Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80V03

- ADCK5_MOUSE

UniProt

Q80V03 - ADCK5_MOUSE

Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

Adck5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

    GO - Molecular functioni

    1. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
    Gene namesi
    Name:Adck5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2679274. Adck5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Uncharacterized aarF domain-containing protein kinase 5PRO_0000271801Add
    BLAST

    Proteomic databases

    MaxQBiQ80V03.
    PaxDbiQ80V03.
    PRIDEiQ80V03.

    PTM databases

    PhosphoSiteiQ80V03.

    Expressioni

    Gene expression databases

    CleanExiMM_ADCK5.
    GenevestigatoriQ80V03.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80V03.
    SMRiQ80V03. Positions 308-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 6920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 419241Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0661.
    HOGENOMiHOG000240338.
    HOVERGENiHBG104406.
    InParanoidiQ80V03.
    KOiK08869.
    PhylomeDBiQ80V03.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80V03-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA    50
    LSATVVGTPF LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD 100
    YWWCTNVVLR GVEENSPKYV EIMSACHQRA ADALVAGAIR NGGLYVKLGQ 150
    GLCSFNHLLP TEYIQTLRVL EDKALTRGFR EVDELFLEDF QALPNELFQE 200
    FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG DVQTLELLLR 250
    LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI 300
    PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ 350
    IFHTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL 400
    WRAIILRDNA AMKKHAAALG VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE 450
    EAAYMQDMAR EHFDGIMEVL KALPRPMLLV LRNINTVRAI NSNLGTPVDR 500
    YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK FEMALRLEIL 550
    AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM 582
    Length:582
    Mass (Da):66,654
    Last modified:January 9, 2007 - v2
    Checksum:i25F612441852B706
    GO
    Isoform 2 (identifier: Q80V03-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.

    Show »
    Length:460
    Mass (Da):52,379
    Checksum:i8C836AE960B45EDF
    GO

    Sequence cautioni

    The sequence BC030881 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331A → T in BAC30280. (PubMed:16141072)Curated
    Sequence conflicti133 – 1331A → T in AAH60528. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 122122Missing in isoform 2. 2 PublicationsVSP_022358Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039217 mRNA. Translation: BAC30280.1.
    AC157566 Genomic DNA. No translation available.
    BC030881 mRNA. No translation available.
    BC060528 mRNA. Translation: AAH60528.1.
    CCDSiCCDS27576.2. [Q80V03-1]
    RefSeqiNP_766548.2. NM_172960.3.
    UniGeneiMm.181624.

    Genome annotation databases

    GeneIDi268822.
    KEGGimmu:268822.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039217 mRNA. Translation: BAC30280.1 .
    AC157566 Genomic DNA. No translation available.
    BC030881 mRNA. No translation available.
    BC060528 mRNA. Translation: AAH60528.1 .
    CCDSi CCDS27576.2. [Q80V03-1 ]
    RefSeqi NP_766548.2. NM_172960.3.
    UniGenei Mm.181624.

    3D structure databases

    ProteinModelPortali Q80V03.
    SMRi Q80V03. Positions 308-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105452.

    PTM databases

    PhosphoSitei Q80V03.

    Proteomic databases

    MaxQBi Q80V03.
    PaxDbi Q80V03.
    PRIDEi Q80V03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 268822.
    KEGGi mmu:268822.

    Organism-specific databases

    CTDi 203054.
    MGIi MGI:2679274. Adck5.

    Phylogenomic databases

    eggNOGi COG0661.
    HOGENOMi HOG000240338.
    HOVERGENi HBG104406.
    InParanoidi Q80V03.
    KOi K08869.
    PhylomeDBi Q80V03.

    Miscellaneous databases

    NextBioi 392527.
    PROi Q80V03.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ADCK5.
    Genevestigatori Q80V03.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Hypothalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiADCK5_MOUSE
    AccessioniPrimary (citable) accession number: Q80V03
    Secondary accession number(s): Q8CAA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3