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Q80UM7 (MOGS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannosyl-oligosaccharide glucosidase
EC=3.2.1.106
Alternative name(s):
Glucosidase 1
Glycoprotein-processing glucosidase I
Gene names
Name:Mogs
Synonyms:Gcs1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor By similarity.

Catalytic activity

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathway

Glycan metabolism; N-glycan degradation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 63 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Mannosyl-oligosaccharide glucosidase
PRO_0000057711

Regions

Topological domain1 – 4343Cytoplasmic Potential
Transmembrane44 – 6421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain65 – 834770Lumenal Potential
Region74 – 13663Required for endoplasmic reticulum targeting By similarity
Motif3 – 97Endoplasmic reticulum targeting

Amino acid modifications

Glycosylation6541N-linked (GlcNAc...) By similarity

Experimental info

Sequence conflict7491G → S in AAD00906. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q80UM7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CB2728BE16EACD0E

FASTA83491,831
        10         20         30         40         50         60 
MARGERRRRA AAAEGARPLE RARAAGRRDG RAGGARGSAS GAALAVVVLA LAFGLSGRWV 

        70         80         90        100        110        120 
LAWLRVRRAL TLHPAPSALP PDSSSPAVAP ELFWGTYRPH VYFGMKTRSP KPLLTGLMWA 

       130        140        150        160        170        180 
QQGATPGTPP KLRHTCEQGD GVGPYGWEFH DGRTFGRQHI HDGALRLTTE FVKRPGGQHG 

       190        200        210        220        230        240 
GDWSWRVTVE PQASGTPSFP LVSLFFYVVT DGQEVLLPEI GAKGQLKSIS GHTSELGDFR 

       250        260        270        280        290        300 
LTLLPPTSPG DTVPKHGSYN VFWSSNPGLP QLTDMVKSRL NSWFQHRPPG ASPDRYLGLP 

       310        320        330        340        350        360 
GSLKWEERGP SGQGQFLIQQ VTLKAPFSVE FVFESGSAAT GGNQASGRLV GSQLTQALES 

       370        380        390        400        410        420 
HAAAFKERFE KTFQLKEKGL SPEEQALGQV ALSGLLGGIG YFYGQGLVLP DTSMEGSEQK 

       430        440        450        460        470        480 
MDPALFPPVP LFSGVPSRSF FPRGFLWDEG FHQLVVQRWD PHLTREALGH WLGLLNADGW 

       490        500        510        520        530        540 
IGREQILGDE ARARVPPEFL VQRAAHANPP TLLLPVVHML EGHDPDDLAF LRKAFPRLHA 

       550        560        570        580        590        600 
WFSWLHQSQA GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPST AERHLDLRCW 

       610        620        630        640        650        660 
VALGARVLSQ LAEQLGETEA AAELGPLAAS LEEPGSLDEL HWAPELGVFA DFGNHTKAVQ 

       670        680        690        700        710        720 
LKSRPPQGLV RVVGRPPPRL QYVDALGYVS LFPLLLQLLD PSSPRLGPLL DVLADSRHLW 

       730        740        750        760        770        780 
SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA VWLNINYLAL GALHHYGHVE GPHKVQAAKL 

       790        800        810        820        830 
YHELRANVVR NVRQQYQATG FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and promoter activity of glucosidase I gene."
Khan F.A., Varma G.M., Vijay I.K.
Glycobiology 9:797-806(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF001797 Genomic DNA. Translation: AAD00906.1.
BC051949 mRNA. Translation: AAH51949.1.
IPIIPI00330323.
RefSeqNP_065644.2. NM_020619.2.
UniGeneMm.28188.

3D structure databases

ProteinModelPortalQ80UM7.
ModBaseSearch...

Protein-protein interaction databases

IntActQ80UM7. 1 interaction.

Protein family/group databases

CAZyGH63. Glycoside Hydrolase Family 63.

PTM databases

PhosphoSiteQ80UM7.

Proteomic databases

PaxDbQ80UM7.
PRIDEQ80UM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032114; ENSMUSP00000032114; ENSMUSG00000030036.
GeneID57377.
KEGGmmu:57377.
UCSCuc009cmn.1. mouse.

Organism-specific databases

CTD7841.
MGIMGI:1929872. Mogs.

Phylogenomic databases

eggNOGNOG305138.
GeneTreeENSGT00390000017452.
HOGENOMHOG000201473.
InParanoidQ80UM7.
KOK01228.
OMAWKAPLYT.
OrthoDBEOG40VVNZ.

Enzyme and pathway databases

UniPathwayUPA00280.

Gene expression databases

ArrayExpressQ80UM7.
BgeeQ80UM7.
CleanExMM_GCS1.
GenevestigatorQ80UM7.
GermOnlineENSMUSG00000030036. Mus musculus.

Family and domain databases

InterProIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERPTHR10412. PTHR10412. 1 hit.
PfamPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMSSF48208. Glyco_trans_6hp. 1 hit.
ProtoNetSearch...

Other

NextBio313756.
SOURCESearch...

Entry information

Entry nameMOGS_MOUSE
AccessionPrimary (citable) accession number: Q80UM7
Secondary accession number(s): Q9Z2W5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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