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Q80UV9

- TAF1_MOUSE

UniProt

Q80UV9 - TAF1_MOUSE

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Protein
Transcription initiation factor TFIID subunit 1
Gene
Taf1, Ccg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4 By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Magnesium By similarity.

Enzyme regulationi

Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1216 – 129479HMG box By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: MGI
  3. histone acetyltransferase activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. histone acetylation Source: UniProtKB
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.3.1.48, EC:2.7.11.1)
Alternative name(s):
Cell cycle gene 1 protein
TBP-associated factor 250 kDa
Short name:
p250
Transcription initiation factor TFIID 250 kDa subunit
Short name:
TAF(II)250
Short name:
TAFII-250
Short name:
TAFII250
Gene namesi
Name:Taf1
Synonyms:Ccg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1336878. Taf1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. MLL1 complex Source: UniProtKB
  2. nucleus Source: MGI
  3. pronucleus Source: MGI
  4. transcription factor TFIID complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18911891Transcription initiation factor TFIID subunit 1
PRO_0000278524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei328 – 3281Phosphoserine; by autocatalysis By similarity
Modified residuei565 – 5651N6-acetyllysine1 Publication
Disulfide bondi1385 ↔ 1640 By similarity
Modified residuei1847 – 18471Phosphoserine By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ80UV9.
PRIDEiQ80UV9.

PTM databases

PhosphoSiteiQ80UV9.

Expressioni

Gene expression databases

BgeeiQ80UV9.
GenevestigatoriQ80UV9.

Interactioni

Subunit structurei

TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ80UV9.
SMRiQ80UV9. Positions 1380-1646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 435435Protein kinase 1
Add
BLAST
Domaini1418 – 148871Bromo 1
Add
BLAST
Domaini1446 – 1891446Protein kinase 2
Add
BLAST
Domaini1541 – 161171Bromo 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni538 – 997460Histone acetyltransferase (HAT) By similarity
Add
BLAST
Regioni1363 – 1650288Interaction with ASF1A and ASF1B By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1372 – 13798Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1659Poly-Pro
Compositional biasi204 – 2118Poly-Ser
Compositional biasi1848 – 18558Poly-Glu

Sequence similaritiesi

Belongs to the TAF1 family.
Contains 2 bromo domains.

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiCOG5076.
GeneTreeiENSGT00390000012659.
HOVERGENiHBG050223.
KOiK03125.
OrthoDBiEOG7QNVK2.

Family and domain databases

Gene3Di1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF003047. TAF1_animal. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80UV9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG     50
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW 100
IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED 150
IDCKLMPPPP PPPGPLKKEK DQDDITGVSE DGEGIILPSI IAPSSLASEK 200
VDFSSSSDSE SEMGPQDAAQ SESKDGQLTL PLAGIMQHDA TKLLPSVTEL 250
FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEGQVQEEE 300
CSVELEVNQK SLWNYDYAPP PLPDQCLSDD EITMMAPVES KFSQSTGDTD 350
KVMDTKPRVA EWRYGPARLW YDMLGVPEDG SGFDYGFKMK KTEHESTIKC 400
NIMKKLRKLE ENSGVDLLAD ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ 450
RASLAGWLPS SMTRNAMAYN VQQGFTATLD DDKPWYSIFP IDNEDLVYGR 500
WEDNIIWDAQ NMPRILEPPV LTLDPNDENL ILEIPDEKEE ATSNSPSKEN 550
KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG 600
LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS 650
QPGPHSVQPL LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI 700
LAEYSEENGP LMMQVGMATK IKNYYKRKPG KDPGAPDCKY GETVYCHTSP 750
FLGSLHPGQL LQAFENNLFR APIYLHKMPE SDFLIIRTRQ GYFIRELVDI 800
FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK DRPRRIRMED 850
IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM 900
VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT 950
APWNTTRAFI AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK 1000
EPQPVKKTVT GTDADLRRLS LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV 1050
RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ ERYKEECQRI FDLQNKVLSS 1100
TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR EREEQERKEL 1150
QRMLLAAGSA AAGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY 1200
VRCETVRKAT VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE 1250
QLRRLKRNQE KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC 1300
PLYYQTNAPP SNPVAMTEEQ EEELEKTVIH NDNEELIKVE GTKIVLGKQL 1350
IESADEVRRK SLVLKFPKQQ LPPKKKRRVG TTVHCDYLNR PHKSIHRRRT 1400
DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK IITRPMDLQT 1450
LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE 1500
KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH 1550
HPVNKKFVPD YYKVIVSPMD LETIRKNISK HKYQSRESFL DDVNLILANS 1600
VKYNGPESQY TKTAQEIVNV CHQTLTEYDE HLTQLEKDIC TAKEAALEEA 1650
ELESLDPMTP GPYTPQPPDL YDNNTSLSVS RDASVYQDES NLSVLDIPSA 1700
TSEKQLTQEG GDGDGDLADE EEGTVQQPQA SVLYEDLLMS EGEDDEEDAG 1750
SDEEGDNPFF AIQLSESGSD SDVESGSLRP KQPRVLQENT RMGMENEESM 1800
MSYEGDGGDA SRGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE 1850
EDEEEQRSGP SVLSQVHLSE DEEDSEDFHS IAGDTDLDSD E 1891
Length:1,891
Mass (Da):214,419
Last modified:March 6, 2007 - v2
Checksum:i9A4EA0475BB3E885
GO
Isoform 2 (identifier: Q80UV9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-962: Missing.

Note: No experimental confirmation available.

Show »
Length:929
Mass (Da):105,780
Checksum:iA92987089CF8811D
GO
Isoform 3 (identifier: Q80UV9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-198: Missing.

Note: No experimental confirmation available.

Show »
Length:1,870
Mass (Da):212,382
Checksum:iC7C3C29E868C630F
GO

Sequence cautioni

The sequence BAC34383.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 962962Missing in isoform 2.
VSP_023320Add
BLAST
Alternative sequencei178 – 19821Missing in isoform 3.
VSP_023321Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171D → E in AAD23348. 1 Publication
Sequence conflicti221 – 2211S → A in AAD23348. 1 Publication
Sequence conflicti261 – 2611R → H in AAD23348. 1 Publication
Sequence conflicti289 – 2891E → K in AAD23348. 1 Publication
Sequence conflicti867 – 8682LK → EG in AAC62118. 1 Publication
Sequence conflicti876 – 8761T → Q in AAD23349. 1 Publication
Sequence conflicti1302 – 13065LYYQT → AFVAS in AAC62118. 1 Publication
Sequence conflicti1358 – 13581R → P in AAD23350. 1 Publication
Sequence conflicti1388 – 13881L → F in AAD23350. 1 Publication
Sequence conflicti1450 – 14501T → E in AAD23350. 1 Publication
Sequence conflicti1469 – 14702HL → QM in AAD23350. 1 Publication
Sequence conflicti1736 – 17361D → N in AAH94568. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL831722, AL806534 Genomic DNA. Translation: CAM20496.1.
AL831722, AL806534 Genomic DNA. Translation: CAM20497.1.
AL806534, AL831722 Genomic DNA. Translation: CAM21283.1.
AL806534, AL831722 Genomic DNA. Translation: CAM21284.1.
BC047418 mRNA. Translation: AAH47418.1.
BC094568 mRNA. Translation: AAH94568.1.
AK045586 mRNA. Translation: BAC32425.1.
AK046668 mRNA. Translation: BAC32828.1.
AK049826 mRNA. Translation: BAC33938.1.
AK050691 mRNA. Translation: BAC34383.1. Different initiation.
AK132088 mRNA. Translation: BAE20976.1.
AK143571 mRNA. Translation: BAE25442.1.
AF081115 mRNA. Translation: AAD23349.1.
AF081116 mRNA. Translation: AAD23348.1.
AF081117 mRNA. Translation: AAD23350.1.
AF022178 mRNA. Translation: AAC62118.1.
RefSeqiNP_001277658.1. NM_001290729.1.
XP_006528113.1. XM_006528050.1. [Q80UV9-1]
XP_006528115.1. XM_006528052.1. [Q80UV9-3]
UniGeneiMm.261750.

Genome annotation databases

EnsembliENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314. [Q80UV9-3]
GeneIDi270627.
KEGGimmu:270627.
UCSCiuc009txv.2. mouse. [Q80UV9-1]
uc009txy.1. mouse. [Q80UV9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL831722 , AL806534 Genomic DNA. Translation: CAM20496.1 .
AL831722 , AL806534 Genomic DNA. Translation: CAM20497.1 .
AL806534 , AL831722 Genomic DNA. Translation: CAM21283.1 .
AL806534 , AL831722 Genomic DNA. Translation: CAM21284.1 .
BC047418 mRNA. Translation: AAH47418.1 .
BC094568 mRNA. Translation: AAH94568.1 .
AK045586 mRNA. Translation: BAC32425.1 .
AK046668 mRNA. Translation: BAC32828.1 .
AK049826 mRNA. Translation: BAC33938.1 .
AK050691 mRNA. Translation: BAC34383.1 . Different initiation.
AK132088 mRNA. Translation: BAE20976.1 .
AK143571 mRNA. Translation: BAE25442.1 .
AF081115 mRNA. Translation: AAD23349.1 .
AF081116 mRNA. Translation: AAD23348.1 .
AF081117 mRNA. Translation: AAD23350.1 .
AF022178 mRNA. Translation: AAC62118.1 .
RefSeqi NP_001277658.1. NM_001290729.1.
XP_006528113.1. XM_006528050.1. [Q80UV9-1 ]
XP_006528115.1. XM_006528052.1. [Q80UV9-3 ]
UniGenei Mm.261750.

3D structure databases

ProteinModelPortali Q80UV9.
SMRi Q80UV9. Positions 1380-1646.
ModBasei Search...

PTM databases

PhosphoSitei Q80UV9.

Proteomic databases

PaxDbi Q80UV9.
PRIDEi Q80UV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000118878 ; ENSMUSP00000112772 ; ENSMUSG00000031314 . [Q80UV9-3 ]
GeneIDi 270627.
KEGGi mmu:270627.
UCSCi uc009txv.2. mouse. [Q80UV9-1 ]
uc009txy.1. mouse. [Q80UV9-2 ]

Organism-specific databases

CTDi 6872.
MGIi MGI:1336878. Taf1.

Phylogenomic databases

eggNOGi COG5076.
GeneTreei ENSGT00390000012659.
HOVERGENi HBG050223.
KOi K03125.
OrthoDBi EOG7QNVK2.

Miscellaneous databases

PROi Q80UV9.
SOURCEi Search...

Gene expression databases

Bgeei Q80UV9.
Genevestigatori Q80UV9.

Family and domain databases

Gene3Di 1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF003047. TAF1_animal. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
[Graphical view ]
SUPFAMi SSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-1891.
    Strain: C57BL/6 and Czech II.
    Tissue: Brain and Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-280 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 849-1237 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401 AND 1143-1891.
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Corpora quadrigemina, Head, Hippocampus and Spleen.
  4. "TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin."
    Saadane N., Alpert L., Chalifour L.E.
    Am. J. Physiol. 276:H803-H814(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-370; 841-876 AND 1199-1488.
    Strain: CD-1.
    Tissue: Heart.
  5. "HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes."
    Weissman J.D., Brown J.A., Howcroft T.K., Hwang J., Chawla A., Roche P.A., Schiltz L., Nakatani Y., Singer D.S.
    Proc. Natl. Acad. Sci. U.S.A. 95:11601-11606(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-1306.
    Tissue: Spleen.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-565, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTAF1_MOUSE
AccessioniPrimary (citable) accession number: Q80UV9
Secondary accession number(s): A2AM32
, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi