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Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

Adck5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
Gene namesi
Name:Adck5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2679274 Adck5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 69HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002718011 – 582Uncharacterized aarF domain-containing protein kinase 5Add BLAST582

Proteomic databases

PaxDbiQ80V03
PRIDEiQ80V03

PTM databases

iPTMnetiQ80V03
PhosphoSitePlusiQ80V03

Expressioni

Gene expression databases

CleanExiMM_ADCK5

Interactioni

Protein-protein interaction databases

BioGridi234564, 1 interactor
STRINGi10090.ENSMUSP00000125055

Structurei

3D structure databases

ProteinModelPortaliQ80V03
SMRiQ80V03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 419Protein kinaseAdd BLAST241

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1235 Eukaryota
COG0661 LUCA
HOGENOMiHOG000240338
HOVERGENiHBG104406
InParanoidiQ80V03
KOiK08869
PhylomeDBiQ80V03

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80V03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA
60 70 80 90 100
LSATVVGTPF LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD
110 120 130 140 150
YWWCTNVVLR GVEENSPKYV EIMSACHQRA ADALVAGAIR NGGLYVKLGQ
160 170 180 190 200
GLCSFNHLLP TEYIQTLRVL EDKALTRGFR EVDELFLEDF QALPNELFQE
210 220 230 240 250
FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG DVQTLELLLR
260 270 280 290 300
LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI
310 320 330 340 350
PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ
360 370 380 390 400
IFHTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL
410 420 430 440 450
WRAIILRDNA AMKKHAAALG VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE
460 470 480 490 500
EAAYMQDMAR EHFDGIMEVL KALPRPMLLV LRNINTVRAI NSNLGTPVDR
510 520 530 540 550
YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK FEMALRLEIL
560 570 580
AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM
Length:582
Mass (Da):66,654
Last modified:January 9, 2007 - v2
Checksum:i25F612441852B706
GO
Isoform 2 (identifier: Q80V03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Show »
Length:460
Mass (Da):52,379
Checksum:i8C836AE960B45EDF
GO

Sequence cautioni

The sequence BC030881 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133A → T in BAC30280 (PubMed:16141072).Curated1
Sequence conflicti133A → T in AAH60528 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0223581 – 122Missing in isoform 2. 2 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039217 mRNA Translation: BAC30280.1
AC157566 Genomic DNA No translation available.
BC030881 mRNA No translation available.
BC060528 mRNA Translation: AAH60528.1
CCDSiCCDS27576.2 [Q80V03-1]
RefSeqiNP_766548.2, NM_172960.3
UniGeneiMm.181624

Genome annotation databases

GeneIDi268822
KEGGimmu:268822

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADCK5_MOUSE
AccessioniPrimary (citable) accession number: Q80V03
Secondary accession number(s): Q8CAA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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