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Protein

FYVE, RhoGEF and PH domain-containing protein 5

Gene

Fgd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri998 – 105760FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 5
Gene namesi
Name:Fgd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2443369. Fgd5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12191219FYVE, RhoGEF and PH domain-containing protein 5PRO_0000080951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei555 – 5551PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80UZ0.
PaxDbiQ80UZ0.
PRIDEiQ80UZ0.

PTM databases

iPTMnetiQ80UZ0.
PhosphoSiteiQ80UZ0.

Expressioni

Tissue specificityi

Expressed in highly vascularized tissues, such as lung, kidney and ovary.1 Publication

Developmental stagei

Detected at 10 dpc in the intersomitic vessels, dorsal aorta and brain vasculature. In retina, strongly expressed in the developing retinal vasculature at postnatal day 4 and down-regulated in preformed vessels at postnatal day 8. Predominantly detected in capillaries and veins, and particularly at the advancing vascular fronts, as compared to arteries.1 Publication

Gene expression databases

CleanExiMM_FGD5.

Interactioni

Protein-protein interaction databases

IntActiQ80UZ0. 1 interaction.
STRINGi10090.ENSMUSP00000109093.

Structurei

3D structure databases

ProteinModelPortaliQ80UZ0.
SMRiQ80UZ0. Positions 645-961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini647 – 840194DHPROSITE-ProRule annotationAdd
BLAST
Domaini869 – 96395PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1120 – 121899PH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi403 – 4064Poly-Lys

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri998 – 105760FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4424. Eukaryota.
ENOG410XRXV. LUCA.
HOVERGENiHBG051609.
InParanoidiQ80UZ0.
KOiK05724.
PhylomeDBiQ80UZ0.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80UZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPESEVSP DVQEQEAATD NPEVFEEDSA DAAEGEDQIE QEEPPNCDEE
60 70 80 90 100
AYNRDAAAAT MQVGEDLGEE GDHVQEDPAE ESCQIIPFES DSVEEDFSPT
110 120 130 140 150
LTENPYEIFP TESTSFCNNT YSLDESANGH EPVCEICVEE VPGVGPPLNQ
160 170 180 190 200
HDSLPDGSGE DSPVVPDVVV VPENEGPVDD ALSSPYVMGV GLLSLGEGAQ
210 220 230 240 250
SDTQAASGTL SGYSTWEEGD SEGGQVPVDR KNIATRARPH SGKVAGHVPE
260 270 280 290 300
TVLEETGPET CSSGMGIRDT SDEVRKIGIL PEGKPPECVR ALPAKPRAFT
310 320 330 340 350
LYPRSFSVEG RESPLSMFRE PEGAGLDSHR VRRKEDNLSL PGAIGSSGSF
360 370 380 390 400
SQRSHLPSSG TSTPSSVVDI PPPFDLACIT KKPITKSSPS LLIDGDTLEK
410 420 430 440 450
ASKKKKSSFK RFLELTFRKK TESKVHVDMN LSSSRSSSES SYHGPARVLE
460 470 480 490 500
LDRRSLSNSP QLKCRTGKLR ASDSPAALIF YRDSKRKGVP FSRTVSRVES
510 520 530 540 550
FEDRSRPPFL PLPLTKPRSI SFPNADTSDY ENIPAMNSDY ENIQIPPRRP
560 570 580 590 600
VRTGTFTKLF EEQSRALSTA NENDGYVDMS SFNAFESKQQ SSEQEAESAY
610 620 630 640 650
TEPYKVCPIS AAPREDLTSD EEQGSSEEED SASRDPSLSH KGEGQSRALV
660 670 680 690 700
IAQELLSSEK AYVQMLQHLS LDFHGAVLRA LENVEQEGRE PLAQEELRQG
710 720 730 740 750
LRELPAICDL HQGILESLEQ RLGDCGEGQP QVADIFLARE QEFEHHAAHI
760 770 780 790 800
LQFDRYLGLL AESCLLSPRL ATTVREFEQS SQGGGQSMKH RMLRVVQRLF
810 820 830 840 850
QYQVLLTDYL NNLCPDSAEY DNTQSALTLI SKVTDRANES MEQGENLQKL
860 870 880 890 900
VHIEYSVRGQ GDLLQPGREF LKEGTLMRVR GKSRHPRHLF LMNDTLLYTH
910 920 930 940 950
PQKDGKYRLK SSLPVANMKV SRPVMDKVPY ALKIETPESC LTLSASSCAE
960 970 980 990 1000
RDEWHYCLSR ALPEDYKTQA LAAFHHSVEI RERLGISLGE RLPTLVPVTH
1010 1020 1030 1040 1050
AMMCMNCGCD FSLTVRRHHC HACGKIVCRN CSRNKYPLKC LKNRMAKVCD
1060 1070 1080 1090 1100
GCFRELKLRN GPVPGSMRER PVSMSFPLSS SRFSSGSALS SVFQSISPST
1110 1120 1130 1140 1150
FKKQKKVPSA LSEVAASGEG SAISGYLSRC KSGKRRWKKL WLVIKGKVLY
1160 1170 1180 1190 1200
TYLASEDKVA MESIPLLGFT IAPEKEEGSS EVGPVFHLYH KKTLFYSFKA
1210
EDSNSAQRWM EAMEDASVL
Length:1,219
Mass (Da):134,719
Last modified:March 15, 2005 - v2
Checksum:i35F0AF51DD0911B4
GO
Isoform 2 (identifier: Q80UZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1001: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,303
Checksum:i03306ADFF63E85BB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10011001Missing in isoform 2. 1 PublicationVSP_013089Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042732 mRNA. Translation: AAH42732.1.
BC060664 mRNA. No translation available.
AK049341 mRNA. Translation: BAC33694.1.
AK086031 mRNA. Translation: BAC39597.1.
RefSeqiNP_766319.3. NM_172731.3.
UniGeneiMm.295740.

Genome annotation databases

GeneIDi232237.
KEGGimmu:232237.
UCSCiuc009cyo.1. mouse. [Q80UZ0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042732 mRNA. Translation: AAH42732.1.
BC060664 mRNA. No translation available.
AK049341 mRNA. Translation: BAC33694.1.
AK086031 mRNA. Translation: BAC39597.1.
RefSeqiNP_766319.3. NM_172731.3.
UniGeneiMm.295740.

3D structure databases

ProteinModelPortaliQ80UZ0.
SMRiQ80UZ0. Positions 645-961.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80UZ0. 1 interaction.
STRINGi10090.ENSMUSP00000109093.

PTM databases

iPTMnetiQ80UZ0.
PhosphoSiteiQ80UZ0.

Proteomic databases

MaxQBiQ80UZ0.
PaxDbiQ80UZ0.
PRIDEiQ80UZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi232237.
KEGGimmu:232237.
UCSCiuc009cyo.1. mouse. [Q80UZ0-2]

Organism-specific databases

CTDi152273.
MGIiMGI:2443369. Fgd5.

Phylogenomic databases

eggNOGiKOG4424. Eukaryota.
ENOG410XRXV. LUCA.
HOVERGENiHBG051609.
InParanoidiQ80UZ0.
KOiK05724.
PhylomeDBiQ80UZ0.

Miscellaneous databases

PROiQ80UZ0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_FGD5.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Heart.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung and Spleen.
  5. "FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells."
    Kurogane Y., Miyata M., Kubo Y., Nagamatsu Y., Kundu R.K., Uemura A., Ishida T., Quertermous T., Hirata K., Rikitake Y.
    Arterioscler. Thromb. Vasc. Biol. 32:988-996(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFGD5_MOUSE
AccessioniPrimary (citable) accession number: Q80UZ0
Secondary accession number(s): Q8BHM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.