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Q80UP8

- S20A2_MOUSE

UniProt

Q80UP8 - S20A2_MOUSE

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Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor (By similarity).By similarity

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_256507. Sodium-coupled phosphate cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Solute carrier family 20 member 2
Type III sodium-dependent phosphate transporter
Gene namesi
Name:Slc20a2
Synonyms:Pit2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:97851. Slc20a2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
BLAST
Topological domaini108 – 1092CytoplasmicSequence Analysis
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Topological domaini212 – 2132ExtracellularSequence Analysis
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence AnalysisAdd
BLAST
Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei573 – 58715HelicalSequence AnalysisAdd
BLAST
Topological domaini588 – 5947ExtracellularSequence Analysis
Transmembranei595 – 61016HelicalSequence AnalysisAdd
BLAST
Topological domaini611 – 62212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST
Topological domaini644 – 65512ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Sodium-dependent phosphate transporter 2PRO_0000341269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Modified residuei268 – 2681Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ80UP8.
PaxDbiQ80UP8.
PRIDEiQ80UP8.

PTM databases

PhosphoSiteiQ80UP8.

Expressioni

Tissue specificityi

Widely expressed including intestine, kidney, heart, liver, brain, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium.1 Publication

Gene expression databases

BgeeiQ80UP8.
ExpressionAtlasiQ80UP8. baseline and differential.
GenevestigatoriQ80UP8.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ80UP8. 1 interaction.
MINTiMINT-4129248.

Structurei

3D structure databases

ProteinModelPortaliQ80UP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ80UP8.
KOiK14640.
OMAiPYGRAFS.
OrthoDBiEOG79KPDT.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES
260 270 280 290 300
ALSRASDESL RKVQEAESPG FKELPGAKPS DDSAVPLTSL AGEAVGASEG
310 320 330 340 350
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHVDRGSEEK PTQENNYRLL RRNNSYTCYT AAICGMPVHT
410 420 430 440 450
TFRASDTSSA PEDSEKLVGD SVSYSKKRLR YDSYSSYCNA VAEAEIEAEE
460 470 480 490 500
GGVEMRLASE LADPDRPHED PTEEEKEEKD SAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYQQGGVTQE AATPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYICG

LFSSSR
Length:656
Mass (Da):70,866
Last modified:July 27, 2011 - v2
Checksum:i0E4678A705B878CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531I → V in AAG28493. (PubMed:11003594)Curated
Sequence conflicti53 – 531I → V in BAE42159. (PubMed:16141072)Curated
Sequence conflicti53 – 531I → V in BAE33999. (PubMed:16141072)Curated
Sequence conflicti53 – 531I → V in AAH46510. (PubMed:15489334)Curated
Sequence conflicti55 – 551E → A in AAG28493. (PubMed:11003594)Curated
Sequence conflicti123 – 1231I → T in AAG28493. (PubMed:11003594)Curated
Sequence conflicti387 – 3871T → A in AAG28493. (PubMed:11003594)Curated
Sequence conflicti487 – 4871L → F in AAG28493. (PubMed:11003594)Curated
Sequence conflicti614 – 6141A → T in BAE42159. (PubMed:16141072)Curated
Sequence conflicti644 – 65613LLMYI…FSSSR → SFMYGILPYV in AAG28493. (PubMed:11003594)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196476 mRNA. Translation: AAG28493.1.
AK157206 mRNA. Translation: BAE33999.1.
AK170985 mRNA. Translation: BAE42159.1.
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1.
CCDSiCCDS22178.1.
RefSeqiNP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.1.
XP_006509107.1. XM_006509044.1.
UniGeneiMm.323901.
Mm.378231.

Genome annotation databases

EnsembliENSMUST00000067786; ENSMUSP00000065935; ENSMUSG00000037656.
GeneIDi20516.
KEGGimmu:20516.
UCSCiuc009ldf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196476 mRNA. Translation: AAG28493.1 .
AK157206 mRNA. Translation: BAE33999.1 .
AK170985 mRNA. Translation: BAE42159.1 .
AC140326 Genomic DNA. No translation available.
AC153017 Genomic DNA. No translation available.
BC046510 mRNA. Translation: AAH46510.1 .
CCDSi CCDS22178.1.
RefSeqi NP_035524.2. NM_011394.3.
XP_006509106.1. XM_006509043.1.
XP_006509107.1. XM_006509044.1.
UniGenei Mm.323901.
Mm.378231.

3D structure databases

ProteinModelPortali Q80UP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80UP8. 1 interaction.
MINTi MINT-4129248.

PTM databases

PhosphoSitei Q80UP8.

Proteomic databases

MaxQBi Q80UP8.
PaxDbi Q80UP8.
PRIDEi Q80UP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067786 ; ENSMUSP00000065935 ; ENSMUSG00000037656 .
GeneIDi 20516.
KEGGi mmu:20516.
UCSCi uc009ldf.2. mouse.

Organism-specific databases

CTDi 6575.
MGIi MGI:97851. Slc20a2.

Phylogenomic databases

eggNOGi COG0306.
GeneTreei ENSGT00390000014879.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
InParanoidi Q80UP8.
KOi K14640.
OMAi PYGRAFS.
OrthoDBi EOG79KPDT.
TreeFami TF314426.

Enzyme and pathway databases

Reactomei REACT_256507. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

ChiTaRSi Slc20a2. mouse.
NextBioi 298727.
PROi Q80UP8.
SOURCEi Search...

Gene expression databases

Bgeei Q80UP8.
ExpressionAtlasi Q80UP8. baseline and differential.
Genevestigatori Q80UP8.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine."
    Bai L., Collins J.F., Ghishan F.K.
    Am. J. Physiol. 279:C1135-C1143(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS20A2_MOUSE
AccessioniPrimary (citable) accession number: Q80UP8
Secondary accession number(s): E9QLQ8, Q3TBZ8, Q9ES96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3