Q80V03 (ADCK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized aarF domain-containing protein kinase 5
EC=2.7.11.-

Gene names

Name:

Adck5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence BC030881 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q80V03-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q80V03-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 582	582	Uncharacterized aarF domain-containing protein kinase 5		PRO_0000271801
Regions
	Transmembrane	50 – 69	20	Helical; Potential
	Domain	179 – 419	241	Protein kinase
Natural variations
	Alternative sequence	1 – 122	122	Missing in isoform 2.		VSP_022358
Experimental info
	Sequence conflict	133	1	A → T in BAC30280. Ref.1
	Sequence conflict	133	1	A → T in AAH60528. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 25F612441852B706	FASTA	582	66,654
	10 20 30 40 50 60 MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA LSATVVGTPF 70 80 90 100 110 120 LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD YWWCTNVVLR GVEENSPKYV 130 140 150 160 170 180 EIMSACHQRA ADALVAGAIR NGGLYVKLGQ GLCSFNHLLP TEYIQTLRVL EDKALTRGFR 190 200 210 220 230 240 EVDELFLEDF QALPNELFQE FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG 250 260 270 280 290 300 DVQTLELLLR LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI 310 320 330 340 350 360 PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ IFHTGFIHSD 370 380 390 400 410 420 PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL WRAIILRDNA AMKKHAAALG 430 440 450 460 470 480 VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE EAAYMQDMAR EHFDGIMEVL KALPRPMLLV 490 500 510 520 530 540 LRNINTVRAI NSNLGTPVDR YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK 550 560 570 580 FEMALRLEIL AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM
	Isoform 2 [UniParc]. Checksum: 8C836AE960B45EDF	FASTA	460	52,379
	10 20 30 40 50 60 MSACHQRAAD ALVAGAIRNG GLYVKLGQGL CSFNHLLPTE YIQTLRVLED KALTRGFREV 70 80 90 100 110 120 DELFLEDFQA LPNELFQEFD YEPMAAASLA QVHRAKLHDG TDVAVKVQYI DLRDRFDGDV 130 140 150 160 170 180 QTLELLLRLV ELMHPSFGFS WVLQDLKGTL VQELDFENEG RNAERCAQEL KHFHYVVIPR 190 200 210 220 230 240 VHWDRSSKRV LTADFCNGCK VNDMEGIKSQ GLAVQDVAKK LIQTFAEQIF HTGFIHSDPH 250 260 270 280 290 300 PGNVLVRKGP DGKAELVLLD HGLYQFLDEK DRSSLCQLWR AIILRDNAAM KKHAAALGVQ 310 320 330 340 350 360 DYMLFSEVLM QRPVRLGQLW GSHLISREEA AYMQDMAREH FDGIMEVLKA LPRPMLLVLR 370 380 390 400 410 420 NINTVRAINS NLGTPVDRYF LMAKSAVWGW SRLVGAAYQG IYGSSLLRHI KVLWEALKFE 430 440 450 460 MALRLEILAM RLTALMLRVL VRLGFAPKAE AEEVYQYLEM

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Hypothalamus.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6 and FVB/N. Tissue: Brain and Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK039217 mRNA. Translation: BAC30280.1. AC157566 Genomic DNA. No translation available. BC030881 mRNA. No translation available. BC060528 mRNA. Translation: AAH60528.1.
IPI	IPI00816878. IPI01008360.
RefSeq	NP_766548.2. NM_172960.3.
UniGene	Mm.181624.
3D structure databases
ProteinModelPortal	Q80V03.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000105452.
PTM databases
PhosphoSite	Q80V03.
Proteomic databases
PaxDb	Q80V03.
PRIDE	Q80V03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	268822.
KEGG	mmu:268822.
UCSC	uc007wkv.2. mouse. uc011zuw.1. mouse.
Organism-specific databases
CTD	203054.
MGI	MGI:2679274. Adck5.
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000240338.
HOVERGEN	HBG104406.
InParanoid	Q80V03.
KO	K08869.
OrthoDB	EOG4NP73D.
Gene expression databases
CleanEx	MM_ADCK5.
Genevestigator	Q80V03.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	392527.
SOURCE	Search...

Entry information

Entry name

ADCK5_MOUSE

Accession

Primary (citable) accession number: Q80V03
Secondary accession number(s): Q8CAA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program