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Q80V03 (ADCK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized aarF domain-containing protein kinase 5

EC=2.7.11.-
Gene names
Name:Adck5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence BC030881 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

   Molecular_functionprotein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80V03-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80V03-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Uncharacterized aarF domain-containing protein kinase 5
PRO_0000271801

Regions

Transmembrane50 – 6920Helical; Potential
Domain179 – 419241Protein kinase

Natural variations

Alternative sequence1 – 122122Missing in isoform 2.
VSP_022358

Experimental info

Sequence conflict1331A → T in BAC30280. Ref.1
Sequence conflict1331A → T in AAH60528. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 25F612441852B706

FASTA58266,654
        10         20         30         40         50         60 
MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA LSATVVGTPF 

        70         80         90        100        110        120 
LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD YWWCTNVVLR GVEENSPKYV 

       130        140        150        160        170        180 
EIMSACHQRA ADALVAGAIR NGGLYVKLGQ GLCSFNHLLP TEYIQTLRVL EDKALTRGFR 

       190        200        210        220        230        240 
EVDELFLEDF QALPNELFQE FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG 

       250        260        270        280        290        300 
DVQTLELLLR LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI 

       310        320        330        340        350        360 
PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ IFHTGFIHSD 

       370        380        390        400        410        420 
PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL WRAIILRDNA AMKKHAAALG 

       430        440        450        460        470        480 
VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE EAAYMQDMAR EHFDGIMEVL KALPRPMLLV 

       490        500        510        520        530        540 
LRNINTVRAI NSNLGTPVDR YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK 

       550        560        570        580 
FEMALRLEIL AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM 

« Hide

Isoform 2 [UniParc].

Checksum: 8C836AE960B45EDF
Show »

FASTA46052,379

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Hypothalamus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK039217 mRNA. Translation: BAC30280.1.
AC157566 Genomic DNA. No translation available.
BC030881 mRNA. No translation available.
BC060528 mRNA. Translation: AAH60528.1.
RefSeqNP_766548.2. NM_172960.3.
UniGeneMm.181624.

3D structure databases

ProteinModelPortalQ80V03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000105452.

PTM databases

PhosphoSiteQ80V03.

Proteomic databases

PaxDbQ80V03.
PRIDEQ80V03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID268822.
KEGGmmu:268822.

Organism-specific databases

CTD203054.
MGIMGI:2679274. Adck5.

Phylogenomic databases

eggNOGCOG0661.
HOGENOMHOG000240338.
HOVERGENHBG104406.
InParanoidQ80V03.
KOK08869.
PhylomeDBQ80V03.

Gene expression databases

CleanExMM_ADCK5.
GenevestigatorQ80V03.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
ProtoNetSearch...

Other

NextBio392527.
PROQ80V03.
SOURCESearch...

Entry information

Entry nameADCK5_MOUSE
AccessionPrimary (citable) accession number: Q80V03
Secondary accession number(s): Q8CAA3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot