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Protein

Mannosyl-oligosaccharide glucosidase

Gene

Mogs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor.By similarity

Catalytic activityi

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathway: N-glycan degradation

This protein is involved in the pathway N-glycan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway N-glycan degradation and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_303840. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
UniPathwayiUPA00280.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
Alternative name(s):
Glucosidase 1
Glycoprotein-processing glucosidase I
Gene namesi
Name:Mogs
Synonyms:Gcs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1929872. Mogs.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini65 – 834770LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi654 – 6541N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80UM7.
PaxDbiQ80UM7.
PRIDEiQ80UM7.

PTM databases

PhosphoSiteiQ80UM7.

Expressioni

Gene expression databases

BgeeiQ80UM7.
CleanExiMM_GCS1.
ExpressionAtlasiQ80UM7. baseline and differential.
GenevisibleiQ80UM7. MM.

Interactioni

Protein-protein interaction databases

BioGridi208276. 1 interaction.
IntActiQ80UM7. 3 interactions.
MINTiMINT-4095856.
STRINGi10090.ENSMUSP00000032114.

Structurei

3D structure databases

ProteinModelPortaliQ80UM7.
SMRiQ80UM7. Positions 92-831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 13663Required for endoplasmic reticulum targetingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 97Endoplasmic reticulum targeting

Sequence similaritiesi

Belongs to the glycosyl hydrolase 63 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305138.
GeneTreeiENSGT00390000017452.
HOGENOMiHOG000201473.
InParanoidiQ80UM7.
KOiK01228.
OMAiDLRCWIA.
OrthoDBiEOG7XSTD6.
PhylomeDBiQ80UM7.
TreeFamiTF300749.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80UM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGERRRRA AAAEGARPLE RARAAGRRDG RAGGARGSAS GAALAVVVLA
60 70 80 90 100
LAFGLSGRWV LAWLRVRRAL TLHPAPSALP PDSSSPAVAP ELFWGTYRPH
110 120 130 140 150
VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH
160 170 180 190 200
DGRTFGRQHI HDGALRLTTE FVKRPGGQHG GDWSWRVTVE PQASGTPSFP
210 220 230 240 250
LVSLFFYVVT DGQEVLLPEI GAKGQLKSIS GHTSELGDFR LTLLPPTSPG
260 270 280 290 300
DTVPKHGSYN VFWSSNPGLP QLTDMVKSRL NSWFQHRPPG ASPDRYLGLP
310 320 330 340 350
GSLKWEERGP SGQGQFLIQQ VTLKAPFSVE FVFESGSAAT GGNQASGRLV
360 370 380 390 400
GSQLTQALES HAAAFKERFE KTFQLKEKGL SPEEQALGQV ALSGLLGGIG
410 420 430 440 450
YFYGQGLVLP DTSMEGSEQK MDPALFPPVP LFSGVPSRSF FPRGFLWDEG
460 470 480 490 500
FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL
510 520 530 540 550
VQRAAHANPP TLLLPVVHML EGHDPDDLAF LRKAFPRLHA WFSWLHQSQA
560 570 580 590 600
GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPST AERHLDLRCW
610 620 630 640 650
VALGARVLSQ LAEQLGETEA AAELGPLAAS LEEPGSLDEL HWAPELGVFA
660 670 680 690 700
DFGNHTKAVQ LKSRPPQGLV RVVGRPPPRL QYVDALGYVS LFPLLLQLLD
710 720 730 740 750
PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA
760 770 780 790 800
VWLNINYLAL GALHHYGHVE GPHKVQAAKL YHELRANVVR NVRQQYQATG
810 820 830
FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY
Length:834
Mass (Da):91,831
Last modified:June 1, 2003 - v1
Checksum:iCB2728BE16EACD0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti749 – 7491G → S in AAD00906 (PubMed:10406845).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001797 Genomic DNA. Translation: AAD00906.1.
BC051949 mRNA. Translation: AAH51949.1.
CCDSiCCDS20273.1.
RefSeqiNP_065644.2. NM_020619.2.
UniGeneiMm.28188.

Genome annotation databases

EnsembliENSMUST00000032114; ENSMUSP00000032114; ENSMUSG00000030036.
GeneIDi57377.
KEGGimmu:57377.
UCSCiuc009cmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001797 Genomic DNA. Translation: AAD00906.1.
BC051949 mRNA. Translation: AAH51949.1.
CCDSiCCDS20273.1.
RefSeqiNP_065644.2. NM_020619.2.
UniGeneiMm.28188.

3D structure databases

ProteinModelPortaliQ80UM7.
SMRiQ80UM7. Positions 92-831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208276. 1 interaction.
IntActiQ80UM7. 3 interactions.
MINTiMINT-4095856.
STRINGi10090.ENSMUSP00000032114.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

PTM databases

PhosphoSiteiQ80UM7.

Proteomic databases

MaxQBiQ80UM7.
PaxDbiQ80UM7.
PRIDEiQ80UM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032114; ENSMUSP00000032114; ENSMUSG00000030036.
GeneIDi57377.
KEGGimmu:57377.
UCSCiuc009cmn.1. mouse.

Organism-specific databases

CTDi7841.
MGIiMGI:1929872. Mogs.

Phylogenomic databases

eggNOGiNOG305138.
GeneTreeiENSGT00390000017452.
HOGENOMiHOG000201473.
InParanoidiQ80UM7.
KOiK01228.
OMAiDLRCWIA.
OrthoDBiEOG7XSTD6.
PhylomeDBiQ80UM7.
TreeFamiTF300749.

Enzyme and pathway databases

UniPathwayiUPA00280.
ReactomeiREACT_303840. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.

Miscellaneous databases

NextBioi313756.
PROiQ80UM7.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UM7.
CleanExiMM_GCS1.
ExpressionAtlasiQ80UM7. baseline and differential.
GenevisibleiQ80UM7. MM.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and promoter activity of glucosidase I gene."
    Khan F.A., Varma G.M., Vijay I.K.
    Glycobiology 9:797-806(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Fetal brain.

Entry informationi

Entry nameiMOGS_MOUSE
AccessioniPrimary (citable) accession number: Q80UM7
Secondary accession number(s): Q9Z2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.