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Q80UV9

- TAF1_MOUSE

UniProt

Q80UV9 - TAF1_MOUSE

Protein

Transcription initiation factor TFIID subunit 1

Gene

Taf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4 By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1216 – 129479HMG boxBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: MGI
    3. histone acetyltransferase activity Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. DNA-templated transcription, initiation Source: InterPro
    3. histone acetylation Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 1 (EC:2.3.1.48, EC:2.7.11.1)
    Alternative name(s):
    Cell cycle gene 1 protein
    TBP-associated factor 250 kDa
    Short name:
    p250
    Transcription initiation factor TFIID 250 kDa subunit
    Short name:
    TAF(II)250
    Short name:
    TAFII-250
    Short name:
    TAFII250
    Gene namesi
    Name:Taf1
    Synonyms:Ccg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1336878. Taf1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. MLL1 complex Source: UniProtKB
    2. nucleus Source: MGI
    3. pronucleus Source: MGI
    4. transcription factor TFIID complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18911891Transcription initiation factor TFIID subunit 1PRO_0000278524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei328 – 3281Phosphoserine; by autocatalysisBy similarity
    Modified residuei565 – 5651N6-acetyllysine1 Publication
    Disulfide bondi1385 ↔ 1640By similarity
    Modified residuei1847 – 18471PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ80UV9.
    PRIDEiQ80UV9.

    PTM databases

    PhosphoSiteiQ80UV9.

    Expressioni

    Gene expression databases

    BgeeiQ80UV9.
    GenevestigatoriQ80UV9.

    Interactioni

    Subunit structurei

    TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80UV9.
    SMRiQ80UV9. Positions 1380-1646.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 435435Protein kinase 1Add
    BLAST
    Domaini1418 – 148871Bromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1446 – 1891446Protein kinase 2Add
    BLAST
    Domaini1541 – 161171Bromo 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni538 – 997460Histone acetyltransferase (HAT)By similarityAdd
    BLAST
    Regioni1363 – 1650288Interaction with ASF1A and ASF1BBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1372 – 13798Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi157 – 1659Poly-Pro
    Compositional biasi204 – 2118Poly-Ser
    Compositional biasi1848 – 18558Poly-Glu

    Sequence similaritiesi

    Belongs to the TAF1 family.Curated
    Contains 2 bromo domains.PROSITE-ProRule annotation
    Contains 1 HMG box DNA-binding domain.Curated
    Contains 2 protein kinase domains.Curated

    Keywords - Domaini

    Bromodomain, Repeat

    Phylogenomic databases

    eggNOGiCOG5076.
    GeneTreeiENSGT00390000012659.
    HOVERGENiHBG050223.
    KOiK03125.
    OrthoDBiEOG7QNVK2.

    Family and domain databases

    Gene3Di1.10.1100.10. 1 hit.
    1.20.920.10. 2 hits.
    InterProiIPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR011177. TAF1_animal.
    IPR009067. TAF_II_230-bd.
    IPR022591. TFIID_sub1_DUF3591.
    [Graphical view]
    PfamiPF00439. Bromodomain. 2 hits.
    PF12157. DUF3591. 1 hit.
    PF09247. TBP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003047. TAF1_animal. 1 hit.
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 2 hits.
    [Graphical view]
    SUPFAMiSSF47055. SSF47055. 1 hit.
    SSF47370. SSF47370. 2 hits.
    PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80UV9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG     50
    QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW 100
    IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED 150
    IDCKLMPPPP PPPGPLKKEK DQDDITGVSE DGEGIILPSI IAPSSLASEK 200
    VDFSSSSDSE SEMGPQDAAQ SESKDGQLTL PLAGIMQHDA TKLLPSVTEL 250
    FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEGQVQEEE 300
    CSVELEVNQK SLWNYDYAPP PLPDQCLSDD EITMMAPVES KFSQSTGDTD 350
    KVMDTKPRVA EWRYGPARLW YDMLGVPEDG SGFDYGFKMK KTEHESTIKC 400
    NIMKKLRKLE ENSGVDLLAD ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ 450
    RASLAGWLPS SMTRNAMAYN VQQGFTATLD DDKPWYSIFP IDNEDLVYGR 500
    WEDNIIWDAQ NMPRILEPPV LTLDPNDENL ILEIPDEKEE ATSNSPSKEN 550
    KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG 600
    LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS 650
    QPGPHSVQPL LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI 700
    LAEYSEENGP LMMQVGMATK IKNYYKRKPG KDPGAPDCKY GETVYCHTSP 750
    FLGSLHPGQL LQAFENNLFR APIYLHKMPE SDFLIIRTRQ GYFIRELVDI 800
    FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK DRPRRIRMED 850
    IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM 900
    VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT 950
    APWNTTRAFI AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK 1000
    EPQPVKKTVT GTDADLRRLS LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV 1050
    RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ ERYKEECQRI FDLQNKVLSS 1100
    TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR EREEQERKEL 1150
    QRMLLAAGSA AAGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY 1200
    VRCETVRKAT VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE 1250
    QLRRLKRNQE KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC 1300
    PLYYQTNAPP SNPVAMTEEQ EEELEKTVIH NDNEELIKVE GTKIVLGKQL 1350
    IESADEVRRK SLVLKFPKQQ LPPKKKRRVG TTVHCDYLNR PHKSIHRRRT 1400
    DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK IITRPMDLQT 1450
    LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE 1500
    KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH 1550
    HPVNKKFVPD YYKVIVSPMD LETIRKNISK HKYQSRESFL DDVNLILANS 1600
    VKYNGPESQY TKTAQEIVNV CHQTLTEYDE HLTQLEKDIC TAKEAALEEA 1650
    ELESLDPMTP GPYTPQPPDL YDNNTSLSVS RDASVYQDES NLSVLDIPSA 1700
    TSEKQLTQEG GDGDGDLADE EEGTVQQPQA SVLYEDLLMS EGEDDEEDAG 1750
    SDEEGDNPFF AIQLSESGSD SDVESGSLRP KQPRVLQENT RMGMENEESM 1800
    MSYEGDGGDA SRGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE 1850
    EDEEEQRSGP SVLSQVHLSE DEEDSEDFHS IAGDTDLDSD E 1891
    Length:1,891
    Mass (Da):214,419
    Last modified:March 6, 2007 - v2
    Checksum:i9A4EA0475BB3E885
    GO
    Isoform 2 (identifier: Q80UV9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-962: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:929
    Mass (Da):105,780
    Checksum:iA92987089CF8811D
    GO
    Isoform 3 (identifier: Q80UV9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-198: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,870
    Mass (Da):212,382
    Checksum:iC7C3C29E868C630F
    GO

    Sequence cautioni

    The sequence BAC34383.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171D → E in AAD23348. (PubMed:10070062)Curated
    Sequence conflicti221 – 2211S → A in AAD23348. (PubMed:10070062)Curated
    Sequence conflicti261 – 2611R → H in AAD23348. (PubMed:10070062)Curated
    Sequence conflicti289 – 2891E → K in AAD23348. (PubMed:10070062)Curated
    Sequence conflicti867 – 8682LK → EG in AAC62118. (PubMed:9751712)Curated
    Sequence conflicti876 – 8761T → Q in AAD23349. (PubMed:10070062)Curated
    Sequence conflicti1302 – 13065LYYQT → AFVAS in AAC62118. (PubMed:9751712)Curated
    Sequence conflicti1358 – 13581R → P in AAD23350. (PubMed:10070062)Curated
    Sequence conflicti1388 – 13881L → F in AAD23350. (PubMed:10070062)Curated
    Sequence conflicti1450 – 14501T → E in AAD23350. (PubMed:10070062)Curated
    Sequence conflicti1469 – 14702HL → QM in AAD23350. (PubMed:10070062)Curated
    Sequence conflicti1736 – 17361D → N in AAH94568. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 962962Missing in isoform 2. 1 PublicationVSP_023320Add
    BLAST
    Alternative sequencei178 – 19821Missing in isoform 3. 1 PublicationVSP_023321Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL831722, AL806534 Genomic DNA. Translation: CAM20496.1.
    AL831722, AL806534 Genomic DNA. Translation: CAM20497.1.
    AL806534, AL831722 Genomic DNA. Translation: CAM21283.1.
    AL806534, AL831722 Genomic DNA. Translation: CAM21284.1.
    BC047418 mRNA. Translation: AAH47418.1.
    BC094568 mRNA. Translation: AAH94568.1.
    AK045586 mRNA. Translation: BAC32425.1.
    AK046668 mRNA. Translation: BAC32828.1.
    AK049826 mRNA. Translation: BAC33938.1.
    AK050691 mRNA. Translation: BAC34383.1. Different initiation.
    AK132088 mRNA. Translation: BAE20976.1.
    AK143571 mRNA. Translation: BAE25442.1.
    AF081115 mRNA. Translation: AAD23349.1.
    AF081116 mRNA. Translation: AAD23348.1.
    AF081117 mRNA. Translation: AAD23350.1.
    AF022178 mRNA. Translation: AAC62118.1.
    RefSeqiNP_001277658.1. NM_001290729.1.
    XP_006528113.1. XM_006528050.1. [Q80UV9-1]
    XP_006528115.1. XM_006528052.1. [Q80UV9-3]
    UniGeneiMm.261750.

    Genome annotation databases

    EnsembliENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314. [Q80UV9-3]
    GeneIDi270627.
    KEGGimmu:270627.
    UCSCiuc009txv.2. mouse. [Q80UV9-1]
    uc009txy.1. mouse. [Q80UV9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL831722 , AL806534 Genomic DNA. Translation: CAM20496.1 .
    AL831722 , AL806534 Genomic DNA. Translation: CAM20497.1 .
    AL806534 , AL831722 Genomic DNA. Translation: CAM21283.1 .
    AL806534 , AL831722 Genomic DNA. Translation: CAM21284.1 .
    BC047418 mRNA. Translation: AAH47418.1 .
    BC094568 mRNA. Translation: AAH94568.1 .
    AK045586 mRNA. Translation: BAC32425.1 .
    AK046668 mRNA. Translation: BAC32828.1 .
    AK049826 mRNA. Translation: BAC33938.1 .
    AK050691 mRNA. Translation: BAC34383.1 . Different initiation.
    AK132088 mRNA. Translation: BAE20976.1 .
    AK143571 mRNA. Translation: BAE25442.1 .
    AF081115 mRNA. Translation: AAD23349.1 .
    AF081116 mRNA. Translation: AAD23348.1 .
    AF081117 mRNA. Translation: AAD23350.1 .
    AF022178 mRNA. Translation: AAC62118.1 .
    RefSeqi NP_001277658.1. NM_001290729.1.
    XP_006528113.1. XM_006528050.1. [Q80UV9-1 ]
    XP_006528115.1. XM_006528052.1. [Q80UV9-3 ]
    UniGenei Mm.261750.

    3D structure databases

    ProteinModelPortali Q80UV9.
    SMRi Q80UV9. Positions 1380-1646.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80UV9.

    Proteomic databases

    PaxDbi Q80UV9.
    PRIDEi Q80UV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000118878 ; ENSMUSP00000112772 ; ENSMUSG00000031314 . [Q80UV9-3 ]
    GeneIDi 270627.
    KEGGi mmu:270627.
    UCSCi uc009txv.2. mouse. [Q80UV9-1 ]
    uc009txy.1. mouse. [Q80UV9-2 ]

    Organism-specific databases

    CTDi 6872.
    MGIi MGI:1336878. Taf1.

    Phylogenomic databases

    eggNOGi COG5076.
    GeneTreei ENSGT00390000012659.
    HOVERGENi HBG050223.
    KOi K03125.
    OrthoDBi EOG7QNVK2.

    Miscellaneous databases

    PROi Q80UV9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80UV9.
    Genevestigatori Q80UV9.

    Family and domain databases

    Gene3Di 1.10.1100.10. 1 hit.
    1.20.920.10. 2 hits.
    InterProi IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR011177. TAF1_animal.
    IPR009067. TAF_II_230-bd.
    IPR022591. TFIID_sub1_DUF3591.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 2 hits.
    PF12157. DUF3591. 1 hit.
    PF09247. TBP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003047. TAF1_animal. 1 hit.
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47055. SSF47055. 1 hit.
    SSF47370. SSF47370. 2 hits.
    PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-1891.
      Strain: C57BL/6 and Czech II.
      Tissue: Brain and Mammary tumor.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-280 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 849-1237 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401 AND 1143-1891.
      Strain: C57BL/6J.
      Tissue: Adipose tissue, Corpora quadrigemina, Head, Hippocampus and Spleen.
    4. "TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin."
      Saadane N., Alpert L., Chalifour L.E.
      Am. J. Physiol. 276:H803-H814(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-370; 841-876 AND 1199-1488.
      Strain: CD-1.
      Tissue: Heart.
    5. "HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes."
      Weissman J.D., Brown J.A., Howcroft T.K., Hwang J., Chawla A., Roche P.A., Schiltz L., Nakatani Y., Singer D.S.
      Proc. Natl. Acad. Sci. U.S.A. 95:11601-11606(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-1306.
      Tissue: Spleen.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-565, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiTAF1_MOUSE
    AccessioniPrimary (citable) accession number: Q80UV9
    Secondary accession number(s): A2AM32
    , A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3