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Q80UJ9

- SETMR_MOUSE

UniProt

Q80UJ9 - SETMR_MOUSE

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Protein

Histone-lysine N-methyltransferase SETMAR

Gene

Setmar

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Zinc 1By similarity
Metal bindingi76 – 761Zinc 2By similarity
Metal bindingi78 – 781Zinc 1By similarity
Metal bindingi83 – 831Zinc 1By similarity
Metal bindingi83 – 831Zinc 3By similarity
Metal bindingi88 – 881Zinc 1By similarity
Metal bindingi90 – 901Zinc 2By similarity
Metal bindingi119 – 1191Zinc 2By similarity
Metal bindingi119 – 1191Zinc 3By similarity
Metal bindingi123 – 1231Zinc 2By similarity
Metal bindingi125 – 1251Zinc 3By similarity
Metal bindingi129 – 1291Zinc 3By similarity
Binding sitei193 – 1931S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei221 – 2211S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi227 – 2271Zinc 4By similarity
Metal bindingi288 – 2881Zinc 4By similarity
Metal bindingi290 – 2901Zinc 4By similarity
Metal bindingi295 – 2951Zinc 4By similarity

GO - Molecular functioni

  1. endonuclease activity Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. structure-specific DNA binding Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: Ensembl
  2. DNA double-strand break processing Source: Ensembl
  3. negative regulation of cell cycle arrest Source: Ensembl
  4. negative regulation of chromosome organization Source: Ensembl
  5. positive regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETMAR (EC:2.1.1.43)
Alternative name(s):
SET domain and mariner transposase fusion gene-containing protein homolog
Gene namesi
Name:Setmar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1921979. Setmar.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Histone-lysine N-methyltransferase SETMARPRO_0000259527Add
BLAST

Proteomic databases

PRIDEiQ80UJ9.

PTM databases

PhosphoSiteiQ80UJ9.

Expressioni

Gene expression databases

BgeeiQ80UJ9.
CleanExiMM_SETMAR.
GenevestigatoriQ80UJ9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048225.

Structurei

3D structure databases

ProteinModelPortaliQ80UJ9.
SMRiQ80UJ9. Positions 24-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 13764Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 264125SETPROSITE-ProRule annotationAdd
BLAST
Domaini284 – 30017Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1523S-adenosyl-L-methionine bindingBy similarity
Regioni224 – 2252S-adenosyl-L-methionine bindingBy similarity

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00760000118855.
HOGENOMiHOG000020052.
HOVERGENiHBG093940.
InParanoidiQ80UJ9.
KOiK11433.
OMAiITFPGCA.
OrthoDBiEOG744T8D.
TreeFamiTF316038.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEGVEKLS LEIAASEEES VAPTEQQDVA CGLENLPVSL WPLGAEPRPK
60 70 80 90 100
PFQYTPDHVA GPGADIDPTQ ITFPGCACIE TPCVPGTCSC LRHENNYDDN
110 120 130 140 150
LCLRDVGSEG KYAKPVFECN VLCQCGMRCR NRVVQNGLHF LLQVFQTEKK
160 170 180 190 200
GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ RRIHLQTSHD SNYIIAVREH
210 220 230 240 250
IYSGQIMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA
260 270 280 290 300
KDILPGEELS YDYSGRFLNQ VSSKDKEKID CSPPRKPCYC GAQSCTTFLP

YDSSLYMAP
Length:309
Mass (Da):34,417
Last modified:July 27, 2011 - v2
Checksum:i38F60C1C5B13D80C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031L → F in AAH45208. (PubMed:15489334)Curated
Sequence conflicti273 – 2731S → R in AAH45208. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1.
CCDSiCCDS51867.1.
RefSeqiNP_848478.2. NM_178391.4.
UniGeneiMm.56539.

Genome annotation databases

EnsembliENSMUST00000049246; ENSMUSP00000048225; ENSMUSG00000034639.
GeneIDi74729.
KEGGimmu:74729.
UCSCiuc009dde.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153916 Genomic DNA. No translation available.
BC045208 mRNA. Translation: AAH45208.1 .
CCDSi CCDS51867.1.
RefSeqi NP_848478.2. NM_178391.4.
UniGenei Mm.56539.

3D structure databases

ProteinModelPortali Q80UJ9.
SMRi Q80UJ9. Positions 24-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048225.

PTM databases

PhosphoSitei Q80UJ9.

Proteomic databases

PRIDEi Q80UJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049246 ; ENSMUSP00000048225 ; ENSMUSG00000034639 .
GeneIDi 74729.
KEGGi mmu:74729.
UCSCi uc009dde.2. mouse.

Organism-specific databases

CTDi 6419.
MGIi MGI:1921979. Setmar.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00760000118855.
HOGENOMi HOG000020052.
HOVERGENi HBG093940.
InParanoidi Q80UJ9.
KOi K11433.
OMAi ITFPGCA.
OrthoDBi EOG744T8D.
TreeFami TF316038.

Miscellaneous databases

NextBioi 341494.
PROi Q80UJ9.
SOURCEi Search...

Gene expression databases

Bgeei Q80UJ9.
CleanExi MM_SETMAR.
Genevestigatori Q80UJ9.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSETMR_MOUSE
AccessioniPrimary (citable) accession number: Q80UJ9
Secondary accession number(s): E9QLD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3