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Q80UG5

- SEPT9_MOUSE

UniProt

Q80UG5 - SEPT9_MOUSE

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Protein

Septin-9

Gene

Sept9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei337 – 3371GTPBy similarity
Binding sitei363 – 3631GTP; via amide nitrogenBy similarity
Binding sitei499 – 4991GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei514 – 5141GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi303 – 3108GTPBy similarity
Nucleotide bindingi443 – 4519GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein heterooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
SL3-3 integration site 1 protein
Gene namesi
Name:Sept9
Synonyms:Kiaa0991, Sint1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1858222. Sept9.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication
Note: In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes with actin stress fibers.

GO - Cellular componenti

  1. microtubule Source: Ensembl
  2. perinuclear region of cytoplasm Source: Ensembl
  3. stress fiber Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Septin-9PRO_0000173536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei30 – 301Phosphoserine1 Publication
Modified residuei42 – 421PhosphothreonineBy similarity
Modified residuei62 – 621N6-acetyllysine1 Publication
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei143 – 1431PhosphothreonineBy similarity
Modified residuei276 – 2761PhosphotyrosineBy similarity
Modified residuei325 – 3251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ80UG5.
PaxDbiQ80UG5.
PRIDEiQ80UG5.

PTM databases

PhosphoSiteiQ80UG5.

Expressioni

Tissue specificityi

Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain.2 Publications

Developmental stagei

At 8 dpc mainly expressed in the lateral plate mesoderm and the somites. Beginning at 9 dpc the lateral plate expression is clearly focused in the developing fore- and hindlimb buds. In the cephalic region, expressed in the first and second branchial arch, in the nasal process and around the otic pit. At 9.5 dpc strongest expression is observed in the mesenchyme of the branchial arches, the limbs, and the developing dorsal root ganglia. Weak to intermediate expression is found in the neural epithelium. Expression is seen in the newly formed somites in the tail bud of older embryos. During formation of the digits, expression seems to outline the surviving tissue bordering it towards the apoptotic webbing. Expression is seen in the developing outer ear and in several areas known to be regulated by intensive epithelial mesenchymal interactions, like the viscera follicles and the developing mammary glands.1 Publication

Gene expression databases

BgeeiQ80UG5.
CleanExiMM_SEPT9.
ExpressionAtlasiQ80UG5. baseline and differential.
GenevestigatoriQ80UG5.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18 By similarity.By similarity

Protein-protein interaction databases

BioGridi207494. 1 interaction.
IntActiQ80UG5. 2 interactions.
MINTiMINT-1866943.

Structurei

3D structure databases

ProteinModelPortaliQ80UG5.
SMRiQ80UG5. Positions 295-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini293 – 565273Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5019.
GeneTreeiENSGT00760000118899.
HOVERGENiHBG098529.
InParanoidiQ80UG5.
KOiK16938.
OMAiNIHFEAY.
OrthoDBiEOG7KWSJ5.
PhylomeDBiQ80UG5.
TreeFamiTF101078.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80UG5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSYSGVTR TSSGRLRRLA DPTGPALKRS FEVEEIEPPN STPPRRVQTP
60 70 80 90 100
LLRATVASSS QKFQDLGVKN SEPAARLVDS LSQRSPKPSL RRVELAGAKA
110 120 130 140 150
PEPMSRRTEI SIDISSKQVE STASAAGPSR FGLKRAEVLG HKTPEPVPRR
160 170 180 190 200
TEITIVKPQE SVLRRVETPA SKIPEGSAVP ATDAAPKRVE IQVPKPAEAP
210 220 230 240 250
NCPLPSQTLE NSEAPMSQLQ SRLEPRPSVA EVPYRNQEDS EVTPSCVGDM
260 270 280 290 300
ADNPRDAMLK QAPASRNEKA PMEFGYVGID SILEQMRRKA MKQGFEFNIM
310 320 330 340 350
VVGQSGLGKS TLINTLFKSK ISRKSVQPTS EERIPKTIEI KSITHDIEEK
360 370 380 390 400
GVRMKLTVID TPGFGDHINN ENCWQPIMKF INDQYEKYLQ EEVNINRKKR
410 420 430 440 450
IPDTRVHCCL YFIPATGHSL RPLDIEFMKR LSKVVNIVPV IAKADTLTLE
460 470 480 490 500
ERVYFKQRIT ADLLSNGIDV YPQKEFDEDA EDRLVNEKFR EMIPFAVVGS
510 520 530 540 550
DHEYQVNGKR ILGRKTKWGT IEVENTTHCE FAYLRDLLIR THMQNIKDIT
560 570 580
SNIHFEAYRV KRLNEGNSAM ANGIEKEPEA QEM
Length:583
Mass (Da):65,575
Last modified:June 1, 2003 - v1
Checksum:i174D2F1E8EA382FC
GO
Isoform 2 (identifier: Q80UG5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.

Show »
Length:334
Mass (Da):38,599
Checksum:i42F7BED2F02F8846
GO
Isoform 3 (identifier: Q80UG5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGVTRTSSGRLRRLADPTGP → MSDPAVNAQLDGIISDFE

Show »
Length:576
Mass (Da):64,775
Checksum:i68E1AD335D980444
GO

Sequence cautioni

The sequence BAC65697.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 249249Missing in isoform 2. 2 PublicationsVSP_012341Add
BLAST
Alternative sequencei1 – 2525MKKSY…DPTGP → MSDPAVNAQLDGIISDFE in isoform 3. 1 PublicationVSP_012342Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250723 mRNA. Translation: CAB59833.1.
AF450142, AF450141 Genomic DNA. Translation: AAL50685.1.
AK031757 mRNA. Translation: BAC27538.1.
AK122415 mRNA. Translation: BAC65697.2. Different initiation.
AK141312 mRNA. Translation: BAE24646.1.
AL603868, AL611935, AL645975 Genomic DNA. Translation: CAM13312.1.
AL645975, AL603868, AL611935 Genomic DNA. Translation: CAM15613.1.
AL611935, AL603868, AL645975 Genomic DNA. Translation: CAM19703.1.
BC046524 mRNA. Translation: AAH46524.1.
CCDSiCCDS25684.1. [Q80UG5-2]
CCDS48990.1. [Q80UG5-1]
CCDS48991.1. [Q80UG5-3]
RefSeqiNP_001106958.1. NM_001113486.1. [Q80UG5-1]
NP_001106959.1. NM_001113487.1. [Q80UG5-3]
NP_001106960.1. NM_001113488.1. [Q80UG5-2]
NP_059076.1. NM_017380.2. [Q80UG5-2]
XP_006533809.1. XM_006533746.1. [Q80UG5-2]
UniGeneiMm.38450.
Mm.451420.

Genome annotation databases

EnsembliENSMUST00000019038; ENSMUSP00000019038; ENSMUSG00000059248. [Q80UG5-3]
ENSMUST00000093907; ENSMUSP00000091435; ENSMUSG00000059248. [Q80UG5-1]
ENSMUST00000100193; ENSMUSP00000097767; ENSMUSG00000059248. [Q80UG5-2]
ENSMUST00000106349; ENSMUSP00000101956; ENSMUSG00000059248. [Q80UG5-2]
GeneIDi53860.
KEGGimmu:53860.
UCSCiuc007mnd.2. mouse. [Q80UG5-1]
uc007mne.2. mouse. [Q80UG5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250723 mRNA. Translation: CAB59833.1 .
AF450142 , AF450141 Genomic DNA. Translation: AAL50685.1 .
AK031757 mRNA. Translation: BAC27538.1 .
AK122415 mRNA. Translation: BAC65697.2 . Different initiation.
AK141312 mRNA. Translation: BAE24646.1 .
AL603868 , AL611935 , AL645975 Genomic DNA. Translation: CAM13312.1 .
AL645975 , AL603868 , AL611935 Genomic DNA. Translation: CAM15613.1 .
AL611935 , AL603868 , AL645975 Genomic DNA. Translation: CAM19703.1 .
BC046524 mRNA. Translation: AAH46524.1 .
CCDSi CCDS25684.1. [Q80UG5-2 ]
CCDS48990.1. [Q80UG5-1 ]
CCDS48991.1. [Q80UG5-3 ]
RefSeqi NP_001106958.1. NM_001113486.1. [Q80UG5-1 ]
NP_001106959.1. NM_001113487.1. [Q80UG5-3 ]
NP_001106960.1. NM_001113488.1. [Q80UG5-2 ]
NP_059076.1. NM_017380.2. [Q80UG5-2 ]
XP_006533809.1. XM_006533746.1. [Q80UG5-2 ]
UniGenei Mm.38450.
Mm.451420.

3D structure databases

ProteinModelPortali Q80UG5.
SMRi Q80UG5. Positions 295-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207494. 1 interaction.
IntActi Q80UG5. 2 interactions.
MINTi MINT-1866943.

PTM databases

PhosphoSitei Q80UG5.

Proteomic databases

MaxQBi Q80UG5.
PaxDbi Q80UG5.
PRIDEi Q80UG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019038 ; ENSMUSP00000019038 ; ENSMUSG00000059248 . [Q80UG5-3 ]
ENSMUST00000093907 ; ENSMUSP00000091435 ; ENSMUSG00000059248 . [Q80UG5-1 ]
ENSMUST00000100193 ; ENSMUSP00000097767 ; ENSMUSG00000059248 . [Q80UG5-2 ]
ENSMUST00000106349 ; ENSMUSP00000101956 ; ENSMUSG00000059248 . [Q80UG5-2 ]
GeneIDi 53860.
KEGGi mmu:53860.
UCSCi uc007mnd.2. mouse. [Q80UG5-1 ]
uc007mne.2. mouse. [Q80UG5-3 ]

Organism-specific databases

CTDi 10801.
MGIi MGI:1858222. Sept9.
Rougei Search...

Phylogenomic databases

eggNOGi COG5019.
GeneTreei ENSGT00760000118899.
HOVERGENi HBG098529.
InParanoidi Q80UG5.
KOi K16938.
OMAi NIHFEAY.
OrthoDBi EOG7KWSJ5.
PhylomeDBi Q80UG5.
TreeFami TF101078.

Miscellaneous databases

ChiTaRSi SEPT9. mouse.
NextBioi 310701.
PROi Q80UG5.
SOURCEi Search...

Gene expression databases

Bgeei Q80UG5.
CleanExi MM_SEPT9.
ExpressionAtlasi Q80UG5. baseline and differential.
Genevestigatori Q80UG5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family."
    Soerensen A.B., Lund A.H., Ethelberg S., Copeland N.G., Jenkins N.A., Pedersen F.S.
    J. Virol. 74:2161-2168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Alternative splicing, expression, and gene structure of the septin-like putative proto-oncogene Sint1."
    Soerensen A.B., Warming S., Fuechtbauer E.-M., Pedersen F.S.
    Gene 285:79-89(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryonic tail.
  4. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Head.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: 129.
    Tissue: Mammary gland.
  8. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 548-559, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  9. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
    Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
    Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSEPT9_MOUSE
AccessioniPrimary (citable) accession number: Q80UG5
Secondary accession number(s): A2A6U2
, A2A6U4, A2A6U6, Q3URP2, Q80TM7, Q9QYX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Targeted by proviral insertion in T-cell lymphomas induced by the murine retrovirus SL3-3 MuLV.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3