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Q80UP8

- S20A2_MOUSE

UniProt

Q80UP8 - S20A2_MOUSE

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Protein
Sodium-dependent phosphate transporter 2
Gene
Slc20a2, Pit2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor By similarity.1 Publication

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Solute carrier family 20 member 2
Type III sodium-dependent phosphate transporter
Gene namesi
Name:Slc20a2
Synonyms:Pit2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:97851. Slc20a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Extracellular Reviewed prediction
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Topological domaini27 – 4620Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Topological domaini68 – 8619Extracellular Reviewed prediction
Add
BLAST
Topological domaini108 – 1092Cytoplasmic Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST
Topological domaini131 – 14212Extracellular Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 19027Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Topological domaini212 – 2132Extracellular Reviewed prediction
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Topological domaini235 – 483249Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 53127Extracellular Reviewed prediction
Add
BLAST
Transmembranei532 – 55221Helical; Reviewed prediction
Add
BLAST
Topological domaini553 – 57220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei573 – 58715Helical; Reviewed prediction
Add
BLAST
Topological domaini588 – 5947Extracellular Reviewed prediction
Transmembranei595 – 61016Helical; Reviewed prediction
Add
BLAST
Topological domaini611 – 62212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei623 – 64321Helical; Reviewed prediction
Add
BLAST
Topological domaini644 – 65512Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Sodium-dependent phosphate transporter 2
PRO_0000341269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Modified residuei268 – 2681Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80UP8.
PRIDEiQ80UP8.

PTM databases

PhosphoSiteiQ80UP8.

Expressioni

Tissue specificityi

Widely expressed including intestine, kidney, heart, liver, brain, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium.1 Publication

Gene expression databases

ArrayExpressiQ80UP8.
BgeeiQ80UP8.
GenevestigatoriQ80UP8.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ80UP8. 1 interaction.
MINTiMINT-4129248.

Structurei

3D structure databases

ProteinModelPortaliQ80UP8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ80UP8.
KOiK14640.
OMAiPYGRAFS.
OrthoDBiEOG79KPDT.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UP8-1 [UniParc]FASTAAdd to Basket

« Hide

MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS 150
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY 200
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES 250
ALSRASDESL RKVQEAESPG FKELPGAKPS DDSAVPLTSL AGEAVGASEG 300
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD 350
SGLYKDLLHK IHVDRGSEEK PTQENNYRLL RRNNSYTCYT AAICGMPVHT 400
TFRASDTSSA PEDSEKLVGD SVSYSKKRLR YDSYSSYCNA VAEAEIEAEE 450
GGVEMRLASE LADPDRPHED PTEEEKEEKD SAEVHLLFHF LQVLTACFGS 500
FAHGGNDVSN AIGPLVALWL IYQQGGVTQE AATPVWLLFY GGVGICTGLW 550
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 600
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYICG 650
LFSSSR 656
Length:656
Mass (Da):70,866
Last modified:July 27, 2011 - v2
Checksum:i0E4678A705B878CB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531I → V in AAG28493. 1 Publication
Sequence conflicti53 – 531I → V in BAE42159. 1 Publication
Sequence conflicti53 – 531I → V in BAE33999. 1 Publication
Sequence conflicti53 – 531I → V in AAH46510. 1 Publication
Sequence conflicti55 – 551E → A in AAG28493. 1 Publication
Sequence conflicti123 – 1231I → T in AAG28493. 1 Publication
Sequence conflicti387 – 3871T → A in AAG28493. 1 Publication
Sequence conflicti487 – 4871L → F in AAG28493. 1 Publication
Sequence conflicti614 – 6141A → T in BAE42159. 1 Publication
Sequence conflicti644 – 65613LLMYI…FSSSR → SFMYGILPYV in AAG28493. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF196476 mRNA. Translation: AAG28493.1.
AK157206 mRNA. Translation: BAE33999.1.
AK170985 mRNA. Translation: BAE42159.1.
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1.
CCDSiCCDS22178.1.
RefSeqiNP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.1.
XP_006509107.1. XM_006509044.1.
UniGeneiMm.323901.
Mm.378231.

Genome annotation databases

EnsembliENSMUST00000067786; ENSMUSP00000065935; ENSMUSG00000037656.
GeneIDi20516.
KEGGimmu:20516.
UCSCiuc009ldf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF196476 mRNA. Translation: AAG28493.1 .
AK157206 mRNA. Translation: BAE33999.1 .
AK170985 mRNA. Translation: BAE42159.1 .
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1 .
CCDSi CCDS22178.1.
RefSeqi NP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.1.
XP_006509107.1. XM_006509044.1.
UniGenei Mm.323901.
Mm.378231.

3D structure databases

ProteinModelPortali Q80UP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80UP8. 1 interaction.
MINTi MINT-4129248.

PTM databases

PhosphoSitei Q80UP8.

Proteomic databases

PaxDbi Q80UP8.
PRIDEi Q80UP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067786 ; ENSMUSP00000065935 ; ENSMUSG00000037656 .
GeneIDi 20516.
KEGGi mmu:20516.
UCSCi uc009ldf.2. mouse.

Organism-specific databases

CTDi 6575.
MGIi MGI:97851. Slc20a2.

Phylogenomic databases

eggNOGi COG0306.
GeneTreei ENSGT00390000014879.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
InParanoidi Q80UP8.
KOi K14640.
OMAi PYGRAFS.
OrthoDBi EOG79KPDT.
TreeFami TF314426.

Miscellaneous databases

ChiTaRSi SLC20A2. mouse.
NextBioi 298727.
PROi Q80UP8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80UP8.
Bgeei Q80UP8.
Genevestigatori Q80UP8.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine."
    Bai L., Collins J.F., Ghishan F.K.
    Am. J. Physiol. 279:C1135-C1143(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS20A2_MOUSE
AccessioniPrimary (citable) accession number: Q80UP8
Secondary accession number(s): E9QLQ8, Q3TBZ8, Q9ES96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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