Q80UJ9 (SETMR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase SETMAR
EC=2.1.1.43

Alternative name(s):
SET domain and mariner transposase fusion gene-containing protein homolog

Gene names

Name:

Setmar

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Histone-lysine N-methyltransferase SETMAR		PRO_0000259527
Regions
	Domain	74 – 137	64	Pre-SET
	Domain	139 – 268	130	SET
	Domain	284 – 300	17	Post-SET
Experimental info
	Sequence conflict	103	1	L → F in AAH45208. Ref.2
	Sequence conflict	273	1	S → R in AAH45208. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q80UJ9 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 38F60C1C5B13D80C	FASTA	309	34,417
	10 20 30 40 50 60 MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK PFQYTPDHVA 70 80 90 100 110 120 GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN LCLRDVGSEG KYAKPVFECN 130 140 150 160 170 180 VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ 190 200 210 220 230 240 RRIHLQTSHD SNYIIAVREH IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS 250 260 270 280 290 300 MVPKLALFAA KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP YDSSLYMAP

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC153916 Genomic DNA. No translation available. BC045208 mRNA. Translation: AAH45208.1.
IPI	IPI00785508.
RefSeq	NP_848478.2. NM_178391.4.
UniGene	Mm.56539.
3D structure databases
HSSP	HSSP built from PDB template 1PEG based on UniProtKB Q8X225.
ProteinModelPortal	Q80UJ9.
SMR	Q80UJ9. Positions 24-304.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000048225.
PTM databases
PhosphoSite	Q80UJ9.
Proteomic databases
PRIDE	Q80UJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneID	74729.
KEGG	mmu:74729.
UCSC	uc009dde.2. mouse.
Organism-specific databases
CTD	6419.
MGI	MGI:1921979. Setmar.
Phylogenomic databases
eggNOG	COG2940.
GeneTree	ENSGT00700000104009.
HOGENOM	HOG000020052.
HOVERGEN	HBG093940.
InParanoid	Q80UJ9.
KO	K11433.
OMA	PYDSSLY.
OrthoDB	EOG4XPQGF.
Gene expression databases
Bgee	Q80UJ9.
CleanEx	MM_SETMAR.
Genevestigator	Q80UJ9.
GermOnline	ENSMUSG00000034639. Mus musculus.
Family and domain databases
InterPro	IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. [Graphical view]
Pfam	PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	341494.
SOURCE	Search...

Entry information

Entry name

SETMR_MOUSE

Accession

Primary (citable) accession number: Q80UJ9
Secondary accession number(s): E9QLD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program