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Protein

Histone-lysine N-methyltransferase SETMAR

Gene

Setmar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Zinc 1By similarity
Metal bindingi76 – 761Zinc 2By similarity
Metal bindingi78 – 781Zinc 1By similarity
Metal bindingi83 – 831Zinc 1By similarity
Metal bindingi83 – 831Zinc 3By similarity
Metal bindingi88 – 881Zinc 1By similarity
Metal bindingi90 – 901Zinc 2By similarity
Metal bindingi119 – 1191Zinc 2By similarity
Metal bindingi119 – 1191Zinc 3By similarity
Metal bindingi123 – 1231Zinc 2By similarity
Metal bindingi125 – 1251Zinc 3By similarity
Metal bindingi129 – 1291Zinc 3By similarity
Binding sitei193 – 1931S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei221 – 2211S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi227 – 2271Zinc 4By similarity
Metal bindingi288 – 2881Zinc 4By similarity
Metal bindingi290 – 2901Zinc 4By similarity
Metal bindingi295 – 2951Zinc 4By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETMARCurated (EC:2.1.1.43By similarity)
Alternative name(s):
SET domain without mariner transposase fusion proteinImported
Gene namesi
Name:SetmarImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921979. Setmar.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Histone-lysine N-methyltransferase SETMARPRO_0000259527Add
BLAST

Proteomic databases

PRIDEiQ80UJ9.

PTM databases

PhosphoSiteiQ80UJ9.

Expressioni

Gene expression databases

BgeeiQ80UJ9.
CleanExiMM_SETMAR.
GenevisibleiQ80UJ9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048225.

Structurei

3D structure databases

ProteinModelPortaliQ80UJ9.
SMRiQ80UJ9. Positions 24-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 13764Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 264125SETPROSITE-ProRule annotationAdd
BLAST
Domaini284 – 30017Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1523S-adenosyl-L-methionine bindingBy similarity
Regioni224 – 2252S-adenosyl-L-methionine bindingBy similarity

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000020052.
HOVERGENiHBG093940.
InParanoidiQ80UJ9.
KOiK11433.
OMAiYDSSLYC.
OrthoDBiEOG744T8D.
TreeFamiTF316038.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK
60 70 80 90 100
PFQYTPDHVA GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN
110 120 130 140 150
LCLRDVGSEG KYAKPVFECN VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK
160 170 180 190 200
GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ RRIHLQTSHD SNYIIAVREH
210 220 230 240 250
IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA
260 270 280 290 300
KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP

YDSSLYMAP
Length:309
Mass (Da):34,417
Last modified:July 27, 2011 - v2
Checksum:i38F60C1C5B13D80C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031L → F in AAH45208 (PubMed:15489334).Curated
Sequence conflicti273 – 2731S → R in AAH45208 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1.
CCDSiCCDS51867.1.
RefSeqiNP_848478.2. NM_178391.4.
UniGeneiMm.56539.

Genome annotation databases

EnsembliENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneIDi74729.
KEGGimmu:74729.
UCSCiuc009dde.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1.
CCDSiCCDS51867.1.
RefSeqiNP_848478.2. NM_178391.4.
UniGeneiMm.56539.

3D structure databases

ProteinModelPortaliQ80UJ9.
SMRiQ80UJ9. Positions 24-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048225.

PTM databases

PhosphoSiteiQ80UJ9.

Proteomic databases

PRIDEiQ80UJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneIDi74729.
KEGGimmu:74729.
UCSCiuc009dde.2. mouse.

Organism-specific databases

CTDi6419.
MGIiMGI:1921979. Setmar.

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000020052.
HOVERGENiHBG093940.
InParanoidiQ80UJ9.
KOiK11433.
OMAiYDSSLYC.
OrthoDBiEOG744T8D.
TreeFamiTF316038.

Miscellaneous databases

NextBioi341494.
PROiQ80UJ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UJ9.
CleanExiMM_SETMAR.
GenevisibleiQ80UJ9. MM.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSETMR_MOUSE
AccessioniPrimary (citable) accession number: Q80UJ9
Secondary accession number(s): E9QLD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.