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Protein
Submitted name:

Phosphatidylinositol 3-kinase regulatory subunit alpha

Gene

Pik3r1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase regulatory subunit alphaImported
Submitted name:
Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (P85 alpha)Imported
Gene namesi
Name:Pik3r1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97583. Pik3r1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000041417.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Gab1Q9QYY05EBI-7314645,EBI-644784

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80UI5. 1 interactor.
MINTiMINT-137238.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 158SH2InterPro annotationAdd BLAST96
Domaini354 – 448SH2InterPro annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 292Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
GeneTreeiENSGT00390000010431.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.

Family and domain databases

CDDicd09930. SH2_cSH2_p85_like. 1 hit.
cd09942. SH2_nSH2_p85_like. 1 hit.
Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR032498. PI3K_P85_iSH2.
IPR035020. PI3kinase_P85_cSH2.
IPR035022. PI3kinase_P85_nSH2.
IPR001720. PI3kinase_P85_p55.
IPR000980. SH2.
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiView protein in Pfam
PF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q80UI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTTVWTMED LDLECAKTDI NCGTDLVFYI EMDPPALPPK PPKPTTVANN
60 70 80 90 100
SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA STKMHGDYTL
110 120 130 140 150
TLRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL
160 170 180 190 200
DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY
210 220 230 240 250
TRTSQEIQMK RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE
260 270 280 290 300
IQRIMHNHDK LKSRISEIID SRRRLEEDLK KQAAEYREID KRMNSIKPDL
310 320 330 340 350
IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN ENTEDQYSLV EDDEDLPHHD
360 370 380 390 400
EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS VVVDGEVKHC
410 420 430 440 450
VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA

QQRR
Length:454
Mass (Da):53,399
Last modified:June 1, 2003 - v1
Checksum:i543B736F6439FFFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107663 Genomic DNA. No translation available.
AC153139 Genomic DNA. No translation available.
BC051106 mRNA. Translation: AAH51106.1.
RefSeqiNP_001020126.1. NM_001024955.2.
UniGeneiMm.259333.

Genome annotation databases

EnsembliENSMUST00000035532; ENSMUSP00000047004; ENSMUSG00000041417.
GeneIDi18708.
UCSCiuc007rrs.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ80UI5_MOUSE
AccessioniPrimary (citable) accession number: Q80UI5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported