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Q80UJ9 (SETMR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SETMAR

EC=2.1.1.43
Alternative name(s):
SET domain and mariner transposase fusion gene-containing protein homolog
Gene names
Name:Setmar
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Ontologies

Keywords
   Cellular componentChromosome
Nucleus
   LigandS-adenosyl-L-methionine
   Molecular functionChromatin regulator
Methyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Histone-lysine N-methyltransferase SETMAR
PRO_0000259527

Regions

Domain74 – 13764Pre-SET
Domain140 – 264125SET
Domain284 – 30017Post-SET

Experimental info

Sequence conflict1031L → F in AAH45208. Ref.2
Sequence conflict2731S → R in AAH45208. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q80UJ9 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 38F60C1C5B13D80C

FASTA30934,417
        10         20         30         40         50         60 
MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK PFQYTPDHVA 

        70         80         90        100        110        120 
GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN LCLRDVGSEG KYAKPVFECN 

       130        140        150        160        170        180 
VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ 

       190        200        210        220        230        240 
RRIHLQTSHD SNYIIAVREH IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS 

       250        260        270        280        290        300 
MVPKLALFAA KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP 


YDSSLYMAP 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1.
RefSeqNP_848478.2. NM_178391.4.
UniGeneMm.56539.

3D structure databases

ProteinModelPortalQ80UJ9.
SMRQ80UJ9. Positions 24-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000048225.

PTM databases

PhosphoSiteQ80UJ9.

Proteomic databases

PRIDEQ80UJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneID74729.
KEGGmmu:74729.
UCSCuc009dde.2. mouse.

Organism-specific databases

CTD6419.
MGIMGI:1921979. Setmar.

Phylogenomic databases

eggNOGCOG2940.
GeneTreeENSGT00750000117632.
HOGENOMHOG000020052.
HOVERGENHBG093940.
InParanoidQ80UJ9.
KOK11433.
OMAYDSSLYC.
OrthoDBEOG744T8D.
TreeFamTF316038.

Gene expression databases

BgeeQ80UJ9.
CleanExMM_SETMAR.
GenevestigatorQ80UJ9.

Family and domain databases

InterProIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio341494.
PROQ80UJ9.
SOURCESearch...

Entry information

Entry nameSETMR_MOUSE
AccessionPrimary (citable) accession number: Q80UJ9
Secondary accession number(s): E9QLD6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot