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Protein

Max dimerization protein 3

Gene

Mxd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.1 Publication

Miscellaneous

Mice deficient for Mxd3 show increased sensitivity of neuronal and lymphoid cells to gamma-radiation induced apoptosis.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Max dimerization protein 3
Short name:
Max dimerizer 3
Alternative name(s):
Max-associated protein 3
Gene namesi
Name:Mxd3
Synonyms:Mad3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:104987. Mxd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537081 – 206Max dimerization protein 3Add BLAST206

Proteomic databases

PaxDbiQ80US8.
PRIDEiQ80US8.

PTM databases

PhosphoSitePlusiQ80US8.

Expressioni

Tissue specificityi

Expressed only in the proliferating areas of the testis and thymus.1 Publication

Developmental stagei

Expressed during neural and epidermal differentiation. Expression restricted to proliferating cells prior to differentiation. Specifically expressed in the S phase of the cell cycle in neuronal progenitor cells. In the developing embryo, detected from 9.5 to 12.5 dpc especially in the ventricular zone of the neuroepithelia, in the progression zone of the limb buds and in the aortic arches and liver. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the cells at the perimeter of the ventricular zone. In the developing epidermis, expressed only in the uppermost differentiated cell layers underneath the stratum corneum.2 Publications

Gene expression databases

BgeeiENSMUSG00000021485.
CleanExiMM_MXD3.
GenevisibleiQ80US8. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201271. 1 interactor.
DIPiDIP-948N.
STRINGi10090.ENSMUSP00000021941.

Structurei

3D structure databases

ProteinModelPortaliQ80US8.
SMRiQ80US8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 109bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 25Interaction with SIN3A and SIN3B1 PublicationAdd BLAST18

Phylogenomic databases

eggNOGiENOG410IPD7. Eukaryota.
ENOG410YHJP. LUCA.
GeneTreeiENSGT00510000046360.
HOGENOMiHOG000247060.
HOVERGENiHBG006314.
InParanoidiQ80US8.
KOiK09114.
OMAiARVHIQK.
OrthoDBiEOG091G0QBK.
PhylomeDBiQ80US8.
TreeFamiTF315654.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80US8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVASNIQV LLQAAEFLER REREAEHGYA SLCPHHSPGT VCRRRKPPLQ
60 70 80 90 100
APGALNSGRS VHNELEKRRR AQLKRCLEQL RQQMPLGVDC TRYTTLSLLR
110 120 130 140 150
RARVHIQKLE EQEQQARRLK EKLRSKQQSL QQQLEQLQGL PGARERERLR
160 170 180 190 200
ADSLDSSGLS SERSDSDQED LEVDVESLVF GTETELLQSF SAGREHSYSH

STCAWL
Length:206
Mass (Da):23,635
Last modified:June 1, 2003 - v1
Checksum:i17E1149064907085
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177S → N in AAB02794 (PubMed:8521822).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32394 mRNA. Translation: AAB02794.1.
AK138742 mRNA. Translation: BAE23764.1.
BC051970 mRNA. Translation: AAH51970.1.
CCDSiCCDS26543.1.
PIRiS60005.
RefSeqiNP_057871.2. NM_016662.4.
UniGeneiMm.20350.

Genome annotation databases

EnsembliENSMUST00000021941; ENSMUSP00000021941; ENSMUSG00000021485.
GeneIDi17121.
KEGGimmu:17121.
UCSCiuc007qqn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMAD3_MOUSE
AccessioniPrimary (citable) accession number: Q80US8
Secondary accession number(s): Q60947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot