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Q80UP8

- S20A2_MOUSE

UniProt

Q80UP8 - S20A2_MOUSE

Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor By similarity.By similarity

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. phosphate ion transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW
    3. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 2
    Alternative name(s):
    Phosphate transporter 2
    Short name:
    PiT-2
    Solute carrier family 20 member 2
    Type III sodium-dependent phosphate transporter
    Gene namesi
    Name:Slc20a2
    Synonyms:Pit2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:97851. Slc20a2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Sodium-dependent phosphate transporter 2PRO_0000341269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei268 – 2681Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ80UP8.
    PRIDEiQ80UP8.

    PTM databases

    PhosphoSiteiQ80UP8.

    Expressioni

    Tissue specificityi

    Widely expressed including intestine, kidney, heart, liver, brain, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium.1 Publication

    Gene expression databases

    ArrayExpressiQ80UP8.
    BgeeiQ80UP8.
    GenevestigatoriQ80UP8.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ80UP8. 1 interaction.
    MINTiMINT-4129248.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80UP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1092CytoplasmicSequence Analysis
    Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2132ExtracellularSequence Analysis
    Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini588 – 5947ExtracellularSequence Analysis
    Topological domaini611 – 62212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini644 – 65512ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei573 – 58715HelicalSequence AnalysisAdd
    BLAST
    Transmembranei595 – 61016HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0306.
    GeneTreeiENSGT00390000014879.
    HOGENOMiHOG000231892.
    HOVERGENiHBG053358.
    InParanoidiQ80UP8.
    KOiK14640.
    OMAiPYGRAFS.
    OrthoDBiEOG79KPDT.
    TreeFamiTF314426.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80UP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
    ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
    WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS 150
    PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY 200
    TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES 250
    ALSRASDESL RKVQEAESPG FKELPGAKPS DDSAVPLTSL AGEAVGASEG 300
    TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD 350
    SGLYKDLLHK IHVDRGSEEK PTQENNYRLL RRNNSYTCYT AAICGMPVHT 400
    TFRASDTSSA PEDSEKLVGD SVSYSKKRLR YDSYSSYCNA VAEAEIEAEE 450
    GGVEMRLASE LADPDRPHED PTEEEKEEKD SAEVHLLFHF LQVLTACFGS 500
    FAHGGNDVSN AIGPLVALWL IYQQGGVTQE AATPVWLLFY GGVGICTGLW 550
    VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 600
    GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYICG 650
    LFSSSR 656
    Length:656
    Mass (Da):70,866
    Last modified:July 27, 2011 - v2
    Checksum:i0E4678A705B878CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531I → V in AAG28493. (PubMed:11003594)Curated
    Sequence conflicti53 – 531I → V in BAE42159. (PubMed:16141072)Curated
    Sequence conflicti53 – 531I → V in BAE33999. (PubMed:16141072)Curated
    Sequence conflicti53 – 531I → V in AAH46510. (PubMed:15489334)Curated
    Sequence conflicti55 – 551E → A in AAG28493. (PubMed:11003594)Curated
    Sequence conflicti123 – 1231I → T in AAG28493. (PubMed:11003594)Curated
    Sequence conflicti387 – 3871T → A in AAG28493. (PubMed:11003594)Curated
    Sequence conflicti487 – 4871L → F in AAG28493. (PubMed:11003594)Curated
    Sequence conflicti614 – 6141A → T in BAE42159. (PubMed:16141072)Curated
    Sequence conflicti644 – 65613LLMYI…FSSSR → SFMYGILPYV in AAG28493. (PubMed:11003594)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF196476 mRNA. Translation: AAG28493.1.
    AK157206 mRNA. Translation: BAE33999.1.
    AK170985 mRNA. Translation: BAE42159.1.
    AC140326 Genomic DNA. No translation available.
    AC153017 Genomic DNA. No translation available.
    BC046510 mRNA. Translation: AAH46510.1.
    CCDSiCCDS22178.1.
    RefSeqiNP_035524.2. NM_011394.3.
    XP_006509106.1. XM_006509043.1.
    XP_006509107.1. XM_006509044.1.
    UniGeneiMm.323901.
    Mm.378231.

    Genome annotation databases

    EnsembliENSMUST00000067786; ENSMUSP00000065935; ENSMUSG00000037656.
    GeneIDi20516.
    KEGGimmu:20516.
    UCSCiuc009ldf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF196476 mRNA. Translation: AAG28493.1 .
    AK157206 mRNA. Translation: BAE33999.1 .
    AK170985 mRNA. Translation: BAE42159.1 .
    AC140326 Genomic DNA. No translation available.
    AC153017 Genomic DNA. No translation available.
    BC046510 mRNA. Translation: AAH46510.1 .
    CCDSi CCDS22178.1.
    RefSeqi NP_035524.2. NM_011394.3.
    XP_006509106.1. XM_006509043.1.
    XP_006509107.1. XM_006509044.1.
    UniGenei Mm.323901.
    Mm.378231.

    3D structure databases

    ProteinModelPortali Q80UP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80UP8. 1 interaction.
    MINTi MINT-4129248.

    PTM databases

    PhosphoSitei Q80UP8.

    Proteomic databases

    PaxDbi Q80UP8.
    PRIDEi Q80UP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067786 ; ENSMUSP00000065935 ; ENSMUSG00000037656 .
    GeneIDi 20516.
    KEGGi mmu:20516.
    UCSCi uc009ldf.2. mouse.

    Organism-specific databases

    CTDi 6575.
    MGIi MGI:97851. Slc20a2.

    Phylogenomic databases

    eggNOGi COG0306.
    GeneTreei ENSGT00390000014879.
    HOGENOMi HOG000231892.
    HOVERGENi HBG053358.
    InParanoidi Q80UP8.
    KOi K14640.
    OMAi PYGRAFS.
    OrthoDBi EOG79KPDT.
    TreeFami TF314426.

    Miscellaneous databases

    ChiTaRSi SLC20A2. mouse.
    NextBioi 298727.
    PROi Q80UP8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80UP8.
    Bgeei Q80UP8.
    Genevestigatori Q80UP8.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine."
      Bai L., Collins J.F., Ghishan F.K.
      Am. J. Physiol. 279:C1135-C1143(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS20A2_MOUSE
    AccessioniPrimary (citable) accession number: Q80UP8
    Secondary accession number(s): E9QLQ8, Q3TBZ8, Q9ES96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3