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Q80UV9

- TAF1_MOUSE

UniProt

Q80UV9 - TAF1_MOUSE

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Protein

Transcription initiation factor TFIID subunit 1

Gene

Taf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Mg2+By similarity

Enzyme regulationi

Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1216 – 129479HMG boxBy similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: MGI
  3. histone acetyltransferase activity Source: UniProtKB
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. DNA-templated transcription, initiation Source: InterPro
  3. histone acetylation Source: UniProtKB
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.3.1.48, EC:2.7.11.1)
Alternative name(s):
Cell cycle gene 1 protein
TBP-associated factor 250 kDa
Short name:
p250
Transcription initiation factor TFIID 250 kDa subunit
Short name:
TAF(II)250
Short name:
TAFII-250
Short name:
TAFII250
Gene namesi
Name:Taf1
Synonyms:Ccg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1336878. Taf1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. MLL1 complex Source: UniProtKB
  2. nucleus Source: MGI
  3. pronucleus Source: MGI
  4. transcription factor TFIID complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18911891Transcription initiation factor TFIID subunit 1PRO_0000278524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei328 – 3281Phosphoserine; by autocatalysisBy similarity
Modified residuei565 – 5651N6-acetyllysine1 Publication
Disulfide bondi1385 ↔ 1640By similarity
Modified residuei1847 – 18471PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ80UV9.
PaxDbiQ80UV9.
PRIDEiQ80UV9.

PTM databases

PhosphoSiteiQ80UV9.

Expressioni

Gene expression databases

BgeeiQ80UV9.
ExpressionAtlasiQ80UV9. baseline and differential.
GenevestigatoriQ80UV9.

Interactioni

Subunit structurei

TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ80UV9.
SMRiQ80UV9. Positions 610-992, 1380-1646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 435435Protein kinase 1Add
BLAST
Domaini1418 – 148871Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini1446 – 1891446Protein kinase 2Add
BLAST
Domaini1541 – 161171Bromo 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni538 – 997460Histone acetyltransferase (HAT)By similarityAdd
BLAST
Regioni1363 – 1650288Interaction with ASF1A and ASF1BBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1372 – 13798Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1659Poly-Pro
Compositional biasi204 – 2118Poly-Ser
Compositional biasi1848 – 18558Poly-Glu

Sequence similaritiesi

Belongs to the TAF1 family.Curated
Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 1 HMG box DNA-binding domain.Curated
Contains 2 protein kinase domains.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiCOG5076.
GeneTreeiENSGT00390000012659.
HOVERGENiHBG050223.
InParanoidiQ80UV9.
KOiK03125.
OrthoDBiEOG7QNVK2.

Family and domain databases

Gene3Di1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF003047. TAF1_animal. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80UV9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG
60 70 80 90 100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW
110 120 130 140 150
IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED
160 170 180 190 200
IDCKLMPPPP PPPGPLKKEK DQDDITGVSE DGEGIILPSI IAPSSLASEK
210 220 230 240 250
VDFSSSSDSE SEMGPQDAAQ SESKDGQLTL PLAGIMQHDA TKLLPSVTEL
260 270 280 290 300
FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEGQVQEEE
310 320 330 340 350
CSVELEVNQK SLWNYDYAPP PLPDQCLSDD EITMMAPVES KFSQSTGDTD
360 370 380 390 400
KVMDTKPRVA EWRYGPARLW YDMLGVPEDG SGFDYGFKMK KTEHESTIKC
410 420 430 440 450
NIMKKLRKLE ENSGVDLLAD ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ
460 470 480 490 500
RASLAGWLPS SMTRNAMAYN VQQGFTATLD DDKPWYSIFP IDNEDLVYGR
510 520 530 540 550
WEDNIIWDAQ NMPRILEPPV LTLDPNDENL ILEIPDEKEE ATSNSPSKEN
560 570 580 590 600
KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG
610 620 630 640 650
LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS
660 670 680 690 700
QPGPHSVQPL LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI
710 720 730 740 750
LAEYSEENGP LMMQVGMATK IKNYYKRKPG KDPGAPDCKY GETVYCHTSP
760 770 780 790 800
FLGSLHPGQL LQAFENNLFR APIYLHKMPE SDFLIIRTRQ GYFIRELVDI
810 820 830 840 850
FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK DRPRRIRMED
860 870 880 890 900
IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM
910 920 930 940 950
VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT
960 970 980 990 1000
APWNTTRAFI AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK
1010 1020 1030 1040 1050
EPQPVKKTVT GTDADLRRLS LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV
1060 1070 1080 1090 1100
RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ ERYKEECQRI FDLQNKVLSS
1110 1120 1130 1140 1150
TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR EREEQERKEL
1160 1170 1180 1190 1200
QRMLLAAGSA AAGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY
1210 1220 1230 1240 1250
VRCETVRKAT VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE
1260 1270 1280 1290 1300
QLRRLKRNQE KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC
1310 1320 1330 1340 1350
PLYYQTNAPP SNPVAMTEEQ EEELEKTVIH NDNEELIKVE GTKIVLGKQL
1360 1370 1380 1390 1400
IESADEVRRK SLVLKFPKQQ LPPKKKRRVG TTVHCDYLNR PHKSIHRRRT
1410 1420 1430 1440 1450
DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK IITRPMDLQT
1460 1470 1480 1490 1500
LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE
1510 1520 1530 1540 1550
KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH
1560 1570 1580 1590 1600
HPVNKKFVPD YYKVIVSPMD LETIRKNISK HKYQSRESFL DDVNLILANS
1610 1620 1630 1640 1650
VKYNGPESQY TKTAQEIVNV CHQTLTEYDE HLTQLEKDIC TAKEAALEEA
1660 1670 1680 1690 1700
ELESLDPMTP GPYTPQPPDL YDNNTSLSVS RDASVYQDES NLSVLDIPSA
1710 1720 1730 1740 1750
TSEKQLTQEG GDGDGDLADE EEGTVQQPQA SVLYEDLLMS EGEDDEEDAG
1760 1770 1780 1790 1800
SDEEGDNPFF AIQLSESGSD SDVESGSLRP KQPRVLQENT RMGMENEESM
1810 1820 1830 1840 1850
MSYEGDGGDA SRGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE
1860 1870 1880 1890
EDEEEQRSGP SVLSQVHLSE DEEDSEDFHS IAGDTDLDSD E
Length:1,891
Mass (Da):214,419
Last modified:March 6, 2007 - v2
Checksum:i9A4EA0475BB3E885
GO
Isoform 2 (identifier: Q80UV9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-962: Missing.

Note: No experimental confirmation available.

Show »
Length:929
Mass (Da):105,780
Checksum:iA92987089CF8811D
GO
Isoform 3 (identifier: Q80UV9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-198: Missing.

Note: No experimental confirmation available.

Show »
Length:1,870
Mass (Da):212,382
Checksum:iC7C3C29E868C630F
GO

Sequence cautioni

The sequence BAC34383.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171D → E in AAD23348. (PubMed:10070062)Curated
Sequence conflicti221 – 2211S → A in AAD23348. (PubMed:10070062)Curated
Sequence conflicti261 – 2611R → H in AAD23348. (PubMed:10070062)Curated
Sequence conflicti289 – 2891E → K in AAD23348. (PubMed:10070062)Curated
Sequence conflicti867 – 8682LK → EG in AAC62118. (PubMed:9751712)Curated
Sequence conflicti876 – 8761T → Q in AAD23349. (PubMed:10070062)Curated
Sequence conflicti1302 – 13065LYYQT → AFVAS in AAC62118. (PubMed:9751712)Curated
Sequence conflicti1358 – 13581R → P in AAD23350. (PubMed:10070062)Curated
Sequence conflicti1388 – 13881L → F in AAD23350. (PubMed:10070062)Curated
Sequence conflicti1450 – 14501T → E in AAD23350. (PubMed:10070062)Curated
Sequence conflicti1469 – 14702HL → QM in AAD23350. (PubMed:10070062)Curated
Sequence conflicti1736 – 17361D → N in AAH94568. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 962962Missing in isoform 2. 1 PublicationVSP_023320Add
BLAST
Alternative sequencei178 – 19821Missing in isoform 3. 1 PublicationVSP_023321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831722, AL806534 Genomic DNA. Translation: CAM20496.1.
AL831722, AL806534 Genomic DNA. Translation: CAM20497.1.
AL806534, AL831722 Genomic DNA. Translation: CAM21283.1.
AL806534, AL831722 Genomic DNA. Translation: CAM21284.1.
BC047418 mRNA. Translation: AAH47418.1.
BC094568 mRNA. Translation: AAH94568.1.
AK045586 mRNA. Translation: BAC32425.1.
AK046668 mRNA. Translation: BAC32828.1.
AK049826 mRNA. Translation: BAC33938.1.
AK050691 mRNA. Translation: BAC34383.1. Different initiation.
AK132088 mRNA. Translation: BAE20976.1.
AK143571 mRNA. Translation: BAE25442.1.
AF081115 mRNA. Translation: AAD23349.1.
AF081116 mRNA. Translation: AAD23348.1.
AF081117 mRNA. Translation: AAD23350.1.
AF022178 mRNA. Translation: AAC62118.1.
RefSeqiNP_001277658.1. NM_001290729.1.
XP_006528113.1. XM_006528050.1. [Q80UV9-1]
XP_006528115.1. XM_006528052.1. [Q80UV9-3]
UniGeneiMm.261750.

Genome annotation databases

EnsembliENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314. [Q80UV9-3]
GeneIDi270627.
KEGGimmu:270627.
UCSCiuc009txv.2. mouse. [Q80UV9-1]
uc009txy.1. mouse. [Q80UV9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831722 , AL806534 Genomic DNA. Translation: CAM20496.1 .
AL831722 , AL806534 Genomic DNA. Translation: CAM20497.1 .
AL806534 , AL831722 Genomic DNA. Translation: CAM21283.1 .
AL806534 , AL831722 Genomic DNA. Translation: CAM21284.1 .
BC047418 mRNA. Translation: AAH47418.1 .
BC094568 mRNA. Translation: AAH94568.1 .
AK045586 mRNA. Translation: BAC32425.1 .
AK046668 mRNA. Translation: BAC32828.1 .
AK049826 mRNA. Translation: BAC33938.1 .
AK050691 mRNA. Translation: BAC34383.1 . Different initiation.
AK132088 mRNA. Translation: BAE20976.1 .
AK143571 mRNA. Translation: BAE25442.1 .
AF081115 mRNA. Translation: AAD23349.1 .
AF081116 mRNA. Translation: AAD23348.1 .
AF081117 mRNA. Translation: AAD23350.1 .
AF022178 mRNA. Translation: AAC62118.1 .
RefSeqi NP_001277658.1. NM_001290729.1.
XP_006528113.1. XM_006528050.1. [Q80UV9-1 ]
XP_006528115.1. XM_006528052.1. [Q80UV9-3 ]
UniGenei Mm.261750.

3D structure databases

ProteinModelPortali Q80UV9.
SMRi Q80UV9. Positions 610-992, 1380-1646.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80UV9.

Proteomic databases

MaxQBi Q80UV9.
PaxDbi Q80UV9.
PRIDEi Q80UV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000118878 ; ENSMUSP00000112772 ; ENSMUSG00000031314 . [Q80UV9-3 ]
GeneIDi 270627.
KEGGi mmu:270627.
UCSCi uc009txv.2. mouse. [Q80UV9-1 ]
uc009txy.1. mouse. [Q80UV9-2 ]

Organism-specific databases

CTDi 6872.
MGIi MGI:1336878. Taf1.

Phylogenomic databases

eggNOGi COG5076.
GeneTreei ENSGT00390000012659.
HOVERGENi HBG050223.
InParanoidi Q80UV9.
KOi K03125.
OrthoDBi EOG7QNVK2.

Enzyme and pathway databases

Reactomei REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.

Miscellaneous databases

ChiTaRSi Taf1. mouse.
PROi Q80UV9.
SOURCEi Search...

Gene expression databases

Bgeei Q80UV9.
ExpressionAtlasi Q80UV9. baseline and differential.
Genevestigatori Q80UV9.

Family and domain databases

Gene3Di 1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF003047. TAF1_animal. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
[Graphical view ]
SUPFAMi SSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-1891.
    Strain: C57BL/6 and Czech II.
    Tissue: Brain and Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-280 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 849-1237 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401 AND 1143-1891.
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Corpora quadrigemina, Head, Hippocampus and Spleen.
  4. "TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin."
    Saadane N., Alpert L., Chalifour L.E.
    Am. J. Physiol. 276:H803-H814(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-370; 841-876 AND 1199-1488.
    Strain: CD-1.
    Tissue: Heart.
  5. "HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes."
    Weissman J.D., Brown J.A., Howcroft T.K., Hwang J., Chawla A., Roche P.A., Schiltz L., Nakatani Y., Singer D.S.
    Proc. Natl. Acad. Sci. U.S.A. 95:11601-11606(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-1306.
    Tissue: Spleen.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-565, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTAF1_MOUSE
AccessioniPrimary (citable) accession number: Q80UV9
Secondary accession number(s): A2AM32
, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3