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Q80UP3

- DGKZ_MOUSE

UniProt

Q80UP3 - DGKZ_MOUSE

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Protein

Diacylglycerol kinase zeta

Gene
Dgkz
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity By similarity.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri98 – 15356Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri173 – 23159Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC
  3. enzyme inhibitor activity Source: MGI
  4. metal ion binding Source: UniProtKB-KW
  5. NAD+ kinase activity Source: InterPro
  6. protein binding Source: IntAct

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. negative regulation of catalytic activity Source: GOC
  3. negative regulation of Ras protein signal transduction Source: MGI
  4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:Dgkz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1278339. Dgkz.

Subcellular locationi

Cytoplasm. Nucleus. Cell membrane By similarity 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929929Diacylglycerol kinase zetaPRO_0000218469Add
BLAST

Proteomic databases

PaxDbiQ80UP3.
PRIDEiQ80UP3.

PTM databases

PhosphoSiteiQ80UP3.

Expressioni

Gene expression databases

ArrayExpressiQ80UP3.
BgeeiQ80UP3.
CleanExiMM_DGKZ.
GenevestigatoriQ80UP3.

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Rb1P134052EBI-971774,EBI-971782

Protein-protein interaction databases

BioGridi222626. 8 interactions.
IntActiQ80UP3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80UP3.
SMRiQ80UP3. Positions 792-927.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini292 – 426135DAGKcAdd
BLAST
Repeati823 – 85331ANK 1Add
BLAST
Repeati858 – 88730ANK 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 417139Mediates interaction with RASGRP1 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi362 – 3709Nuclear export signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Pro
Compositional biasi260 – 2634Poly-Lys
Compositional biasi372 – 3754Poly-Pro

Sequence similaritiesi

Contains 2 ANK repeats.
Contains 1 DAGKc domain.

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00740000115137.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.
KOiK00901.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UP3-1 [UniParc]FASTAAdd to Basket

« Hide

MEPRDPSPEG RSSDSESASA SSSGSERDAG PEPDKAPRRL TKRRFPGLRL    50
FGHRKAITKS GLQHLAPPPP TPGAPCGESE EQIQSTVDWS ESAVYGEHIW 100
FETNVSGDFC YVGEQHCVAK MLPKSAPRKK CAACKIVVHT QCIKQLEKIN 150
FRCKPSFRES GSRNVREPTF VRHHWVHRRR QDGKCRHCGK GFQQKFTFHS 200
KEIVAISCSW CKQAYHSKVS CFMMQQIEEP CSLGVHAAVV IPPTWILRAR 250
RPQNTLKASK KKKRASFKRR SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF 300
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPREALEM YRKVHNLRIL 350
ACGGDGTVGW ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE 400
PVSKILSHVE EGNVVQLDRW DLRAEPNPEA GPEERDDGAT DRLPLDVFNN 450
YFSLGFDAHV TLEFHESREA NPEKFNSRFR NKMFYAGTAF SDFLMGSSKD 500
LAKHIRVVCD GMDLTPKIQD LKPQCIVFLN IPRYCAGTMP WGHPGEHHDF 550
EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVLL TTAKAIPVQV 600
DGEPCKLSAS RIRIALRNQA TMVQKAKRRS TAPLHSDQQP VPEQLRIQVS 650
RVSMHDYEAL HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQREPD 700
GAGAKSPMCH QLSSKWCFLD ATTASRFYRI DRAQEHLNYV TEIAQDEIYI 750
LDPELLGASA RPDLPTPTSP LPASPCSPTP GSMQGDTALP QGEELIEAAK 800
RNDCCKLQEL HRAGGDLMHR DQKSRTLLHH AVSTGSKEVV RYLLDHAPPE 850
ILDAVEENGE TCLHQAAALG QRTICHYIVE AGASLMKTDL QGDTPRQRAE 900
KAQDTELAAY LENRQHYQMI QREDQETAV 929
Length:929
Mass (Da):104,031
Last modified:July 27, 2011 - v2
Checksum:iAC3E48790E3C3463
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti908 – 9081A → S in AAH49228. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731772, AL732484 Genomic DNA. Translation: CAM19275.1.
AL732484, AL731772 Genomic DNA. Translation: CAM22583.1.
BC049228 mRNA. Translation: AAH49228.1.
CCDSiCCDS16441.1.
RefSeqiNP_612179.2. NM_138306.2.
UniGeneiMm.314923.

Genome annotation databases

EnsembliENSMUST00000028667; ENSMUSP00000028667; ENSMUSG00000040479.
GeneIDi104418.
KEGGimmu:104418.
UCSCiuc008kxc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731772 , AL732484 Genomic DNA. Translation: CAM19275.1 .
AL732484 , AL731772 Genomic DNA. Translation: CAM22583.1 .
BC049228 mRNA. Translation: AAH49228.1 .
CCDSi CCDS16441.1.
RefSeqi NP_612179.2. NM_138306.2.
UniGenei Mm.314923.

3D structure databases

ProteinModelPortali Q80UP3.
SMRi Q80UP3. Positions 792-927.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222626. 8 interactions.
IntActi Q80UP3. 1 interaction.

PTM databases

PhosphoSitei Q80UP3.

Proteomic databases

PaxDbi Q80UP3.
PRIDEi Q80UP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028667 ; ENSMUSP00000028667 ; ENSMUSG00000040479 .
GeneIDi 104418.
KEGGi mmu:104418.
UCSCi uc008kxc.2. mouse.

Organism-specific databases

CTDi 8525.
MGIi MGI:1278339. Dgkz.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00740000115137.
HOGENOMi HOG000231472.
HOVERGENi HBG067303.
KOi K00901.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSi DGKZ. mouse.
NextBioi 357101.
PROi Q80UP3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80UP3.
Bgeei Q80UP3.
CleanExi MM_DGKZ.
Genevestigatori Q80UP3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  3. "Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta."
    Evangelisti C., Gaboardi G.C., Billi A.M., Ognibene A., Goto K., Tazzari P.L., McCubrey J.A., Martelli A.M.
    Cell Cycle 9:384-388(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.

Entry informationi

Entry nameiDGKZ_MOUSE
AccessioniPrimary (citable) accession number: Q80UP3
Secondary accession number(s): A2AHJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi