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Protein

Membrane-associated progesterone receptor component 2

Gene

Pgrmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for steroids.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2
Gene namesi
Name:Pgrmc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918054. Pgrmc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Membrane-associated progesterone receptor component 2PRO_0000121744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei204 – 2041PhosphotyrosineBy similarity
Modified residuei205 – 2051PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80UU9.
MaxQBiQ80UU9.
PaxDbiQ80UU9.
PRIDEiQ80UU9.

PTM databases

iPTMnetiQ80UU9.
PhosphoSiteiQ80UU9.
SwissPalmiQ80UU9.

Expressioni

Gene expression databases

BgeeiQ80UU9.
CleanExiMM_PGRMC2.
GenevisibleiQ80UU9. MM.

Interactioni

Protein-protein interaction databases

BioGridi214264. 2 interactions.
IntActiQ80UU9. 3 interactions.
MINTiMINT-4997589.
STRINGi10090.ENSMUSP00000056643.

Structurei

3D structure databases

ProteinModelPortaliQ80UU9.
SMRiQ80UU9. Positions 96-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 195100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 131 and 155.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ80UU9.
KOiK17278.
OMAiKDHSKQD.
OrthoDBiEOG7KWSKJ.
PhylomeDBiQ80UU9.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80UU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGDGDVKL STLGSGGESG GDGSPGGAGA TAARSSWVAA LLATGGEMLL
60 70 80 90 100
NVALVALVLL GAYRLWVRWG RRGLCSGPGA GEESPAATLP RMKKRDFSLE
110 120 130 140 150
QLRQYDGART PRILLAVNGK VFDVTKGSKF YGPAGPYGIF AGRDASRGLA
160 170 180 190 200
TFCLDKDALR DEYDDLSDLN AVQMESVREW EMQFKEKYDY VGRLLKPGEE
210
PSEYTDEEDT KDHSKQD
Length:217
Mass (Da):23,334
Last modified:January 9, 2007 - v2
Checksum:i0291B0EFE8AD3403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100511 Genomic DNA. No translation available.
BC044759 mRNA. Translation: AAH44759.1.
CCDSiCCDS50899.1.
RefSeqiNP_081834.1. NM_027558.1.
UniGeneiMm.40321.

Genome annotation databases

EnsembliENSMUST00000058578; ENSMUSP00000056643; ENSMUSG00000049940.
GeneIDi70804.
KEGGimmu:70804.
UCSCiuc008pce.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100511 Genomic DNA. No translation available.
BC044759 mRNA. Translation: AAH44759.1.
CCDSiCCDS50899.1.
RefSeqiNP_081834.1. NM_027558.1.
UniGeneiMm.40321.

3D structure databases

ProteinModelPortaliQ80UU9.
SMRiQ80UU9. Positions 96-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214264. 2 interactions.
IntActiQ80UU9. 3 interactions.
MINTiMINT-4997589.
STRINGi10090.ENSMUSP00000056643.

PTM databases

iPTMnetiQ80UU9.
PhosphoSiteiQ80UU9.
SwissPalmiQ80UU9.

Proteomic databases

EPDiQ80UU9.
MaxQBiQ80UU9.
PaxDbiQ80UU9.
PRIDEiQ80UU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058578; ENSMUSP00000056643; ENSMUSG00000049940.
GeneIDi70804.
KEGGimmu:70804.
UCSCiuc008pce.2. mouse.

Organism-specific databases

CTDi10424.
MGIiMGI:1918054. Pgrmc2.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ80UU9.
KOiK17278.
OMAiKDHSKQD.
OrthoDBiEOG7KWSKJ.
PhylomeDBiQ80UU9.
TreeFamiTF314562.

Miscellaneous databases

ChiTaRSiPgrmc2. mouse.
PROiQ80UU9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UU9.
CleanExiMM_PGRMC2.
GenevisibleiQ80UU9. MM.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-217.
    Strain: 129.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPGRC2_MOUSE
AccessioniPrimary (citable) accession number: Q80UU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.