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Protein

Septin-9

Gene

Sept9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Miscellaneous

Targeted by proviral insertion in T-cell lymphomas induced by the murine retrovirus SL3-3 MuLV.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei337GTPBy similarity1
Binding sitei363GTP; via amide nitrogenBy similarity1
Binding sitei499GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei514GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi303 – 310GTPBy similarity8
Nucleotide bindingi443 – 451GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
SL3-3 integration site 1 protein
Gene namesi
Name:Sept9
Synonyms:Kiaa0991, Sint1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858222 Sept9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735361 – 583Septin-9Add BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei42PhosphothreonineBy similarity1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei62N6-acetyllysineCombined sources1
Modified residuei82PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei143PhosphothreonineCombined sources1
Modified residuei276PhosphotyrosineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80UG5
PeptideAtlasiQ80UG5
PRIDEiQ80UG5

PTM databases

iPTMnetiQ80UG5
PhosphoSitePlusiQ80UG5

Expressioni

Tissue specificityi

Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain.2 Publications

Developmental stagei

At 8 dpc mainly expressed in the lateral plate mesoderm and the somites. Beginning at 9 dpc the lateral plate expression is clearly focused in the developing fore- and hindlimb buds. In the cephalic region, expressed in the first and second branchial arch, in the nasal process and around the otic pit. At 9.5 dpc strongest expression is observed in the mesenchyme of the branchial arches, the limbs, and the developing dorsal root ganglia. Weak to intermediate expression is found in the neural epithelium. Expression is seen in the newly formed somites in the tail bud of older embryos. During formation of the digits, expression seems to outline the surviving tissue bordering it towards the apoptotic webbing. Expression is seen in the developing outer ear and in several areas known to be regulated by intensive epithelial mesenchymal interactions, like the viscera follicles and the developing mammary glands.1 Publication

Gene expression databases

BgeeiENSMUSG00000059248
CleanExiMM_SEPT9
ExpressionAtlasiQ80UG5 baseline and differential
GenevisibleiQ80UG5 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207494, 40 interactors
IntActiQ80UG5, 41 interactors
STRINGi10090.ENSMUSP00000091435

Structurei

3D structure databases

ProteinModelPortaliQ80UG5
SMRiQ80UG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 565Septin-type GPROSITE-ProRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni303 – 310G1 motifPROSITE-ProRule annotation8
Regioni360 – 363G3 motifPROSITE-ProRule annotation4
Regioni442 – 445G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1547 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOVERGENiHBG098529
InParanoidiQ80UG5
KOiK16938
OMAiNIHFEAY
OrthoDBiEOG091G08V5
PhylomeDBiQ80UG5
TreeFamiTF101078

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030645 SEPT9
IPR016491 Septin
PANTHERiPTHR18884:SF47 PTHR18884:SF47, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80UG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSYSGVTR TSSGRLRRLA DPTGPALKRS FEVEEIEPPN STPPRRVQTP
60 70 80 90 100
LLRATVASSS QKFQDLGVKN SEPAARLVDS LSQRSPKPSL RRVELAGAKA
110 120 130 140 150
PEPMSRRTEI SIDISSKQVE STASAAGPSR FGLKRAEVLG HKTPEPVPRR
160 170 180 190 200
TEITIVKPQE SVLRRVETPA SKIPEGSAVP ATDAAPKRVE IQVPKPAEAP
210 220 230 240 250
NCPLPSQTLE NSEAPMSQLQ SRLEPRPSVA EVPYRNQEDS EVTPSCVGDM
260 270 280 290 300
ADNPRDAMLK QAPASRNEKA PMEFGYVGID SILEQMRRKA MKQGFEFNIM
310 320 330 340 350
VVGQSGLGKS TLINTLFKSK ISRKSVQPTS EERIPKTIEI KSITHDIEEK
360 370 380 390 400
GVRMKLTVID TPGFGDHINN ENCWQPIMKF INDQYEKYLQ EEVNINRKKR
410 420 430 440 450
IPDTRVHCCL YFIPATGHSL RPLDIEFMKR LSKVVNIVPV IAKADTLTLE
460 470 480 490 500
ERVYFKQRIT ADLLSNGIDV YPQKEFDEDA EDRLVNEKFR EMIPFAVVGS
510 520 530 540 550
DHEYQVNGKR ILGRKTKWGT IEVENTTHCE FAYLRDLLIR THMQNIKDIT
560 570 580
SNIHFEAYRV KRLNEGNSAM ANGIEKEPEA QEM
Length:583
Mass (Da):65,575
Last modified:June 1, 2003 - v1
Checksum:i174D2F1E8EA382FC
GO
Isoform 2 (identifier: Q80UG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.

Show »
Length:334
Mass (Da):38,599
Checksum:i42F7BED2F02F8846
GO
Isoform 3 (identifier: Q80UG5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGVTRTSSGRLRRLADPTGP → MSDPAVNAQLDGIISDFE

Show »
Length:576
Mass (Da):64,775
Checksum:i68E1AD335D980444
GO

Sequence cautioni

The sequence BAC65697 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123411 – 249Missing in isoform 2. 2 PublicationsAdd BLAST249
Alternative sequenceiVSP_0123421 – 25MKKSY…DPTGP → MSDPAVNAQLDGIISDFE in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250723 mRNA Translation: CAB59833.1
AF450142, AF450141 Genomic DNA Translation: AAL50685.1
AK031757 mRNA Translation: BAC27538.1
AK122415 mRNA Translation: BAC65697.2 Different initiation.
AK141312 mRNA Translation: BAE24646.1
AL603868, AL611935, AL645975 Genomic DNA Translation: CAM13312.1
AL645975, AL603868, AL611935 Genomic DNA Translation: CAM15613.1
AL611935, AL603868, AL645975 Genomic DNA Translation: CAM19703.1
BC046524 mRNA Translation: AAH46524.1
CCDSiCCDS25684.1 [Q80UG5-2]
CCDS48990.1 [Q80UG5-1]
CCDS48991.1 [Q80UG5-3]
RefSeqiNP_001106958.1, NM_001113486.1 [Q80UG5-1]
NP_001106959.1, NM_001113487.1 [Q80UG5-3]
NP_001106960.1, NM_001113488.1 [Q80UG5-2]
NP_059076.1, NM_017380.2 [Q80UG5-2]
XP_006533808.2, XM_006533745.3 [Q80UG5-2]
XP_006533809.1, XM_006533746.3 [Q80UG5-2]
UniGeneiMm.38450
Mm.451420

Genome annotation databases

EnsembliENSMUST00000019038; ENSMUSP00000019038; ENSMUSG00000059248 [Q80UG5-3]
ENSMUST00000093907; ENSMUSP00000091435; ENSMUSG00000059248 [Q80UG5-1]
ENSMUST00000100193; ENSMUSP00000097767; ENSMUSG00000059248 [Q80UG5-2]
ENSMUST00000106349; ENSMUSP00000101956; ENSMUSG00000059248 [Q80UG5-2]
GeneIDi53860
KEGGimmu:53860
UCSCiuc007mnd.2 mouse [Q80UG5-1]
uc007mne.2 mouse [Q80UG5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT9_MOUSE
AccessioniPrimary (citable) accession number: Q80UG5
Secondary accession number(s): A2A6U2
, A2A6U4, A2A6U6, Q3URP2, Q80TM7, Q9QYX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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