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Q80V03

- ADCK5_MOUSE

UniProt

Q80V03 - ADCK5_MOUSE

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Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

Adck5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

GO - Molecular functioni

  1. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
Gene namesi
Name:Adck5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2679274. Adck5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 6920HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Uncharacterized aarF domain-containing protein kinase 5PRO_0000271801Add
BLAST

Proteomic databases

MaxQBiQ80V03.
PaxDbiQ80V03.
PRIDEiQ80V03.

PTM databases

PhosphoSiteiQ80V03.

Expressioni

Gene expression databases

CleanExiMM_ADCK5.
GenevestigatoriQ80V03.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105452.

Structurei

3D structure databases

ProteinModelPortaliQ80V03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 419241Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0661.
HOGENOMiHOG000240338.
HOVERGENiHBG104406.
InParanoidiQ80V03.
KOiK08869.
PhylomeDBiQ80V03.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80V03-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA
60 70 80 90 100
LSATVVGTPF LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD
110 120 130 140 150
YWWCTNVVLR GVEENSPKYV EIMSACHQRA ADALVAGAIR NGGLYVKLGQ
160 170 180 190 200
GLCSFNHLLP TEYIQTLRVL EDKALTRGFR EVDELFLEDF QALPNELFQE
210 220 230 240 250
FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG DVQTLELLLR
260 270 280 290 300
LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI
310 320 330 340 350
PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ
360 370 380 390 400
IFHTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL
410 420 430 440 450
WRAIILRDNA AMKKHAAALG VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE
460 470 480 490 500
EAAYMQDMAR EHFDGIMEVL KALPRPMLLV LRNINTVRAI NSNLGTPVDR
510 520 530 540 550
YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK FEMALRLEIL
560 570 580
AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM
Length:582
Mass (Da):66,654
Last modified:January 9, 2007 - v2
Checksum:i25F612441852B706
GO
Isoform 2 (identifier: Q80V03-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Show »
Length:460
Mass (Da):52,379
Checksum:i8C836AE960B45EDF
GO

Sequence cautioni

The sequence BC030881 differs from that shown. Reason: Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331A → T in BAC30280. (PubMed:16141072)Curated
Sequence conflicti133 – 1331A → T in AAH60528. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 122122Missing in isoform 2. 2 PublicationsVSP_022358Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039217 mRNA. Translation: BAC30280.1.
AC157566 Genomic DNA. No translation available.
BC030881 mRNA. No translation available.
BC060528 mRNA. Translation: AAH60528.1.
CCDSiCCDS27576.2. [Q80V03-1]
RefSeqiNP_766548.2. NM_172960.3.
UniGeneiMm.181624.

Genome annotation databases

GeneIDi268822.
KEGGimmu:268822.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039217 mRNA. Translation: BAC30280.1 .
AC157566 Genomic DNA. No translation available.
BC030881 mRNA. No translation available.
BC060528 mRNA. Translation: AAH60528.1 .
CCDSi CCDS27576.2. [Q80V03-1 ]
RefSeqi NP_766548.2. NM_172960.3.
UniGenei Mm.181624.

3D structure databases

ProteinModelPortali Q80V03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000105452.

PTM databases

PhosphoSitei Q80V03.

Proteomic databases

MaxQBi Q80V03.
PaxDbi Q80V03.
PRIDEi Q80V03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 268822.
KEGGi mmu:268822.

Organism-specific databases

CTDi 203054.
MGIi MGI:2679274. Adck5.

Phylogenomic databases

eggNOGi COG0661.
HOGENOMi HOG000240338.
HOVERGENi HBG104406.
InParanoidi Q80V03.
KOi K08869.
PhylomeDBi Q80V03.

Miscellaneous databases

NextBioi 392527.
PROi Q80V03.
SOURCEi Search...

Gene expression databases

CleanExi MM_ADCK5.
Genevestigatori Q80V03.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view ]
Pfami PF03109. ABC1. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiADCK5_MOUSE
AccessioniPrimary (citable) accession number: Q80V03
Secondary accession number(s): Q8CAA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3