TEAD4Q155613EBI-9253433,EBI-747736From a different organism.
Tead4Q622963EBI-9253433,EBI-9253444

Protein-protein interaction databases

IntActiQ80V24. 2 interactions.

Structurei

Secondary structure

1
287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi204 – 21411Combined sources
Helixi215 – 2173Combined sources
Beta strandi227 – 2304Combined sources
Helixi234 – 2429Combined sources
Helixi244 – 2507Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LN0X-ray2.90C203-256[»]
ProteinModelPortaliQ80V24.
SMRiQ80V24. Positions 203-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IFGD. Eukaryota.
ENOG410XX71. LUCA.
GeneTreeiENSGT00390000003282.
HOGENOMiHOG000290700.
HOVERGENiHBG054970.
InParanoidiQ80V24.
OMAiNEHVAKM.
OrthoDBiEOG091G0S09.
PhylomeDBiQ80V24.
TreeFamiTF330846.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR028184. VGLL4.
[Graphical view]
PfamiPF15245. VGLL4. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80V24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFMKMDLLN YQYLDKMNNN IGVLCYEGEA SLRGEPRMQT LPVASALSSH
60 70 80 90 100
RTGPPPISPS KRKFSMEPGD KDLDCENDHV SKMSRIFSPH LNKTVNGDCR
110 120 130 140 150
RDPRERSRSP IERAAAPAVS LHGGHLYASL PSLMEQPLAL TKNSSDTGRS
160 170 180 190 200
AVERQQNRPS VITCASAGAR NCNLSHCPIA HSGCSAPGSA SYRRPPSATA
210 220 230 240 250
TCDPVVEEHF RRSLGKNYKE PEPAPNSVSI TGSVDDHFAK ALGDTWLQIK
260 270 280
AAKDSASSSP ESASRRGQPA SPTAHMVSHS HSPSVVS
Length:287
Mass (Da):30,999
Last modified:June 1, 2003 - v1
Checksum:iD146298040801D8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048841 mRNA. Translation: AAH48841.1.
BC060305 mRNA. Translation: AAH60305.1.
CCDSiCCDS20436.1.
RefSeqiNP_808351.1. NM_177683.2.
UniGeneiMm.268357.
Mm.446323.

Genome annotation databases

EnsembliENSMUST00000032459; ENSMUSP00000032459; ENSMUSG00000030315.
GeneIDi232334.
KEGGimmu:232334.
UCSCiuc009dif.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048841 mRNA. Translation: AAH48841.1.
BC060305 mRNA. Translation: AAH60305.1.
CCDSiCCDS20436.1.
RefSeqiNP_808351.1. NM_177683.2.
UniGeneiMm.268357.
Mm.446323.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LN0X-ray2.90C203-256[»]
ProteinModelPortaliQ80V24.
SMRiQ80V24. Positions 203-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80V24. 2 interactions.

PTM databases

iPTMnetiQ80V24.
PhosphoSiteiQ80V24.

Proteomic databases

MaxQBiQ80V24.
PaxDbiQ80V24.
PeptideAtlasiQ80V24.
PRIDEiQ80V24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032459; ENSMUSP00000032459; ENSMUSG00000030315.
GeneIDi232334.
KEGGimmu:232334.
UCSCiuc009dif.2. mouse.

Organism-specific databases

CTDi9686.
MGIiMGI:2652840. Vgll4.

Phylogenomic databases

eggNOGiENOG410IFGD. Eukaryota.
ENOG410XX71. LUCA.
GeneTreeiENSGT00390000003282.
HOGENOMiHOG000290700.
HOVERGENiHBG054970.
InParanoidiQ80V24.
OMAiNEHVAKM.
OrthoDBiEOG091G0S09.
PhylomeDBiQ80V24.
TreeFamiTF330846.

Miscellaneous databases

ChiTaRSiVgll4. mouse.
PROiQ80V24.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030315.
CleanExiMM_VGLL4.
ExpressionAtlasiQ80V24. baseline and differential.
GenevisibleiQ80V24. MM.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR028184. VGLL4.
[Graphical view]
PfamiPF15245. VGLL4. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLL4_MOUSE
AccessioniPrimary (citable) accession number: Q80V24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.