true
2005-04-12
2024-03-27
137
SAS6_MOUSE
The transcriptional landscape of the mammalian genome.
Carninci P.
Kasukawa T.
Katayama S.
Gough J.
Frith M.C.
Maeda N.
Oyama R.
Ravasi T.
Lenhard B.
Wells C.
Kodzius R.
Shimokawa K.
Bajic V.B.
Brenner S.E.
Batalov S.
Forrest A.R.
Zavolan M.
Davis M.J.
Wilming L.G.
Aidinis V.
Allen J.E.
Ambesi-Impiombato A.
Apweiler R.
Aturaliya R.N.
Bailey T.L.
Bansal M.
Baxter L.
Beisel K.W.
Bersano T.
Bono H.
Chalk A.M.
Chiu K.P.
Choudhary V.
Christoffels A.
Clutterbuck D.R.
Crowe M.L.
Dalla E.
Dalrymple B.P.
de Bono B.
Della Gatta G.
di Bernardo D.
Down T.
Engstrom P.
Fagiolini M.
Faulkner G.
Fletcher C.F.
Fukushima T.
Furuno M.
Futaki S.
Gariboldi M.
Georgii-Hemming P.
Gingeras T.R.
Gojobori T.
Green R.E.
Gustincich S.
Harbers M.
Hayashi Y.
Hensch T.K.
Hirokawa N.
Hill D.
Huminiecki L.
Iacono M.
Ikeo K.
Iwama A.
Ishikawa T.
Jakt M.
Kanapin A.
Katoh M.
Kawasawa Y.
Kelso J.
Kitamura H.
Kitano H.
Kollias G.
Krishnan S.P.
Kruger A.
Kummerfeld S.K.
Kurochkin I.V.
Lareau L.F.
Lazarevic D.
Lipovich L.
Liu J.
Liuni S.
McWilliam S.
Madan Babu M.
Madera M.
Marchionni L.
Matsuda H.
Matsuzawa S.
Miki H.
Mignone F.
Miyake S.
Morris K.
Mottagui-Tabar S.
Mulder N.
Nakano N.
Nakauchi H.
Ng P.
Nilsson R.
Nishiguchi S.
Nishikawa S.
Nori F.
Ohara O.
Okazaki Y.
Orlando V.
Pang K.C.
Pavan W.J.
Pavesi G.
Pesole G.
Petrovsky N.
Piazza S.
Reed J.
Reid J.F.
Ring B.Z.
Ringwald M.
Rost B.
Ruan Y.
Salzberg S.L.
Sandelin A.
Schneider C.
Schoenbach C.
Sekiguchi K.
Semple C.A.
Seno S.
Sessa L.
Sheng Y.
Shibata Y.
Shimada H.
Shimada K.
Silva D.
Sinclair B.
Sperling S.
Stupka E.
Sugiura K.
Sultana R.
Takenaka Y.
Taki K.
Tammoja K.
Tan S.L.
Tang S.
Taylor M.S.
Tegner J.
Teichmann S.A.
Ueda H.R.
van Nimwegen E.
Verardo R.
Wei C.L.
Yagi K.
Yamanishi H.
Zabarovsky E.
Zhu S.
Zimmer A.
Hide W.
Bult C.
Grimmond S.M.
Teasdale R.D.
Liu E.T.
Brusic V.
Quackenbush J.
Wahlestedt C.
Mattick J.S.
Hume D.A.
Kai C.
Sasaki D.
Tomaru Y.
Fukuda S.
Kanamori-Katayama M.
Suzuki M.
Aoki J.
Arakawa T.
Iida J.
Imamura K.
Itoh M.
Kato T.
Kawaji H.
Kawagashira N.
Kawashima T.
Kojima M.
Kondo S.
Konno H.
Nakano K.
Ninomiya N.
Nishio T.
Okada M.
Plessy C.
Shibata K.
Shiraki T.
Suzuki S.
Tagami M.
Waki K.
Watahiki A.
Okamura-Oho Y.
Suzuki H.
Kawai J.
Hayashizaki Y.
doi:10.1126/science.1112014
2005
Science
309
1559-1563
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
C57BL/6J
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.
doi:10.1371/journal.pbio.1000112
2009
PLoS Biol.
7
E1000112
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
ICR
Trophoblast stem cell
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Zhao H.
Zhu L.
Zhu Y.
Cao J.
Li S.
Huang Q.
Xu T.
Huang X.
Yan X.
Zhu X.
doi:10.1038/ncb2880
2013
Nat. Cell Biol.
15
1434-1444
FUNCTION
SUBCELLULAR LOCATION
20
CPAP-STIL complex
21
3 sites, 1 O-linked glycan (3 sites)
157 antibodies from 20 providers
mouse
mouse
Sass6
Eukaryota
8 hits in 80 CRISPR screens
mouse
Protein
Expressed in spermatid and 199 other cell types or tissues
baseline and differential
HD_SAS6_N
Spindle assembly abnormal protein 6, N-terminal domain
SAS-6_N
SAS-6_N_sf
SAS6_CC
SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG
SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG
SAS-6_N
Sas6_CC
MM
Spindle assembly abnormal protein 6 homolog
Sass6
Sas6
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:24240477). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity).
Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets. Interacts with FBXW5. Forms a complex with CENPJ and STIL. Interacts with NUP62 and TUBG1 at the centrosome. Interacts with CENATAC; the interaction increases with CENATAC acetylation. Interacts with FZR1; the interaction is regulated by CENATAC and leads to SASS6 proteasomal degradation (By similarity).
Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (PubMed:24240477).
The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation and preventing centriole reduplication. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex, leading to its degradation and preventing centriole reduplication.
Spindle assembly abnormal protein 6 homolog
74054
1
654
PISA
39
91
Disordered
568
589
Disordered
634
175
471
Phosphoserine
509
Phosphoserine
612
Phosphoserine
In isoform 2.
AKC
558
560
In isoform 2.
561
R
19
N
395
D
579
2011-07-27
2
74054
892c10425cd84a654e63b64dbb254341
1
MSQVLFQQLVPLLVKCKDCEERRGSVRVSIELQSLSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKLQQGLLVDFLAFPQKFIDLLQQCMQEHAKETPRFLLQLLSSATLLENSPVLLNVVETNPFKHLIHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLTRSLDDVTRQLHITQETLSEKMQELDKLRSEWASHTASLTNKHSQELTAEKEKALQTQVQCQQQHEQQKKELETLHQRNIHQLQSRLSELEAANKELTERKYKGDSTVRELKAKLAGVEEELQRAKQEVLSLRRENCTLDTECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQIQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEMLQKERKESQDAGQFLRAKEQEVCRLQEQLETTVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDTLGTSATPHSTSNSTIRSGLSPNLNVVDRLNYPSCGIGYPVSSALTFQNAFPHVVAAKNTSHPISGPKVHFNLQLTKPSASIDGQPGAAVNRPCSNDKENGETLGLESKYLKRREASIPLRGLSQNLLSDSDHQKDGMLGAFQLSSKPTVLPSSSSAYFPGQLPSS
2
MSQVLFQQLVPLLVKCKDCEERRGSVRVSIELQSLSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKLQQGLLVDFLAFPQKFIDLLQQCMQEHAKETPRFLLQLLSSATLLENSPVLLNVVETNPFKHLIHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLTRSLDDVTRQLHITQETLSEKMQELDKLRSEWASHTASLTNKHSQELTAEKEKALQTQVQCQQQHEQQKKELETLHQRNIHQLQSRLSELEAANKELTERKYKGDSTVRELKAKLAGVEEELQRAKQEVLSLRRENCTLDTECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQIQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEMLQKERKESQDAGQFLRAKEQEVCRLQEQLETTVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDTLGTSATPHSTSNSTIRSGLSPNLNVVDRLNYPSCGIGYPVSSALTFQNAFPHVVAAKNTSHPISGPKVAKC
true
true
true
true
true
true
true
true
true
true
true