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Protein

Solute carrier family 22 member 20

Gene

Slc22a20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter.2 Publications

Kineticsi

  1. KM=109.8 µM for estrone sulfate3 Publications
  1. Vmax=40 pmol/h/mg enzyme for ES uptake3 Publications
  2. Vmax=4.6 pmol/h/mg enzyme for PAH uptake3 Publications
  3. Vmax=0.9 pmol/h/mg enzyme for prostaglandin E2 uptake3 Publications
  4. Vmax=0.28 pmol/h/mg enzyme for ibuprofen uptake3 Publications
  5. Vmax=4.8 pmol/h/mg enzyme for ochratoxin A uptake3 Publications
  6. Vmax=5.1 pmol/h/mg enzyme for fluorescein uptake3 Publications
  7. Vmax=2.1 pmol/h/mg enzyme for 2-carboxyfluorescein-DM uptake3 Publications
  8. Vmax=3.9 pmol/h/mg enzyme for eosin-Y uptake3 Publications

GO - Molecular functioni

GO - Biological processi

  • organic anion transport Source: UniProtKB
  • sodium-independent organic anion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.19.16. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 20
Alternative name(s):
Organic anion transporter 6
Gene namesi
Name:Slc22a20
Synonyms:Gm963Imported, Oat6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685809. Slc22a20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 137ExtracellularSequence analysisAdd BLAST101
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 166CytoplasmicSequence analysis8
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 194ExtracellularSequence analysis7
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 225CytoplasmicSequence analysis10
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 250ExtracellularSequence analysis4
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 339CytoplasmicSequence analysisAdd BLAST68
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 366ExtracellularSequence analysis6
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 397CytoplasmicSequence analysis10
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 425ExtracellularSequence analysis7
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 457CytoplasmicSequence analysisAdd BLAST11
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 485ExtracellularSequence analysis7
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 556CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205121 – 556Solute carrier family 22 member 20Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80UJ1.
PRIDEiQ80UJ1.

PTM databases

iPTMnetiQ80UJ1.
PhosphoSitePlusiQ80UJ1.

Expressioni

Tissue specificityi

Highly expressed in olfactory mucosa. Weakly expressed in testis. Not detected in heart, spleen, lung, kidney or brain.2 Publications

Developmental stagei

Expressed at embryonic day 7, but not later in embryogenesis. Expressed in adult.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049473.

Chemistry databases

BindingDBiQ80UJ1.

Structurei

3D structure databases

ProteinModelPortaliQ80UJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ80UJ1.
KOiK08216.
OrthoDBiEOG091G07CO.
PhylomeDBiQ80UJ1.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTDLLDAL GGVGRFQLVY TALLLLPCGL LACHTFLQNF TAAAPPHHCQ
60 70 80 90 100
HPANYTEPTT NVSGVWLRAA IPLNQHGDPE PCRRYVEPQW ALLKPNASSH
110 120 130 140 150
GVATEGCKDG WVYDRSIFPS TIVMEWDLVC EARTLRDLAQ SIYMSGVLVG
160 170 180 190 200
AALFGGLADR LGRKAPLVWS YLQLAVSGAA TAYVGSFSAY CVFRFLMGMT
210 220 230 240 250
FSGIILNSLS LVVEWMPTRG RTVAGILLGF SFTLGQLILA GVAYLIRPWR
260 270 280 290 300
WLQFAVSAPF LVFFLYSWWL PESSRWLLLH GKAQQAVQNL QKVAMMNGRK
310 320 330 340 350
AEGERLTTEV VSSYIQDEFA SVRTSNSILD LFRTPAIRRV TCCLMGVWFS
360 370 380 390 400
NSVAYYGLAM DLQKFGLSIY LVQALFGIID IPAMLVATTT MIYVGRRATV
410 420 430 440 450
SSFLILAGLM VIANMFMPED LQTLRTVQAA LGKGCLASSF ICVYLFTGEL
460 470 480 490 500
YPTEIRQMGM GFASVNARLG GLVAPLITTL GEISPVLPPV SFGATSVLAG
510 520 530 540 550
MAVACFLTET RNVPLVETIA AMERRVKQGR SKRDTEQKSE EISLQQLGAS

PLKETI
Length:556
Mass (Da):60,944
Last modified:June 1, 2003 - v1
Checksum:iB0A89E00824AFC39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194118 mRNA. Translation: AAO91751.1.
BC046588 mRNA. Translation: AAH46588.1.
CCDSiCCDS29486.1.
RefSeqiNP_941052.1. NM_198650.2.
UniGeneiMm.329638.

Genome annotation databases

EnsembliENSMUST00000041827; ENSMUSP00000049473; ENSMUSG00000037451.
GeneIDi381203.
KEGGimmu:381203.
UCSCiuc008ggh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194118 mRNA. Translation: AAO91751.1.
BC046588 mRNA. Translation: AAH46588.1.
CCDSiCCDS29486.1.
RefSeqiNP_941052.1. NM_198650.2.
UniGeneiMm.329638.

3D structure databases

ProteinModelPortaliQ80UJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049473.

Chemistry databases

BindingDBiQ80UJ1.
ChEMBLiCHEMBL5269.

Protein family/group databases

TCDBi2.A.1.19.16. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ80UJ1.
PhosphoSitePlusiQ80UJ1.

Proteomic databases

PaxDbiQ80UJ1.
PRIDEiQ80UJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041827; ENSMUSP00000049473; ENSMUSG00000037451.
GeneIDi381203.
KEGGimmu:381203.
UCSCiuc008ggh.1. mouse.

Organism-specific databases

CTDi440044.
MGIiMGI:2685809. Slc22a20.

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ80UJ1.
KOiK08216.
OrthoDBiEOG091G07CO.
PhylomeDBiQ80UJ1.
TreeFamiTF315847.

Miscellaneous databases

PROiQ80UJ1.
SOURCEiSearch...

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AK_MOUSE
AccessioniPrimary (citable) accession number: Q80UJ1
Secondary accession number(s): Q5JBT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.