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Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

Sestd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 domain and spectrin repeat-containing protein 1
Alternative name(s):
Huntingtin-interacting protein-like protein
Gene namesi
Name:Sestd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916262. Sestd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696SEC14 domain and spectrin repeat-containing protein 1PRO_0000309480Add
BLAST

Proteomic databases

MaxQBiQ80UK0.
PaxDbiQ80UK0.
PeptideAtlasiQ80UK0.
PRIDEiQ80UK0.

PTM databases

iPTMnetiQ80UK0.
PhosphoSiteiQ80UK0.

Expressioni

Gene expression databases

BgeeiQ80UK0.
CleanExiMM_SESTD1.
GenevisibleiQ80UK0. MM.

Interactioni

Subunit structurei

Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.By similarity

Protein-protein interaction databases

BioGridi230712. 4 interactions.
IntActiQ80UK0. 5 interactions.
STRINGi10090.ENSMUSP00000099720.

Structurei

3D structure databases

ProteinModelPortaliQ80UK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 153153CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Repeati275 – 378104Spectrin 1Add
BLAST
Repeati381 – 494114Spectrin 2Add
BLAST
Repeati500 – 602103Spectrin 3Add
BLAST

Sequence similaritiesi

Belongs to the SOLO family.Curated
Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 3 spectrin repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4240. Eukaryota.
ENOG410XPZN. LUCA.
GeneTreeiENSGT00730000111148.
HOGENOMiHOG000072717.
HOVERGENiHBG104429.
InParanoidiQ80UK0.
OMAiCTTRSSG.
OrthoDBiEOG7D59MS.
PhylomeDBiQ80UK0.
TreeFamiTF332003.

Family and domain databases

InterProiIPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTSM DELSVTLDYL
60 70 80 90 100
LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VLMLQNVVPA EVSLVCVVKP
110 120 130 140 150
DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT
160 170 180 190 200
YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNEQ EKERSVDLNF
210 220 230 240 250
LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL
260 270 280 290 300
LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW
310 320 330 340 350
GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV
360 370 380 390 400
ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM
410 420 430 440 450
LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS
460 470 480 490 500
WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF
510 520 530 540 550
KCEEDASQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS
560 570 580 590 600
TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TVASEERVHR
610 620 630 640 650
LEMAIAFHSN AEKILQDCPE EPEAMNDEEQ FEEIEAIGKS LLDRLTIPVV
660 670 680 690
YPDGTEQYFG SPSDMASTAE HIRDRMKLVS LKRQQLRHPE LVTTES
Length:696
Mass (Da):79,376
Last modified:June 1, 2003 - v1
Checksum:i8354593E717D73F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti480 – 4823QRC → HAS in AAH38005 (PubMed:19468303).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772242 Genomic DNA. Translation: CAM15773.1.
BC038005 mRNA. Translation: AAH38005.1.
BC044853 mRNA. Translation: AAH44853.1.
BC048358 mRNA. Translation: AAH48358.1.
AK166483 mRNA. Translation: BAE38801.1.
CCDSiCCDS16163.1.
RefSeqiNP_780674.1. NM_175465.6.
XP_006499263.1. XM_006499200.2.
XP_006499264.1. XM_006499201.2.
XP_006499265.1. XM_006499202.2.
UniGeneiMm.27120.

Genome annotation databases

EnsembliENSMUST00000102659; ENSMUSP00000099720; ENSMUSG00000042272.
ENSMUST00000102660; ENSMUSP00000099721; ENSMUSG00000042272.
GeneIDi228071.
KEGGimmu:228071.
UCSCiuc008kfx.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772242 Genomic DNA. Translation: CAM15773.1.
BC038005 mRNA. Translation: AAH38005.1.
BC044853 mRNA. Translation: AAH44853.1.
BC048358 mRNA. Translation: AAH48358.1.
AK166483 mRNA. Translation: BAE38801.1.
CCDSiCCDS16163.1.
RefSeqiNP_780674.1. NM_175465.6.
XP_006499263.1. XM_006499200.2.
XP_006499264.1. XM_006499201.2.
XP_006499265.1. XM_006499202.2.
UniGeneiMm.27120.

3D structure databases

ProteinModelPortaliQ80UK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230712. 4 interactions.
IntActiQ80UK0. 5 interactions.
STRINGi10090.ENSMUSP00000099720.

PTM databases

iPTMnetiQ80UK0.
PhosphoSiteiQ80UK0.

Proteomic databases

MaxQBiQ80UK0.
PaxDbiQ80UK0.
PeptideAtlasiQ80UK0.
PRIDEiQ80UK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102659; ENSMUSP00000099720; ENSMUSG00000042272.
ENSMUST00000102660; ENSMUSP00000099721; ENSMUSG00000042272.
GeneIDi228071.
KEGGimmu:228071.
UCSCiuc008kfx.3. mouse.

Organism-specific databases

CTDi91404.
MGIiMGI:1916262. Sestd1.

Phylogenomic databases

eggNOGiKOG4240. Eukaryota.
ENOG410XPZN. LUCA.
GeneTreeiENSGT00730000111148.
HOGENOMiHOG000072717.
HOVERGENiHBG104429.
InParanoidiQ80UK0.
OMAiCTTRSSG.
OrthoDBiEOG7D59MS.
PhylomeDBiQ80UK0.
TreeFamiTF332003.

Miscellaneous databases

ChiTaRSiSestd1. mouse.
PROiQ80UK0.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UK0.
CleanExiMM_SESTD1.
GenevisibleiQ80UK0. MM.

Family and domain databases

InterProiIPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 498-696.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiSESD1_MOUSE
AccessioniPrimary (citable) accession number: Q80UK0
Secondary accession number(s): Q3TLJ1, Q810W3, Q8CI09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.