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Protein

Plexin-A4

Gene

Plxna4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

GO - Molecular functioni

  • semaphorin receptor activity Source: MGI

GO - Biological processi

  • anterior commissure morphogenesis Source: MGI
  • axon guidance Source: MGI
  • branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
  • chemorepulsion of branchiomotor axon Source: MGI
  • cranial nerve morphogenesis Source: MGI
  • facial nerve morphogenesis Source: MGI
  • facial nerve structural organization Source: ParkinsonsUK-UCL
  • glossopharyngeal nerve morphogenesis Source: MGI
  • motor neuron axon guidance Source: ParkinsonsUK-UCL
  • nervous system development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • postganglionic parasympathetic fiber development Source: MGI
  • regulation of axon extension involved in axon guidance Source: MGI
  • regulation of cell migration Source: GO_Central
  • regulation of negative chemotaxis Source: MGI
  • semaphorin-plexin signaling pathway Source: MGI
  • semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • sympathetic nervous system development Source: MGI
  • trigeminal nerve morphogenesis Source: MGI
  • trigeminal nerve structural organization Source: ParkinsonsUK-UCL
  • vagus nerve morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-399956. CRMPs in Sema3A signaling.
R-MMU-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A4
Gene namesi
Name:Plxna4
Synonyms:Kiaa1550
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2179061. Plxna4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 12361213ExtracellularSequence analysisAdd
BLAST
Transmembranei1237 – 125721HelicalSequence analysisAdd
BLAST
Topological domaini1258 – 1893636CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
  • semaphorin receptor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 18931870Plexin-A4PRO_0000240284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi129 ↔ 137PROSITE-ProRule annotation
Disulfide bondi283 ↔ 404PROSITE-ProRule annotation
Disulfide bondi299 ↔ 355PROSITE-ProRule annotation
Disulfide bondi373 ↔ 392PROSITE-ProRule annotation
Disulfide bondi509 ↔ 526PROSITE-ProRule annotation
Disulfide bondi515 ↔ 557PROSITE-ProRule annotation
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi592 ↔ 611PROSITE-ProRule annotation
Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence analysis
Glycosylationi1006 – 10061N-linked (GlcNAc...)Sequence analysis
Glycosylationi1131 – 11311N-linked (GlcNAc...)Sequence analysis
Glycosylationi1179 – 11791N-linked (GlcNAc...)Sequence analysis
Modified residuei1349 – 13491N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80UG2.
PaxDbiQ80UG2.
PRIDEiQ80UG2.

PTM databases

iPTMnetiQ80UG2.
PhosphoSiteiQ80UG2.

Expressioni

Tissue specificityi

Expressed in the developing nervous system. Widely expressed in both the central and peripheral nervous systems. Expressed in the peripheral ganglia, somatosensory, olfactory, visual, auditory and equilibrium systems.1 Publication

Gene expression databases

BgeeiENSMUSG00000029765.
CleanExiMM_PLXNA4.
GenevisibleiQ80UG2. MM.

Interactioni

Subunit structurei

Interacts with NRP1 and NRP2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sema6aO354643EBI-8057809,EBI-8057848

Protein-protein interaction databases

IntActiQ80UG2. 1 interaction.
MINTiMINT-7996686.
STRINGi10090.ENSMUSP00000110748.

Structurei

3D structure databases

ProteinModelPortaliQ80UG2.
SMRiQ80UG2. Positions 1272-1889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 506483SemaPROSITE-ProRule annotationAdd
BLAST
Domaini508 – 55851PSI 1Add
BLAST
Domaini654 – 70148PSI 2Add
BLAST
Domaini802 – 85554PSI 3Add
BLAST
Domaini857 – 95195IPT/TIG 1Add
BLAST
Domaini953 – 103684IPT/TIG 2Add
BLAST
Domaini1039 – 1138100IPT/TIG 3Add
BLAST
Domaini1141 – 122989IPT/TIG 4Add
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 3 PSI domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiQ80UG2.
KOiK06820.
OMAiNGHFNID.
OrthoDBiEOG091G00EK.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80UG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PQLSQKPSFV TFRGEPAEGF
60 70 80 90 100
NHLVVDERTG HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV
110 120 130 140 150
QTCNEPLAST NNVNKMLLID YKENRLIACG SLYQGICKLL RLEDLFKLGE
160 170 180 190 200
PFHKKEHYLS GVNESGSVFG VIVSYSNFDD KLFIATAVDG KPEYFPTISS
210 220 230 240 250
RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD IYYVYGFSSG
260 270 280 290 300
NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE
310 320 330 340 350
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD
360 370 380 390 400
ESALCIFILK QINDRIKDRL QSCYRGEGTL DLAWLKVKDI PCSSALLTID
410 420 430 440 450
DNFCGLDMNA PLGVSEMVRG IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK
460 470 480 490 500
SGKLKKIRVD GPKGNALQYE TVQVVDSGPV LRDMAFSKDH EQLYIMSERQ
510 520 530 540 550
LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER CERSREPRRF
560 570 580 590 600
ASEMKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM
610 620 630 640 650
DGLVIGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF
660 670 680 690 700
VFYNCSVHNS CLSCVESPYR CHWCKYRHVC THDPNTCSFQ EGRVKLPEDC
710 720 730 740 750
PQLLRVDKIL VPVEVIKPIT LKAKNLPQPQ SGQRGYECIL NIQGIEQRVP
760 770 780 790 800
ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL TVVWNGHFNI DNPAQNKVYL
810 820 830 840 850
YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH ESRWLELSGA
860 870 880 890 900
NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC
910 920 930 940 950
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF
960 970 980 990 1000
MTLTLADLKP NRGPMSGGTQ VTITGTNLNA GSNVVVMFGS QPCLFHRRSP
1010 1020 1030 1040 1050
SYIICNTTSS EEVLDMKVTV QVDRARIRQD LVFQYVEDPT IVRIEPEWSI
1060 1070 1080 1090 1100
VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE HINICEVLNA TEMTCQAPAL
1110 1120 1130 1140 1150
ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN PVFEAFSPSG
1160 1170 1180 1190 1200
ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC
1210 1220 1230 1240 1250
ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII
1260 1270 1280 1290 1300
FIVAVLIAYK RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH
1310 1320 1330 1340 1350
ELTSDLDGAG IPFLDYRTYT MRVLFPGIED HPVLRDLEVP GYRQERVEKG
1360 1370 1380 1390 1400
LKLFAQLINN KVFLLSFIRT LESQRSFSMR DRGNVASLIM TVLQSKLEYA
1410 1420 1430 1440 1450
TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLYKFLK
1460 1470 1480 1490 1500
ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV
1510 1520 1530 1540 1550
LSCVSPDNVN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM
1560 1570 1580 1590 1600
DLEWRQGSGA RMILQDEDIT TKIENDWKRL NTVAHYQVPD GSVVALVSKQ
1610 1620 1630 1640 1650
VTAYNAVNNS TVSRTSASKY ENMIRYTGSP DSLRSRTPMI TPDLESGVKL
1660 1670 1680 1690 1700
WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL LATKGTLQKF VDDLFETIFS
1710 1720 1730 1740 1750
TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN CLPLRFWVNM
1760 1770 1780 1790 1800
IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA
1810 1820 1830 1840 1850
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS
1860 1870 1880 1890
EIFSYVGKYS EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS
Length:1,893
Mass (Da):212,560
Last modified:July 27, 2011 - v3
Checksum:iC785B0D895AD8DB7
GO

Sequence cautioni

The sequence BAC56599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti683 – 6842DP → GR in BAC56599 (PubMed:12591607).Curated
Sequence conflicti1607 – 16071V → E in BAC34692 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073228 mRNA. Translation: BAC56599.1. Different initiation.
AC153629 Genomic DNA. No translation available.
AC153867 Genomic DNA. No translation available.
AC158678 Genomic DNA. No translation available.
AK051614 mRNA. Translation: BAC34692.1.
AK220402 mRNA. Translation: BAD90257.1.
CCDSiCCDS19985.2.
RefSeqiNP_786926.2. NM_175750.3.
UniGeneiMm.444029.

Genome annotation databases

EnsembliENSMUST00000115096; ENSMUSP00000110748; ENSMUSG00000029765.
GeneIDi243743.
KEGGimmu:243743.
UCSCiuc009bgm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073228 mRNA. Translation: BAC56599.1. Different initiation.
AC153629 Genomic DNA. No translation available.
AC153867 Genomic DNA. No translation available.
AC158678 Genomic DNA. No translation available.
AK051614 mRNA. Translation: BAC34692.1.
AK220402 mRNA. Translation: BAD90257.1.
CCDSiCCDS19985.2.
RefSeqiNP_786926.2. NM_175750.3.
UniGeneiMm.444029.

3D structure databases

ProteinModelPortaliQ80UG2.
SMRiQ80UG2. Positions 1272-1889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80UG2. 1 interaction.
MINTiMINT-7996686.
STRINGi10090.ENSMUSP00000110748.

PTM databases

iPTMnetiQ80UG2.
PhosphoSiteiQ80UG2.

Proteomic databases

MaxQBiQ80UG2.
PaxDbiQ80UG2.
PRIDEiQ80UG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115096; ENSMUSP00000110748; ENSMUSG00000029765.
GeneIDi243743.
KEGGimmu:243743.
UCSCiuc009bgm.3. mouse.

Organism-specific databases

CTDi91584.
MGIiMGI:2179061. Plxna4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiQ80UG2.
KOiK06820.
OMAiNGHFNID.
OrthoDBiEOG091G00EK.
TreeFamiTF312962.

Enzyme and pathway databases

ReactomeiR-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-399956. CRMPs in Sema3A signaling.
R-MMU-416700. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSiPlxna4. mouse.
PROiQ80UG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029765.
CleanExiMM_PLXNA4.
GenevisibleiQ80UG2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA4_MOUSE
AccessioniPrimary (citable) accession number: Q80UG2
Secondary accession number(s): E9QN64, Q5DTW8, Q8BKK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.