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Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-427652. Sodium-coupled phosphate cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Solute carrier family 20 member 2
Type III sodium-dependent phosphate transporter
Gene namesi
Name:Slc20a2
Synonyms:Pit2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97851. Slc20a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 46CytoplasmicSequence analysisAdd BLAST20
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Topological domaini108 – 109CytoplasmicSequence analysis2
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 190CytoplasmicSequence analysisAdd BLAST27
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213ExtracellularSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 483CytoplasmicSequence analysisAdd BLAST249
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 531ExtracellularSequence analysisAdd BLAST27
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 572CytoplasmicSequence analysisAdd BLAST20
Transmembranei573 – 587HelicalSequence analysisAdd BLAST15
Topological domaini588 – 594ExtracellularSequence analysis7
Transmembranei595 – 610HelicalSequence analysisAdd BLAST16
Topological domaini611 – 622CytoplasmicSequence analysisAdd BLAST12
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 655ExtracellularSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412691 – 656Sodium-dependent phosphate transporter 2Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Modified residuei253PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei316PhosphoserineBy similarity1
Modified residuei385PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ80UP8.
PaxDbiQ80UP8.
PeptideAtlasiQ80UP8.
PRIDEiQ80UP8.

PTM databases

iPTMnetiQ80UP8.
PhosphoSitePlusiQ80UP8.

Expressioni

Tissue specificityi

Widely expressed including intestine, kidney, heart, liver, brain, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium.1 Publication

Gene expression databases

BgeeiENSMUSG00000037656.
GenevisibleiQ80UP8. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ80UP8. 1 interactor.
MINTiMINT-4129248.
STRINGi10090.ENSMUSP00000065935.

Structurei

3D structure databases

ProteinModelPortaliQ80UP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ80UP8.
KOiK14640.
OMAiSWFVTPV.
OrthoDBiEOG091G07J5.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES
260 270 280 290 300
ALSRASDESL RKVQEAESPG FKELPGAKPS DDSAVPLTSL AGEAVGASEG
310 320 330 340 350
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHVDRGSEEK PTQENNYRLL RRNNSYTCYT AAICGMPVHT
410 420 430 440 450
TFRASDTSSA PEDSEKLVGD SVSYSKKRLR YDSYSSYCNA VAEAEIEAEE
460 470 480 490 500
GGVEMRLASE LADPDRPHED PTEEEKEEKD SAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYQQGGVTQE AATPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYICG

LFSSSR
Length:656
Mass (Da):70,866
Last modified:July 27, 2011 - v2
Checksum:i0E4678A705B878CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53I → V in AAG28493 (PubMed:11003594).Curated1
Sequence conflicti53I → V in BAE42159 (PubMed:16141072).Curated1
Sequence conflicti53I → V in BAE33999 (PubMed:16141072).Curated1
Sequence conflicti53I → V in AAH46510 (PubMed:15489334).Curated1
Sequence conflicti55E → A in AAG28493 (PubMed:11003594).Curated1
Sequence conflicti123I → T in AAG28493 (PubMed:11003594).Curated1
Sequence conflicti387T → A in AAG28493 (PubMed:11003594).Curated1
Sequence conflicti487L → F in AAG28493 (PubMed:11003594).Curated1
Sequence conflicti614A → T in BAE42159 (PubMed:16141072).Curated1
Sequence conflicti644 – 656LLMYI…FSSSR → SFMYGILPYV in AAG28493 (PubMed:11003594).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196476 mRNA. Translation: AAG28493.1.
AK157206 mRNA. Translation: BAE33999.1.
AK170985 mRNA. Translation: BAE42159.1.
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1.
CCDSiCCDS22178.1.
RefSeqiNP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.2.
XP_006509107.1. XM_006509044.1.
UniGeneiMm.323901.
Mm.378231.
Mm.454460.

Genome annotation databases

EnsembliENSMUST00000067786; ENSMUSP00000065935; ENSMUSG00000037656.
GeneIDi20516.
KEGGimmu:20516.
UCSCiuc009ldf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196476 mRNA. Translation: AAG28493.1.
AK157206 mRNA. Translation: BAE33999.1.
AK170985 mRNA. Translation: BAE42159.1.
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1.
CCDSiCCDS22178.1.
RefSeqiNP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.2.
XP_006509107.1. XM_006509044.1.
UniGeneiMm.323901.
Mm.378231.
Mm.454460.

3D structure databases

ProteinModelPortaliQ80UP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80UP8. 1 interactor.
MINTiMINT-4129248.
STRINGi10090.ENSMUSP00000065935.

PTM databases

iPTMnetiQ80UP8.
PhosphoSitePlusiQ80UP8.

Proteomic databases

MaxQBiQ80UP8.
PaxDbiQ80UP8.
PeptideAtlasiQ80UP8.
PRIDEiQ80UP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067786; ENSMUSP00000065935; ENSMUSG00000037656.
GeneIDi20516.
KEGGimmu:20516.
UCSCiuc009ldf.2. mouse.

Organism-specific databases

CTDi6575.
MGIiMGI:97851. Slc20a2.

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ80UP8.
KOiK14640.
OMAiSWFVTPV.
OrthoDBiEOG091G07J5.
TreeFamiTF314426.

Enzyme and pathway databases

ReactomeiR-MMU-427652. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

ChiTaRSiSlc20a2. mouse.
PROiQ80UP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037656.
GenevisibleiQ80UP8. MM.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS20A2_MOUSE
AccessioniPrimary (citable) accession number: Q80UP8
Secondary accession number(s): E9QLQ8, Q3TBZ8, Q9ES96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.