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Q80UJ9

- SETMR_MOUSE

UniProt

Q80UJ9 - SETMR_MOUSE

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Protein
Histone-lysine N-methyltransferase SETMAR
Gene
Setmar
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Zinc 1 By similarity
Metal bindingi76 – 761Zinc 2 By similarity
Metal bindingi78 – 781Zinc 1 By similarity
Metal bindingi83 – 831Zinc 1 By similarity
Metal bindingi83 – 831Zinc 3 By similarity
Metal bindingi88 – 881Zinc 1 By similarity
Metal bindingi90 – 901Zinc 2 By similarity
Metal bindingi119 – 1191Zinc 2 By similarity
Metal bindingi119 – 1191Zinc 3 By similarity
Metal bindingi123 – 1231Zinc 2 By similarity
Metal bindingi125 – 1251Zinc 3 By similarity
Metal bindingi129 – 1291Zinc 3 By similarity
Binding sitei193 – 1931S-adenosyl-L-methionine By similarity
Binding sitei221 – 2211S-adenosyl-L-methionine By similarity
Metal bindingi227 – 2271Zinc 4 By similarity
Metal bindingi288 – 2881Zinc 4 By similarity
Metal bindingi290 – 2901Zinc 4 By similarity
Metal bindingi295 – 2951Zinc 4 By similarity

GO - Molecular functioni

  1. endonuclease activity Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. structure-specific DNA binding Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: Ensembl
  2. DNA double-strand break processing Source: Ensembl
  3. negative regulation of cell cycle arrest Source: Ensembl
  4. negative regulation of chromosome organization Source: Ensembl
  5. positive regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETMAR (EC:2.1.1.43)
Alternative name(s):
SET domain and mariner transposase fusion gene-containing protein homolog
Gene namesi
Name:Setmar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1921979. Setmar.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Histone-lysine N-methyltransferase SETMAR
PRO_0000259527Add
BLAST

Proteomic databases

PRIDEiQ80UJ9.

PTM databases

PhosphoSiteiQ80UJ9.

Expressioni

Gene expression databases

BgeeiQ80UJ9.
CleanExiMM_SETMAR.
GenevestigatoriQ80UJ9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048225.

Structurei

3D structure databases

ProteinModelPortaliQ80UJ9.
SMRiQ80UJ9. Positions 24-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 13764Pre-SET
Add
BLAST
Domaini140 – 264125SET
Add
BLAST
Domaini284 – 30017Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1523S-adenosyl-L-methionine binding By similarity
Regioni224 – 2252S-adenosyl-L-methionine binding By similarity

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00750000117632.
HOGENOMiHOG000020052.
HOVERGENiHBG093940.
InParanoidiQ80UJ9.
KOiK11433.
OMAiITFPGCA.
OrthoDBiEOG744T8D.
TreeFamiTF316038.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK    50
PFQYTPDHVA GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN 100
LCLRDVGSEG KYAKPVFECN VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK 150
GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ RRIHLQTSHD SNYIIAVREH 200
IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA 250
KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP 300
YDSSLYMAP 309
Length:309
Mass (Da):34,417
Last modified:July 27, 2011 - v2
Checksum:i38F60C1C5B13D80C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031L → F in AAH45208. 1 Publication
Sequence conflicti273 – 2731S → R in AAH45208. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1.
CCDSiCCDS51867.1.
RefSeqiNP_848478.2. NM_178391.4.
UniGeneiMm.56539.

Genome annotation databases

EnsembliENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneIDi74729.
KEGGimmu:74729.
UCSCiuc009dde.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1 .
CCDSi CCDS51867.1.
RefSeqi NP_848478.2. NM_178391.4.
UniGenei Mm.56539.

3D structure databases

ProteinModelPortali Q80UJ9.
SMRi Q80UJ9. Positions 24-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048225.

PTM databases

PhosphoSitei Q80UJ9.

Proteomic databases

PRIDEi Q80UJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049246 ; ENSMUSP00000048225 ; ENSMUSG00000034639 .
GeneIDi 74729.
KEGGi mmu:74729.
UCSCi uc009dde.2. mouse.

Organism-specific databases

CTDi 6419.
MGIi MGI:1921979. Setmar.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00750000117632.
HOGENOMi HOG000020052.
HOVERGENi HBG093940.
InParanoidi Q80UJ9.
KOi K11433.
OMAi ITFPGCA.
OrthoDBi EOG744T8D.
TreeFami TF316038.

Miscellaneous databases

NextBioi 341494.
PROi Q80UJ9.
SOURCEi Search...

Gene expression databases

Bgeei Q80UJ9.
CleanExi MM_SETMAR.
Genevestigatori Q80UJ9.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSETMR_MOUSE
AccessioniPrimary (citable) accession number: Q80UJ9
Secondary accession number(s): E9QLD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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