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Q80UJ9

- SETMR_MOUSE

UniProt

Q80UJ9 - SETMR_MOUSE

Protein

Histone-lysine N-methyltransferase SETMAR

Gene

Setmar

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Zinc 1By similarity
    Metal bindingi76 – 761Zinc 2By similarity
    Metal bindingi78 – 781Zinc 1By similarity
    Metal bindingi83 – 831Zinc 1By similarity
    Metal bindingi83 – 831Zinc 3By similarity
    Metal bindingi88 – 881Zinc 1By similarity
    Metal bindingi90 – 901Zinc 2By similarity
    Metal bindingi119 – 1191Zinc 2By similarity
    Metal bindingi119 – 1191Zinc 3By similarity
    Metal bindingi123 – 1231Zinc 2By similarity
    Metal bindingi125 – 1251Zinc 3By similarity
    Metal bindingi129 – 1291Zinc 3By similarity
    Binding sitei193 – 1931S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei221 – 2211S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi227 – 2271Zinc 4By similarity
    Metal bindingi288 – 2881Zinc 4By similarity
    Metal bindingi290 – 2901Zinc 4By similarity
    Metal bindingi295 – 2951Zinc 4By similarity

    GO - Molecular functioni

    1. endonuclease activity Source: Ensembl
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    3. structure-specific DNA binding Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA catabolic process, endonucleolytic Source: Ensembl
    2. DNA double-strand break processing Source: Ensembl
    3. negative regulation of cell cycle arrest Source: Ensembl
    4. negative regulation of chromosome organization Source: Ensembl
    5. positive regulation of double-strand break repair via nonhomologous end joining Source: Ensembl

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETMAR (EC:2.1.1.43)
    Alternative name(s):
    SET domain and mariner transposase fusion gene-containing protein homolog
    Gene namesi
    Name:Setmar
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1921979. Setmar.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Histone-lysine N-methyltransferase SETMARPRO_0000259527Add
    BLAST

    Proteomic databases

    PRIDEiQ80UJ9.

    PTM databases

    PhosphoSiteiQ80UJ9.

    Expressioni

    Gene expression databases

    BgeeiQ80UJ9.
    CleanExiMM_SETMAR.
    GenevestigatoriQ80UJ9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000048225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80UJ9.
    SMRiQ80UJ9. Positions 24-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 13764Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 264125SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 30017Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 1523S-adenosyl-L-methionine bindingBy similarity
    Regioni224 – 2252S-adenosyl-L-methionine bindingBy similarity

    Domaini

    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00750000117632.
    HOGENOMiHOG000020052.
    HOVERGENiHBG093940.
    InParanoidiQ80UJ9.
    KOiK11433.
    OMAiITFPGCA.
    OrthoDBiEOG744T8D.
    TreeFamiTF316038.

    Family and domain databases

    InterProiIPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80UJ9-1 [UniParc]FASTAAdd to Basket

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    MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK    50
    PFQYTPDHVA GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN 100
    LCLRDVGSEG KYAKPVFECN VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK 150
    GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ RRIHLQTSHD SNYIIAVREH 200
    IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA 250
    KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP 300
    YDSSLYMAP 309
    Length:309
    Mass (Da):34,417
    Last modified:July 27, 2011 - v2
    Checksum:i38F60C1C5B13D80C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031L → F in AAH45208. (PubMed:15489334)Curated
    Sequence conflicti273 – 2731S → R in AAH45208. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153916 Genomic DNA. No translation available.
    BC045208 mRNA. Translation: AAH45208.1.
    CCDSiCCDS51867.1.
    RefSeqiNP_848478.2. NM_178391.4.
    UniGeneiMm.56539.

    Genome annotation databases

    EnsembliENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
    GeneIDi74729.
    KEGGimmu:74729.
    UCSCiuc009dde.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153916 Genomic DNA. No translation available.
    BC045208 mRNA. Translation: AAH45208.1 .
    CCDSi CCDS51867.1.
    RefSeqi NP_848478.2. NM_178391.4.
    UniGenei Mm.56539.

    3D structure databases

    ProteinModelPortali Q80UJ9.
    SMRi Q80UJ9. Positions 24-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000048225.

    PTM databases

    PhosphoSitei Q80UJ9.

    Proteomic databases

    PRIDEi Q80UJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049246 ; ENSMUSP00000048225 ; ENSMUSG00000034639 .
    GeneIDi 74729.
    KEGGi mmu:74729.
    UCSCi uc009dde.2. mouse.

    Organism-specific databases

    CTDi 6419.
    MGIi MGI:1921979. Setmar.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00750000117632.
    HOGENOMi HOG000020052.
    HOVERGENi HBG093940.
    InParanoidi Q80UJ9.
    KOi K11433.
    OMAi ITFPGCA.
    OrthoDBi EOG744T8D.
    TreeFami TF316038.

    Miscellaneous databases

    NextBioi 341494.
    PROi Q80UJ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80UJ9.
    CleanExi MM_SETMAR.
    Genevestigatori Q80UJ9.

    Family and domain databases

    InterProi IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSETMR_MOUSE
    AccessioniPrimary (citable) accession number: Q80UJ9
    Secondary accession number(s): E9QLD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3