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Q80UM7

- MOGS_MOUSE

UniProt

Q80UM7 - MOGS_MOUSE

Protein

Mannosyl-oligosaccharide glucosidase

Gene

Mogs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor.By similarity

    Catalytic activityi

    Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

    Pathwayi

    GO - Molecular functioni

    1. mannosyl-oligosaccharide glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. oligosaccharide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198618. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
    UniPathwayiUPA00280.

    Protein family/group databases

    CAZyiGH63. Glycoside Hydrolase Family 63.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
    Alternative name(s):
    Glucosidase 1
    Glycoprotein-processing glucosidase I
    Gene namesi
    Name:Mogs
    Synonyms:Gcs1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1929872. Mogs.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi654 – 6541N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ80UM7.
    PaxDbiQ80UM7.
    PRIDEiQ80UM7.

    PTM databases

    PhosphoSiteiQ80UM7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80UM7.
    BgeeiQ80UM7.
    CleanExiMM_GCS1.
    GenevestigatoriQ80UM7.

    Interactioni

    Protein-protein interaction databases

    BioGridi208276. 1 interaction.
    IntActiQ80UM7. 3 interactions.
    MINTiMINT-4095856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80UM7.
    SMRiQ80UM7. Positions 92-831.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 834770LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 13663Required for endoplasmic reticulum targetingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi3 – 97Endoplasmic reticulum targeting

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 63 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305138.
    GeneTreeiENSGT00390000017452.
    HOGENOMiHOG000201473.
    InParanoidiQ80UM7.
    KOiK01228.
    OMAiWKAPLYT.
    OrthoDBiEOG7XSTD6.
    PhylomeDBiQ80UM7.
    TreeFamiTF300749.

    Family and domain databases

    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR004888. Glycoside_hydrolase_63.
    [Graphical view]
    PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
    PfamiPF03200. Glyco_hydro_63. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q80UM7-1 [UniParc]FASTAAdd to Basket

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    MARGERRRRA AAAEGARPLE RARAAGRRDG RAGGARGSAS GAALAVVVLA    50
    LAFGLSGRWV LAWLRVRRAL TLHPAPSALP PDSSSPAVAP ELFWGTYRPH 100
    VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH 150
    DGRTFGRQHI HDGALRLTTE FVKRPGGQHG GDWSWRVTVE PQASGTPSFP 200
    LVSLFFYVVT DGQEVLLPEI GAKGQLKSIS GHTSELGDFR LTLLPPTSPG 250
    DTVPKHGSYN VFWSSNPGLP QLTDMVKSRL NSWFQHRPPG ASPDRYLGLP 300
    GSLKWEERGP SGQGQFLIQQ VTLKAPFSVE FVFESGSAAT GGNQASGRLV 350
    GSQLTQALES HAAAFKERFE KTFQLKEKGL SPEEQALGQV ALSGLLGGIG 400
    YFYGQGLVLP DTSMEGSEQK MDPALFPPVP LFSGVPSRSF FPRGFLWDEG 450
    FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL 500
    VQRAAHANPP TLLLPVVHML EGHDPDDLAF LRKAFPRLHA WFSWLHQSQA 550
    GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPST AERHLDLRCW 600
    VALGARVLSQ LAEQLGETEA AAELGPLAAS LEEPGSLDEL HWAPELGVFA 650
    DFGNHTKAVQ LKSRPPQGLV RVVGRPPPRL QYVDALGYVS LFPLLLQLLD 700
    PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA 750
    VWLNINYLAL GALHHYGHVE GPHKVQAAKL YHELRANVVR NVRQQYQATG 800
    FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY 834
    Length:834
    Mass (Da):91,831
    Last modified:June 1, 2003 - v1
    Checksum:iCB2728BE16EACD0E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti749 – 7491G → S in AAD00906. (PubMed:10406845)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001797 Genomic DNA. Translation: AAD00906.1.
    BC051949 mRNA. Translation: AAH51949.1.
    CCDSiCCDS20273.1.
    RefSeqiNP_065644.2. NM_020619.2.
    UniGeneiMm.28188.

    Genome annotation databases

    EnsembliENSMUST00000032114; ENSMUSP00000032114; ENSMUSG00000030036.
    GeneIDi57377.
    KEGGimmu:57377.
    UCSCiuc009cmn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001797 Genomic DNA. Translation: AAD00906.1 .
    BC051949 mRNA. Translation: AAH51949.1 .
    CCDSi CCDS20273.1.
    RefSeqi NP_065644.2. NM_020619.2.
    UniGenei Mm.28188.

    3D structure databases

    ProteinModelPortali Q80UM7.
    SMRi Q80UM7. Positions 92-831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208276. 1 interaction.
    IntActi Q80UM7. 3 interactions.
    MINTi MINT-4095856.

    Protein family/group databases

    CAZyi GH63. Glycoside Hydrolase Family 63.

    PTM databases

    PhosphoSitei Q80UM7.

    Proteomic databases

    MaxQBi Q80UM7.
    PaxDbi Q80UM7.
    PRIDEi Q80UM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032114 ; ENSMUSP00000032114 ; ENSMUSG00000030036 .
    GeneIDi 57377.
    KEGGi mmu:57377.
    UCSCi uc009cmn.1. mouse.

    Organism-specific databases

    CTDi 7841.
    MGIi MGI:1929872. Mogs.

    Phylogenomic databases

    eggNOGi NOG305138.
    GeneTreei ENSGT00390000017452.
    HOGENOMi HOG000201473.
    InParanoidi Q80UM7.
    KOi K01228.
    OMAi WKAPLYT.
    OrthoDBi EOG7XSTD6.
    PhylomeDBi Q80UM7.
    TreeFami TF300749.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .
    Reactomei REACT_198618. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.

    Miscellaneous databases

    NextBioi 313756.
    PROi Q80UM7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80UM7.
    Bgeei Q80UM7.
    CleanExi MM_GCS1.
    Genevestigatori Q80UM7.

    Family and domain databases

    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR004888. Glycoside_hydrolase_63.
    [Graphical view ]
    PANTHERi PTHR10412:SF1. PTHR10412:SF1. 1 hit.
    Pfami PF03200. Glyco_hydro_63. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and promoter activity of glucosidase I gene."
      Khan F.A., Varma G.M., Vijay I.K.
      Glycobiology 9:797-806(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiMOGS_MOUSE
    AccessioniPrimary (citable) accession number: Q80UM7
    Secondary accession number(s): Q9Z2W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3