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Protein

Ankyrin repeat domain-containing protein 13A

Gene

Ankrd13a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13A
Gene namesi
Name:Ankrd13a
Synonyms:Ankrd13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915670. Ankrd13a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669101 – 588Ankyrin repeat domain-containing protein 13AAdd BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205PhosphoserineCombined sources1
Modified residuei584PhosphoserineBy similarity1

Post-translational modificationi

Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80UP5.
MaxQBiQ80UP5.
PaxDbiQ80UP5.
PRIDEiQ80UP5.

PTM databases

iPTMnetiQ80UP5.
PhosphoSitePlusiQ80UP5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041870.
CleanExiMM_ANKRD13A.
ExpressionAtlasiQ80UP5. baseline and differential.
GenevisibleiQ80UP5. MM.

Interactioni

Subunit structurei

Interacts (via the UIM 3 and 4 repeats) with EGFR (ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.By similarity

Protein-protein interaction databases

IntActiQ80UP5. 1 interactor.
STRINGi10090.ENSMUSP00000099638.

Structurei

3D structure databases

ProteinModelPortaliQ80UP5.
SMRiQ80UP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 69ANK 1Add BLAST30
Repeati73 – 102ANK 2Add BLAST30
Domaini481 – 500UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini517 – 536UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini547 – 566UIM 3PROSITE-ProRule annotationAdd BLAST20
Domaini572 – 588UIM 4PROSITE-ProRule annotationAdd BLAST17

Domaini

The UIM repeats 3 and 4 are required for binding to ubiquitinated EGFR and 'Lys-63'-linked ubiquitin.By similarity

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0522. Eukaryota.
ENOG410XNMS. LUCA.
GeneTreeiENSGT00410000025381.
HOGENOMiHOG000230821.
HOVERGENiHBG059287.
InParanoidiQ80UP5.
OMAiAYDAQYE.
OrthoDBiEOG091G0JTJ.
PhylomeDBiQ80UP5.
TreeFamiTF314176.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR021832. ANKRD13.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003903. UIM_dom.
PANTHERiPTHR12447. PTHR12447. 1 hit.
PfamiView protein in Pfam
PF11904. GPCR_chapero_1. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SM00726. UIM. 3 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50330. UIM. 2 hits.

Sequencei

Sequence statusi: Complete.

Q80UP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARDTSSR FPLHLLVWNN DYEQLEKELR DQNAEALDPR GRTLLHLAVS
60 70 80 90 100
LGHLESARVL LRHKADVTKE NGQGWTVLHE AVSTGDPEMV YTVLQHRDYH
110 120 130 140 150
NTSMALEGVP ELLHKILEAP DFYVQMKWEF TSWVPLVSRI CPNDVCRIWK
160 170 180 190 200
SGAKLRVDIT LLGFENMSWI RGRRSFIFKG GDNWAELMEV NHDDRVVTTE
210 220 230 240 250
HFDLSQEMER LTLDLMKPKS REVERRLTSP VINTSLDTKN VAFERTKSGF
260 270 280 290 300
WGWRTDKAEV VNGYEAKVYS VNNVSVITRI RTEHLTEEEK KRYKEDRNPL
310 320 330 340 350
ESLLGTVEHQ FGAQGDLATE CATVNNPTAI TPDEYFDEDF DLKDRDIGRP
360 370 380 390 400
KELTIRTQKF KATLWMCEEF PLSLVEQVIP IIDLMARTSA HFARLRDFIK
410 420 430 440 450
LDFPPGFPVK IEIPLFHVLN ARITFGNVNG CSTADESQGV EGTPAEAVSE
460 470 480 490 500
ATNFEVDQSV FEIPESYHIQ DNGRNVHLQD EDYEIMQFAI QQSLLESSRS
510 520 530 540 550
QDLSGPASNG GVSHTHSYEA QYERAIQESL LTNMEGRCPG GLSESSRFDS
560 570 580
DLQLAMELSA KELAERELRL QEEEAELQQV LQLSLTEK
Length:588
Mass (Da):67,177
Last modified:July 19, 2004 - v2
Checksum:i70F5B9E0588DECF9
GO

Sequence cautioni

The sequence AAH49187 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049187 mRNA. Translation: AAH49187.1. Different initiation.
BC061692 mRNA. Translation: AAH61692.1.
BC108413 mRNA. Translation: AAI08414.1.
CCDSiCCDS19572.1.
RefSeqiNP_080994.2. NM_026718.2.
UniGeneiMm.275554.

Genome annotation databases

EnsembliENSMUST00000102578; ENSMUSP00000099638; ENSMUSG00000041870.
GeneIDi68420.
KEGGimmu:68420.
UCSCiuc008zaf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiAN13A_MOUSE
AccessioniPrimary (citable) accession number: Q80UP5
Secondary accession number(s): Q2VPQ7, Q6P7F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot