Q80UU2 (RPP38_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 66.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ribonuclease P protein subunit p38 Short name=RNaseP protein p38 EC=3.1.26.5 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 280 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus By similarity. |
| Catalytic activity | Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. |
| Subunit structure | RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RPP38 is probably a dimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the ribosomal protein L7Ae family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | tRNA processing |
| Cellular component | Nucleus |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ribonuclease P activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 280 | 280 | Ribonuclease P protein subunit p38 | PRO_0000136784 | |||||
Regions | |||||||||
| Compositional bias | 63 – 68 | 6 | Poly-Lys | ||||||
Amino acid modifications | |||||||||
| Modified residue | 221 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 230 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 26 | 1 | N → D in BAE23865. Ref.1 | ||||||
| Sequence conflict | 107 | 1 | Q → K in BAE23865. Ref.1 | ||||||
| Sequence conflict | 177 | 1 | S → F in BAC40000. Ref.1 | ||||||
| Sequence conflict | 177 | 1 | S → F in BAE23865. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Aorta and Ovary. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He. Tissue: Mesenchymal stem cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC051448 mRNA. Translation: AAH51448.1. AK087782 mRNA. Translation: BAC40000.1. AK139023 mRNA. Translation: BAE23865.1. |
| IPI | IPI00330367. |
| UniGene | Mm.293948. |
3D structure databases | |
| ProteinModelPortal | Q80UU2. |
| SMR | Q80UU2. Positions 105-192. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 10090.ENSMUSP00000050992. |
PTM databases | |
| PhosphoSite | Q80UU2. |
Proteomic databases | |
| PaxDb | Q80UU2. |
| PRIDE | Q80UU2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| MGI | MGI:2443607. Rpp38. |
Phylogenomic databases | |
| eggNOG | NOG308103. |
| HOGENOM | HOG000231566. |
| HOVERGEN | HBG060241. |
| InParanoid | Q80UU2. |
| OrthoDB | EOG4Q84ZM. |
Gene expression databases | |
| CleanEx | MM_RPP38. |
| Genevestigator | Q80UU2. |
Family and domain databases | |
| InterPro | IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45. [Graphical view] |
| Pfam | PF01248. Ribosomal_L7Ae. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | RPP38_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q80UU2 Secondary accession number(s): Q3UTW5, Q8BU46 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Ribosomal proteins Ribosomal proteins families and list of entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |