Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q80UM7

- MOGS_MOUSE

UniProt

Q80UM7 - MOGS_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mannosyl-oligosaccharide glucosidase

Gene

Mogs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor.By similarity

Catalytic activityi

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathwayi

GO - Molecular functioni

  1. mannosyl-oligosaccharide glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. oligosaccharide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198618. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
UniPathwayiUPA00280.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
Alternative name(s):
Glucosidase 1
Glycoprotein-processing glucosidase I
Gene namesi
Name:Mogs
Synonyms:Gcs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1929872. Mogs.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini65 – 834770LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi654 – 6541N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80UM7.
PaxDbiQ80UM7.
PRIDEiQ80UM7.

PTM databases

PhosphoSiteiQ80UM7.

Expressioni

Gene expression databases

BgeeiQ80UM7.
CleanExiMM_GCS1.
ExpressionAtlasiQ80UM7. baseline and differential.
GenevestigatoriQ80UM7.

Interactioni

Protein-protein interaction databases

BioGridi208276. 1 interaction.
IntActiQ80UM7. 3 interactions.
MINTiMINT-4095856.

Structurei

3D structure databases

ProteinModelPortaliQ80UM7.
SMRiQ80UM7. Positions 92-831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 13663Required for endoplasmic reticulum targetingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 97Endoplasmic reticulum targeting

Sequence similaritiesi

Belongs to the glycosyl hydrolase 63 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305138.
GeneTreeiENSGT00390000017452.
HOGENOMiHOG000201473.
InParanoidiQ80UM7.
KOiK01228.
OMAiWKAPLYT.
OrthoDBiEOG7XSTD6.
PhylomeDBiQ80UM7.
TreeFamiTF300749.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80UM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGERRRRA AAAEGARPLE RARAAGRRDG RAGGARGSAS GAALAVVVLA
60 70 80 90 100
LAFGLSGRWV LAWLRVRRAL TLHPAPSALP PDSSSPAVAP ELFWGTYRPH
110 120 130 140 150
VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH
160 170 180 190 200
DGRTFGRQHI HDGALRLTTE FVKRPGGQHG GDWSWRVTVE PQASGTPSFP
210 220 230 240 250
LVSLFFYVVT DGQEVLLPEI GAKGQLKSIS GHTSELGDFR LTLLPPTSPG
260 270 280 290 300
DTVPKHGSYN VFWSSNPGLP QLTDMVKSRL NSWFQHRPPG ASPDRYLGLP
310 320 330 340 350
GSLKWEERGP SGQGQFLIQQ VTLKAPFSVE FVFESGSAAT GGNQASGRLV
360 370 380 390 400
GSQLTQALES HAAAFKERFE KTFQLKEKGL SPEEQALGQV ALSGLLGGIG
410 420 430 440 450
YFYGQGLVLP DTSMEGSEQK MDPALFPPVP LFSGVPSRSF FPRGFLWDEG
460 470 480 490 500
FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL
510 520 530 540 550
VQRAAHANPP TLLLPVVHML EGHDPDDLAF LRKAFPRLHA WFSWLHQSQA
560 570 580 590 600
GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPST AERHLDLRCW
610 620 630 640 650
VALGARVLSQ LAEQLGETEA AAELGPLAAS LEEPGSLDEL HWAPELGVFA
660 670 680 690 700
DFGNHTKAVQ LKSRPPQGLV RVVGRPPPRL QYVDALGYVS LFPLLLQLLD
710 720 730 740 750
PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA
760 770 780 790 800
VWLNINYLAL GALHHYGHVE GPHKVQAAKL YHELRANVVR NVRQQYQATG
810 820 830
FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY
Length:834
Mass (Da):91,831
Last modified:June 1, 2003 - v1
Checksum:iCB2728BE16EACD0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti749 – 7491G → S in AAD00906. (PubMed:10406845)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001797 Genomic DNA. Translation: AAD00906.1.
BC051949 mRNA. Translation: AAH51949.1.
CCDSiCCDS20273.1.
RefSeqiNP_065644.2. NM_020619.2.
UniGeneiMm.28188.

Genome annotation databases

EnsembliENSMUST00000032114; ENSMUSP00000032114; ENSMUSG00000030036.
GeneIDi57377.
KEGGimmu:57377.
UCSCiuc009cmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001797 Genomic DNA. Translation: AAD00906.1 .
BC051949 mRNA. Translation: AAH51949.1 .
CCDSi CCDS20273.1.
RefSeqi NP_065644.2. NM_020619.2.
UniGenei Mm.28188.

3D structure databases

ProteinModelPortali Q80UM7.
SMRi Q80UM7. Positions 92-831.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208276. 1 interaction.
IntActi Q80UM7. 3 interactions.
MINTi MINT-4095856.

Protein family/group databases

CAZyi GH63. Glycoside Hydrolase Family 63.

PTM databases

PhosphoSitei Q80UM7.

Proteomic databases

MaxQBi Q80UM7.
PaxDbi Q80UM7.
PRIDEi Q80UM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032114 ; ENSMUSP00000032114 ; ENSMUSG00000030036 .
GeneIDi 57377.
KEGGi mmu:57377.
UCSCi uc009cmn.1. mouse.

Organism-specific databases

CTDi 7841.
MGIi MGI:1929872. Mogs.

Phylogenomic databases

eggNOGi NOG305138.
GeneTreei ENSGT00390000017452.
HOGENOMi HOG000201473.
InParanoidi Q80UM7.
KOi K01228.
OMAi WKAPLYT.
OrthoDBi EOG7XSTD6.
PhylomeDBi Q80UM7.
TreeFami TF300749.

Enzyme and pathway databases

UniPathwayi UPA00280 .
Reactomei REACT_198618. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.

Miscellaneous databases

NextBioi 313756.
PROi Q80UM7.
SOURCEi Search...

Gene expression databases

Bgeei Q80UM7.
CleanExi MM_GCS1.
ExpressionAtlasi Q80UM7. baseline and differential.
Genevestigatori Q80UM7.

Family and domain databases

InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view ]
PANTHERi PTHR10412:SF1. PTHR10412:SF1. 1 hit.
Pfami PF03200. Glyco_hydro_63. 1 hit.
[Graphical view ]
SUPFAMi SSF48208. SSF48208. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and promoter activity of glucosidase I gene."
    Khan F.A., Varma G.M., Vijay I.K.
    Glycobiology 9:797-806(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Fetal brain.

Entry informationi

Entry nameiMOGS_MOUSE
AccessioniPrimary (citable) accession number: Q80UM7
Secondary accession number(s): Q9Z2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3