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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

Ankzf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 12025C2H2-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Gene namesi
Name:Ankzf1
Synonyms:D1Ertd161e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098746. Ankzf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Ankyrin repeat and zinc finger domain-containing protein 1PRO_0000247279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei282 – 2821PhosphoserineBy similarity
Modified residuei555 – 5551PhosphoserineBy similarity
Modified residuei629 – 6291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80UU1.
MaxQBiQ80UU1.
PaxDbiQ80UU1.
PRIDEiQ80UU1.

PTM databases

PhosphoSiteiQ80UU1.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
VcpQ018532EBI-9510971,EBI-80597

Protein-protein interaction databases

IntActiQ80UU1. 1 interaction.
STRINGi10090.ENSMUSP00000136163.

Structurei

3D structure databases

ProteinModelPortaliQ80UU1.
SMRiQ80UU1. Positions 523-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati515 – 54531ANK 1Add
BLAST
Repeati556 – 58530ANK 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni654 – 66613VCP/p97-interacting motif (VIM)By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili628 – 68154Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 12025C2H2-typeAdd
BLAST

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
HOVERGENiHBG080842.
InParanoidiQ80UU1.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80UU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPAGDAAV GSRSGELFLP SVSSSATSPA PSAAPAPASV SLLSLNGEAP
60 70 80 90 100
LIRGLSLVSQ APGEALAWAP RTSCPGENTS SGGKVSPYSL EISEKLFCSA
110 120 130 140 150
CDQIFQNHQE QREHYKLDWH RFNLKQRLKN KPLLSASDFE QQSSTGDLSS
160 170 180 190 200
ISGSDDTDSS SEEDLLPLDE GRAESEKPNR PPGFYPHRVL FKNAQGQFLY
210 220 230 240 250
AYRCVLGPHQ IPPEKAELLL QNLQNGGPRY YVVLMAAAGH FAGAIFQGRE
260 270 280 290 300
VVAHKTFHRY TVRAKRGTAQ GLQDAHGRAS RSAGANLRRY NEAMLYKDVR
310 320 330 340 350
NLLAGPIWSK ALGEAETVLF RAPRSGRSLF FGGQGAPLQR DDPRLWDIPL
360 370 380 390 400
TTRRPTFGEL QRVLHKLTTL QVYDEDPREM VRFHSPETHW KPVREERKKD
410 420 430 440 450
TEKEKTKVPS DANKPLGQDE EPLKQGSESQ EEDGSEVELE LVELTLGTLD
460 470 480 490 500
LREFEVLPKR RRRRKKKERS QEQQCGAHGP LPQQPQDEPF SQPTQEVETP
510 520 530 540 550
LDTLVYEAKA PGQPELWDTL LAACRAGEVE VLKLQLATGL VDPGVKSLLN
560 570 580 590 600
APLGSGGFTL LHAAAAAGRG LVVRLLLEAG ADPTVQDSRA RPPYTVAADK
610 620 630 640 650
STRNEFRRFM EKNLDAYDYN KARVPGPLTQ EMEARQATRK KEQKAARRQR
660 670 680 690 700
EQQQRKQREQ EEQEQEEQRR FAALSDREKR ALAAERRLAA QLGAPSPPVP
710 720 730 740
DSAVASAGRC WSCGVSLQGL IPFHYLDFSF CSTRCLRDHR SQAGRPSS
Length:748
Mass (Da):82,976
Last modified:July 25, 2006 - v2
Checksum:i38E877B35B4A7594
GO
Isoform 2 (identifier: Q80UU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-225: IPPEKAELLLQNLQN → ASNSPDCVLTPNF
     226-748: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):23,908
Checksum:i1FBB0EABB06F42F8
GO

Sequence cautioni

The sequence AK157405 differs from that shown. Reason: Frameshift at position 358. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → S in AAH51449 (PubMed:15489334).Curated
Sequence conflicti35 – 351P → S in AAH51449 (PubMed:15489334).Curated
Sequence conflicti73 – 731S → T in AAH51449 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei211 – 22515IPPEK…QNLQN → ASNSPDCVLTPNF in isoform 2. 1 PublicationVSP_019961Add
BLAST
Alternative sequencei226 – 748523Missing in isoform 2. 1 PublicationVSP_019962Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012672 mRNA. Translation: BAB28398.1.
AK156255 mRNA. Translation: BAE33643.1.
AK157405 mRNA. No translation available.
BC051449 mRNA. Translation: AAH51449.1.
BC057896 mRNA. Translation: AAH57896.1.
BC150879 mRNA. Translation: AAI50880.1.
CCDSiCCDS56632.1. [Q80UU1-1]
RefSeqiNP_001254549.1. NM_001267620.1.
UniGeneiMm.259326.

Genome annotation databases

GeneIDi52231.
KEGGimmu:52231.
UCSCiuc029qpf.2. mouse. [Q80UU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012672 mRNA. Translation: BAB28398.1.
AK156255 mRNA. Translation: BAE33643.1.
AK157405 mRNA. No translation available.
BC051449 mRNA. Translation: AAH51449.1.
BC057896 mRNA. Translation: AAH57896.1.
BC150879 mRNA. Translation: AAI50880.1.
CCDSiCCDS56632.1. [Q80UU1-1]
RefSeqiNP_001254549.1. NM_001267620.1.
UniGeneiMm.259326.

3D structure databases

ProteinModelPortaliQ80UU1.
SMRiQ80UU1. Positions 523-646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80UU1. 1 interaction.
STRINGi10090.ENSMUSP00000136163.

PTM databases

PhosphoSiteiQ80UU1.

Proteomic databases

EPDiQ80UU1.
MaxQBiQ80UU1.
PaxDbiQ80UU1.
PRIDEiQ80UU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi52231.
KEGGimmu:52231.
UCSCiuc029qpf.2. mouse. [Q80UU1-1]

Organism-specific databases

CTDi55139.
MGIiMGI:1098746. Ankzf1.

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
HOVERGENiHBG080842.
InParanoidiQ80UU1.

Miscellaneous databases

NextBioi308684.
PROiQ80UU1.
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6NCr.
    Tissue: Brain and Hematopoietic stem cell.

Entry informationi

Entry nameiANKZ1_MOUSE
AccessioniPrimary (citable) accession number: Q80UU1
Secondary accession number(s): B9EKG0, Q9CZF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.